The Isolation of Mutagen-Sensitive nuv Mutants of
... More than 200 mutants Aspergillus of nidulans were isolated as hypersensitiveto the monofunctional alkylating agent MNNG and/or UV-irradiation (designated nuu mutants). Of these, 23 were selected for further characterization. All were markedly hypersensitive to both MNNG and the quasi-UVmimetic muta ...
... More than 200 mutants Aspergillus of nidulans were isolated as hypersensitiveto the monofunctional alkylating agent MNNG and/or UV-irradiation (designated nuu mutants). Of these, 23 were selected for further characterization. All were markedly hypersensitive to both MNNG and the quasi-UVmimetic muta ...
Cluster Analysis in DNA Microarray Experiments
... Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. In spite of recent progress, there are still uncertainties in diagnosis. Also, it is likely that the existing classes are heterogeneous and comprise diseases which are molecularl ...
... Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. In spite of recent progress, there are still uncertainties in diagnosis. Also, it is likely that the existing classes are heterogeneous and comprise diseases which are molecularl ...
The Organellar Genome and Metabolic Potential
... a [FeFe] hydrogenase, it can be regarded as a hydrogenosome with genome, although thus far no hydrogenase activity has been demonstrated in this species (Lantsman et al. 2008; Stechmann et al. 2008). Also for other (genome-less) types of hydrogen-producing organelles evidence is accumulating that th ...
... a [FeFe] hydrogenase, it can be regarded as a hydrogenosome with genome, although thus far no hydrogenase activity has been demonstrated in this species (Lantsman et al. 2008; Stechmann et al. 2008). Also for other (genome-less) types of hydrogen-producing organelles evidence is accumulating that th ...
Mutation, Mutagens, and DNA Repair
... the DNA strand around the lesion; one participates in removing the damaged bit; DNA polymerase replaces the portion which was removed; and a final enzyme called DNA ligase glues the new and old portions back together. Mutations in the genes coding for any of these proteins will interfere with the pr ...
... the DNA strand around the lesion; one participates in removing the damaged bit; DNA polymerase replaces the portion which was removed; and a final enzyme called DNA ligase glues the new and old portions back together. Mutations in the genes coding for any of these proteins will interfere with the pr ...
ADP Ribosylation Factor is an Essential Protein in Saccharomyces cerevisiae and is Encoded by Two Genes.
... Media, genetic techniques, and transformation. Media for yeast growth and sporulation were as described by Sherman et al. (40), except for 5-fluoro-orotic acid plates, described by Boeke et al. (5), and YEPGal, which is identical to YEPD except that 2% galactose is substituted for the glucose. Yeast ...
... Media, genetic techniques, and transformation. Media for yeast growth and sporulation were as described by Sherman et al. (40), except for 5-fluoro-orotic acid plates, described by Boeke et al. (5), and YEPGal, which is identical to YEPD except that 2% galactose is substituted for the glucose. Yeast ...
Multifractal characterisation of length sequences of coding and
... in the complete genome. This integer sequence is named coding length sequence. (ii) Order all lengths of noncoding segments according to the order of noncoding segments in the complete genome. This integer sequence is named noncoding length sequence. Yu and Anh [20] proposed a time series model for ...
... in the complete genome. This integer sequence is named coding length sequence. (ii) Order all lengths of noncoding segments according to the order of noncoding segments in the complete genome. This integer sequence is named noncoding length sequence. Yu and Anh [20] proposed a time series model for ...
Analysis of Binary Relations and Hierarchies of Enzymes in the
... computerize the knowledge of the information pathways of biomolecules[6]. As an initial part of the project, we have collected and computerized the metabolic pathway data into the electronic form. The WWW implementation of KEGG serves several purposes. It allows researchers to examine the functional ...
... computerize the knowledge of the information pathways of biomolecules[6]. As an initial part of the project, we have collected and computerized the metabolic pathway data into the electronic form. The WWW implementation of KEGG serves several purposes. It allows researchers to examine the functional ...
DNA and RNA Extraction Controls Performance Summary
... The DEC/REC cells are of a known concentration, containing the Internal Control DNA or RNA sequence. This sequence contains no known homology to any organism and, importantly, has minimal interference with detection of sample. The DEC/REC cells are spiked into the lysis buffer with the target sample ...
... The DEC/REC cells are of a known concentration, containing the Internal Control DNA or RNA sequence. This sequence contains no known homology to any organism and, importantly, has minimal interference with detection of sample. The DEC/REC cells are spiked into the lysis buffer with the target sample ...
Evaluation of the phylogenetic position of the planctomycete
... They are supposed to have very strong resolving power in evaluating close and intermediate evolutionary distances, i.e. the relationships between species and between major lineages (Wolf et al., 2002). Besides concatenation of protein sequences, three different methods to infer phylogeny from coding ...
... They are supposed to have very strong resolving power in evaluating close and intermediate evolutionary distances, i.e. the relationships between species and between major lineages (Wolf et al., 2002). Besides concatenation of protein sequences, three different methods to infer phylogeny from coding ...
Complex Signatures of Natural Selection at the Duffy Blood Group
... (implying that populations are not at equilibrium), the theoretical expectations of an equilibrium model are not a valid null hypothesis for testing neutrality. To overcome the latter problem, one can compare the pattern of variation at positively selected loci to empirical—rather than theoretical—e ...
... (implying that populations are not at equilibrium), the theoretical expectations of an equilibrium model are not a valid null hypothesis for testing neutrality. To overcome the latter problem, one can compare the pattern of variation at positively selected loci to empirical—rather than theoretical—e ...
the Gene Ontology
... Bio-ontologies are used to capture biological information in a way that can be read by both humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
... Bio-ontologies are used to capture biological information in a way that can be read by both humans and computers. necessary for high-throughput “omics” datasets allows data sharing across databases ...
Paraoxonase-2 Gene (PON2) G148 Variant Associated with
... specific, although the codon 148 change may be in linkage disequilibrium with the actual functional DNA variant within this gene. The association of homozygosity for PON2 G148 with worsened hyperglycemia in NIDDM suggests that the variation in PON2 modulates a quantitative NIDDMrelated phenotype, bu ...
... specific, although the codon 148 change may be in linkage disequilibrium with the actual functional DNA variant within this gene. The association of homozygosity for PON2 G148 with worsened hyperglycemia in NIDDM suggests that the variation in PON2 modulates a quantitative NIDDMrelated phenotype, bu ...
Genome-wide analysis of the distribution of AP2/ERF transcription
... cabbage genome sequence and more than fifty thousand proteins have been obtained to date. However a high degree of sequence similarity and conserved genome structure remain between cabbage and Arabidopsis; therefore, Arabidopsis is a viable reference species for comparative genomics studies. Transcr ...
... cabbage genome sequence and more than fifty thousand proteins have been obtained to date. However a high degree of sequence similarity and conserved genome structure remain between cabbage and Arabidopsis; therefore, Arabidopsis is a viable reference species for comparative genomics studies. Transcr ...
Biology EOCEP Review
... organelles. What kind of cell am I? I am a cell that has a cell wall and ribosomes. I have cell membrane but my DNA is not in strands. I can be found by myself many times. What kind of cell am I? ...
... organelles. What kind of cell am I? I am a cell that has a cell wall and ribosomes. I have cell membrane but my DNA is not in strands. I can be found by myself many times. What kind of cell am I? ...
Transcriptome and metabolite profiling the infection cycle of
... establishing this initial symptomless colonization through suppression of chitin (PAMP) recognition by the wheat chitin receptor proteins TaCEBiP and TaCERK1 (Marshall et al., 2011; Lee et al., 2014). However at some point after 7-10 days post infection, and for reasons that are currently unclear, w ...
... establishing this initial symptomless colonization through suppression of chitin (PAMP) recognition by the wheat chitin receptor proteins TaCEBiP and TaCERK1 (Marshall et al., 2011; Lee et al., 2014). However at some point after 7-10 days post infection, and for reasons that are currently unclear, w ...
Compound leaves: equal to the sum of their parts?
... has been made in understanding the molecular mechanisms that regulate leaf development in a few model plant species. This has been achieved by combining careful morphological observations and traditional genetic analyses with advances in molecular biology, such as genetic transformation, and with in ...
... has been made in understanding the molecular mechanisms that regulate leaf development in a few model plant species. This has been achieved by combining careful morphological observations and traditional genetic analyses with advances in molecular biology, such as genetic transformation, and with in ...
X chromosome inactivation- Review
... region in Xist gene and is required for X inactivation Model- Mutually exclusive binding of blocking factor to Xce on one X, and of initiator factor to Xist on other X Marsupials and in mice extraembyonic tissues- paternal X always inactivated in females ...
... region in Xist gene and is required for X inactivation Model- Mutually exclusive binding of blocking factor to Xce on one X, and of initiator factor to Xist on other X Marsupials and in mice extraembyonic tissues- paternal X always inactivated in females ...
Conservation of Brachyury (T) genes in amphioxus and vertebrates
... The two amphioxus cDNA clones share extremely high sequence identity throughout their coding regions (94% amino acid identity over 444 sites), but differ markedly over their 5′ and 3′ untranslated regions (UTRs). The lengths of the 3′ UTRs are also quite different, being 825 nt for AmBra-1 and 377 n ...
... The two amphioxus cDNA clones share extremely high sequence identity throughout their coding regions (94% amino acid identity over 444 sites), but differ markedly over their 5′ and 3′ untranslated regions (UTRs). The lengths of the 3′ UTRs are also quite different, being 825 nt for AmBra-1 and 377 n ...
chapt 10
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
... Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display. ...
The complete inventory of the yeast Saccharomyces cerevisiae P
... such as 10 predicted transmembrane spans, and characteristic sequence similarities. These sequence similarities are most pronounced in the transmembrane spans 4 and 6 which contain a total of 3 residues (E, N, D) believed to be specifically involved in calcium binding (Table 4). The E residue locate ...
... such as 10 predicted transmembrane spans, and characteristic sequence similarities. These sequence similarities are most pronounced in the transmembrane spans 4 and 6 which contain a total of 3 residues (E, N, D) believed to be specifically involved in calcium binding (Table 4). The E residue locate ...
Deletion of a conserved noncoding sequence in Plzf intron leads to
... we identified 70 sequence variants (Fig. 4A and Supp. Table S1). There are 47 substitutions or SNPs in strict sense; 22 small indels (insertions and deletions up to 14 bp), from which 12 appear to be in a single base “run” and 5 in more complex ...
... we identified 70 sequence variants (Fig. 4A and Supp. Table S1). There are 47 substitutions or SNPs in strict sense; 22 small indels (insertions and deletions up to 14 bp), from which 12 appear to be in a single base “run” and 5 in more complex ...
Inheriting Genetic Conditions Handbook
... X-linked dominant disorders are caused by fragile X syndrome mutations in genes on the X chromosome. Females are more frequently affected than males, and the chance of passing on an X-linked dominant disorder differs between men (illustration on page 16) and women (illustration on page 17). Families ...
... X-linked dominant disorders are caused by fragile X syndrome mutations in genes on the X chromosome. Females are more frequently affected than males, and the chance of passing on an X-linked dominant disorder differs between men (illustration on page 16) and women (illustration on page 17). Families ...
Enzymatic cleavage of RNA by RNA
... While the biochemical purification was proceeding, studies of temperature sensitive mutants of E. coli made by Schedl and Primakoff (1973; Schedl et al., 1974), Shimura, Ozeki and their coworkers (Ozeki et al., 1974; Sakano et al., 1974) showed that RNase P is essential in E. coli for the biosynthes ...
... While the biochemical purification was proceeding, studies of temperature sensitive mutants of E. coli made by Schedl and Primakoff (1973; Schedl et al., 1974), Shimura, Ozeki and their coworkers (Ozeki et al., 1974; Sakano et al., 1974) showed that RNase P is essential in E. coli for the biosynthes ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.