Obesity — a genetic disease of adipose tissue?
... Although the rapid increase in the prevalence of obesity in many countries suggests that environmental factors (mainly overeating and physical inactivity) play the most important role in the development of overweight, it is very likely that genetic factors also contribute. It appears that one major ...
... Although the rapid increase in the prevalence of obesity in many countries suggests that environmental factors (mainly overeating and physical inactivity) play the most important role in the development of overweight, it is very likely that genetic factors also contribute. It appears that one major ...
Relationships between a new type IV secretion system and the icm
... of L. pneumophila to grow within or kill human macrophages or A. castellanii. The lvh genes are partially required for RSF1010 conjugation In previous reports, we showed that RSF1010-related plasmids can conjugate between two L. pneumophila strains, and conjugation was shown to be dependent on sever ...
... of L. pneumophila to grow within or kill human macrophages or A. castellanii. The lvh genes are partially required for RSF1010 conjugation In previous reports, we showed that RSF1010-related plasmids can conjugate between two L. pneumophila strains, and conjugation was shown to be dependent on sever ...
- Wiley Online Library
... induced under anaerobiosis and not under the control of the global nitrogen regulatory network that operates in B. subtilis and which governs the expression of genes encoding the assimilatory nitrate reductase (see below). More intensive and systematic studies have been undertaken over the past 3 ye ...
... induced under anaerobiosis and not under the control of the global nitrogen regulatory network that operates in B. subtilis and which governs the expression of genes encoding the assimilatory nitrate reductase (see below). More intensive and systematic studies have been undertaken over the past 3 ye ...
The wbbD gene of E. coli strain VW187
... subunits is thought to occur at the cytosolic face of the plasma membrane (Whitfield and Valvano, 1993). Four additional sugars are subsequently added to the GlcNAc-PP-Und intermediate to complete the formation of the O7 subunits. These reactions are catalyzed by specific glycosyltransferases, which ...
... subunits is thought to occur at the cytosolic face of the plasma membrane (Whitfield and Valvano, 1993). Four additional sugars are subsequently added to the GlcNAc-PP-Und intermediate to complete the formation of the O7 subunits. These reactions are catalyzed by specific glycosyltransferases, which ...
Case Report Section
... reported t(4;12) AML cases; seven were characterized as AML-M0 and four AML-M1. Previous reports suggest that less than 50% of cases achieve remission with intensive induction chemotherapy. Of the patients who do not achieve morphologic remission, none survived beyond six months (Hamaguchi et al., 1 ...
... reported t(4;12) AML cases; seven were characterized as AML-M0 and four AML-M1. Previous reports suggest that less than 50% of cases achieve remission with intensive induction chemotherapy. Of the patients who do not achieve morphologic remission, none survived beyond six months (Hamaguchi et al., 1 ...
PowerPoint Slides - Evo-Ed
... • Promoters: DNA sequences that bind RNA polymerase and transcription factors. Promoters initiate transcription (turn on genes) for production of mRNA; usually located upstream of the gene it controls. • Operators: regions of DNA associated with promoters that bind regulatory proteins to either prom ...
... • Promoters: DNA sequences that bind RNA polymerase and transcription factors. Promoters initiate transcription (turn on genes) for production of mRNA; usually located upstream of the gene it controls. • Operators: regions of DNA associated with promoters that bind regulatory proteins to either prom ...
Overexpression of Rice OSH Genes Induces Ectopic
... class 1 homeobox genes from rice: OSH1, OSH3, OSH6, OSH10, OSH15, OSH43, and OSH71 (Sentoku et al., 1999). When the homeobox gene OSH1 was overexpressed in transgenic rice plants under the control of the 35S promoter, unique phenotypic alterations in leaf structure, ligule displacement, and loss of ...
... class 1 homeobox genes from rice: OSH1, OSH3, OSH6, OSH10, OSH15, OSH43, and OSH71 (Sentoku et al., 1999). When the homeobox gene OSH1 was overexpressed in transgenic rice plants under the control of the 35S promoter, unique phenotypic alterations in leaf structure, ligule displacement, and loss of ...
Resistance genes in barley - Journal of Applied Genetics
... the quality of both spring and winter cultivars depend on seasonal conditions. Barley has recently been studied extensively in relation to the mapping of major resistance genes (R genes) and partial disease resistance genes as well as QTL linked to resistance reaction (CHEN et al. 1994, BACKES et al ...
... the quality of both spring and winter cultivars depend on seasonal conditions. Barley has recently been studied extensively in relation to the mapping of major resistance genes (R genes) and partial disease resistance genes as well as QTL linked to resistance reaction (CHEN et al. 1994, BACKES et al ...
Oakley
... morphological feature in the descendent. Yet, if the second eye duplicated by either of the mechanisms discussed above, then it develops through the same process as the first eye. In short, a new eye (one that was not present in its immediate ancestor) evolved and uses the same genes as an older eye ...
... morphological feature in the descendent. Yet, if the second eye duplicated by either of the mechanisms discussed above, then it develops through the same process as the first eye. In short, a new eye (one that was not present in its immediate ancestor) evolved and uses the same genes as an older eye ...
Fundamentals of Genetics Review
... that during gamete formation, the two parental alleles for a gene separate and go into different gametes ...
... that during gamete formation, the two parental alleles for a gene separate and go into different gametes ...
PDF
... Npc2, a small, secreted protein that binds cholesterol strongly, was first found as an abundant component of human epididymal fluid and later linked through human genetics to the inherited cause of NPC disease in about 5% of the families studied (Naureckiene et al., 2000). The crystal structure of N ...
... Npc2, a small, secreted protein that binds cholesterol strongly, was first found as an abundant component of human epididymal fluid and later linked through human genetics to the inherited cause of NPC disease in about 5% of the families studied (Naureckiene et al., 2000). The crystal structure of N ...
2q32 deletions and microdeletions FTNP
... members of each pair of chromosomes normally line up together and then break and rejoin to create new chromosomes. These new chromosomes contain different combinations of the genes passed down by the grandparents to the parents of the child. It is believed that after the chromosomes break, the rejoi ...
... members of each pair of chromosomes normally line up together and then break and rejoin to create new chromosomes. These new chromosomes contain different combinations of the genes passed down by the grandparents to the parents of the child. It is believed that after the chromosomes break, the rejoi ...
Lac Operon - Faculty Web Pages
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
Bacterial Gene Expression—Lac Operon
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
Tabby pattern genetics – a whole new breed of cat
... patterns? A genetic approach to this question began nearly a century ago when Phineas Whiting described three tabby ‘banding factors’, noting a simple pattern of inheritance for each: ticked is dominantly inherited relative to mackerel and blotched, whereas blotched is recessively inherited relative ...
... patterns? A genetic approach to this question began nearly a century ago when Phineas Whiting described three tabby ‘banding factors’, noting a simple pattern of inheritance for each: ticked is dominantly inherited relative to mackerel and blotched, whereas blotched is recessively inherited relative ...
The Topology of the Possible
... conditions under which a phenotypic innovation can, once generated, invade an existing population. The classical fields of inquiry concerned with selection are population genetics and ecology. The main variables are frequencies of genes or species representatives whose change is typically described ...
... conditions under which a phenotypic innovation can, once generated, invade an existing population. The classical fields of inquiry concerned with selection are population genetics and ecology. The main variables are frequencies of genes or species representatives whose change is typically described ...
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant
... pathway. As a note of caution, one should keep in mind that the phenotypic effect of genetic modifications of genetically altered animals in a nonhomogeneous genetic background are prone to epigenetic effects. However, we tried to minimize this risk by using double heterozygous animals throughout th ...
... pathway. As a note of caution, one should keep in mind that the phenotypic effect of genetic modifications of genetically altered animals in a nonhomogeneous genetic background are prone to epigenetic effects. However, we tried to minimize this risk by using double heterozygous animals throughout th ...
Williams syndrome deficits in visual spatial Chromosome 7q11.23
... in 11 typical WS cases. Further analysis was performed using 1008H17 (containing the genes for FZD9 and FKBP6 genes) in 11 cases. The results indicated that BAC 1008H17 generated intermediate signals in 8 cases. Preliminary analyses on a subset of these were referred to in Kimura et al., 2000.34 The ...
... in 11 typical WS cases. Further analysis was performed using 1008H17 (containing the genes for FZD9 and FKBP6 genes) in 11 cases. The results indicated that BAC 1008H17 generated intermediate signals in 8 cases. Preliminary analyses on a subset of these were referred to in Kimura et al., 2000.34 The ...
Synonymous codon usage patterns in different parasitic
... Most amino acids are encoded by multiple codons. In most cases, the synonymous codons are not used randomly in different genomes (Grantham et al., 1980; Lloyd and Sharp, 1992). Furthermore, the pattern of codon usage can vary considerably among organisms, and also among genes from the same genome. C ...
... Most amino acids are encoded by multiple codons. In most cases, the synonymous codons are not used randomly in different genomes (Grantham et al., 1980; Lloyd and Sharp, 1992). Furthermore, the pattern of codon usage can vary considerably among organisms, and also among genes from the same genome. C ...
Antibiotics involved in Clostridium difficile
... genes encoding known, or putative, colonization factors: three adhesins, P47 (one of the two Slayer proteins), Cwp66 and Fbp68, and a protease, Cwp84. The conditions studied included hyperosmolarity, iron depletion and exposure to several antibiotics (ampicillin, clindamycin, ofloxacin, moxifloxacin ...
... genes encoding known, or putative, colonization factors: three adhesins, P47 (one of the two Slayer proteins), Cwp66 and Fbp68, and a protease, Cwp84. The conditions studied included hyperosmolarity, iron depletion and exposure to several antibiotics (ampicillin, clindamycin, ofloxacin, moxifloxacin ...
Tissue- and Development-specific Expression of Multiple
... Isolation of multiple nNOS transcripts with unique 59UTRs. Cloning and sequencing of cDNA by RACE from brain, kidney, heart, intestine, and embryo led to the identification of three different nNOS mRNA species that are designated as nNOSa, nNOSb, and nNOSc. nNOSa was overall the most abundant isofor ...
... Isolation of multiple nNOS transcripts with unique 59UTRs. Cloning and sequencing of cDNA by RACE from brain, kidney, heart, intestine, and embryo led to the identification of three different nNOS mRNA species that are designated as nNOSa, nNOSb, and nNOSc. nNOSa was overall the most abundant isofor ...
Nucleoside Phosphoramidate Monoesters: Potential
... Mutated tRNA recognized stop codon as Tyr and prevents chain termination ...
... Mutated tRNA recognized stop codon as Tyr and prevents chain termination ...
(type I) and mannose-resistant F8 (P) fimbriae of Escherichia coli
... Several attempts have been made to find out whether the gene clusters coding for fimbrial adhesions are located on the chromosome or on plasmids. It was shown that the great majority, if not all of adhesin determinants of extra-intestinal E. coli, are chromosomally encoded. In addition, it is genera ...
... Several attempts have been made to find out whether the gene clusters coding for fimbrial adhesions are located on the chromosome or on plasmids. It was shown that the great majority, if not all of adhesin determinants of extra-intestinal E. coli, are chromosomally encoded. In addition, it is genera ...
Inheritance Problems
... 27. A woman of normal vision, whose father was color-blind, marries a man of normal vision whose maternal grandfather was colorblind. What type of vision will be expected in their children? Color-blindness is sex linked recessive. XAXa x XAY Offspring: XAXA XAXa XAY XaY 28. Yellow body (y)...the rec ...
... 27. A woman of normal vision, whose father was color-blind, marries a man of normal vision whose maternal grandfather was colorblind. What type of vision will be expected in their children? Color-blindness is sex linked recessive. XAXa x XAY Offspring: XAXA XAXa XAY XaY 28. Yellow body (y)...the rec ...
SNP Set Analysis for Detecting Disease Association Using Exon
... the past few years. They have been recently applied to genome-wide association studies (GWAS) to study the effects of both common and rare variants. The different natures of these two types of variants call for distinct methods. For common variants, association tests based on individual SNPs are sti ...
... the past few years. They have been recently applied to genome-wide association studies (GWAS) to study the effects of both common and rare variants. The different natures of these two types of variants call for distinct methods. For common variants, association tests based on individual SNPs are sti ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.