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Developmental buffering: how many genes?
Developmental buffering: how many genes?

... Although most studies of Hsp90 and phenotypic variability have been conducted in Drosophila, similar patterns appear also to hold for other organisms. In zebrafish, pharmacological inhibition and knockdown of Hsp90 induced a range of specific abnormalities depending on the genotype (Yeyati et al. 2007 ...
multicopy gene family evolution on primate y chromosomes
multicopy gene family evolution on primate y chromosomes

... Contrary to previous theories, the Y chromosome is an important determinant of male phenotype [15–17]. The Y chromosome has been found to be associated with male fertility in humans [18] and even less obvious traits like lifespan [19] and locomotive activity [20] in Drosophila species. Therefore, an ...
bantam Encodes a Developmentally Regulated microRNA that
bantam Encodes a Developmentally Regulated microRNA that

... mfold/old/rna/; Figure 1C). The region of highest similarity between these sequences was found on the same arm of the hairpin (shading). These observations suggested that the predicted hairpins might be precursors in the production of a microRNA. Indeed, a small RNA of ⵑ21 nt was detected by Norther ...
Mapping the Horns (Ho) Locus in Sheep: A Further Locus
Mapping the Horns (Ho) Locus in Sheep: A Further Locus

... mal female (Hamerton et al. 1969). Histologically the gonads of intersex animals were testicular in appearance, but germ cells were never seen in the seminiferous tubules after birth (Hamerton et al. 1969). Y-specific sequences including SRY (sexdetermining region Y chromosome) were not detected in ...
The role of Pax-1 in axial skeleton development
The role of Pax-1 in axial skeleton development

... boundaries. By cell labelling experiments it has been shown that one vertebral body is derived from cells originating from two adjacent somites (Bagnall, 1992; Ewan and Everett, 1992). The mechanisms that control these morphological events in axial and lateral regions have not been studied, however. ...
Molecular and Genetic Characterization of a
Molecular and Genetic Characterization of a

... controlled and highly programmed developmental event. Identifying the components of this developmental switch is important not only for manipulating this key plant process but also for understanding the regulation of plant development. The biochemical and molecular basis of ripening in both climacte ...
Kinds of gene rearrangement
Kinds of gene rearrangement

... rearrange different genes, but only exchanges alleles.) Genetically it consists in exchange of normally equal and homologous segments of a gene string (MORGAN1911, STURTEVANT 1915, MULLER1916). It has been proved, by the microscope, to consist in the exchange, a t meiosis, of normally equal portions ...
What determines a leaf`s shape? | SpringerLink
What determines a leaf`s shape? | SpringerLink

... their review on angiosperm leaf shape, Nicotra et al. [1] defined a leaf as a ‘vascular asymmetric appendicular structure initiated at the shoot apical meristem’. This definition is applicable to all vascular plants, but does not hold true for bryophytes (mosses, liverworts, and hornworts) as they l ...
- Wiley Online Library
- Wiley Online Library

... chromatin and when it mediates sister chromatid cohesion? Separase cleaves Scc1 into amino- and a carboxy-terminal fragments, both of which subsequently dissociate from chromatin. If cohesin had formed a ring on chromatin, then the two Scc1 cleavage fragments released from chromatin by separase shou ...
Goings on in Mendel`s Garden
Goings on in Mendel`s Garden

... Mendel enabled modern genetics to take off rapidly once his results became known, and we rightly credit him for his perceptive insight. The particulate nature of genetic inheritance is now beyond question and has been confirmed in intimate detail at the molecular level across the spectrum of biologi ...
Tracing the Thread of Plastid Diversity through the Tapestry of Life
Tracing the Thread of Plastid Diversity through the Tapestry of Life

... genome; gene loss, substitution, and transfer. First, in the case of gene loss, genes that no longer confer a selective advantage in the endosymbiotic environment may be lost outright. A probable example of such a loss is that of the cyanobacterial cell wall, which is entirely lacking in most plasti ...
Lesson Overview
Lesson Overview

... pollen-bearing male parts of a flower and then dusting the pollen from a different plant onto the female part of that flower, as shown in the figure. ...
Two Classes of sir3 Mutants Enhance the sir1
Two Classes of sir3 Mutants Enhance the sir1

... Immunoblot analysis: Preparation of protein extracts, SDSPAGE electrophoresis, and immunoblotting for Sir3p detection were performed as described (Stone and Pillus 1996). High-copy 2␮ plasmids were used to facilitate detection of Sir3p from wild-type and mutant strains. For all parameters tested pre ...
Genetics - York University
Genetics - York University

... genes are somehow locations on the chromosomes. ¾ The presence of genes on pairs of chromosomes – one from each parent – corresponded with Mendel’ Mendel’s factors. ...
Loss of Hox-A1 (Hox-1.6) function results in the
Loss of Hox-A1 (Hox-1.6) function results in the

... Position of branchiomotor neurons in the control mouse hindbrain Previous observations on developing chick (Lumsden and Keynes, 1989) and mouse hindbrains (Marshall et al., 1992; Baker and Noden, personal communications) have demonstrated a precise and stereotypic pattern of development of the branc ...
Population Differences in the Polyalanine Domain and 6
Population Differences in the Polyalanine Domain and 6

... HLXB9 has 3 exons encoding a 403-amino acid protein. The HLXB9 protein functions as a transcription factor regulating gene expression in both developing and adult tissues, although little is known about target genes or protein partners. Structurally, HLXB9 contains a homeodomain, a highly conserved ...
PH4 of Petunia Is an R2R3 MYB Protein That Activates
PH4 of Petunia Is an R2R3 MYB Protein That Activates

... of the pathway, in all pigmented tissues (Quattrocchio et al., 1993) and encode a basic-helix-loop-helix (BHLH) transcription factor and a WD40 protein, respectively (de Vetten et al., 1997; Spelt et al., 2000). AN2 encodes a MYB-type transcription factor whose function appears to be (partially) red ...
jing is required for wing development and to establish the
jing is required for wing development and to establish the

... Like most transcription factors, those that are required for PD axis formation in the Drosophila leg have additional and very distinct functions at other stages and tissues during development. For example, dac plays an important role in the development of the eye, central nervous system (CNS), and t ...
Alu - Environmental
Alu - Environmental

... • The AAAA of Alu transcript binds to the TTTT of the nicked DNA – the acts as a primer for the L1 to bind to ...
by Attila Mokanszki Supervisor: Prof. Dr. Eva Olah
by Attila Mokanszki Supervisor: Prof. Dr. Eva Olah

... abortions because of the higher frequency of sperm with unbalanced chromosome translocation (20-80%). Robertsonian translocations result in the formation of a chromosome composed of the long arms of two acrocentric chromosomes and the subsequent loss of their short arms. The translocated dicentric c ...
Assessing homology at different levels of the biological hierarchy
Assessing homology at different levels of the biological hierarchy

... (phylogenetic history) and of shared developmental and genetic pathways or networks. Behavioural homology Homology has predominantly been used for structures; hence structural homology. It would be more inclusion to speak of phenotypic homology to reflect the fact that other aspects of the phenotype ...
TRANSLOCATIONS INVOLVING T H E THIRD AND THE FOURTH
TRANSLOCATIONS INVOLVING T H E THIRD AND THE FOURTH

... the third chromosome, one fragment being attached to the fourthchromosome. These gametes carry, therefore, the gene D and the normal allelomorph of ev. The other kind of gametes contains the normal (that is, the unbroken) third chromosome andthe free fourth chromosome. These gametes carry ey but do ...
Application of molecular markers in plant breeding
Application of molecular markers in plant breeding

... genotypes can be done directly at the DNA-level in a non-destructive manner with no interference of the environment and regardless of the plant developmental stages, thus allowing a greater efficiency of field trials (Peleman & van der Voort, 2003). The use of molecular information can enhance bree ...
Prediction and investigation of novel proteins in DNA double
Prediction and investigation of novel proteins in DNA double

... causing fragmentation of the DNA strands. Mis-repaired and unrepaired DSBs lead to chromosomal rearrangement and genomic instability promoting tumorigenesis or cell death. DSBs are primarily repaired by two independent and highly conserved pathways: homologous recombination (HR) and non-homologous e ...
Localization and structural analysis of the ribosomal RNA operons of
Localization and structural analysis of the ribosomal RNA operons of

... post-transcriptional levels. The cellular content of specific mRNA and protein components unique to photosynthetic growth are either not detectable or present at extremely low levels in aerobically growing cells (3). Because of the apparent translational coupling between the synthesis of specific IC ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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