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spontaneous change: entropy and free energy
spontaneous change: entropy and free energy

... where S is the entropy, k is the Boltzmann constant, and W is the number of microstates. We can think of the Boltzmann constant as the gas constant per molecule; that is, k = R>NA . (Although we didn’t specifically introduce k in the discussion of kinetic–molecular theory, R>NA appears in equation 6 ...
Kitchen Chemistry Review
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...  I am making pancakes. I am going to use artificial sugar instead of regular sugar. My pancakes are light and fluffy, but they never turned brown. What happened?  A. You work cooking at too low of a temperature  B. You did not have sugar which helps it brown  C. You used the wrong type of flour ...
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... 5 Corrosion – The process of slow conversion of metals into their undesirable compounds due to their reaction with oxygen, water, acids, gases etc. present in the atmosphere is called corrosion. Rusting – Iron when reacts with oxygen and moisture forms red substance called rust. Chemical composition ...
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... about these exercises, we will provide an opportunity to discuss these exercises (and other matters) with their fellow students from all over the world, even before they come together in Melbourne. We have set up a web-based chat forum so that they can get to know one another (after all - isn’t that ...
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... 1. Basic Research – carried out for the sake of increasing knowledge, such as how and why a specific reaction occurs and what the properties of a substance are. 2. Applied Research – generally carried out to _______ __ __________. (Example: Refrigerants that escape into the atmosphere – research has ...
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Bioorthogonal chemistry



The term bioorthogonal chemistry refers to any chemical reaction that can occur inside of living systems without interfering with native biochemical processes. The term was coined by Carolyn R. Bertozzi in 2003. Since its introduction, the concept of the bioorthogonal reaction has enabled the study of biomolecules such as glycans, proteins, and lipids in real time in living systems without cellular toxicity. A number of chemical ligation strategies have been developed that fulfill the requirements of bioorthogonality, including the 1,3-dipolar cycloaddition between azides and cyclooctynes (also termed copper-free click chemistry), between nitrones and cyclooctynes, oxime/hydrazone formation from aldehydes and ketones, the tetrazine ligation, the isocyanide-based click reaction, and most recently, the quadricyclane ligation.The use of bioorthogonal chemistry typically proceeds in two steps. First, a cellular substrate is modified with a bioorthogonal functional group (chemical reporter) and introduced to the cell; substrates include metabolites, enzyme inhibitors, etc. The chemical reporter must not alter the structure of the substrate dramatically to avoid affecting its bioactivity. Secondly, a probe containing the complementary functional group is introduced to react and label the substrate.Although effective bioorthogonal reactions such as copper-free click chemistry have been developed, development of new reactions continues to generate orthogonal methods for labeling to allow multiple methods of labeling to be used in the same biosystems.
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