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oncogenes
... these receptors constitute an important class of protooncogenes. Examples include erb B, erb B-2, fms, kit, met, ret, ros, and trk. Mutation or abnormal expression of growth factor receptors can convert them into oncogenes.54 For example, deletion of the ligand-binding domain of erb B (the epidermal ...
... these receptors constitute an important class of protooncogenes. Examples include erb B, erb B-2, fms, kit, met, ret, ros, and trk. Mutation or abnormal expression of growth factor receptors can convert them into oncogenes.54 For example, deletion of the ligand-binding domain of erb B (the epidermal ...
Nucleoside Phosphoramidate Monoesters: Potential
... • RNA Pol II can not initiate transcription by itself ...
... • RNA Pol II can not initiate transcription by itself ...
Poster - Protein Information Resource
... Correct protein annotation relies on both global (whole protein) and local (domain and motif) sequence similarities. We have developed a method by which annotation of site-specific features can be confidently propagated from experimentallycharacterized proteins to uncharacterized proteins. The metho ...
... Correct protein annotation relies on both global (whole protein) and local (domain and motif) sequence similarities. We have developed a method by which annotation of site-specific features can be confidently propagated from experimentallycharacterized proteins to uncharacterized proteins. The metho ...
A Novel Role of Annexin A2 in Human Type I Collagen Gene
... spectrometry of the CME-binding protein complex revealed involvement of nuclear annexin A2 (AnxA2) which was increased in SV40transformed cells. Further EMSA analysis demonstrated that AnxA2 did not directly bind to the DNA but stabilised the complex and led to an increase in protein binding to the ...
... spectrometry of the CME-binding protein complex revealed involvement of nuclear annexin A2 (AnxA2) which was increased in SV40transformed cells. Further EMSA analysis demonstrated that AnxA2 did not directly bind to the DNA but stabilised the complex and led to an increase in protein binding to the ...
A mutation in the Zn-finger of the GAL4 homolog
... four possible combinations of two LAC9 gene copies as outlined in Figure 5A. The Southern blot (Figure 5B) shows that not more than one plasmid copy had been integrated since the intensity of the HindUl fragment of 2.7 kb and 3.1 kb resulting from plasmid and flanking sequences, respectively, were a ...
... four possible combinations of two LAC9 gene copies as outlined in Figure 5A. The Southern blot (Figure 5B) shows that not more than one plasmid copy had been integrated since the intensity of the HindUl fragment of 2.7 kb and 3.1 kb resulting from plasmid and flanking sequences, respectively, were a ...
The RNA polymerase factory: a robotic in vitro assembly platform for
... expression vectors. The full-length open reading frames are shown with the codon-optimized sequences in light blue. The position of the sequences encoding key functional RNAP domains are shown in color (Zipper, Lid, Rudder, Switch-2 in red, Bridge Helix in dark green and Fork Loops in blue). The num ...
... expression vectors. The full-length open reading frames are shown with the codon-optimized sequences in light blue. The position of the sequences encoding key functional RNAP domains are shown in color (Zipper, Lid, Rudder, Switch-2 in red, Bridge Helix in dark green and Fork Loops in blue). The num ...
High-resolution dynamics of the transcriptional response to nutrition
... 45). Furthermore, the links between nutrient-sensing systems and regulation of oxidative phosphorylation genes are unclear, and disease-associated decreases are small, in the range of 20%, requiring sensitive methods of detecting global transcriptional changes. To understand how genes and gene netwo ...
... 45). Furthermore, the links between nutrient-sensing systems and regulation of oxidative phosphorylation genes are unclear, and disease-associated decreases are small, in the range of 20%, requiring sensitive methods of detecting global transcriptional changes. To understand how genes and gene netwo ...
Expression and Purification of Toxoplasma gondii Cell Cycle
... CYC2 genes there is a cyclin box fold present, thus indicating that they may carry out a ...
... CYC2 genes there is a cyclin box fold present, thus indicating that they may carry out a ...
Figure: Treatment with TNFa increases expression
... Making a CASE for Your Favorite Pathway Understanding cellular signal transduction is essential for characterizing human diseases and for developing effective therapies. The Pathway Focused DNA Microarrays from SuperArray, known as the GEArrays, have been widely used for analyzing gene expression as ...
... Making a CASE for Your Favorite Pathway Understanding cellular signal transduction is essential for characterizing human diseases and for developing effective therapies. The Pathway Focused DNA Microarrays from SuperArray, known as the GEArrays, have been widely used for analyzing gene expression as ...
pdf version
... The concept of quorum sensing (QS) originated with studies in Vibrio fischeri (formerly known as Photobacterium fischeri), which has two lifestyle modes: first, it grows in the sea to a low population density and does not luminesce; second, it forms symbiotic associations with fish and squid species ...
... The concept of quorum sensing (QS) originated with studies in Vibrio fischeri (formerly known as Photobacterium fischeri), which has two lifestyle modes: first, it grows in the sea to a low population density and does not luminesce; second, it forms symbiotic associations with fish and squid species ...
Full text in pdf - International Microbiology
... including high radiation doses, and is also amenable to a whole suite of genetic manipulations. A more sophisticated—and surely promising—approach to augment the presence of biodegradative genes in a community is promoting the dissemination of DNA encoding the products of interest among indigenous p ...
... including high radiation doses, and is also amenable to a whole suite of genetic manipulations. A more sophisticated—and surely promising—approach to augment the presence of biodegradative genes in a community is promoting the dissemination of DNA encoding the products of interest among indigenous p ...
Prokaryotic Gene Expression (Learning Objectives)
... - Structural genes transcribed as one long mRNA molecule (polycistronic mRNA) - Promoter region-RNA polymerase binding - Operator region “on-off switch” between the promotor and the first gene - Regulatory gene coding for a specific allosteric repressor protein ...
... - Structural genes transcribed as one long mRNA molecule (polycistronic mRNA) - Promoter region-RNA polymerase binding - Operator region “on-off switch” between the promotor and the first gene - Regulatory gene coding for a specific allosteric repressor protein ...
DNA Replication/Transcription/RNA Splicing
... Sites of Ongoing Transcription The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA production and RNA polymerase II seem to be localized into discrete foci or ...
... Sites of Ongoing Transcription The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA production and RNA polymerase II seem to be localized into discrete foci or ...
PDF - The Journal of Immunology
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
What is bioinformatics? A proposed definition and overview of the field
... distinction between coding regions and non-coding regions –‘junk’ repetitive sequences making up the bulk of base sequences especially in eukaryotes. Within the coding regions, genes are annotated with their translated protein sequence, and often with their cellular function. ...
... distinction between coding regions and non-coding regions –‘junk’ repetitive sequences making up the bulk of base sequences especially in eukaryotes. Within the coding regions, genes are annotated with their translated protein sequence, and often with their cellular function. ...
Phosphorylase Kinase
... dephosphorylated states this is in turn dependent on the relative activities of protein kinases and protein phosphatase about 1/3 of all mammalian proteins have covalently-bound phosphates which may impact on some aspect of their regulation there are about 1,000 different protein kinases encod ...
... dephosphorylated states this is in turn dependent on the relative activities of protein kinases and protein phosphatase about 1/3 of all mammalian proteins have covalently-bound phosphates which may impact on some aspect of their regulation there are about 1,000 different protein kinases encod ...
Gene Regulation Topic Guide
... 15. What is the function of the operon? 16. What is the function of the repressor? 17. Why is this called positive control? 18. What happens to the lac operon when lactose is present? (be specific) 19. What happens to the lac operon when lactose is absent? (be specific) 20. OK, now on to the trp ope ...
... 15. What is the function of the operon? 16. What is the function of the repressor? 17. Why is this called positive control? 18. What happens to the lac operon when lactose is present? (be specific) 19. What happens to the lac operon when lactose is absent? (be specific) 20. OK, now on to the trp ope ...
Gene Regulation - Blanche Ely High School
... have the ability to respond to many different stimuli Single gene is regulated in different ways in different cell types Although transcriptional-level control is important, control at other levels of gene expression is also important ...
... have the ability to respond to many different stimuli Single gene is regulated in different ways in different cell types Although transcriptional-level control is important, control at other levels of gene expression is also important ...
ELUCIDATION OF A PERIBACTEROID MEMBRANE
... relatively even keel, and those that have helped in both. My thanks go to my supervisors Brent Kaiser and Steve Tyerman, who took me on nearly four years ago now and hopefully they haven’t regretted it. Brent in particular has helped me when results were looking grim having the knack of turning a se ...
... relatively even keel, and those that have helped in both. My thanks go to my supervisors Brent Kaiser and Steve Tyerman, who took me on nearly four years ago now and hopefully they haven’t regretted it. Brent in particular has helped me when results were looking grim having the knack of turning a se ...
fibulins: a versatile family of extracellular matrix proteins
... chicken12 and Drosophila melanogaster — these variants are somewhat larger than their mammalian counterparts and have a lower sequence similarity. This indicates that fibulin-1 is ancient in origin and that there has been a distinct modulation of its function during evolution. Modular protein struct ...
... chicken12 and Drosophila melanogaster — these variants are somewhat larger than their mammalian counterparts and have a lower sequence similarity. This indicates that fibulin-1 is ancient in origin and that there has been a distinct modulation of its function during evolution. Modular protein struct ...
Pepsin-Mediated Processing of the Cytoplasmic Histone H2A to
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
... The intestinal epithelium forms a first line of innate host defense by secretion of proteins with antimicrobial activity against microbial infection. Despite the extensive studies on the antimicrobial host defense in many gastrointestinal tracts, little is known about the antimicrobial defense syste ...
Gene Regulation = Control of Gene Expression Dr. A. Abouelmagd
... An inducible operon is one that is usually off; a molecule called an inducer inactivates the repressor and turns on transcription The classic example of an inducible operon is the lac operon, which contains genes coding for enzymes in hydrolysis and metabolism of lactose A repressible operon is one ...
... An inducible operon is one that is usually off; a molecule called an inducer inactivates the repressor and turns on transcription The classic example of an inducible operon is the lac operon, which contains genes coding for enzymes in hydrolysis and metabolism of lactose A repressible operon is one ...
Role of Template Activating Factor-I as a
... cell lines and mouse embryonic stem cells (Meshorer et al., 2006; Yellajoshyula and Brown, 2006). In such histone H1 dynamics, covalent modifications such as phosphorylation, acetylation and methylation of both N- and C-terminal tails of histone H1 are crucial as epigenetic molecular signatures (Tro ...
... cell lines and mouse embryonic stem cells (Meshorer et al., 2006; Yellajoshyula and Brown, 2006). In such histone H1 dynamics, covalent modifications such as phosphorylation, acetylation and methylation of both N- and C-terminal tails of histone H1 are crucial as epigenetic molecular signatures (Tro ...
supplementary text
... Another parameter related to protein function is the pI (isoelectric point), which for TdT-long isoform is 0.5 units higher than TdT-short isoform. This is due to the presence of five charged amino acid residues in Loop3, which may indirectly affect the temperature dependence of chemical equilibrium ...
... Another parameter related to protein function is the pI (isoelectric point), which for TdT-long isoform is 0.5 units higher than TdT-short isoform. This is due to the presence of five charged amino acid residues in Loop3, which may indirectly affect the temperature dependence of chemical equilibrium ...
Molecular basis of differential gene expression in the mouse
... made by the embryonic genome. Approximately 70-90% of the polyadenylated RNA in unfertilized eggs is lost between fertilization and the late 2-cell stage, although there is little, if any, difference in total RNA content (Piko and Clegg, 1982; Hamatani et al., 2004). This indicates that much of the ...
... made by the embryonic genome. Approximately 70-90% of the polyadenylated RNA in unfertilized eggs is lost between fertilization and the late 2-cell stage, although there is little, if any, difference in total RNA content (Piko and Clegg, 1982; Hamatani et al., 2004). This indicates that much of the ...
Histone acetylation and deacetylation
![](https://commons.wikimedia.org/wiki/Special:FilePath/Nucleosome_1KX5_colour_coded.png?width=300)
Histone acetylation and deacetylation are the processes by which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with ""histone acetyltransferase"" (HAT) or ""histone deacetylase"" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, Acetyl-Coenzyme A) to another. Deacetylation is simply the reverse reaction where an acetyl group is removed from a molecule.Acetylated histones, octameric proteins that organize chromatin into nucleosomes and ultimately higher order structures, represent a type of epigenetic marker within chromatin. Acetylation removes the positive charge on the histones, thereby decreasing the interaction of the N termini of histones with the negatively charged phosphate groups of DNA. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. This relaxation can be reversed by HDAC activity. Relaxed, transcriptionally active DNA is referred to as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation can be brought about by processes including deacetylation and methylation; the action of methylation is indirect and has no effect upon charge.