Molecular and Cellular Mechanisms of Reelin Signaling in the Adult
... intact brain and further emphasize that extracellular proteolysis of Reelin by tPA and other yet-to-be identified proteases is important to consider when trying to understand how altered Reelin processing and/or expression contribute to cognitive impairments associated with disease states. In Chapte ...
... intact brain and further emphasize that extracellular proteolysis of Reelin by tPA and other yet-to-be identified proteases is important to consider when trying to understand how altered Reelin processing and/or expression contribute to cognitive impairments associated with disease states. In Chapte ...
The dynamic cytoskeleton: backbone of dendritic spine plasticity
... tip of the filopodium, dendritic filopodia appear to form from a mixed network of both linear and branched actin filaments that extend to form a filopodium. Furthermore, in contrast to other filopodia, they appear to contain concentrations of Arp2/3, capping protein and myosin II, while lacking fasc ...
... tip of the filopodium, dendritic filopodia appear to form from a mixed network of both linear and branched actin filaments that extend to form a filopodium. Furthermore, in contrast to other filopodia, they appear to contain concentrations of Arp2/3, capping protein and myosin II, while lacking fasc ...
Neural Mechanisms of Extinction Learning and Retrieval
... been observed with systemic administration of the voltagegated calcium channel (VGCC) antagonist nifedipine (Cain et al, 2002; Barad et al, 2004). Together with the NMDA findings, this suggests that calcium currents are required for the initial decrements in responding that occur during an extinctio ...
... been observed with systemic administration of the voltagegated calcium channel (VGCC) antagonist nifedipine (Cain et al, 2002; Barad et al, 2004). Together with the NMDA findings, this suggests that calcium currents are required for the initial decrements in responding that occur during an extinctio ...
The supramammillary area: its organization, functions
... particularly memory. We argue, on several different grounds, therefore, that its modulation of telencephalic activity is fundamental to cognitive–emotional interactions. This claim is subject to two caveats. First, we are claiming only a modulatory role for SuM. It is likely to pace information arou ...
... particularly memory. We argue, on several different grounds, therefore, that its modulation of telencephalic activity is fundamental to cognitive–emotional interactions. This claim is subject to two caveats. First, we are claiming only a modulatory role for SuM. It is likely to pace information arou ...
A role for sleep in brain plasticity
... [3], tissue restoration [4] and immune defence [5]. Another hypothesis has focused much attention for the last years and proposes that sleep might participate in brain plasticity [6]. The latter refers to the ability of the brain to persistently modify its structure and function according to genetic ...
... [3], tissue restoration [4] and immune defence [5]. Another hypothesis has focused much attention for the last years and proposes that sleep might participate in brain plasticity [6]. The latter refers to the ability of the brain to persistently modify its structure and function according to genetic ...
RESULTATS Capítol 1 __________________________________________________________________________ 71
... by specific signals as the main mechanism by which neuronal connections are first established between brain areas (Huber et al., 2003; Mueller, 1999), while activitydependent plasticity has been proposed as a mechanism for the final refinement and maturation of connections (Katz and Shatz, 1996). A ...
... by specific signals as the main mechanism by which neuronal connections are first established between brain areas (Huber et al., 2003; Mueller, 1999), while activitydependent plasticity has been proposed as a mechanism for the final refinement and maturation of connections (Katz and Shatz, 1996). A ...
Learning and memory in zebrafish larvae
... Dishabituation of the rapid escape response in zebrafish larvae (5–7 dpf) has been observed by three laboratories. After habituating the escape response in larvae to auditory pips, Best et al. (2008) produced dishabituation by delivering a brief stimulus of a different sensory modality (a pulse of l ...
... Dishabituation of the rapid escape response in zebrafish larvae (5–7 dpf) has been observed by three laboratories. After habituating the escape response in larvae to auditory pips, Best et al. (2008) produced dishabituation by delivering a brief stimulus of a different sensory modality (a pulse of l ...
Serotonin synthesis, release and reuptake in terminals: a
... Even this brief discussion shows why understanding the casual mechanisms in serotonergic signaling is a challenging problem. Not only does one have to understand mechanism and function on four different levels, genomic, biochemical, electrophysiological, and behavioral, but changes on each level aff ...
... Even this brief discussion shows why understanding the casual mechanisms in serotonergic signaling is a challenging problem. Not only does one have to understand mechanism and function on four different levels, genomic, biochemical, electrophysiological, and behavioral, but changes on each level aff ...
Full Text
... fluorescence microscopy. However, little is known about the biochemical and physical properties of these chimaeric proteins, and whether they behave similarly to their untagged SOD1 counterparts. Methodology/Principal Findings: Here we compare the physicochemical properties of SOD1 and the effects o ...
... fluorescence microscopy. However, little is known about the biochemical and physical properties of these chimaeric proteins, and whether they behave similarly to their untagged SOD1 counterparts. Methodology/Principal Findings: Here we compare the physicochemical properties of SOD1 and the effects o ...
Csercsa Richárd
... Sleep is a condition during which animals are resting and their responses to external sensory stimuli (sounds, touch, smell) and processing of the information these stimuli carry are altered compared to the waking state. Most of these stimuli don’t reach the conscious level, they fade in the neurona ...
... Sleep is a condition during which animals are resting and their responses to external sensory stimuli (sounds, touch, smell) and processing of the information these stimuli carry are altered compared to the waking state. Most of these stimuli don’t reach the conscious level, they fade in the neurona ...
DEPARTAMENT DE FARMACOLOGIA, DE TERAPÈUTICA I DE TOXICOLOGIA
... “techno” parties. Ecstasy is usually sold in the form of tablets of different colours decorated with a wide variety of designs and logos, it can also be found as crystals. The content in “ecstasy” tablets of MDMA varies greatly from batch to batch, but regularly it has been found to contain between ...
... “techno” parties. Ecstasy is usually sold in the form of tablets of different colours decorated with a wide variety of designs and logos, it can also be found as crystals. The content in “ecstasy” tablets of MDMA varies greatly from batch to batch, but regularly it has been found to contain between ...
Bacterial ribosome requires multiple L12 dimers for efficient initiation
... hinges were proposed to form the core dimer (12). However, this model failed to justify the strong dimer interaction in L12 dimer, had no functional relevance and was contradicted by an NMR structure where both the hinges were seen in fully extended form (9,11). Thus it is now universally accepted t ...
... hinges were proposed to form the core dimer (12). However, this model failed to justify the strong dimer interaction in L12 dimer, had no functional relevance and was contradicted by an NMR structure where both the hinges were seen in fully extended form (9,11). Thus it is now universally accepted t ...
IMAGERY PERSPECTIVE AND MEMORY RECALL 1 Accepted for
... used externally generated images (e.g. Jackson et al., 2006). When participants were shown video clips of hand and foot actions, either from a first-person- or a third-person perspective, more activity was shown in the left sensory-motor cortex when viewing the video clips from a first-person perspe ...
... used externally generated images (e.g. Jackson et al., 2006). When participants were shown video clips of hand and foot actions, either from a first-person- or a third-person perspective, more activity was shown in the left sensory-motor cortex when viewing the video clips from a first-person perspe ...
Memory
... – Strategies—the use of mental activities to improve the processing of information—improve in these areas: • Organization: More likely to be used by older children and adults. • Elaboration: Adolescents are more likely to use elaboration spontaneously than children. • Imagery: Encouraging children t ...
... – Strategies—the use of mental activities to improve the processing of information—improve in these areas: • Organization: More likely to be used by older children and adults. • Elaboration: Adolescents are more likely to use elaboration spontaneously than children. • Imagery: Encouraging children t ...
Program
and
Abstracts
from
the
Fifth
Annual
Canadian
Neuroscience
Meeting
May
29
–
June
1
2011
Quebec
City
Convention
Center
... 54%, FoxO3 ‐ 71%. The functional domains of these genes was conserved to a far greater extent suggesting that the cellular functions of these genes is highly conserved. By in situ, we found that AptFoxP2 and AptOtx1 transcripts were expressed predominantly in DC; the dorsolateral pallium (DL) con ...
... 54%, FoxO3 ‐ 71%. The functional domains of these genes was conserved to a far greater extent suggesting that the cellular functions of these genes is highly conserved. By in situ, we found that AptFoxP2 and AptOtx1 transcripts were expressed predominantly in DC; the dorsolateral pallium (DL) con ...
Huntingtin Aggregation Kinetics and Their Pathological
... of trafficked organelles and proteins such as synaptic vesicles (Sinadinos et al. 2009) and transcription factors (Chai et al. 2002). However, there is also evidence that aggregates may be inert or even neuroprotective. Medium spiny projection neurons of the striatum exhibit fewer Htt aggregates than ...
... of trafficked organelles and proteins such as synaptic vesicles (Sinadinos et al. 2009) and transcription factors (Chai et al. 2002). However, there is also evidence that aggregates may be inert or even neuroprotective. Medium spiny projection neurons of the striatum exhibit fewer Htt aggregates than ...
Creating associative memory distortions
... Memory illusions, which have fascinated researchers for decades, refer to situations in which a person either declares that he or she remembers something that did not really occur or remembers a fact that did occur but in a manner that seriously differs from actually experienced events (Roediger, 19 ...
... Memory illusions, which have fascinated researchers for decades, refer to situations in which a person either declares that he or she remembers something that did not really occur or remembers a fact that did occur but in a manner that seriously differs from actually experienced events (Roediger, 19 ...
Validation of hippocampal volumes measured using a
... hippocampal volumetry method was introduced in the late 1980s, and its precision was validated with a phantom [12– 17]. The advent of thin-slice three-dimensional (3-D) MRI with slice thicknesses of 1 to 2 mm and advanced measurement techniques for brain volumetry has enabled the detection of mild h ...
... hippocampal volumetry method was introduced in the late 1980s, and its precision was validated with a phantom [12– 17]. The advent of thin-slice three-dimensional (3-D) MRI with slice thicknesses of 1 to 2 mm and advanced measurement techniques for brain volumetry has enabled the detection of mild h ...
Technologies émergentes de mémoire résistive pour les systèmes
... (CBRAM) and Metal-Oxide based Memory (OXRAM) can play in dedicated neuromorphic hardware. We focus on the emulation of synaptic plasticity effects such as long-term potentiation (LTP), long term depression (LTD) and spike-timing dependent plasticity (STDP) with RRAM synapses. We developed novel low- ...
... (CBRAM) and Metal-Oxide based Memory (OXRAM) can play in dedicated neuromorphic hardware. We focus on the emulation of synaptic plasticity effects such as long-term potentiation (LTP), long term depression (LTD) and spike-timing dependent plasticity (STDP) with RRAM synapses. We developed novel low- ...
Regulation of Starch Synthesis in Cassava Yona Baguma
... of PP2A, did not, suggesting that sugar and ABA signaling pathways converge at the PP1 level downstream of the sugar signaling pathway. Chloramphenicol, which specifically inhibits plastid de novo protein synthesis, with or without sucrose, blocked sbe expression but cycloheximide, a cytosolic de no ...
... of PP2A, did not, suggesting that sugar and ABA signaling pathways converge at the PP1 level downstream of the sugar signaling pathway. Chloramphenicol, which specifically inhibits plastid de novo protein synthesis, with or without sucrose, blocked sbe expression but cycloheximide, a cytosolic de no ...
Hippocampal CA1 atrophy and synaptic loss during
... and the mechanisms underlying these deficits remain poorly understood. Neuronal injury and synaptic loss have been shown to occur within the hippocampus in other neurodegenerative disease models, and these pathologies have been correlated with cognitive impairment. Whether hippocampal abnormalities ...
... and the mechanisms underlying these deficits remain poorly understood. Neuronal injury and synaptic loss have been shown to occur within the hippocampus in other neurodegenerative disease models, and these pathologies have been correlated with cognitive impairment. Whether hippocampal abnormalities ...
Traveling Theta Waves along the Entire
... *Correspondence: [email protected] http://dx.doi.org/10.1016/j.neuron.2012.07.015 ...
... *Correspondence: [email protected] http://dx.doi.org/10.1016/j.neuron.2012.07.015 ...
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and
... The human gene encoding TDP-43 (TARDP) on chromosome 1 was cloned and shown to bind a polypyrimidine-rich motif in the HIV transactive response DNA (20), but it was later identified independently as part of a complex involved in the splicing of the cystic fibrosis transmembrane conductance regulator ...
... The human gene encoding TDP-43 (TARDP) on chromosome 1 was cloned and shown to bind a polypyrimidine-rich motif in the HIV transactive response DNA (20), but it was later identified independently as part of a complex involved in the splicing of the cystic fibrosis transmembrane conductance regulator ...
Distinct Roles for Somatically and Dendritically Synthesized Brain
... Dendritic spines undergo the processes of formation, maturation, and pruning during development. Molecular mechanisms controlling spine maturation and pruning remain largely unknown. The gene for brain-derived neurotrophic factor (BDNF) produces two pools of mRNA, with either a short or long 3⬘ untr ...
... Dendritic spines undergo the processes of formation, maturation, and pruning during development. Molecular mechanisms controlling spine maturation and pruning remain largely unknown. The gene for brain-derived neurotrophic factor (BDNF) produces two pools of mRNA, with either a short or long 3⬘ untr ...
Different neurotrophins are expressed and act in a developmental
... raised the issue of whether similar correlations between target field innervation, neurotrophin synthesis and neuronal responsiveness exist for these more recently identified neurotrophins. This is especially pertinent as these neurotrophins, in contrast to NGF, have additional roles in neuronal dev ...
... raised the issue of whether similar correlations between target field innervation, neurotrophin synthesis and neuronal responsiveness exist for these more recently identified neurotrophins. This is especially pertinent as these neurotrophins, in contrast to NGF, have additional roles in neuronal dev ...