![Slide 1](http://s1.studyres.com/store/data/008278378_1-5a06eb5a76e756f7ff4bf7ceaf195869-300x300.png)
Slide 1
... Transcription factors can inhibit or encourage the binding of the RNA Polymerase. And, through signal transduction, environmental factors can influence the activity of these transcription factors. So cells can respond genetically to changes in their environment. ...
... Transcription factors can inhibit or encourage the binding of the RNA Polymerase. And, through signal transduction, environmental factors can influence the activity of these transcription factors. So cells can respond genetically to changes in their environment. ...
... An important question raised by the presence of such a large sigma factor repertoire is how the RNAPc is able to distinguish between different sigma factors to ensure proper gene regulation, especially when σECF are activated. The concentration of primary σ70 factor within the cell is known to remai ...
Epigenetic Regulation of Higher Order Chromatin
... expansion of epigenetic marks associated with diverse nuclear processes has made it necessary to define the word epigenome. The epigenome of each cell comprises of mitotically and sometimes even meiotically stable, yet reversible modifications of the DNA itself, the posttranslational modifications o ...
... expansion of epigenetic marks associated with diverse nuclear processes has made it necessary to define the word epigenome. The epigenome of each cell comprises of mitotically and sometimes even meiotically stable, yet reversible modifications of the DNA itself, the posttranslational modifications o ...
Regulation of hepatic metabolism by AMPK - HAL
... by phosphorylation of the carbohydrate response element binding protein (ChREBP), reducing its DNA binding capacity and nuclear translocation, and down-regulating sterol regulatory element-binding protein-1c (SREBP-1c) gene expression and stability probably through SIRT1-dependent deacetylation [1, ...
... by phosphorylation of the carbohydrate response element binding protein (ChREBP), reducing its DNA binding capacity and nuclear translocation, and down-regulating sterol regulatory element-binding protein-1c (SREBP-1c) gene expression and stability probably through SIRT1-dependent deacetylation [1, ...
Regulation of Gene expression
... - rapid and drastic changes in the nutrients - reversible control reactions needed ...
... - rapid and drastic changes in the nutrients - reversible control reactions needed ...
sv-lncs - Department of Computer Science and Engineering
... vector is the number of proteins available. Every protein has a unique id where the id is the index in the vector. Every protein also has a linked list of domains. This list contains all the domains this protein contains. The second data structure is similar to the first but instead of each protein ...
... vector is the number of proteins available. Every protein has a unique id where the id is the index in the vector. Every protein also has a linked list of domains. This list contains all the domains this protein contains. The second data structure is similar to the first but instead of each protein ...
The Escherichia coli mar Locus— Antibiotic Resistance and More
... The three-dimensional structures for both the E. coli MarA and Rob proteins in complex with their DNA substrates are now known (Fig. 4). These structural data directly support a wealth of genetic and biochemical evidence that first suggested the presence of the unique dual helix-turn-helix (HTH) DNA ...
... The three-dimensional structures for both the E. coli MarA and Rob proteins in complex with their DNA substrates are now known (Fig. 4). These structural data directly support a wealth of genetic and biochemical evidence that first suggested the presence of the unique dual helix-turn-helix (HTH) DNA ...
DNA binding
... A circuit based on repressor and Cro form a genetic switch from lysogenic state to lytic state The affinity of repressor bound to DNA is regulated through repressor cleavage by Rec A protein. Cro is a small protein that binds to the same sites as the repressor does, but with a different ord ...
... A circuit based on repressor and Cro form a genetic switch from lysogenic state to lytic state The affinity of repressor bound to DNA is regulated through repressor cleavage by Rec A protein. Cro is a small protein that binds to the same sites as the repressor does, but with a different ord ...
ppt - Chair of Computational Biology
... that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patterns is the best understood epigenetic cause of disease. I ...
... that bind to unmethylated CpGs and initiate gene transcription. In contrast, methylated CpGs are generally associated with silent DNA, can block methylation-sensitive proteins and can be easily mutated. The loss of normal DNA methylation patterns is the best understood epigenetic cause of disease. I ...
The Guanine Nucleotide–Binding Switch in Three Dimensions
... Because affinity studies showed the -phosphate–P loop interaction to be the most important element for tight binding of nucleotide, structural disturbance of the P loop is most likely the major reason for the drastically decreased affinity. In all the presently known complex structures besides RanR ...
... Because affinity studies showed the -phosphate–P loop interaction to be the most important element for tight binding of nucleotide, structural disturbance of the P loop is most likely the major reason for the drastically decreased affinity. In all the presently known complex structures besides RanR ...
Effect of Flik mutation on the transcriptional activity
... • Helicobacter pylori is a bacterium that may cause a variety of gastrointestinal disorders • The FliK protein plays an important role in H. pylori motility • Microarrays constructed and confirmed with Comparative genomic hybridization • Results indicate that mutations in FliK affect transcription • ...
... • Helicobacter pylori is a bacterium that may cause a variety of gastrointestinal disorders • The FliK protein plays an important role in H. pylori motility • Microarrays constructed and confirmed with Comparative genomic hybridization • Results indicate that mutations in FliK affect transcription • ...
SuccFind: a novel succinylation sites online
... 3 Results and discussion Based on the succinylation data sets, we firstly generated the graphical sequence logo (P < 0.01; t-test) and detected a statistically significant differences in position-specific symbol compositions and biochemical environment (Fig. 1a, Supplementary Fig. S1). We then calcu ...
... 3 Results and discussion Based on the succinylation data sets, we firstly generated the graphical sequence logo (P < 0.01; t-test) and detected a statistically significant differences in position-specific symbol compositions and biochemical environment (Fig. 1a, Supplementary Fig. S1). We then calcu ...
p53
... – Some portions of certain chromosomes exist in a very condensed state that can be seen under light microscope. This is called heterochromatin and is distinguished from the less compact chromatin that is called euchromatin. ...
... – Some portions of certain chromosomes exist in a very condensed state that can be seen under light microscope. This is called heterochromatin and is distinguished from the less compact chromatin that is called euchromatin. ...
dependent phosphotransferase system – two highly similar glucose
... Previous sequence analysis of the glucose-specific PTS gene locus from Staphylococcus carnosus revealed the unexpected finding of two adjacent, highly similar ORFs, glcA and glcB, each encoding a glucose-specific membrane permease EIICBAGlc. glcA and glcB show 73 % identity at the nucleotide level a ...
... Previous sequence analysis of the glucose-specific PTS gene locus from Staphylococcus carnosus revealed the unexpected finding of two adjacent, highly similar ORFs, glcA and glcB, each encoding a glucose-specific membrane permease EIICBAGlc. glcA and glcB show 73 % identity at the nucleotide level a ...
Central Dogma of Genetics
... is removed by reversing synthesis reaction. – Enzyme moves back one or more nucleotides, cleaves RNA, then resumes synthesis in forward direction. ...
... is removed by reversing synthesis reaction. – Enzyme moves back one or more nucleotides, cleaves RNA, then resumes synthesis in forward direction. ...
Roles of Chromatin insulators in gene regulation and diseases
... responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of chromosomal structures. These elements are DNA-protein complexes which can mediate interactions within and between chromosomes. In doing so, th ...
... responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of chromosomal structures. These elements are DNA-protein complexes which can mediate interactions within and between chromosomes. In doing so, th ...
HydF as a scaffold protein in [FeFe] hydrogenase H
... gands. In addition to these ligands, the irons of the subcluster are bridged by a non-protein dithiolate linkage. While progress has been made in defining the role of specific gene products and identifying the precursors of the non-protein ligands in the [NiFe] hydrogenases [3] relatively little is kn ...
... gands. In addition to these ligands, the irons of the subcluster are bridged by a non-protein dithiolate linkage. While progress has been made in defining the role of specific gene products and identifying the precursors of the non-protein ligands in the [NiFe] hydrogenases [3] relatively little is kn ...
Analytical and Chromatography - Sigma
... syndromes: Werner and Bloom Syndromes. MRE11 complex is mutated in genetic instability syndromes: Nijmegen breakage syndrome and ataxia telangiectasia-like disorder. All three may be involved in the resolution of a stalled replication fork and in checkpoint signaling during S phase. DNA replication ...
... syndromes: Werner and Bloom Syndromes. MRE11 complex is mutated in genetic instability syndromes: Nijmegen breakage syndrome and ataxia telangiectasia-like disorder. All three may be involved in the resolution of a stalled replication fork and in checkpoint signaling during S phase. DNA replication ...
Cell Cycle - University of Bath
... architectural parameters that control cell cycle progression. These parameters include the intracellular levels of regulatory proteins, structural and informational integrity of the genome, as well as extracellular signals governing cell cycle progression. The integration of this regulatory input ca ...
... architectural parameters that control cell cycle progression. These parameters include the intracellular levels of regulatory proteins, structural and informational integrity of the genome, as well as extracellular signals governing cell cycle progression. The integration of this regulatory input ca ...
Alvin_20.385_Presentation
... Our understanding of simple protein-DNA interaction is limited (CRP7/Om7) Bases that do not contact CRP can have impact in binding affinity Possible to create orthogonal pathways with small number of mutations ...
... Our understanding of simple protein-DNA interaction is limited (CRP7/Om7) Bases that do not contact CRP can have impact in binding affinity Possible to create orthogonal pathways with small number of mutations ...
YEO_RNA_2006
... Center of Theoretical and Computational Biology 2Laboratory of Genetics The Salk Institute for Biological Studies, La Jolla, CA ...
... Center of Theoretical and Computational Biology 2Laboratory of Genetics The Salk Institute for Biological Studies, La Jolla, CA ...
The Kaposi`s sarcoma-associated herpesvirus ORF57 protein: a
... also involved in self-interaction [27]. Although they have not been functionally characterized, two putative zinc finger-like motifs occur in the C-terminal domain of ORF57 based on amino acid similarity [48]. Moreover, a hydrophobic GLFF domain, highly conserved in γ -herpesviruses also occurs in t ...
... also involved in self-interaction [27]. Although they have not been functionally characterized, two putative zinc finger-like motifs occur in the C-terminal domain of ORF57 based on amino acid similarity [48]. Moreover, a hydrophobic GLFF domain, highly conserved in γ -herpesviruses also occurs in t ...
Assembly and function of DNA double
... DNA damage arises continuously as the result of intracellular metabolism and upon the exposure of cells to a multitude of genotoxic agents [1,2]. If left unrepaired, such insults can be lifethreatening for cells and organisms as they alter the content and organization of the genetic material. To ove ...
... DNA damage arises continuously as the result of intracellular metabolism and upon the exposure of cells to a multitude of genotoxic agents [1,2]. If left unrepaired, such insults can be lifethreatening for cells and organisms as they alter the content and organization of the genetic material. To ove ...
Histone acetylation and deacetylation
![](https://commons.wikimedia.org/wiki/Special:FilePath/Nucleosome_1KX5_colour_coded.png?width=300)
Histone acetylation and deacetylation are the processes by which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with ""histone acetyltransferase"" (HAT) or ""histone deacetylase"" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, Acetyl-Coenzyme A) to another. Deacetylation is simply the reverse reaction where an acetyl group is removed from a molecule.Acetylated histones, octameric proteins that organize chromatin into nucleosomes and ultimately higher order structures, represent a type of epigenetic marker within chromatin. Acetylation removes the positive charge on the histones, thereby decreasing the interaction of the N termini of histones with the negatively charged phosphate groups of DNA. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. This relaxation can be reversed by HDAC activity. Relaxed, transcriptionally active DNA is referred to as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation can be brought about by processes including deacetylation and methylation; the action of methylation is indirect and has no effect upon charge.