Supplementary Data File Supplementary Figures Figure S1
... reference distribution corresponds to a hypothetical data set with 10,000 genes where 2,500 genes are in the low variability category, 5000 in the medium and 2500 in the high variability category. B. The count distribution of Pathway 1 contains a total of 100 genes from the dataset. From these 100 g ...
... reference distribution corresponds to a hypothetical data set with 10,000 genes where 2,500 genes are in the low variability category, 5000 in the medium and 2500 in the high variability category. B. The count distribution of Pathway 1 contains a total of 100 genes from the dataset. From these 100 g ...
In Silico method for identification of MHC class I
... microbat (myoLuc2), guinea pig (canPor3), and rabbit (oryCun2). For all of these species 1 or more CD1 homologs were found (Figure 2, Table 1, Table S1). Our data show that in the tested mammals, multiplication of CD1a is very common, and multiplication of CD1b, CD1c, and CD1d is m ...
... microbat (myoLuc2), guinea pig (canPor3), and rabbit (oryCun2). For all of these species 1 or more CD1 homologs were found (Figure 2, Table 1, Table S1). Our data show that in the tested mammals, multiplication of CD1a is very common, and multiplication of CD1b, CD1c, and CD1d is m ...
Leptin
... The incidence：1 in 25,000 and 1 in 10,000 live births. The paternal origin; particular region of ch.15 involved; parent of origin imprinting, i.e. for a number of genes in this region only one copy of the gene is expressed while the other is silenced through imprinting. Parent-specific gene activati ...
... The incidence：1 in 25,000 and 1 in 10,000 live births. The paternal origin; particular region of ch.15 involved; parent of origin imprinting, i.e. for a number of genes in this region only one copy of the gene is expressed while the other is silenced through imprinting. Parent-specific gene activati ...
Somatic Cell Gene Mutations in Humans
... in the bone marrow, undergo maturation (rearrangement of TcR genes) in the thymus, and then have a prolonged life span in peripheral tissue, e.g., in lymph nodes, spleen, gut. They travel from site to site via the blood. This traffic from bone marrow to thymus to periphery is pronounced during fetal ...
... in the bone marrow, undergo maturation (rearrangement of TcR genes) in the thymus, and then have a prolonged life span in peripheral tissue, e.g., in lymph nodes, spleen, gut. They travel from site to site via the blood. This traffic from bone marrow to thymus to periphery is pronounced during fetal ...
Chpt12_RNAProcessing.doc
... (3) Effects of mutations at the splice junctions demonstrate their importance in the splicing mechanism. Mutation of the GT at the donor site in DNA to an AT prevents splicing (this was seen in a mutation of the -globin gene that caused 0 thalassemia.) A different mutation of the -globin gene tha ...
... (3) Effects of mutations at the splice junctions demonstrate their importance in the splicing mechanism. Mutation of the GT at the donor site in DNA to an AT prevents splicing (this was seen in a mutation of the -globin gene that caused 0 thalassemia.) A different mutation of the -globin gene tha ...
Introduction and Preliminaries - Department of Computer and
... Human genome: about 100,000 proteins, with each protein a few hundred amino acids long Bacteria make 500-1500 proteins Made by genes (fragments of DNA) that are roughly three times longer than the corresponding proteins. Why? Every 3 nucleotides in the DNA alphabet code one letter in the pro ...
... Human genome: about 100,000 proteins, with each protein a few hundred amino acids long Bacteria make 500-1500 proteins Made by genes (fragments of DNA) that are roughly three times longer than the corresponding proteins. Why? Every 3 nucleotides in the DNA alphabet code one letter in the pro ...
GENETIC DISORDERS AND PEDIGREES
... Asians. It affects about 30,000 children and adults in the U.S. b. Deficiency of the protein cystic fibrosis transmembrane conductance regulator (CFTR). This protein is found in the membrane of cells. The normal function of this protein is to transport chlorine across the cell membrane. The dysfunct ...
... Asians. It affects about 30,000 children and adults in the U.S. b. Deficiency of the protein cystic fibrosis transmembrane conductance regulator (CFTR). This protein is found in the membrane of cells. The normal function of this protein is to transport chlorine across the cell membrane. The dysfunct ...
Review Process - The EMBO Journal
... authors have asked if CP190 associates with proteins that might explain its chromatin binding behavior. Tagged CP190 protein expressed in cultured cells was affinity purified and analysed by mass spectrometry. Two prominent components, among others, were found to be previously undescribed proteins t ...
... authors have asked if CP190 associates with proteins that might explain its chromatin binding behavior. Tagged CP190 protein expressed in cultured cells was affinity purified and analysed by mass spectrometry. Two prominent components, among others, were found to be previously undescribed proteins t ...
1. Which of the following are connected by hydrogen bonds? A
... PanI is a gene in cod fish that codes for an integral membrane protein called pantophysin. Two alleles of the gene, PanIA and PanIB, code for versions of pantophysin, that differ by four amino acids in one region of the protein. Samples of cod fish were collected from 23 locations in the north Atlan ...
... PanI is a gene in cod fish that codes for an integral membrane protein called pantophysin. Two alleles of the gene, PanIA and PanIB, code for versions of pantophysin, that differ by four amino acids in one region of the protein. Samples of cod fish were collected from 23 locations in the north Atlan ...
生物信息学主要英文术语及释义
... than S that are expected to occur in a database search by chance. The lower the E value, the more significant the score. In a database similarity search, the probability that an alignment score as good as the one found between a query sequence and a database sequence would be found in as many compar ...
... than S that are expected to occur in a database search by chance. The lower the E value, the more significant the score. In a database similarity search, the probability that an alignment score as good as the one found between a query sequence and a database sequence would be found in as many compar ...
Bruce Wallace Biotechnology Lab Program Student Guide 5th
... The plasmid pARA is 4058 base pairs (bp) in size. A “base pair” would be adenine:thymine or guanine:cytosine and is the common method used to express the size of DNA molecules. The plasmid carries the ampr gene, which encodes the protein beta lactamase, an enzyme that destroys the antibiotic ampicil ...
... The plasmid pARA is 4058 base pairs (bp) in size. A “base pair” would be adenine:thymine or guanine:cytosine and is the common method used to express the size of DNA molecules. The plasmid carries the ampr gene, which encodes the protein beta lactamase, an enzyme that destroys the antibiotic ampicil ...
Rabbit Genetics - Heavenly Hares Rabbitry
... head and around the nose and eyes. But one thing that all solids have in common is that their pattern is not interspersed with white fur (not accounting for Himalayans). Broken patterned Holland Lops can be any color of Holland Lops, except that the colored portions occur in a patched or a blanketed ...
... head and around the nose and eyes. But one thing that all solids have in common is that their pattern is not interspersed with white fur (not accounting for Himalayans). Broken patterned Holland Lops can be any color of Holland Lops, except that the colored portions occur in a patched or a blanketed ...
Endogenous Retroviral Elements in Human DNA1
... manner includes both sequence elements, which seem to have used cellular mechanisms for passive retroposition, as well as retroelements containing reverse transcriptase- and/or integrase-related sequences possibly initiating their own retrotransposition. Members of the former group are called retros ...
... manner includes both sequence elements, which seem to have used cellular mechanisms for passive retroposition, as well as retroelements containing reverse transcriptase- and/or integrase-related sequences possibly initiating their own retrotransposition. Members of the former group are called retros ...
a nine-base pair deletion distinguishes two en/spm
... The En insertions in the distinguishable a1-m(papu) and a1-m(Au) alleles reside at the same site in exon 2 of the A1 gene. Their phenotypic difference (Figures 1 and 2) can be ascribed to the nine-base pair deletion in the distal side (3') of the insert, 45 bases away from the site of the insert. Ea ...
... The En insertions in the distinguishable a1-m(papu) and a1-m(Au) alleles reside at the same site in exon 2 of the A1 gene. Their phenotypic difference (Figures 1 and 2) can be ascribed to the nine-base pair deletion in the distal side (3') of the insert, 45 bases away from the site of the insert. Ea ...
Osmoadaptative Strategy and Its Molecular
... of halophilic proteins possibly allows them to avoid overly rigid folded conformations. On the other hand, the proteomes of halophiles that use organic solutes as their main osmolytes (salt-out organisms) are not enriched in highly acidic proteins, although they typically produce extracellular prote ...
... of halophilic proteins possibly allows them to avoid overly rigid folded conformations. On the other hand, the proteomes of halophiles that use organic solutes as their main osmolytes (salt-out organisms) are not enriched in highly acidic proteins, although they typically produce extracellular prote ...
Genetics Homework Packet
... Dominance is the simplest example of how genes interact with each other. Earlier, you learned that the effects of the dominant allele are seen even when the recessive allele is present. But what causes dominance? Remember that a gene is a section of DNA, and DNA codes for a polypeptide, or string of ...
... Dominance is the simplest example of how genes interact with each other. Earlier, you learned that the effects of the dominant allele are seen even when the recessive allele is present. But what causes dominance? Remember that a gene is a section of DNA, and DNA codes for a polypeptide, or string of ...
LAB 1: Scientific Method/Tools of Scientific Inquiry
... This is the Hardy-Weinberg equation in which p represents the frequency of one genetic allele in a population (e.g., the B allele in your predator/prey simulations), and q represents the frequency of the other allele (e.g., the b allele). Under conditions of Hardy-Weinberg equilibrium, these allele ...
... This is the Hardy-Weinberg equation in which p represents the frequency of one genetic allele in a population (e.g., the B allele in your predator/prey simulations), and q represents the frequency of the other allele (e.g., the b allele). Under conditions of Hardy-Weinberg equilibrium, these allele ...
Protein A gene expression is regulated by DNA supercoiling which
... (Dorman, 1991; Hsieh et al., 1991). In Escherichia coli, it has been estimated that roughly 50 % of the supercoiling is constrained by proteins bound to DNA. The remaining supercoils are maintained actively at the cost of ATP hydrolysis, via topoisomerase activities (Hatfield & Benham, 2002). Thus, ...
... (Dorman, 1991; Hsieh et al., 1991). In Escherichia coli, it has been estimated that roughly 50 % of the supercoiling is constrained by proteins bound to DNA. The remaining supercoils are maintained actively at the cost of ATP hydrolysis, via topoisomerase activities (Hatfield & Benham, 2002). Thus, ...
Transcriptome analysis of the two unrelated fungal
... Penicillium chrysogenum, two taxonomically unrelated fungi. Both were subjects of long-term strain development programs to reach economically relevant antibiotic titers. It is so far unknown, whether equivalent changes in gene expression lead to elevated antibiotic titers in production strains. Resu ...
... Penicillium chrysogenum, two taxonomically unrelated fungi. Both were subjects of long-term strain development programs to reach economically relevant antibiotic titers. It is so far unknown, whether equivalent changes in gene expression lead to elevated antibiotic titers in production strains. Resu ...
misinformation, misrepresentation, and misuse of human behavioral
... universal outcomes, even though only some resources are shared universally. Researchers interested in understanding either the causes of variation in human behaviors or how human behaviors develop are at a disadvantage compared to researchers interested in answering similar questions associated with ...
... universal outcomes, even though only some resources are shared universally. Researchers interested in understanding either the causes of variation in human behaviors or how human behaviors develop are at a disadvantage compared to researchers interested in answering similar questions associated with ...
Characterization of Rice Anthranilate Synthase
... and digoxigenin-labeled antisense riboprobes prepared from the corresponding cDNAs; hybridization was performed under high-stringency conditions to prevent cross-hybridization of OASA1 and OASA2 mRNAs with the two probes. The sizes of the OASA1 and OASA2 transcripts, estimated from the sizes of ribo ...
... and digoxigenin-labeled antisense riboprobes prepared from the corresponding cDNAs; hybridization was performed under high-stringency conditions to prevent cross-hybridization of OASA1 and OASA2 mRNAs with the two probes. The sizes of the OASA1 and OASA2 transcripts, estimated from the sizes of ribo ...
CH # 13-3
... Sickle cell disease is a disorder associated with changes in the shape of red blood cells. Normal red blood cells are round. Sickle cells appear long and pointed. Sickle cell disease is caused by a point mutation in one of the polypeptides found in hemoglobin, the blood’s principal oxygencarrying pr ...
... Sickle cell disease is a disorder associated with changes in the shape of red blood cells. Normal red blood cells are round. Sickle cells appear long and pointed. Sickle cell disease is caused by a point mutation in one of the polypeptides found in hemoglobin, the blood’s principal oxygencarrying pr ...
Mutations
... Sickle cell disease is a disorder associated with changes in the shape of red blood cells. Normal red blood cells are round. Sickle cells appear long and pointed. Sickle cell disease is caused by a point mutation in one of the polypeptides found in hemoglobin, the blood’s principal oxygencarrying pr ...
... Sickle cell disease is a disorder associated with changes in the shape of red blood cells. Normal red blood cells are round. Sickle cells appear long and pointed. Sickle cell disease is caused by a point mutation in one of the polypeptides found in hemoglobin, the blood’s principal oxygencarrying pr ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.