Molecular Evolution of Functional Nucleic Acids
... Nucleic acid aptamers have attracted keen interest, especially for their potential medical uses. For applications in the medical field, improvement of nuclease resistance, i.e., biostability in serum or cells as well as affinity to target molecules, became an important issue. An effective solution i ...
... Nucleic acid aptamers have attracted keen interest, especially for their potential medical uses. For applications in the medical field, improvement of nuclease resistance, i.e., biostability in serum or cells as well as affinity to target molecules, became an important issue. An effective solution i ...
Nutrigenomics in the Patient Care Process: Figuring Out the Puzzle
... sequence to another (switching nucleotide) • We all have SNPs • A person’s genome (and their SNPs) do not change ...
... sequence to another (switching nucleotide) • We all have SNPs • A person’s genome (and their SNPs) do not change ...
chromosome disorders.
... cytogenetically but are really unbalanced at the molecular level. • Even when structural rearrangements are truly balanced, they can pose a threat to the subsequent generation because carriers are likely to produce a high frequency of unbalanced gametes and therefore have an increased risk of having ...
... cytogenetically but are really unbalanced at the molecular level. • Even when structural rearrangements are truly balanced, they can pose a threat to the subsequent generation because carriers are likely to produce a high frequency of unbalanced gametes and therefore have an increased risk of having ...
Structural changes following the reversal of a Y chromosome to an
... following a Y chromosome reversal, we investigated an autosome-Y translocation in a wellstudied and tractable organism, Drosophila pseudoobscura. About 10-15 Mya, the ancestral Y chromosome fused to a small autosome (the dot chromosome) in an ancestor of D. pseudoobscura. We used single molecule rea ...
... following a Y chromosome reversal, we investigated an autosome-Y translocation in a wellstudied and tractable organism, Drosophila pseudoobscura. About 10-15 Mya, the ancestral Y chromosome fused to a small autosome (the dot chromosome) in an ancestor of D. pseudoobscura. We used single molecule rea ...
Chromosome - World of Teaching
... DNA) and one to several small bands. These small bands are referred to as “Satellite DNAs”. For e.g., in Drosophila virilis, contain three distinct satellite DNAs. ...
... DNA) and one to several small bands. These small bands are referred to as “Satellite DNAs”. For e.g., in Drosophila virilis, contain three distinct satellite DNAs. ...
NeuroGeM, a knowledgebase of genetic modifiers
... Modifiers can be grouped into aggregation modifiers and toxicity modifiers depending on the quantification method: the primary effect of aggregation modifiers is to increase or decrease aggregates while the primary effect of toxicity modifiers is to change the phenotype eventually leading to cell de ...
... Modifiers can be grouped into aggregation modifiers and toxicity modifiers depending on the quantification method: the primary effect of aggregation modifiers is to increase or decrease aggregates while the primary effect of toxicity modifiers is to change the phenotype eventually leading to cell de ...
Symposium Poster - uospur
... Abstract: Defects in the development and formation of synapses can cause neuronal and synaptic overgrowth, which can lead to many neurological disorders including autism. Previous studies have shown that defective FMR1 and ADAR genes result in synaptic overgrowth in Drosophila neuromuscular junction ...
... Abstract: Defects in the development and formation of synapses can cause neuronal and synaptic overgrowth, which can lead to many neurological disorders including autism. Previous studies have shown that defective FMR1 and ADAR genes result in synaptic overgrowth in Drosophila neuromuscular junction ...
Highly Recurrent RET Mutations and Novel Mutations in
... The RET and the EDNRB signaling pathways are critical for the normal development of the ENS (18, 20, 21 ). We analyzed the coding regions of the RET, GDNF, EDNRB, and EDN3 genes in 84 Chinese patients with sporadic HSCR. Twenty patients had at least one mutation in the genes investigated, representi ...
... The RET and the EDNRB signaling pathways are critical for the normal development of the ENS (18, 20, 21 ). We analyzed the coding regions of the RET, GDNF, EDNRB, and EDN3 genes in 84 Chinese patients with sporadic HSCR. Twenty patients had at least one mutation in the genes investigated, representi ...
Thermostable glycerol kinase from a
... The Pk-glpK gene, which encodes glycerol kinase (GK) from a hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1, was cloned and expressed in Escherichia coli. The amino acid sequence of this enzyme (Pk-GK) deduced from the nucleotide sequence showed 57% identity with that of E.coli GK and 47% i ...
... The Pk-glpK gene, which encodes glycerol kinase (GK) from a hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1, was cloned and expressed in Escherichia coli. The amino acid sequence of this enzyme (Pk-GK) deduced from the nucleotide sequence showed 57% identity with that of E.coli GK and 47% i ...
T cell antigen receptor diversity Generation of
... The CD3 or (zeta) chains are required for cell surface expression of the TcR-CD3 complex and signalling through the TcR ...
... The CD3 or (zeta) chains are required for cell surface expression of the TcR-CD3 complex and signalling through the TcR ...
DNA Testing - Who Murdered Robert Wone
... known for many years that a single germ (bacterial cell or virus) contaminating a wound can produce a massive infection. Similarly, a DNA molecule can contaminate (infect) a PCR and become a significant problem. The ability of small amounts of DNA to produce false and misleading results is well-know ...
... known for many years that a single germ (bacterial cell or virus) contaminating a wound can produce a massive infection. Similarly, a DNA molecule can contaminate (infect) a PCR and become a significant problem. The ability of small amounts of DNA to produce false and misleading results is well-know ...
The Structural Basis of Molecular Adaptation
... between pattern and process. That this is the case is hardly surprising, as a brief reflection quickly exposes the difficulty in their unification. A large number of sequence differences accumulate over evolutionary time, but not all need be adaptive. Even with relatively recent selective events, hi ...
... between pattern and process. That this is the case is hardly surprising, as a brief reflection quickly exposes the difficulty in their unification. A large number of sequence differences accumulate over evolutionary time, but not all need be adaptive. Even with relatively recent selective events, hi ...
No Slide Title
... The CD3 or (zeta) chains are required for cell surface expression of the TcR-CD3 complex and signalling through the TcR ...
... The CD3 or (zeta) chains are required for cell surface expression of the TcR-CD3 complex and signalling through the TcR ...
MS-Word format
... 1c. How many total (direct and indirect) number of proteins are associated to the GO term polysaccharide metabolism? Are there any proteins which are not directly associated to this term? If so, which child term has the greatest number of associations? 1) In the same Summary page, examine the number ...
... 1c. How many total (direct and indirect) number of proteins are associated to the GO term polysaccharide metabolism? Are there any proteins which are not directly associated to this term? If so, which child term has the greatest number of associations? 1) In the same Summary page, examine the number ...
Nonsense mutations CORRECT ANSWER
... Self Assessment Question 9 Answer • Ionizing radiation damages DNA by: A. Directly interacting with the DNA molecule B. Depurinating the DNA C. Interacting with water to form reactive ions called free radicals CORRECT ANSWER D. A process called intercalation E. Replication slippage ...
... Self Assessment Question 9 Answer • Ionizing radiation damages DNA by: A. Directly interacting with the DNA molecule B. Depurinating the DNA C. Interacting with water to form reactive ions called free radicals CORRECT ANSWER D. A process called intercalation E. Replication slippage ...
Chapter 21
... An insertion sequence is a transposon that codes for the enzyme(s) needed for transposition flanked by short inverted terminal repeats. The target site at which a transposon is inserted is duplicated during the insertion process to form two repeats in direct orientation at the ends of the transposon ...
... An insertion sequence is a transposon that codes for the enzyme(s) needed for transposition flanked by short inverted terminal repeats. The target site at which a transposon is inserted is duplicated during the insertion process to form two repeats in direct orientation at the ends of the transposon ...
1 - SMIC Biology
... (#?) chromosomes in every cell. Of these, pairs are autosomes. An autosome is any chromosome except the sex chromosomes. Each person has one pair of sex chromosomes. Females have 2 X chromosomes while males have ...
... (#?) chromosomes in every cell. Of these, pairs are autosomes. An autosome is any chromosome except the sex chromosomes. Each person has one pair of sex chromosomes. Females have 2 X chromosomes while males have ...
Duchenne and Becker Types of Muscular Dystrophy
... properly. This variation is called a mutation or pathogenic variant, and means that the product produced by the gene, called a protein, is impaired or even absent. Gene mutations may be inherited from a parent, or occur for the first time in an individual. Once you have a gene mutation however, it m ...
... properly. This variation is called a mutation or pathogenic variant, and means that the product produced by the gene, called a protein, is impaired or even absent. Gene mutations may be inherited from a parent, or occur for the first time in an individual. Once you have a gene mutation however, it m ...
Improved production of poly-γ-glutamate by newly Bacillus subtilis
... Therefore,further experiments were carried out without pH control during fermentation. The dissolved oxygen has been recognized as an important factor in aerobic fermentation affecting the nature and/or rate of metabolic product formation. Dissolved oxygen is often controlled by ventilation, stirrin ...
... Therefore,further experiments were carried out without pH control during fermentation. The dissolved oxygen has been recognized as an important factor in aerobic fermentation affecting the nature and/or rate of metabolic product formation. Dissolved oxygen is often controlled by ventilation, stirrin ...
PDF - Fred Hutchinson Cancer Research Center
... even sophisticated computer programs cannot reliably predict the impact of mutations (Potapov et al. 2009). Methods have been developed to infer site-specific selection from naturally occurring sequences (Rodrigue et al. 2010; Tamuri et al. 2012, 2014). Because the number of possible mutations is la ...
... even sophisticated computer programs cannot reliably predict the impact of mutations (Potapov et al. 2009). Methods have been developed to infer site-specific selection from naturally occurring sequences (Rodrigue et al. 2010; Tamuri et al. 2012, 2014). Because the number of possible mutations is la ...
Mendel and modern genetics: the legacy for today
... Indeed, it is much more likely that the direction of Mendel’s hybridization research was guided by the strong agricultural interests around him. It was precisely through hybridization that breeders hoped to generate new combinations of characters that they could exploit to form new breeds. The probl ...
... Indeed, it is much more likely that the direction of Mendel’s hybridization research was guided by the strong agricultural interests around him. It was precisely through hybridization that breeders hoped to generate new combinations of characters that they could exploit to form new breeds. The probl ...
WormBase Advisory Board Meeting RNAi
... ≈ redundancy existed between terms ≈ no phenotype term definitions, references ≈ many RNAi experiments annotated to ‘Unclassified’ phenotype term ≈ ‘Not’ phenotype associations were not captured ≈ Phenotype vocabulary was not used for annotation of alleles and transgene objects PATO, December 2006 ...
... ≈ redundancy existed between terms ≈ no phenotype term definitions, references ≈ many RNAi experiments annotated to ‘Unclassified’ phenotype term ≈ ‘Not’ phenotype associations were not captured ≈ Phenotype vocabulary was not used for annotation of alleles and transgene objects PATO, December 2006 ...
515-527 - CiteSeerX
... a ground state, possibly a leaf-like organ. In actuality, organs with features of both carpels (such as stigmatic tissue, fusion of organs along their margins, and ovules) and leaves (stellate trichomes and stipules) develop in the triple mutant flowers (Bowman et al 1991). Thus, there must exist ge ...
... a ground state, possibly a leaf-like organ. In actuality, organs with features of both carpels (such as stigmatic tissue, fusion of organs along their margins, and ovules) and leaves (stellate trichomes and stipules) develop in the triple mutant flowers (Bowman et al 1991). Thus, there must exist ge ...
Mendel and modern genetics: the legacy for today
... Indeed, it is much more likely that the direction of Mendel’s hybridization research was guided by the strong agricultural interests around him. It was precisely through hybridization that breeders hoped to generate new combinations of characters that they could exploit to form new breeds. The probl ...
... Indeed, it is much more likely that the direction of Mendel’s hybridization research was guided by the strong agricultural interests around him. It was precisely through hybridization that breeders hoped to generate new combinations of characters that they could exploit to form new breeds. The probl ...
NIH Public Access
... (or resistance) of particular genes to silencing remains poorly understood. In recent years substantial progress has been made in defining the series of heterochromatic chromatin modifications that spread across the chromosome shortly after XIST RNA first paints the chromosome (reviewed in (Heard, 2 ...
... (or resistance) of particular genes to silencing remains poorly understood. In recent years substantial progress has been made in defining the series of heterochromatic chromatin modifications that spread across the chromosome shortly after XIST RNA first paints the chromosome (reviewed in (Heard, 2 ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.