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A novel role for the floral homeotic gene APETALA2
A novel role for the floral homeotic gene APETALA2

... suggesting that m413 is a new allele of ap2. To further confirm this, the AP2 locus (At4g36920) from the m413 suppressor line was sequenced and a G-to-A change in the first exon was found that caused a premature stop codon truncating the protein before the first AP2 domain (supplementary material Fi ...
Bioinformatics
Bioinformatics

... molecules (in the sense of physical-chemistry) and then applying “informatics” techniques (derived from disciplines such as applied math, CS, and statistics) to understand and organize the information associated with these molecules, on a large-scale. • Bioinformatics is a practical discipline with ...
Practice final key
Practice final key

... locus closely linked to the centromere of a chromosome and heterozygous Bb for another locus weakly linked to the centromere of the same chromosome. It is found that cells of the teratoma have the normal human female karyotype (XX; 22AA) and are homozygous A/A and heterozygous B/b. Which of the foll ...
Pet_SUMO manual
Pet_SUMO manual

... proteins; however, unlike ubiquitin modification, SUMO modification leads to changes in protein function and activity rather than protein degradation. Studies at Invitrogen have shown that fusion of a heterologous protein to SUMO can lead to increased expression levels as well as enhanced solubility ...
Microbiology
Microbiology

... In several Pseudomonas species, the gacA and gacS genes are subject to spontaneous mutation, and gac mutants appear for example in nutrient-rich liquid medium (Bull et al., 2001; Duffy & Defago, 1995; van den Broek et al., 2003) and on plant roots (Sanchez-Contreras et al., 2002; Chancey et al., 200 ...
Endoderm development in vertebrates: fate mapping
Endoderm development in vertebrates: fate mapping

... that their expression is regulated by Nodal signaling (Alexander & Stainier 1999; Rodaway et al. 1999; Reiter et al. 2001). bon and fau/gata5 mutants contain approximately 10% and approximately 60% of the normal number of endoderm cells, respectively, as assessed by the early endoderm marker genes s ...
Commentary: A century of Mendelism: on Johannsen`s genotype
Commentary: A century of Mendelism: on Johannsen`s genotype

... whole organism’s biology and its cells’ interactions with neighbouring cells, produce the embryo and the organism that emerges. There are no specific cellular elements, neither nuclear nor chromosomal, involved in heredity. These two ideas: that ‘elements’ in the zygote correspond to special organs, ...
Complex regulation of sister kinetochore orientation in meiosis-I
Complex regulation of sister kinetochore orientation in meiosis-I

... some chromosomes segregate reductionally as in meiosisI, whereas others segregate equationally as in meiosis-II, leading to a reduction in viability of the spores. Deletion of the gene SPO11 in a background of spo12 deletion causes complete lack of viability of the spores in a MAM1- dependent manner ...
The universal reagent for genome tailoring
The universal reagent for genome tailoring

... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
AmiGO
AmiGO

... search for GO terms and view the genes or gene products they are annotated to perform a sequence identity BLAST search and view the GO term associations for the genes or proteins returned ...
11.1-11.3 Notes
11.1-11.3 Notes

... Mendel realized that the principles of probability could be used to explain the results of his genetic crosses. Probability is the likelihood that a particular event will occur. For example, there are two possible outcomes of a coin flip: The coin may land either heads up or tails up. The chance, or ...
Hereditary hemorrhagic telangiectasia: genetics and molecular
Hereditary hemorrhagic telangiectasia: genetics and molecular

... both genes. Although less common than missense mutations in ENG and ACVRL1, the proportion of mutations causing a truncating frameshift or stop codon (i.e., indels and non-sense mutations) are more frequent in ENG than in ACVRL1 (Lesca et al., 2004 3 ). No common mutation “hotspots” have been observ ...
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics
Gene Section ATF2 (activating transcription factor 2) Atlas of Genetics and Cytogenetics

factor involved in dorsal-ventral axis formation and neurogenesis
factor involved in dorsal-ventral axis formation and neurogenesis

... Figure 2. Molecular characterization of spi. (A) Restriction map of the spi region. Genomic DNA encompassing the spi region is indicated by the top line. Arrows above the line mark the boundaries of phage R37. The 2.9-kb BamHI-EcoRI restriction fragment is altered in spi dppta (data not shown). The ...
PDF
PDF

... inducing ROS species (Gazzano et al., 2012; Zhang et al., 2012). In recent years, many new synthetic routes to produce amorphous silica stabilized nanoparticles have been developed and a few publications describe that even the synthetic procedure can influence their effects on cells (Zhang et al., 2 ...
Molecular Biology and Applied Genetics
Molecular Biology and Applied Genetics

... health institutions. It can also be used in teaching any introductory course on medical Applied Genetics and Molecular Biology and as a reference material. This lecture note is specifically designed for medical laboratory technologists, and includes only those areas of molecular cell biology and App ...
Computational Identification of Plant MicroRNAs and
Computational Identification of Plant MicroRNAs and

... MicroRNAs (miRNAs) are ⵑ21-nucleotide RNAs, some of which have been shown to play important generegulatory roles during plant development. We developed comparative genomic approaches to systematically identify both miRNAs and their targets that are conserved in Arabidopsis thaliana and rice (Oryza s ...
Multiple domain structure in a chitinase gene (chic)
Multiple domain structure in a chitinase gene (chic)

... 1992; Kuranda & Robbins, 1991), but these sequences are not always homologous. This suggests that chitinase genes have spread through various organisms in the process of evolution and have formed several gene families. Streptomyces spp. are typical soil inhabitants, and produce various carbohydrases ...
XYY Syndrome - Society for the Study of Behavioural Phenotypes
XYY Syndrome - Society for the Study of Behavioural Phenotypes

... The prevalence of XYY syndrome among psychiatric patients is approximately 3 times that of the general population prevalence. Psychiatric diagnoses are more common in boys diagnosed postnatally and are often the reason these boys had karyotype evaluation (Bardsley,2013). Risk for psychosis is high i ...
Regulation of limb bud initiation and limbtype
Regulation of limb bud initiation and limbtype

... bud will appear and, thus, their identity (Cohn et al., 1997; Cohn and Tickle, 1999) (Fig. 1A). For example, Hoxc4-5 is expressed mostly in the mesenchyme of the presumptive forelimb area (Savard et al., 1988; Tabin, 1989; Molven et al., 1990; Burke et al., 1995), Hoxc9, Hoxc10, Hoxc11 are, predomin ...
Relation of the Wnt/β-catenin signaling pathway
Relation of the Wnt/β-catenin signaling pathway

... Abstract: The Wnt signaling pathway is evolutionary conserved and controls many biological processes like cell proliferation and differentiation. It also provides planar polarity, regulation of the cell cycle, and cell adhesion during both the embryonic and adult period. However, it has been widely ...
Molecular Biology Reports
Molecular Biology Reports

... Carotenoids have important functions in photosynthesis and protecting plant cells against excess light energy and photooxidative damage [1–3]. Carotenoids are metabolites of phytoene, which is synthesized by phytoene synthase (PSY) from geranylgeranyl pyrophosphates (GGPP) that originate in the isop ...
Bcl-2–Modifying Factor Induces Renal Proximal Tubular
Bcl-2–Modifying Factor Induces Renal Proximal Tubular

... Ó 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details. ...
Chromosome Variation
Chromosome Variation

... White Lightning. Like his brother, White Lightning possessed mule chromosomes and appeared to have inherited only horse chromosomes from his mother. Additional reports of fertile female mules support the idea that their offspring inherit only horse chromosomes from their mother. When the father of a ...
1 shared allele
1 shared allele

... D’ = [PAB - PAPB]/DMAX PA = frequency of allele A in population PB = frequency of allele B in population PAB = frequency of association of alleles A and B DMAX = Maximal value of |PAB-PAPB| D’ = 0 when there is no LD; ±1 for complete association or dissociation. ...
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Epigenetics of human development

Development before birth, including gametogenesis, embryogenesis, and fetal development, is the process of body development from the gametes are formed to eventually combine into a zygote to when the fully developed organism exits the uterus. Epigenetic processes are vital to fetal development due to the need to differentiate from a single cell to a variety of cell types that are arranged in such a way to produce cohesive tissues, organs, and systems.Epigenetic modifications such as methylation of CpGs (a dinucleotide composed of a 2'-deoxycytosine and a 2' deoxyguanosine) and histone tail modifications allow activation or repression of certain genes within a cell, in order to create cell memory either in favor of using a gene or not using a gene. These modifications can either originate from the parental DNA, or can be added to the gene by various proteins and can contribute to differentiation. Processes that alter the epigenetic profile of a gene include production of activating or repressing protein complexes, usage of non-coding RNAs to guide proteins capable of modification, and the proliferation of a signal by having protein complexes attract either another protein complex or more DNA in order to modify other locations in the gene.
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