Identifying Common Genetic Variants by High
... easiest to distinguish on difference plots (Fig. 1B). Although the identity of the sequence variants was initially not known, samples with melting curves identical to those in a normal population should be benign variants. To test this method of eliminating common variants, we analyzed a blinded pan ...
... easiest to distinguish on difference plots (Fig. 1B). Although the identity of the sequence variants was initially not known, samples with melting curves identical to those in a normal population should be benign variants. To test this method of eliminating common variants, we analyzed a blinded pan ...
Collaborative coupling between polymerase and helicase for
... holoenzyme destabilizes the first few base pairs of the fork thereby increasing the efficiency of helicase unwinding. The model implies that both enzymes are localized at the fork, but does not require a specific interaction between them. The model quantitatively reproduces homologous and heterologo ...
... holoenzyme destabilizes the first few base pairs of the fork thereby increasing the efficiency of helicase unwinding. The model implies that both enzymes are localized at the fork, but does not require a specific interaction between them. The model quantitatively reproduces homologous and heterologo ...
The Effects of Zygotic Lethal Mutations on Female Germ
... set (20 out of 48) exhibited maternal effects on oogenesis, embryogenesis, or both. In 13 of this last group, only a few eggs were produced before a progressive deterioration of development occurred. It is suggested that perdurance of the wild-type gene product could produce this result. The third g ...
... set (20 out of 48) exhibited maternal effects on oogenesis, embryogenesis, or both. In 13 of this last group, only a few eggs were produced before a progressive deterioration of development occurred. It is suggested that perdurance of the wild-type gene product could produce this result. The third g ...
Completion of a parasexual cycle in Candida
... at MTL and one was tri-allelic, consistent with relatively stable propagation of the tetraploid on this medium. In comparison, analysis of 32 colonies randomly picked from pre-spo plates indicated that 35% (14/40) of the colonies were di-allelic at MTL, 35% were tri-allelic (14/40) and 30% were tetr ...
... at MTL and one was tri-allelic, consistent with relatively stable propagation of the tetraploid on this medium. In comparison, analysis of 32 colonies randomly picked from pre-spo plates indicated that 35% (14/40) of the colonies were di-allelic at MTL, 35% were tri-allelic (14/40) and 30% were tetr ...
Molecular Plant-Microbe Interactions
... IAA amounts; even when grown without Trp (29.3 ng ml–1). In culture filtrates obtained from cells grown in the presence of tryptophan, IAA production was significantly higher. Bacterial media supplemented with 0.1 and 1 mM Trp yielded significantly different (P < 0.05) mean values of 51.0 and 54.0 n ...
... IAA amounts; even when grown without Trp (29.3 ng ml–1). In culture filtrates obtained from cells grown in the presence of tryptophan, IAA production was significantly higher. Bacterial media supplemented with 0.1 and 1 mM Trp yielded significantly different (P < 0.05) mean values of 51.0 and 54.0 n ...
The amelogenin gene
... Mapping of human amelogenin gene loci on the X- and V-chromosomes Lau et al. (1989) mapped human amelogenin genes on the short arm of the X-chromosome in the p22.1-p22.3 region and in the peri centric region of the V-chromosome. The amelogenin sequence on the human V-chromosome was tentatively mappe ...
... Mapping of human amelogenin gene loci on the X- and V-chromosomes Lau et al. (1989) mapped human amelogenin genes on the short arm of the X-chromosome in the p22.1-p22.3 region and in the peri centric region of the V-chromosome. The amelogenin sequence on the human V-chromosome was tentatively mappe ...
Exploratory data analysis for microarray data
... of the correlation distance is useful when looking for patterns of relative changes - independent of their magnitude. ❍ Clustering samples: Standardizing genes gives relatively smaller weight for genes with high variance across the samples - not generally clear whether this is desirable. ❍ Gene filt ...
... of the correlation distance is useful when looking for patterns of relative changes - independent of their magnitude. ❍ Clustering samples: Standardizing genes gives relatively smaller weight for genes with high variance across the samples - not generally clear whether this is desirable. ❍ Gene filt ...
Sample
... c. very important, since in humans there are only a handful of genes that code for “race” in our DNA (each corresponding to a difference racial group) d. of some importance, since genes that code for racial characteristics also code for intelligence Answer: b Page: 37-38 Learning Objective 2.1 Conce ...
... c. very important, since in humans there are only a handful of genes that code for “race” in our DNA (each corresponding to a difference racial group) d. of some importance, since genes that code for racial characteristics also code for intelligence Answer: b Page: 37-38 Learning Objective 2.1 Conce ...
Sequence variation characteristics of D
... inner membrane. Other proteins in this membrane include enzymes involved in mitochondrial lipid synthesis and enzymes that convert lipid substrates into forms that are subsequently metabolized in the matrix. The intermembrane space contains several enzymes that use the ATP passing out of the matrix ...
... inner membrane. Other proteins in this membrane include enzymes involved in mitochondrial lipid synthesis and enzymes that convert lipid substrates into forms that are subsequently metabolized in the matrix. The intermembrane space contains several enzymes that use the ATP passing out of the matrix ...
[PDF]
... exists post-zygotically (28). The supportive evidence is that full mutation carriers are found to be somatic mosaicisms of CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although rece ...
... exists post-zygotically (28). The supportive evidence is that full mutation carriers are found to be somatic mosaicisms of CGG repeats (28,29). However, the length of CGG repeats on a particular allele in a differentiated cell derived from these carriers is generally mitotically stable although rece ...
No Slide Title
... The Island of Tristan de Cunha is one of the most interesting populations with asthma, with over 44% of the population affected. Of all the islands in the world, Tristan de Cunha is the most remote. The island is located in the southern Atlantic Ocean and the closest human habitation to Tristan de ...
... The Island of Tristan de Cunha is one of the most interesting populations with asthma, with over 44% of the population affected. Of all the islands in the world, Tristan de Cunha is the most remote. The island is located in the southern Atlantic Ocean and the closest human habitation to Tristan de ...
DNA breathing dynamics distinguish binding from nonbinding
... Figure 1. LMD simulations distinguish true YY1 binding in cells from nonbinding PLG promoter sites. (A) YY1 binding sites location relative to the TSS (+1) of the human PLG promoter (http://www.biobaseinternational.com). The YY1 DRS is highlighted in gray and the position of the restriction enzymes ...
... Figure 1. LMD simulations distinguish true YY1 binding in cells from nonbinding PLG promoter sites. (A) YY1 binding sites location relative to the TSS (+1) of the human PLG promoter (http://www.biobaseinternational.com). The YY1 DRS is highlighted in gray and the position of the restriction enzymes ...
Chromosomal translocations deregulated BCL6
... 1995). Its features and pattern of expression suggest that BCL6 may function as a DNA-binding transcription factor involved in the control of B cell differentiation and lymphoid organ development. Chromosomal translocations affecting band 3q27 represent reciprocal recombinations between this genomic ...
... 1995). Its features and pattern of expression suggest that BCL6 may function as a DNA-binding transcription factor involved in the control of B cell differentiation and lymphoid organ development. Chromosomal translocations affecting band 3q27 represent reciprocal recombinations between this genomic ...
Control of human β-globin mRNA stability and its impact on beta
... Human α- and b-globin genes descend from a common ancestral gene, share general and specific structural features, and both encode extraordinarily stable mRNAs in erythroid cells, which allow co-expression of α- and bglobin proteins to reach high levels. Human globin gene expression is a highly regul ...
... Human α- and b-globin genes descend from a common ancestral gene, share general and specific structural features, and both encode extraordinarily stable mRNAs in erythroid cells, which allow co-expression of α- and bglobin proteins to reach high levels. Human globin gene expression is a highly regul ...
Convergent Evolution in the Genetic Basis of Müllerian
... mimetic red wing phenotypes in H. erato. A methionine rich storage protein (MRSP) gene was identified within this BAC clone, and comparative genetic mapping shows red wing color loci are in homologous regions of the genome of H. erato and H. melpomene. Subtle differences in these convergent phenotyp ...
... mimetic red wing phenotypes in H. erato. A methionine rich storage protein (MRSP) gene was identified within this BAC clone, and comparative genetic mapping shows red wing color loci are in homologous regions of the genome of H. erato and H. melpomene. Subtle differences in these convergent phenotyp ...
Convergent Evolution in the Genetic Basis of Müllerian Mimicry in
... mimetic red wing phenotypes in H. erato. A methionine rich storage protein (MRSP) gene was identified within this BAC clone, and comparative genetic mapping shows red wing color loci are in homologous regions of the genome of H. erato and H. melpomene. Subtle differences in these convergent phenotyp ...
... mimetic red wing phenotypes in H. erato. A methionine rich storage protein (MRSP) gene was identified within this BAC clone, and comparative genetic mapping shows red wing color loci are in homologous regions of the genome of H. erato and H. melpomene. Subtle differences in these convergent phenotyp ...
MOLECULAR BIOLOGY OF FRUIT MATURATION AND
... A clarification of the common genetic regulatory elements that are shared among climacteric and non-climacteric species is central to a full understanding of fruit ripening. Such primary regulators of fruit maturation might be shared by, or at least related to, those that regulate maturation of dehi ...
... A clarification of the common genetic regulatory elements that are shared among climacteric and non-climacteric species is central to a full understanding of fruit ripening. Such primary regulators of fruit maturation might be shared by, or at least related to, those that regulate maturation of dehi ...
Biology Test- Chapter 11: Introduction to Genetics
... a. two genetically identical cells. b. four genetically different cells. c. four genetically identical cells. d. two genetically different cells. 31. In a 2 factor cross where both parents are heterozygous for both traits (TtYy x TtYy), the expected phenotypic ratio would be: a. 1:1:1:1 c. 3:1 b. 12 ...
... a. two genetically identical cells. b. four genetically different cells. c. four genetically identical cells. d. two genetically different cells. 31. In a 2 factor cross where both parents are heterozygous for both traits (TtYy x TtYy), the expected phenotypic ratio would be: a. 1:1:1:1 c. 3:1 b. 12 ...
A non-canonical pathway for aromatic amino acid biosynthesis in
... Diese Dissertation wurde im Sinne von §13 Abs. 3 bzw. 4 der Promotionsordnung vom 29. Januar 1998 von Herrn Prof. Dr. Dieter Oesterhelt betreut. ...
... Diese Dissertation wurde im Sinne von §13 Abs. 3 bzw. 4 der Promotionsordnung vom 29. Januar 1998 von Herrn Prof. Dr. Dieter Oesterhelt betreut. ...
twin studies - Institute for Behavioral Genetics
... What is dyslexia? A standard answer would be something like “dyslexia is a specific, significant impairment in reading ability that is not explained by deficits in general intelligence, opportunity, motivation or sensory acuity”. The deceptive simplicity of this definition breaks down as soon as one ...
... What is dyslexia? A standard answer would be something like “dyslexia is a specific, significant impairment in reading ability that is not explained by deficits in general intelligence, opportunity, motivation or sensory acuity”. The deceptive simplicity of this definition breaks down as soon as one ...
Loss of heterozygosity at D8S262: an early genetic event of
... precancerous lesion of HCC. However, many professional scholars considered that the histopathological characteristics of NAH was similar to that of DN when our previous studies were reviewed by them [10], and it should be classified as DN according to their comments and WHO criteria. As the scheme o ...
... precancerous lesion of HCC. However, many professional scholars considered that the histopathological characteristics of NAH was similar to that of DN when our previous studies were reviewed by them [10], and it should be classified as DN according to their comments and WHO criteria. As the scheme o ...
Role of sexlinked genes in quantitative inheritance
... Living organisms are composed of functioning cells each of which possesses a governing structure appropriately called "nucleus". ...
... Living organisms are composed of functioning cells each of which possesses a governing structure appropriately called "nucleus". ...
Test Bank
... 11. The characteristics of an organism are determined by two factors: ____________________. 12. In four o’clock plants, flower color is controlled by two alleles that show _________________________. 13. An organism’s gametes have ____________________ the number of chromosomes found in the organism’s ...
... 11. The characteristics of an organism are determined by two factors: ____________________. 12. In four o’clock plants, flower color is controlled by two alleles that show _________________________. 13. An organism’s gametes have ____________________ the number of chromosomes found in the organism’s ...
Arsenite as an Electron Donor for Anoxygenic Photosynthesis
... of As(III)-dependent growth via anoxygenic photosynthesis and contained homologs of arxA, but displayed different phenotypes. Comparisons were made with three related species: Ectothiorhodospira shaposhnikovii DSM 2111, Ectothiorhodospira shaposhnikovii DSM 243T , and Halorhodospira halophila DSM 24 ...
... of As(III)-dependent growth via anoxygenic photosynthesis and contained homologs of arxA, but displayed different phenotypes. Comparisons were made with three related species: Ectothiorhodospira shaposhnikovii DSM 2111, Ectothiorhodospira shaposhnikovii DSM 243T , and Halorhodospira halophila DSM 24 ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.