Feline Genetics: a Combinatorial Approach
... sharply instead of gradually: their effect shows up completely or not at all, according to which variant (allele) of the gene is considered. So, rather than DNA proteins, we shall have the combinatorics of symbols, standing for genes. Please be warned that the mathematical models are aimed to explai ...
... sharply instead of gradually: their effect shows up completely or not at all, according to which variant (allele) of the gene is considered. So, rather than DNA proteins, we shall have the combinatorics of symbols, standing for genes. Please be warned that the mathematical models are aimed to explai ...
Liver Effects of Clinical Drugs Differentiated in Human Liver
... In this study, the ex vivo human liver slice model was used to characterize the initial effects of drugs associated with liver adverse effects clinically which encompass diverse mechanisms contributing to liver dysfunction and injury. All drugs were dosed daily and compared side-by-side within each ...
... In this study, the ex vivo human liver slice model was used to characterize the initial effects of drugs associated with liver adverse effects clinically which encompass diverse mechanisms contributing to liver dysfunction and injury. All drugs were dosed daily and compared side-by-side within each ...
Molecular genetics of Rett syndrome and clinical
... mechanism that might account for this is dif®cult to predict. These genes may be neuronal-speci®c or widely expressed but detrimental only to neuronal development when misexpressed. In support of the idea that MeCP2 might regulate only a subset of genes, the CpG islands associated with the promoters ...
... mechanism that might account for this is dif®cult to predict. These genes may be neuronal-speci®c or widely expressed but detrimental only to neuronal development when misexpressed. In support of the idea that MeCP2 might regulate only a subset of genes, the CpG islands associated with the promoters ...
8p interstitial deletions including 8p12 FTNW
... support evolved between 8 months and almost 4 years. Mobility also comes late, and some babies never crawl, using other means such as rolling, creeping, pulling themselves forward on their arms or bottom-shuffling. Four children learned to walk between 2 years, 2 months and 12 years, but walking may ...
... support evolved between 8 months and almost 4 years. Mobility also comes late, and some babies never crawl, using other means such as rolling, creeping, pulling themselves forward on their arms or bottom-shuffling. Four children learned to walk between 2 years, 2 months and 12 years, but walking may ...
Loss And Gain Of Function Experiments Implicate TMEM18
... Mutagenesis Program (EUCOMM) (23). The introduction of the allele results in targeted disruption of exon 2 of Tmem18. Generation of hypomorphic mice, as well as the disruption of neighboring genes, has previously been demonstrated using the “knockout first” strategy (24-27). We therefore determined ...
... Mutagenesis Program (EUCOMM) (23). The introduction of the allele results in targeted disruption of exon 2 of Tmem18. Generation of hypomorphic mice, as well as the disruption of neighboring genes, has previously been demonstrated using the “knockout first” strategy (24-27). We therefore determined ...
The role of hermaphrodites in the experimental evolution of
... and had to assume random mating between the competitors in order to estimate an haploid fitness coefficient, which we took as a surrogate of population-wide fitness. As a result, increased performance under outcrossing will be underestimated since the direction of outcrossing, between GFP males with ...
... and had to assume random mating between the competitors in order to estimate an haploid fitness coefficient, which we took as a surrogate of population-wide fitness. As a result, increased performance under outcrossing will be underestimated since the direction of outcrossing, between GFP males with ...
Recruitment of CRABS CLAW to promote nectary development
... stamens. Thus, Fahn (Fahn, 1953) argued that there is a trend in nectary position within flowers, shifting from peripheral perianth positions in basal taxa to central positions associated with reproductive organs in more derived taxa. In addition, extrafloral nectaries are currently known in 68 angi ...
... stamens. Thus, Fahn (Fahn, 1953) argued that there is a trend in nectary position within flowers, shifting from peripheral perianth positions in basal taxa to central positions associated with reproductive organs in more derived taxa. In addition, extrafloral nectaries are currently known in 68 angi ...
Genome-wide histone modification patterns in
... bioRxiv preprint first posted online Feb. 15, 2016; doi: http://dx.doi.org/10.1101/039776. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
... bioRxiv preprint first posted online Feb. 15, 2016; doi: http://dx.doi.org/10.1101/039776. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY 4.0 International license. ...
09ConsensusGene
... A SYMPTOTIC C ONSENSUS T REES Consensus trees are used to summarize a set of trees defined on the same set of taxa. A consensus algorithm takes the trees as input, so that the method of producing the input trees is not part of the consensus algorithm. Typically, the trees summarized might be estimat ...
... A SYMPTOTIC C ONSENSUS T REES Consensus trees are used to summarize a set of trees defined on the same set of taxa. A consensus algorithm takes the trees as input, so that the method of producing the input trees is not part of the consensus algorithm. Typically, the trees summarized might be estimat ...
Genome Mapping in the Horse
... attempts were made to identify single nucleotide polymorphisms (SNPs) on the horse Y chromosome. The development of a genome map relies on the information generated by both linkage and cytogenetical studies. To integrate genetical and physical assignments in the very early phase of equine genome map ...
... attempts were made to identify single nucleotide polymorphisms (SNPs) on the horse Y chromosome. The development of a genome map relies on the information generated by both linkage and cytogenetical studies. To integrate genetical and physical assignments in the very early phase of equine genome map ...
Natural Selection, Infectious Transfer and the Existence Conditions
... and computer simulations to explore the existence conditions of plasmids. The most reasonable interpretation of the available evidence is that plasmids cannot be maintained solely by horizontal transfer in single populations. We therefore explore other processes that can maintain plasmids. In part i ...
... and computer simulations to explore the existence conditions of plasmids. The most reasonable interpretation of the available evidence is that plasmids cannot be maintained solely by horizontal transfer in single populations. We therefore explore other processes that can maintain plasmids. In part i ...
Shoot Branching and Leaf Dissection in Tomato Are
... of both plant species. Most eudicots originated from an ancient hexaploid progenitor (Van de Peer et al., 2009). During subsequent evolution, the Brassicaceae underwent two rounds of WGD (Simillion et al., 2002), tomato had one WGD (Fawcett et al., 2009) and some species (e. g., grape) had no additi ...
... of both plant species. Most eudicots originated from an ancient hexaploid progenitor (Van de Peer et al., 2009). During subsequent evolution, the Brassicaceae underwent two rounds of WGD (Simillion et al., 2002), tomato had one WGD (Fawcett et al., 2009) and some species (e. g., grape) had no additi ...
Operon review
... Is the repressor produced in an active or inactive form? What conditions are necessary for the repressor protein to become ACTIVE? ...
... Is the repressor produced in an active or inactive form? What conditions are necessary for the repressor protein to become ACTIVE? ...
Document
... KEY CONCEPT Genes encode proteins that produce a diverse range of traits. A gene is a segment of DNA that tells the cell how to make a particular polypeptide. The location of a gene on a chromosome is called a locus. A gene has the same locus on both chromosomes in a pair of homologous chromosomes. ...
... KEY CONCEPT Genes encode proteins that produce a diverse range of traits. A gene is a segment of DNA that tells the cell how to make a particular polypeptide. The location of a gene on a chromosome is called a locus. A gene has the same locus on both chromosomes in a pair of homologous chromosomes. ...
A method to detect single-nucleotide
... covariate-based affected relative pair linkage analysis in a conditional-logistic model framework using all 200 replicates of the Genetic Analysis Workshop 17 family data set. We begin by combining the multiple known covariate values into a single variable, a propensity score. We also use each SNP a ...
... covariate-based affected relative pair linkage analysis in a conditional-logistic model framework using all 200 replicates of the Genetic Analysis Workshop 17 family data set. We begin by combining the multiple known covariate values into a single variable, a propensity score. We also use each SNP a ...
Pattern of diversity in the genomic region near the
... previously published tb1 cDNA sequence (33). Of this, 783 bp are coding if the first in-frame ATG in the tb1 ORF is defined as the translational start site. The remaining nine regions are noncoding and are referred to by distance (in kilobases) from the 5⬘ cDNA site. The 162.9-kb site is located imm ...
... previously published tb1 cDNA sequence (33). Of this, 783 bp are coding if the first in-frame ATG in the tb1 ORF is defined as the translational start site. The remaining nine regions are noncoding and are referred to by distance (in kilobases) from the 5⬘ cDNA site. The 162.9-kb site is located imm ...
understanding heredity
... may be studied in a frog, a fish, a leaf, or a microscopic alga but will apply to man as well as to any other organism. Similarly, all cells multiply by a very typical process of division which is the same in man, bird, insect, infusorian, and plant. The process of heredity belongs to this most incl ...
... may be studied in a frog, a fish, a leaf, or a microscopic alga but will apply to man as well as to any other organism. Similarly, all cells multiply by a very typical process of division which is the same in man, bird, insect, infusorian, and plant. The process of heredity belongs to this most incl ...
Quantitative Genetics
... somewhat additive, in other words, an aabbcc organism is all white, whereas an AABBCC organism is dark red. ...
... somewhat additive, in other words, an aabbcc organism is all white, whereas an AABBCC organism is dark red. ...
Package `fcros`
... conparison of samples to obtain a matrix of fold changes. The fold changes are sorted and their rank values are used to associate statistic with genes/probes. The function to use with datasets from two biological biological conditions. The datasets should be in two separate tables as inputs. The fun ...
... conparison of samples to obtain a matrix of fold changes. The fold changes are sorted and their rank values are used to associate statistic with genes/probes. The function to use with datasets from two biological biological conditions. The datasets should be in two separate tables as inputs. The fun ...
Molecular mechanisms of floor plate formation and neural patterning
... single ptn gene in zebrafish. Molecular phylogenetic analyses have shown that these genes evolved after two large gene block duplications. In contrast to higher vertebrates, zebrafish mdk and ptn genes have undergone functional divergence, resulting in mostly non-redundant expression patterns and fu ...
... single ptn gene in zebrafish. Molecular phylogenetic analyses have shown that these genes evolved after two large gene block duplications. In contrast to higher vertebrates, zebrafish mdk and ptn genes have undergone functional divergence, resulting in mostly non-redundant expression patterns and fu ...
CTSC and PapillonLefvre syndrome: detection of recurrent
... In 1999, the first eight mutations of the CTSC gene were identified in consanguineous PLS families (Toomes et al. 1999). Since 1999, several reports have described mutations in the CTSC gene in different PLS cases from around the world (Table 1). CTSC mutations have also been reported in patients wi ...
... In 1999, the first eight mutations of the CTSC gene were identified in consanguineous PLS families (Toomes et al. 1999). Since 1999, several reports have described mutations in the CTSC gene in different PLS cases from around the world (Table 1). CTSC mutations have also been reported in patients wi ...
Progress in the Understanding of the Genetic Etiology of Vertebral
... be erroneous. Instead, a cis mechanism of interaction with Notch was demonstrated, one that results in inhibition of Notch signaling.30,31 Further DLL3 is predominantly expressed in the Golgi apparatus in contrast to other DSL ligands which are expressed on the cell surface.30 Phenotypic Analysis of ...
... be erroneous. Instead, a cis mechanism of interaction with Notch was demonstrated, one that results in inhibition of Notch signaling.30,31 Further DLL3 is predominantly expressed in the Golgi apparatus in contrast to other DSL ligands which are expressed on the cell surface.30 Phenotypic Analysis of ...
Resistance genes in barley - Journal of Applied Genetics
... strated by the 29 alleles that have already been assigned to this locus (KINTZIOS et al. 1995). Table 3 reviews information on resistance genes against 20 pathogens and pests. Recent works by FRANCKOWIAK et al. (1996) and CHEN, LINE (2001) summarise data on Rph and Rps genes, respectively. Sequencin ...
... strated by the 29 alleles that have already been assigned to this locus (KINTZIOS et al. 1995). Table 3 reviews information on resistance genes against 20 pathogens and pests. Recent works by FRANCKOWIAK et al. (1996) and CHEN, LINE (2001) summarise data on Rph and Rps genes, respectively. Sequencin ...
Supplementary Table 1 Entrez Gene (http://www.ncbi.nlm.nih.gov
... multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011) This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo prot ...
... multiple isoforms have been observed for this gene. (provided by RefSeq, Nov 2011) This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo prot ...