paper
... shows that essentially all mutations occur in males. Wilkin et al. report 40 sporadic cases, of which all the mutations were paternal12. In 57 cases of Apert syndrome (acrocephalosyndactyly)13, 25 of multiple endocrine neoplasia 2B (MEN 2B)14, ten of MEN 2A (REF. 15),and 22 of Crouzon and Pfeiffer s ...
... shows that essentially all mutations occur in males. Wilkin et al. report 40 sporadic cases, of which all the mutations were paternal12. In 57 cases of Apert syndrome (acrocephalosyndactyly)13, 25 of multiple endocrine neoplasia 2B (MEN 2B)14, ten of MEN 2A (REF. 15),and 22 of Crouzon and Pfeiffer s ...
Genetic Causes of Phenotypic Adaptation to the Second
... ABSTRACT Hybridization is known to improve complex traits due to heterosis and phenotypic robustness. However, these phenomena have been rarely explained at the molecular level. Here, the genetic determinism of Saccharomyces cerevisiae fermentation performance was investigated using a QTL mapping ap ...
... ABSTRACT Hybridization is known to improve complex traits due to heterosis and phenotypic robustness. However, these phenomena have been rarely explained at the molecular level. Here, the genetic determinism of Saccharomyces cerevisiae fermentation performance was investigated using a QTL mapping ap ...
Genetic features of a pollen-part mutation suggest an inhibitory role
... tissue and entered the ovary—in clear contrast to the typical SI response where the pollen tube growth is arrested within the top one-third of transmitting track. This ‘normal’ pollen tube growth by apparently SI pollen pointed to these tubes being able to overcome the classical SI barrier for self ...
... tissue and entered the ovary—in clear contrast to the typical SI response where the pollen tube growth is arrested within the top one-third of transmitting track. This ‘normal’ pollen tube growth by apparently SI pollen pointed to these tubes being able to overcome the classical SI barrier for self ...
Understanding Lynch Syndrome - Hereditary Nonpolyposis
... division. When mutations occur in these genes, a cell may begin to divide without control. Cells that divide when they are not supposed to may eventually become a cancer. See Appendix on page 25 for more information about genes, chromosomes and DNA. ...
... division. When mutations occur in these genes, a cell may begin to divide without control. Cells that divide when they are not supposed to may eventually become a cancer. See Appendix on page 25 for more information about genes, chromosomes and DNA. ...
file
... the situation such that only one locus with two alleles, say A and a, determines the condition of both males and females (see table 1 for a list of symbols). Condition in turn determines viability, and in the case of males it can also have an influence on their sexual appearance. We introduce female ...
... the situation such that only one locus with two alleles, say A and a, determines the condition of both males and females (see table 1 for a list of symbols). Condition in turn determines viability, and in the case of males it can also have an influence on their sexual appearance. We introduce female ...
word
... Epigenetic regulation of the X chromosome in C. elegans The X chromosome has no partner during XO male meiosis in C. elegans, and as such is targeted for repression by meiotic silencing mechanisms recognizing unsynapsed/unpaired chromatin. The near-complete paucity of germlineexpressed genes on the ...
... Epigenetic regulation of the X chromosome in C. elegans The X chromosome has no partner during XO male meiosis in C. elegans, and as such is targeted for repression by meiotic silencing mechanisms recognizing unsynapsed/unpaired chromatin. The near-complete paucity of germlineexpressed genes on the ...
Brassinosteroid-6-Oxidases from Arabidopsis and
... the same gene, but only F5F3 had sufficient length to contain the full-length cDNA (data not shown). When the entire nucleotide sequence of the cDNA insert of F5F3 was determined and compared with the Dwarf gene, it was apparent that the first intron remained un-spliced with the consensus splice sit ...
... the same gene, but only F5F3 had sufficient length to contain the full-length cDNA (data not shown). When the entire nucleotide sequence of the cDNA insert of F5F3 was determined and compared with the Dwarf gene, it was apparent that the first intron remained un-spliced with the consensus splice sit ...
draft - IC
... When more than two genomes are considered, we have the more challenging problem of rearrangement-based phylogeny reconstruction, where we want to nd a tree that minimizes the total number of rearrangement events. Early approaches were based on a breakpoint distance (e.g., BPAnalysis [13], and GRAPP ...
... When more than two genomes are considered, we have the more challenging problem of rearrangement-based phylogeny reconstruction, where we want to nd a tree that minimizes the total number of rearrangement events. Early approaches were based on a breakpoint distance (e.g., BPAnalysis [13], and GRAPP ...
Characteristics of a Laboratory Strain of Coleomegilla maculata with
... Heliconius butterflies [12]. The genes involved in color patterning in beetles have not yet been discovered. The ladybird beetle C. maculata has appealing characteristics for use as a genetic model organism. It is relatively easy to find and maintain in culture, it is visually appealing and unthreat ...
... Heliconius butterflies [12]. The genes involved in color patterning in beetles have not yet been discovered. The ladybird beetle C. maculata has appealing characteristics for use as a genetic model organism. It is relatively easy to find and maintain in culture, it is visually appealing and unthreat ...
genetics genetics - Cystic Fibrosis Association of New Zealand
... When both parents are carriers of the faulty CF gene they have a 1 in 4 chance of having a baby with CF with every pregnancy (see page 3 Why is a baby born with CF). While there have been great improvements in the length and quality of life for people with CF, it still remains a serious condition an ...
... When both parents are carriers of the faulty CF gene they have a 1 in 4 chance of having a baby with CF with every pregnancy (see page 3 Why is a baby born with CF). While there have been great improvements in the length and quality of life for people with CF, it still remains a serious condition an ...
Non-cell-autonomous regulation of root hair patterning genes by
... The establishment of a pattern of files forming root hairs and non-root hairs in the root epidermis is a wellstudied developmental model system (Schiefelbein et al., 2009; Tominaga-Wada et al., 2011; Grebe, 2012). Root hair cells (H-cells) develop from cell files over the cleft of two underlying cor ...
... The establishment of a pattern of files forming root hairs and non-root hairs in the root epidermis is a wellstudied developmental model system (Schiefelbein et al., 2009; Tominaga-Wada et al., 2011; Grebe, 2012). Root hair cells (H-cells) develop from cell files over the cleft of two underlying cor ...
Conserved syntenic clusters of protein coding genes are missing in
... and curated avian genomes available in Ensembl at the time we began this study. Out of 18,596 protein coding genes in lizard, 12,113 are predicted to have 1-to-1 orthologs in humans. Of these, only 10,554 also have 1to-1 orthologs in chicken and/or zebra finch, thus revealing a total of 1,559 genes ...
... and curated avian genomes available in Ensembl at the time we began this study. Out of 18,596 protein coding genes in lizard, 12,113 are predicted to have 1-to-1 orthologs in humans. Of these, only 10,554 also have 1to-1 orthologs in chicken and/or zebra finch, thus revealing a total of 1,559 genes ...
Dynamic Programming and Graph Algorithms in Computer Vision
... problems in terms of optimization we can easily take into account multiple sources of information. Another advantage of the optimization approach is that in principle it provides a clean separation between how a problem is formulated (the objective function) and how the problem is solved (the optim ...
... problems in terms of optimization we can easily take into account multiple sources of information. Another advantage of the optimization approach is that in principle it provides a clean separation between how a problem is formulated (the objective function) and how the problem is solved (the optim ...
An Introduction to Peutz Jeghers Syndrome
... (a condition known as intussusception). Because of this, it is sensible for new babies to be seen by a specialist paediatrician so that in the event of an emergency, the child is known to the hospital department and an emergency appointment can be arranged without any delay. ...
... (a condition known as intussusception). Because of this, it is sensible for new babies to be seen by a specialist paediatrician so that in the event of an emergency, the child is known to the hospital department and an emergency appointment can be arranged without any delay. ...
doc - Lonely Joe Parker
... genetic changes, must also be parallel, as above. However the reciprocal position – that all parallel changes must be parallel – does not follow and should not be assumed. How, then, are we to distinguish cases of mere parallelism in unrelated taxa from meaningful convergence? The problem is compoun ...
... genetic changes, must also be parallel, as above. However the reciprocal position – that all parallel changes must be parallel – does not follow and should not be assumed. How, then, are we to distinguish cases of mere parallelism in unrelated taxa from meaningful convergence? The problem is compoun ...
The role of linkage disequilibrium in the evolution of
... single instance of speciation can include both one-allele and two-allele components of premating isolation (see also Felsenstein, 1981, p 133). In one of the variants of their sympatric speciation model, speciation relies on both divergence of a marker trait and the evolution of assortative mating f ...
... single instance of speciation can include both one-allele and two-allele components of premating isolation (see also Felsenstein, 1981, p 133). In one of the variants of their sympatric speciation model, speciation relies on both divergence of a marker trait and the evolution of assortative mating f ...
How many lethal alleles? - University of Edinburgh
... population is important for our understanding of population genetics and evolution, and yet there have been few attempts to measure their number in wild populations. A new study has revealed unexpectedly low numbers of segregating lethal alleles in two species of fish. More experiments are needed, h ...
... population is important for our understanding of population genetics and evolution, and yet there have been few attempts to measure their number in wild populations. A new study has revealed unexpectedly low numbers of segregating lethal alleles in two species of fish. More experiments are needed, h ...
RESISTANCE AS A RESPONSE TO STRESS
... expression of a gene is altered to increase the amount of gene product made (note that gene expression may also be altered to decrease the amount of product made) (c) the genetic code is rewritten to produce a structurally different product. ...
... expression of a gene is altered to increase the amount of gene product made (note that gene expression may also be altered to decrease the amount of product made) (c) the genetic code is rewritten to produce a structurally different product. ...
Complete Thyroxine-Binding Globulin (TBG) Deficiency Produced
... cleotide 1671 of the acceptor splice site in intron II (Fig. 4). The mutation was present in all affected family members as confirmed by genotyping. Affected and normal males showed only the mutant allele or normal allele, respectively, and heterozygous females had both normal and mutant allele (Fig ...
... cleotide 1671 of the acceptor splice site in intron II (Fig. 4). The mutation was present in all affected family members as confirmed by genotyping. Affected and normal males showed only the mutant allele or normal allele, respectively, and heterozygous females had both normal and mutant allele (Fig ...
Identification of causal genes for complex traits
... suboptimal in this context. Furthermore, it fails to provide a guarantee that the true causal variant is selected. A recent work (Maller et al., 2012) addressed this issue by estimating the probabilities for variants to be causal under the simplifying assumption that each fine-mapping locus contains ...
... suboptimal in this context. Furthermore, it fails to provide a guarantee that the true causal variant is selected. A recent work (Maller et al., 2012) addressed this issue by estimating the probabilities for variants to be causal under the simplifying assumption that each fine-mapping locus contains ...
Coupling of zygotic transcription to mitotic control at the Drosophila
... 2102 RESEARCH ARTICLE ...
... 2102 RESEARCH ARTICLE ...
Evaluation of the Water Stress-Inducible
... being a constant source of support throughout this program. I am grateful to Ray Zabulionis, who made my experience as a teaching assistant an enjoyable one. His example is one that I will strive to follow in any teaching or leadership role. A special thank you also to Alex Molnar for assistance wit ...
... being a constant source of support throughout this program. I am grateful to Ray Zabulionis, who made my experience as a teaching assistant an enjoyable one. His example is one that I will strive to follow in any teaching or leadership role. A special thank you also to Alex Molnar for assistance wit ...
Transvection and pairing of a Drosophila Hox long noncoding RNA
... nascent transcriptional sites in embryos heterozygous for a gain of function mutation, we directly visualize this transvection, and observe that the ectopic lincX transcriptional state appears to be relayed in trans to the homologous wild-type chromosome. This trans-activation of lincX correlates wi ...
... nascent transcriptional sites in embryos heterozygous for a gain of function mutation, we directly visualize this transvection, and observe that the ectopic lincX transcriptional state appears to be relayed in trans to the homologous wild-type chromosome. This trans-activation of lincX correlates wi ...
Kinds and Rates of Human Heritable Mutations
... The genetic code specified in DNA directs the transcription of RNA, which is translated into polypeptide chains; these chains, in turn, are assembled into proteins, which are the body’s tools for the regulation of physiological, biochemical, and behavioral functioning. Mutations, transmissible alter ...
... The genetic code specified in DNA directs the transcription of RNA, which is translated into polypeptide chains; these chains, in turn, are assembled into proteins, which are the body’s tools for the regulation of physiological, biochemical, and behavioral functioning. Mutations, transmissible alter ...
Monitoring BCR-ABL transcript levels by real-time
... when, according to the current recommendation,3 it was replaced by ABL. In order to compare results previously obtained using the B2M gene and those obtained using the ABL gene, we performed RQ-PCR on 50 peripheral blood or bone marrow fresh and stored leukemic samples in duplicate with both ABL and ...
... when, according to the current recommendation,3 it was replaced by ABL. In order to compare results previously obtained using the B2M gene and those obtained using the ABL gene, we performed RQ-PCR on 50 peripheral blood or bone marrow fresh and stored leukemic samples in duplicate with both ABL and ...