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Unit 3.3 Genetics
Unit 3.3 Genetics

... These traits are NOT just dominant or recessive, there for they do not follow the Mendelian genetics. ...
DNA sequencing - Rarechromo.org
DNA sequencing - Rarechromo.org

... What are chromosomes and DNA? Chromosomes are the structures in each of the body’s cells that carry the genetic information (DNA) that tells the body how to develop and function. Chromosomes (and genes) usually come in pairs with one half of each chromosome pair being inherited from each parent. Hu ...
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... Every chromosome contains thousands of genes which may be thought of as individual instruction booklets (or recipes) that contain all the genetic information telling the body how to develop, grow and function. The human genome contains around 20,000 genes. A gene is a functional region of DNA that p ...
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... What are the stages of meiosis? What is the difference between asexual and sexual reproduction? ...
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... 31. Describe the main events of the cell cycle. 32. Differentiate between G1, S, and G2 of the cell cycle. 33. Differentiate between Interphase, mitosis and cytokinesis. 34. List the stages of mitosis and describe the main events that occur in each step. 35. Describe the various methods of cancer tr ...
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... g. Counting the chromosomes involves the X-inactivation center (XIC in humans, Xic in mice). Experiments in transgenic mice show that: i. Inactivation requires the presence of at least two Xic sequences, one on each X chromosome. ii. Autosomes with an Xic inserted are randomly inactivated, showing t ...
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Chromosome



A chromosome (chromo- + -some) is a packaged and organized structure containing most of the DNA of a living organism. It is not usually found on its own, but rather is complexed with many structural proteins called histones as well as associated transcription (copying of genetic sequences) factors and several other macromolecules. Two ""sister"" chromatids (half a chromosome) join together at a protein junction called a centromere. Chromosomes are normally visible under a light microscope only when the cell is undergoing mitosis. Even then, the full chromosome containing both joined sister chromatids becomes visible only during a sequence of mitosis known as metaphase (when chromosomes align together, attached to the mitotic spindle and prepare to divide). This DNA and its associated proteins and macromolecules is collectively known as chromatin, which is further packaged along with its associated molecules into a discrete structure called a nucleosome. Chromatin is present in most cells, with a few exceptions - erythrocytes for example. Occurring only in the nucleus of eukaryotic cells, chromatin composes the vast majority of all DNA, except for a small amount inherited maternally which is found in mitochondria. In prokaryotic cells, chromatin occurs free-floating in cytoplasm, as these cells lack organelles and a defined nucleus. The main information-carrying macromolecule is a single piece of coiled double-stranded DNA, containing many genes, regulatory elements and other noncoding DNA. The DNA-bound macromolecules are proteins, which serve to package the DNA and control its functions. Chromosomes vary widely between different organisms. Some species such as certain bacteria also contain plasmids or other extrachromosomal DNA. These are circular structures in the cytoplasm which contain cellular DNA and play a role in horizontal gene transfer.Compaction of the duplicated chromosomes during cell division (mitosis or meiosis) results either in a four-arm structure (pictured to the right) if the centromere is located in the middle of the chromosome or a two-arm structure if the centromere is located near one of the ends. Chromosomal recombination during meiosis and subsequent sexual reproduction plays a vital role in genetic diversity. If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell may undergo mitotic catastrophe and die, or it may unexpectedly evade apoptosis leading to the progression of cancer.In prokaryotes (see nucleoids) and viruses, the DNA is often densely packed and organized. In the case of archaea by homologs to eukaryotic histones, in the case of bacteria by histone-like proteins. Small circular genomes called plasmids are often found in bacteria and also in mitochondria and chloroplasts, reflecting their bacterial origins.
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