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Unit 8: Reactions
Unit 8: Reactions

Unit 13: Electrochemistry (Link to Prentice Hall Text: Chapters 22
Unit 13: Electrochemistry (Link to Prentice Hall Text: Chapters 22

... A car battery powers the car through a spontaneous reaction, but what can you do if the battery dies? (c) To coat one metal on top of another one, as with jewelry, or exhaust pipes. a. To make something look more expensive or shinier b. To improve corrosion resistance ...
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... point or freezing point (constant temperatures) can experience a change in heat without experiencing a change in temperature. Most equilibrium systems are not studied at their boiling point or freezing point, though. Consequently, a change in heat generally corresponds to a change in temperature and ...
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... Many formulas for substances cannot be explained in terms of ionic bonding. Consider the substance Cl2O. Both the chlorine and the oxygen atom need more electrons for a stable electron population. A model proposed that would allow both atoms to gain electrons is shown in the diagram on this page. Th ...
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Bioorthogonal chemistry



The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes. The term was coined by Carolyn R. Bertozzi in 2003. Since its introduction, the concept of the bioorthogonal reaction has enabled the study of biomolecules such as glycans, proteins, and lipids in real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality, including the 1,3-dipolar cycloaddition between azides and cyclooctynes (also termed copper-free click chemistry), between nitrones and cyclooctynes, oxime/hydrazone formation from aldehydes and ketones, the tetrazine ligation, the isocyanide-based click reaction, and most recently, the quadricyclane ligation.The use of bioorthogonal chemistry typically proceeds in two steps. First, a cellular substrate is modified with a bioorthogonal functional group (chemical reporter) and introduced to the cell; substrates include metabolites, enzyme inhibitors, etc. The chemical reporter must not alter the structure of the substrate dramatically to avoid affecting its bioactivity. Secondly, a probe containing the complementary functional group is introduced to react and label the substrate.Although effective bioorthogonal reactions such as copper-free click chemistry have been developed, development of new reactions continues to generate orthogonal methods for labeling to allow multiple methods of labeling to be used in the same biosystems.
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