SPT4, a gene important for tr
... Plasmids. The plasmids pJF17, pJF42, and pBM25 contain subclones of the cloned SPT4 gene in the centromere-containing vector YCp50 (Johnston and Davis 1984) and were used to delimit the SPT4 gene (Fig. 1). The HindIII fragment that contains SPT4 function was cloned in the integrating vector YIp5 (St ...
... Plasmids. The plasmids pJF17, pJF42, and pBM25 contain subclones of the cloned SPT4 gene in the centromere-containing vector YCp50 (Johnston and Davis 1984) and were used to delimit the SPT4 gene (Fig. 1). The HindIII fragment that contains SPT4 function was cloned in the integrating vector YIp5 (St ...
Multiple Routes to Subfunctionalization and Gene Duplicate
... universally agree on this point (Innan and Kondrashov 2010), they differ in their view of how the duplication itself originally spreads and how the loci then diverge. Here I develop models of the gene duplication process that consider the functional effects of mutations in coding or regulatory regio ...
... universally agree on this point (Innan and Kondrashov 2010), they differ in their view of how the duplication itself originally spreads and how the loci then diverge. Here I develop models of the gene duplication process that consider the functional effects of mutations in coding or regulatory regio ...
The Normal Uniform Differential Gene Expression
... If there is no dye-swap, a loess normalization of the mean will be done using span1 proportion of the data. No mean normalization will be necessary if there is a balanced dye-swap. The argument quant is the quantity used to choose the constant that the (meannormalized) average log ratio for a gene i ...
... If there is no dye-swap, a loess normalization of the mean will be done using span1 proportion of the data. No mean normalization will be necessary if there is a balanced dye-swap. The argument quant is the quantity used to choose the constant that the (meannormalized) average log ratio for a gene i ...
HW4_final
... Make sure that you are using the “Single strand” mode for RNA sequences. Provide the motif logo. 2. What is the significance of the identified motif? Look at the occurrences distribution by clicking on “view occurrences distribution” or by downloading the motif occurrences file and explain how come ...
... Make sure that you are using the “Single strand” mode for RNA sequences. Provide the motif logo. 2. What is the significance of the identified motif? Look at the occurrences distribution by clicking on “view occurrences distribution” or by downloading the motif occurrences file and explain how come ...
Genome Biology - Department of Computer Science and
... regions from ChIP-chip experiments [23]. Since TFs bind to the upstream sequence of ORFs, we focused on histone modification signals 1kb flanking translation start sites (ATGs), because TFBSs were enriched in these regions. For TF PSSMs, 2 independent sets were obtained from previous studies. One se ...
... regions from ChIP-chip experiments [23]. Since TFs bind to the upstream sequence of ORFs, we focused on histone modification signals 1kb flanking translation start sites (ATGs), because TFBSs were enriched in these regions. For TF PSSMs, 2 independent sets were obtained from previous studies. One se ...
Pleiotropic effects of methoprene-tolerant (Met), a gene involved in
... metabolism will exhibit pleiotropy because alleles at such loci affect the regulation of hormones, which, in turn, have multiple phenotypic effects (Rose, 1991; Finch & Rose, 1995; Sinervo & Svensson, 1998). Furthermore, alleles may vary in their pleiotropic effects upon life history because they differ ...
... metabolism will exhibit pleiotropy because alleles at such loci affect the regulation of hormones, which, in turn, have multiple phenotypic effects (Rose, 1991; Finch & Rose, 1995; Sinervo & Svensson, 1998). Furthermore, alleles may vary in their pleiotropic effects upon life history because they differ ...
Molecular cloning, characterization and gene expression of an
... organisms from eubacteria to eukaryotes [9,20e26], they are essential, strongly expressed, and tightly regulated [27]. Catalase comprises four ferriphotophorphyrin groups per molecule, and its enzymatic activity in tissues varies greatly [28,29]. Each monomer harbors a single heme and nicotinamide a ...
... organisms from eubacteria to eukaryotes [9,20e26], they are essential, strongly expressed, and tightly regulated [27]. Catalase comprises four ferriphotophorphyrin groups per molecule, and its enzymatic activity in tissues varies greatly [28,29]. Each monomer harbors a single heme and nicotinamide a ...
Distribution and phylogenies of enzymes of the Embden
... has gained wide acceptance, although it has detractors. However, even a putative RNA-based “organism” could have arisen only from a prebiotic chemical environment conducive to its existence (Poole et al. 1999). Although these theories and their associated predictions have done much to provide explan ...
... has gained wide acceptance, although it has detractors. However, even a putative RNA-based “organism” could have arisen only from a prebiotic chemical environment conducive to its existence (Poole et al. 1999). Although these theories and their associated predictions have done much to provide explan ...
Inhibition of RNA Synthesis by Anthracycline Analogs
... and inactivate its template function essential for nucleic acid synthesis. Recently, several structural analogs of these antineoplastic agents have been synthesized and some of them were shown to be considerably more effective against experimental tumors than the parent compounds. The majority of re ...
... and inactivate its template function essential for nucleic acid synthesis. Recently, several structural analogs of these antineoplastic agents have been synthesized and some of them were shown to be considerably more effective against experimental tumors than the parent compounds. The majority of re ...
PDF
... (Hanisch et al., 2013; Schroter et al., 2012; Trofka et al., 2012). Furthermore, these models focused on simulating the system only in a wild-type background and were therefore largely unconstrained. More rigorous models can be built by constraining them to explain the spatiotemporal dynamics of the ...
... (Hanisch et al., 2013; Schroter et al., 2012; Trofka et al., 2012). Furthermore, these models focused on simulating the system only in a wild-type background and were therefore largely unconstrained. More rigorous models can be built by constraining them to explain the spatiotemporal dynamics of the ...
A TaqI polymorphism in the 3 UTR of the IL-12
... Given their central role in the immune response, the IL12 genes are potential candidate genes for infectious as well as Th1-mediated autoimmune diseases. Indeed, increased expression of IL-12 is found in several immune-mediated diseases, whereas mutations in the IL-12 genes and its receptors are ass ...
... Given their central role in the immune response, the IL12 genes are potential candidate genes for infectious as well as Th1-mediated autoimmune diseases. Indeed, increased expression of IL-12 is found in several immune-mediated diseases, whereas mutations in the IL-12 genes and its receptors are ass ...
Genetic regulation of cold-induced albinism in
... Herein the characterization of the maize inbred line A661 which shows a cold-induced albino phenotype is reported. The data show that exposure of seedlings to low temperatures during early leaf biogenesis led to chlorophyll losses in this inbred. A661 shows a high plasticity, recovering resting leve ...
... Herein the characterization of the maize inbred line A661 which shows a cold-induced albino phenotype is reported. The data show that exposure of seedlings to low temperatures during early leaf biogenesis led to chlorophyll losses in this inbred. A661 shows a high plasticity, recovering resting leve ...
uncorrected page proofs
... as the two number-5 chromosomes, are said to be homologous. Nonmatching chromosomes, such as a number-5 chromosome and a number-14 chromosome are said to be nonhomologous. At a particular location along its length, each chromosome has a constriction that is known as a centromere. In human chromosome ...
... as the two number-5 chromosomes, are said to be homologous. Nonmatching chromosomes, such as a number-5 chromosome and a number-14 chromosome are said to be nonhomologous. At a particular location along its length, each chromosome has a constriction that is known as a centromere. In human chromosome ...
Phylogenetic analysis of three complete gap
... S.D. Eastman et al. / Genomics 87 (2006) 265 – 274 Connexin genes are arranged in clades identifiable by similar colors used on phylogram tree (Fig. 1). Zebrafish connexin genes are subsequently organized by ascending molecular weight within a clade. ‘‘Previous name’’ indicates previous publication ...
... S.D. Eastman et al. / Genomics 87 (2006) 265 – 274 Connexin genes are arranged in clades identifiable by similar colors used on phylogram tree (Fig. 1). Zebrafish connexin genes are subsequently organized by ascending molecular weight within a clade. ‘‘Previous name’’ indicates previous publication ...
Unraveling the Genetic Mysteries of the Corneal Dystrophies
... Three types have been described based upon the presence of antigenic keratan sulfate Vision more severely affected than in other stromal dystrophies Characterized by stromal haze, and milky white opacities (glucosamineglycans; descemet’s membrane and the endothelium can be involved –with gutatta) • ...
... Three types have been described based upon the presence of antigenic keratan sulfate Vision more severely affected than in other stromal dystrophies Characterized by stromal haze, and milky white opacities (glucosamineglycans; descemet’s membrane and the endothelium can be involved –with gutatta) • ...
Pharmacogenomics: Analyzing SNPs in the CYP2D6 Gene Using
... polymorphisms (SNPs) within an individual’s CYP2D6 gene, functionality problems ranging from overly active metabolism to complete loss of function may result. Therefore, for the purpose of safety, it is necessary to identify these problems before prescribing drugs. Thus far there have been various m ...
... polymorphisms (SNPs) within an individual’s CYP2D6 gene, functionality problems ranging from overly active metabolism to complete loss of function may result. Therefore, for the purpose of safety, it is necessary to identify these problems before prescribing drugs. Thus far there have been various m ...
Trans-acting siRNA-mediated repression of ETTIN
... The interaction between zip-2 and ett-7, ett-15 and arf4-2 was studied in F2 families generated by the self-pollination of plants heterozygous for both mutations. The genotype of the plants in these families was determined by PCR, using allele-specific primers. The first two leaves of double mutants ...
... The interaction between zip-2 and ett-7, ett-15 and arf4-2 was studied in F2 families generated by the self-pollination of plants heterozygous for both mutations. The genotype of the plants in these families was determined by PCR, using allele-specific primers. The first two leaves of double mutants ...
document
... design 2 oligos which amplified the partial COMT gene from the bm3 and non bm3 lines, and then these fragments were then cloned and sent to Cogenics to obtain the full length sequence of ~1800 bases. The bm3 lines tested all contain a large deletion mutation at the 3’ exon of the COMT gene and this ...
... design 2 oligos which amplified the partial COMT gene from the bm3 and non bm3 lines, and then these fragments were then cloned and sent to Cogenics to obtain the full length sequence of ~1800 bases. The bm3 lines tested all contain a large deletion mutation at the 3’ exon of the COMT gene and this ...
Annotation Strategy Guide - GEP Community Server
... the exon at 54,816. While there are TopHat junctions suggesting both of these splice donor sites are possible (and both junctions have the same splice acceptor site), the splice site at 54,817-54,818 is supported by the SGP and Genscan gene predictions, the modENCODE RNA-Seq data and a medium qualit ...
... the exon at 54,816. While there are TopHat junctions suggesting both of these splice donor sites are possible (and both junctions have the same splice acceptor site), the splice site at 54,817-54,818 is supported by the SGP and Genscan gene predictions, the modENCODE RNA-Seq data and a medium qualit ...
A Common Polygenic Basis for Quinine and
... mice were indifferent to both. Therefore, 12 BXH/Ty recombinant inbred strains, derived from these strains, were tested with both solutions to begin identification of the unknown bitter loci. Naive mice were tested for four consecutive days with each compound (order counterbalanced). Some BXH/Ty str ...
... mice were indifferent to both. Therefore, 12 BXH/Ty recombinant inbred strains, derived from these strains, were tested with both solutions to begin identification of the unknown bitter loci. Naive mice were tested for four consecutive days with each compound (order counterbalanced). Some BXH/Ty str ...
Taxonomic evaluation of the Streptomyces griseus clade using
... strains. GenBank accession numbers of the sequences obtained in this study are listed in Table 1. The features of each gene locus are displayed in Supplementary Table S1, available in IJSEM Online. The five genes used here are widely distributed, unique within the streptomycete genome and of adequat ...
... strains. GenBank accession numbers of the sequences obtained in this study are listed in Table 1. The features of each gene locus are displayed in Supplementary Table S1, available in IJSEM Online. The five genes used here are widely distributed, unique within the streptomycete genome and of adequat ...
Epigenetic Regulation ofbdnfGene Transcription in the
... Long-term memory formation requires selective changes in gene expression. Here, we determined the contribution of chromatin remodeling to learning-induced changes in brain-derived neurotrophic factor (bdnf) gene expression in the adult hippocampus. Contextual fear learning induced differential regul ...
... Long-term memory formation requires selective changes in gene expression. Here, we determined the contribution of chromatin remodeling to learning-induced changes in brain-derived neurotrophic factor (bdnf) gene expression in the adult hippocampus. Contextual fear learning induced differential regul ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.