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Gene Section BOK (Bcl2-related ovarian killer) Atlas of Genetics and Cytogenetics
Gene Section BOK (Bcl2-related ovarian killer) Atlas of Genetics and Cytogenetics

... kb with the 639 bp open reading frame. The truncated form (Bok-S) results from skipping of exon three and a deletion of 43 bp in the Bok-L coding region. It has been shown that transcription activity of the Bok gene depends on expression of p53 and can be directly regulated at the gene promoter leve ...
The energy equivalents of ATP and the energy values of food
The energy equivalents of ATP and the energy values of food

... depending upon the source of the protein (Schulz, 1975). On observing that the number of mol ATP yielded/g protein N varied considerably between proteins, McGilvery (1979) emphasized the need for estimating protein energy values of individual foods. The precise biochemical energy values obtained are ...
FN303-WSV
FN303-WSV

... 1 DFE = 1 mcg food folate = 0.6 mcg synthetic folic acid in combination with food = ...
Chloroplast phosphoglycerate kinase from Euglena gracilis
Chloroplast phosphoglycerate kinase from Euglena gracilis

... cytosolic and and chloroplast PGK protein sequences from Euglena gracilis with a representative sample of homologues from archaebacteria, eubacteria and eukaryotes was generated from LogDet distances based on a CLUSTALW alignment of the sequences (Fig. 4). As seen in many other analyses involving pr ...
Investigating semantic similarity measures across the
Investigating semantic similarity measures across the

... another term. These orphan terms within GO need to be provided with links for the purposes of our investigation. We simply linked them directly to the root of their taxonomy. This is perhaps semantically impoverished (for example, a “granum”, (GO:0009542) becomes a kind of “cellular component”, (GO: ...
A New Type of a Multifunctional ß
A New Type of a Multifunctional ß

... Figure 1. Most common pathways for the degradation of fatty acid CoA esters by ␤-oxidation enzymes in the different organisms. In the first reaction of the ␤-oxidation cycle, acyl-CoA esters are desaturated to ⌬2-trans enoyl-CoA esters by acyl CoA oxidases or acyl CoA dehydrogenases. Oxidases are lo ...
Ribosomal crystallography: a flexible nucleotide anchoring tRNA
Ribosomal crystallography: a flexible nucleotide anchoring tRNA

... It seems, therefore, that the primary catalytic activity of the ribosome is the provision of an ingeniously designed structural framework, capable of guaranteeing smooth amino-acid polymerization. Composed of the structural components crucial for accurate tRNA substrates alignment, translocation alo ...
A New Type of a Multifunctional ß-Oxidation
A New Type of a Multifunctional ß-Oxidation

... Figure 1. Most common pathways for the degradation of fatty acid CoA esters by ␤-oxidation enzymes in the different organisms. In the first reaction of the ␤-oxidation cycle, acyl-CoA esters are desaturated to ⌬2-trans enoyl-CoA esters by acyl CoA oxidases or acyl CoA dehydrogenases. Oxidases are lo ...
Structure, function and evolution of armless mitochondrial tRNAs
Structure, function and evolution of armless mitochondrial tRNAs

... secondary structure composed of two helices with classical Watson-Crick base pairs. The helices are separated by a central bulge that does not contain any specific internal tertiary base pairings. Due to the designed 3D structure, we suppose an increased intrinsic flexibility of armless tRNAs which ...
Peroxisomes: family of versatile organelles
Peroxisomes: family of versatile organelles

... Plants can convert lipids to sugars using glyoxylate cycle that is short variant of the citric acid cycle. Animal cells can not carry out the net synthesis of carbohydrate from fat because they have no glyoxylate cycle. ...
Thermo Scientific Solutions for Quantitative
Thermo Scientific Solutions for Quantitative

... Western blotting almost always requires a priori knowledge of the system and the expected changes in order to obtain an appropriate target antibody. Antibodies are often not available, not specific, or very expensive. Antibodies for site-specific modifications can be even more difficult to obtain. I ...
Spinalin, a new glycine- and histidine
Spinalin, a new glycine- and histidine

... which punches a hole in the prey’s integument. Nematocyst discharge is driven by the very high osmotic pressure (15 MPa; Weber, 1989) in the resting capsule, which results from the high concentration of poly-γ-glutamic acid and the corresponding cations in the matrix (Weber, 1990, 1991). The high os ...
Isolation of Proteins which Interact with Phospholipase A2 (PLA
Isolation of Proteins which Interact with Phospholipase A2 (PLA

... as in healthy blood serum without inhibitors. In sample 2 (phospholipase A2 with calmodulin), we can observe an interaction with unidentified protein of 25−30 kDa. In sample 3 (PLA2 with anti-PLA2), we cannot observe the same effect. Figure 11 shows the results of the pull-down assay after treatment ...
User`s Guide - Structural Bioinformatics Group
User`s Guide - Structural Bioinformatics Group

... structures. The user provides an alignment of a sequence to be modeled with known related structures and MODELLER automatically calculates a model containing all non-hydrogen atoms. MODELLER implements comparative protein structure modeling by satisfaction of spatial restraints, and can perform many ...
Proteasome inhibition induces reversible impairments in protein
Proteasome inhibition induces reversible impairments in protein

... In the next set of experiment, we sought to elucidate the basis for observed impairments in protein synthesis. In this first set we focused on the possibility that proteasome inhibitor treatment impaired protein synthesis by decreasing the amount of polyribosomes present in neurons, and thereby prom ...
Slide 1
Slide 1

... Scoring matrices for DNA sequence alignment  A simple positive score for matches and a negative for mismatches and gaps are most often used.  Transversions penalized more than transitions – transitions: replacement of a purine base with another purine or replacement of a pyrimidine with another p ...
Induction of CDPK (ZmCPK11)- and MAPK
Induction of CDPK (ZmCPK11)- and MAPK

... Expression of ZmCPK11, a member of the maize (Zea mays L.) Calcium-Dependent Protein Kinases (CDPKs) family, is induced by mechanical wounding. A rapid increase of the activity of a 56-kDa CDPK has been observed in damaged leaves. In the present work, it is shown that the 56-kDa CDPK, identified as ...
Field Guide to Protein Folds
Field Guide to Protein Folds

... The bromodomain is central to epigenetic control of gene transcription through its role in acetylating histone lysine. The structure adopts a conserved left-handed bundle of four α helices, with two interhelical loops of variable length and sequence between the first and second and third and fourth ...
A 1-Megadalton Translocation Complex Containing
A 1-Megadalton Translocation Complex Containing

... of Integrative Biosciences and Biotechnology and Division of Molecular and Life Sciences, POSTECH, Pohang ...
Answers - Study of Life
Answers - Study of Life

... A. a genetically identical clone of bacteria containing the same plasmid. B. a possible spread of tetracycline resistance to other bacteria in the hospital. C. the subsequent loss of tetracycline resistance in the initially resistant strain. D. production of endospores in the bacterial progeny. E. t ...
P - GMC Surat
P - GMC Surat

...  High fidelity of translation of the genetic message.  Enzyme also have a “proofreading” or “editing” activity that can remove mischarged amino acids from the enzyme or the t-RNA molecule. ...
The Interaction between Dietary Protein and Bone Health
The Interaction between Dietary Protein and Bone Health

... protein, soy protein and milk protein respectively and either bone, bone density or fractures. All papers generally dealing with human subjects and the interaction between dietary protein and bone density, bone markers or fractures whether crosssectional, longitudinal were deemed suitable for discus ...
Separation and analysis of amino acids
Separation and analysis of amino acids

... • Because a molecule of water (Mr 18) is removed to create each peptide bond, the average molecular weight of an amino acid residue in a protein is about 128 -18 = 110. ...
magamtol talalt cikkek
magamtol talalt cikkek

... Abstract The sequences of two Drosophila and one rabbit protein phosphatase (PP) 1 catalytic subunits were determined from their cDNA. The sequence of Drosophila PP1 alpha 1 was deduced from a 2.2-kb cDNA purified from an embryonic cDNA library, while that for Drosophila PP1 beta was obtained from o ...
Definition of Protein Superfamily
Definition of Protein Superfamily

... the published literature to refer to a group of structurally or functionally related proteins not necessarily of common evolutionary origin. The term domain has been employed in the Protein Sequence Database to mean a region of special biological interest within a single protein chain. This term als ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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