Full Text - Labs / Projects - Fred Hutchinson Cancer Research Center
... oligonucleotides are 5⬘-TAAACCGGTTGGCAGCCGGCACGCGACAGGGCCAGGTTTT and 5⬘-AAAACCTGGCCCTGTCGCGTGCCGGCTGCCAACCGGTTTA, where the Hairy-binding sites are underlined. Oligonucleotides with an altered Hairy C-box previously shown to disrupt Hairy DNA binding (5) are 5⬘-TAAACCGGTTGGCAGCCGGGACGCGACAGGGCCAGGTT ...
... oligonucleotides are 5⬘-TAAACCGGTTGGCAGCCGGCACGCGACAGGGCCAGGTTTT and 5⬘-AAAACCTGGCCCTGTCGCGTGCCGGCTGCCAACCGGTTTA, where the Hairy-binding sites are underlined. Oligonucleotides with an altered Hairy C-box previously shown to disrupt Hairy DNA binding (5) are 5⬘-TAAACCGGTTGGCAGCCGGGACGCGACAGGGCCAGGTT ...
and paralogue-specific functions of acyl-CoA
... acyl-CoAs to acyl-CoA-utilizing enzymes and modulate their regulatory functions [12]. The ACBP family comprises basal acyl-CoA-binding proteins containing only the ACBP domain and larger proteins that contain an N-terminal ACBD (acyl-CoAbinding domain) as well as other domains. The prototypical basa ...
... acyl-CoAs to acyl-CoA-utilizing enzymes and modulate their regulatory functions [12]. The ACBP family comprises basal acyl-CoA-binding proteins containing only the ACBP domain and larger proteins that contain an N-terminal ACBD (acyl-CoAbinding domain) as well as other domains. The prototypical basa ...
Strain in Protein Structures as Viewed Through Nonrotameric Side
... side chain forms the backbone. By using data from 19 well-refined crystallographic structures, Ponder and Richards6 assembled a library of rotamers for each amino acid type based on clustering techniques. They observed that most side chains adopt one of the rotameric states. Schrauber et al.1 used a ...
... side chain forms the backbone. By using data from 19 well-refined crystallographic structures, Ponder and Richards6 assembled a library of rotamers for each amino acid type based on clustering techniques. They observed that most side chains adopt one of the rotameric states. Schrauber et al.1 used a ...
APG Phytochemical Database - American Pistachio Growers
... Carotenoids like beta-carotene are fat-soluble antioxidant present in plant foods and are responsible for their yellows and orange colors. Research shows that diets rich in beta-carotene protect against cardiovascular disease and keep eyes and skin healthy. Beta-carotene may also boost immune functi ...
... Carotenoids like beta-carotene are fat-soluble antioxidant present in plant foods and are responsible for their yellows and orange colors. Research shows that diets rich in beta-carotene protect against cardiovascular disease and keep eyes and skin healthy. Beta-carotene may also boost immune functi ...
Physical and chemical interactions between
... may be different for other phloem-specific proteins. In cucurbits, mRNAs encoding for the most abundant SE proteins PP1 and PP2 (both involved in sieve plate protein plugging) were only found in the CCs, not in the SEs (Bostwick et al., 1992; Clark et al., 1997; Dannenhoffer et al., 1997). Turnover ...
... may be different for other phloem-specific proteins. In cucurbits, mRNAs encoding for the most abundant SE proteins PP1 and PP2 (both involved in sieve plate protein plugging) were only found in the CCs, not in the SEs (Bostwick et al., 1992; Clark et al., 1997; Dannenhoffer et al., 1997). Turnover ...
A1060 GM Corn Line 5307 AppR SD1 Safety Assess
... and Lawrence) and Mexican corn rootworm (D. virgifera zeae Krysan and Smith). These coleopteran pests cause significant damage annually to corn crops grown in the United States of America (U.S). The engineered Cry protein binds specifically to receptors in midgut epithelial cells of target insects, ...
... and Lawrence) and Mexican corn rootworm (D. virgifera zeae Krysan and Smith). These coleopteran pests cause significant damage annually to corn crops grown in the United States of America (U.S). The engineered Cry protein binds specifically to receptors in midgut epithelial cells of target insects, ...
Poster
... afferent arteriole in male rats was evaluated with renal vascular experiments. Blood pressure and heart rate were monitored using telemetry transmitters. Their work established 11,12-ether-EET-8-ZE as a promising lead and provided the first evidence that EET analogs have potential for the treatment ...
... afferent arteriole in male rats was evaluated with renal vascular experiments. Blood pressure and heart rate were monitored using telemetry transmitters. Their work established 11,12-ether-EET-8-ZE as a promising lead and provided the first evidence that EET analogs have potential for the treatment ...
No Slide Title
... that these side chains cannot discriminate between AT and TA basepairs. The sequence selectivity is due to the differential DNA flexibility of the basepair steps, as revealed by MD/PMF calculations, and to the ability of these steps to form H-bonds in the major groove. At the central basepair step o ...
... that these side chains cannot discriminate between AT and TA basepairs. The sequence selectivity is due to the differential DNA flexibility of the basepair steps, as revealed by MD/PMF calculations, and to the ability of these steps to form H-bonds in the major groove. At the central basepair step o ...
4. Characterisation of novel proteins
... and Lawrence) and Mexican corn rootworm (D. virgifera zeae Krysan and Smith). These coleopteran pests cause significant damage annually to corn crops grown in the United States of America (U.S). The engineered Cry protein binds specifically to receptors in midgut epithelial cells of target insects, ...
... and Lawrence) and Mexican corn rootworm (D. virgifera zeae Krysan and Smith). These coleopteran pests cause significant damage annually to corn crops grown in the United States of America (U.S). The engineered Cry protein binds specifically to receptors in midgut epithelial cells of target insects, ...
Glycogen Metabolism Gluconeogenesis
... • In the “resting” state, Gα is bound to the Gβ-Gγ dimer. Gα contains the nucleotide binding site, holding GDP in the inactive form, and is the “warhead” of the G protein. At least 20 different forms of Ga exist in mammalian cells. • Binding of the extracellular signal by the GPCR causes it to under ...
... • In the “resting” state, Gα is bound to the Gβ-Gγ dimer. Gα contains the nucleotide binding site, holding GDP in the inactive form, and is the “warhead” of the G protein. At least 20 different forms of Ga exist in mammalian cells. • Binding of the extracellular signal by the GPCR causes it to under ...
Molecular modeling of HIV-1 reverse
... would produce quantative trends that might shed light on the mechanistic effects of mutations on polymerase activity and resistance to NNIRTs, it was felt that the method was valid within these limits. This model was modified separately at each of 12 key amino acid residues (see Table I) and the res ...
... would produce quantative trends that might shed light on the mechanistic effects of mutations on polymerase activity and resistance to NNIRTs, it was felt that the method was valid within these limits. This model was modified separately at each of 12 key amino acid residues (see Table I) and the res ...
Feed Ingredients and Feeds for Channel Catfish
... meal, are more expensive than plant proteins. Although there have been conflicting reports, properly balanced diets with all-plant proteins can provide satisfactory growth of catfish raised in ponds from advanced fingerlings to market size. Soybean meal, dehulled, solvent-extracted, is obtained by ...
... meal, are more expensive than plant proteins. Although there have been conflicting reports, properly balanced diets with all-plant proteins can provide satisfactory growth of catfish raised in ponds from advanced fingerlings to market size. Soybean meal, dehulled, solvent-extracted, is obtained by ...
Identification of the ribonucleoprotein complex required for efficient
... herpesvirus mRNA export, whereby ORF57 mimics splicing in order to recruit the mRNA export machinery to intronless viral mRNAs. We are now determining the structure of the interaction interface at atomic-resolution between ORF57 homologues and the hTREX proteins, such as Aly, In collaboration with ...
... herpesvirus mRNA export, whereby ORF57 mimics splicing in order to recruit the mRNA export machinery to intronless viral mRNAs. We are now determining the structure of the interaction interface at atomic-resolution between ORF57 homologues and the hTREX proteins, such as Aly, In collaboration with ...
Course Home - Haldia Institute of Technology
... Case study based on stability of Proteins, enzymes including basic knowledge of its stability and energy calculation Relative thermodynamic stability of different Biochemical compounds LECTURE PLAN LectureNo. ...
... Case study based on stability of Proteins, enzymes including basic knowledge of its stability and energy calculation Relative thermodynamic stability of different Biochemical compounds LECTURE PLAN LectureNo. ...
Calcium binding to chromaffin vesicle matrix proteins
... (Gratzl, 1984). After centrifugation, the secretory vesicles were concentrated around the 1.8/2.0 M sucrose interface. In order to lower the sucmse mcentration, the collected secretory vesicles were dialyzed for 60 min in homogenization buffer and condensed by centrifugation (146000g,, 30 min). Afte ...
... (Gratzl, 1984). After centrifugation, the secretory vesicles were concentrated around the 1.8/2.0 M sucrose interface. In order to lower the sucmse mcentration, the collected secretory vesicles were dialyzed for 60 min in homogenization buffer and condensed by centrifugation (146000g,, 30 min). Afte ...
APC2 Antibody
... APC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase ...
... APC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase ...
tRNA Core Hypothesis for the Transition from the RNA World to the
... of new strands, and they formed new mini-helixes with catalytic function, i.e. ribozymes. With the stabilization of the catalytic reactions, these ribozymes began to participate in the first catalytic cycles. At this stage, the structural information emerged and was involved in the direct replicatio ...
... of new strands, and they formed new mini-helixes with catalytic function, i.e. ribozymes. With the stabilization of the catalytic reactions, these ribozymes began to participate in the first catalytic cycles. At this stage, the structural information emerged and was involved in the direct replicatio ...
Making sense of Sequences: Comparative Genomics and the New GIS
... Another Genomic Revolution An explosion in genomic data The rise of population genomics & proteomics ...
... Another Genomic Revolution An explosion in genomic data The rise of population genomics & proteomics ...
No Slide Title
... large family of myosin-related proteins ~14 in human common features: one or two heavy chains and several light chains heavy chain: 1) large globular head: contains actin-binding and ATPase domains 2) a-helical neck region - binds light chains 3) tail domain - for oligomerization or cargo binding ...
... large family of myosin-related proteins ~14 in human common features: one or two heavy chains and several light chains heavy chain: 1) large globular head: contains actin-binding and ATPase domains 2) a-helical neck region - binds light chains 3) tail domain - for oligomerization or cargo binding ...
Repositório da Universidade de Lisboa
... diversity in Eukaryotes and to make these results available to community. To this end, machine learning and sequence manipulation techniques were used, leading to the identification of more than five thousand sequences in 182 species. The identified sequences are available on the TrafficDB website ( ...
... diversity in Eukaryotes and to make these results available to community. To this end, machine learning and sequence manipulation techniques were used, leading to the identification of more than five thousand sequences in 182 species. The identified sequences are available on the TrafficDB website ( ...
Ch16b: Peptides
... ‣ This was the first protein to have its primary structure determined. ‣ Sanger was awarded the 1958 Nobel Prize in Chemistry for this work. ‣ The primary structure of two polypeptide chains linked by disulfide bonds ‣ The A chain of insulin has 21 amino acids. ‣ The B chain has 30 amino acids ...
... ‣ This was the first protein to have its primary structure determined. ‣ Sanger was awarded the 1958 Nobel Prize in Chemistry for this work. ‣ The primary structure of two polypeptide chains linked by disulfide bonds ‣ The A chain of insulin has 21 amino acids. ‣ The B chain has 30 amino acids ...
The novel genome organization of the insect picorna
... sequences in ORF-2 (SKPTVQ and VMGEDL). The third Nterminal sequence (ANFQTN) was found to be situated upstream of the first methionine of ORF-2 (see Fig. 1). This sequence is encoded in the same frame ; thus if there were another initiation codon which was recognized 5« of this sequence then all th ...
... sequences in ORF-2 (SKPTVQ and VMGEDL). The third Nterminal sequence (ANFQTN) was found to be situated upstream of the first methionine of ORF-2 (see Fig. 1). This sequence is encoded in the same frame ; thus if there were another initiation codon which was recognized 5« of this sequence then all th ...
Bacteria Binding by DMBT1/SAG/gp-340 Is Confined to
... the macrophage scavenger receptor (MSR1), the Mac 2-binding protein (Mac-2bp), and MARCO. Both MSR1 and MARCO are known to interact with bacteria (6, 7). In contrast to MARCO (8), the SRCR domain of MSR1 does not seem to be involved in bacteria binding (9, 10). Bacteria binding by MARCO involves an ...
... the macrophage scavenger receptor (MSR1), the Mac 2-binding protein (Mac-2bp), and MARCO. Both MSR1 and MARCO are known to interact with bacteria (6, 7). In contrast to MARCO (8), the SRCR domain of MSR1 does not seem to be involved in bacteria binding (9, 10). Bacteria binding by MARCO involves an ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.