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Infectious Salmon Anaemia Virus (ISAV) RNA Binding Protein
Infectious Salmon Anaemia Virus (ISAV) RNA Binding Protein

... protein (M2) from collinear and spliced mRNA, respectively. No homologue to the influenza virus ion channel protein has been identified in ISAV. Infection with ISAV leads to activation and production of type I interferon (IFN) in Atlantic salmon and in cell lines derived from Atlantic salmon [7–9]. ...
Computer-Based Design of Novel Protein Structures
Computer-Based Design of Novel Protein Structures

... published a review of the diiron proteins they have designed from idealized models of fourhelix bundles. Coiled-coils are special because an analytic expression can be used to describe their allowed geometries. This property of coiledcoils was first explored by Francis Crick (7) and more recently has ...
Nitrogen lectures (Part 2)
Nitrogen lectures (Part 2)

... • Messenger RNA migrates to ribosomes where it acts as the template for protein • To be used in protein synthesis, amino acids are bound to transfer RNA • Transfer RNA travels along the messenger RNA to place amino acid in chain ...
Agrobacterium Rhizogeneze
Agrobacterium Rhizogeneze

... activities as virE2 (ssDNA binding and nuclear targeting), or does Galls compensate for absence of virE2? Is the Galls gene regulated by virA/virG and phenolic compounds and sugars released by wounded plant cells?. Galls protein will help us learn more about gene transfer to plants. ...
cytology_enzyme_13
cytology_enzyme_13

... The catalytic cycle of an enzyme 1 Substrates enter active site; enzyme changes shape so its active site embraces the substrates (induced fit). ...
A metaproteomic assessment of winter and summer
A metaproteomic assessment of winter and summer

... oxygenic photosynthesis decline during the winter season, some groups of microorganisms increase in abundance (Murray and Grzymski, 2007). Shifts in microbial community composition between summer and winter have been documented (Murray et al., 1998; Massana et al., 2001; Murray and Grzymski, 2007; P ...
Biol 1406 Ch 5
Biol 1406 Ch 5

... ii)
What
kinds
of
proteins
are
integrated
into
the
membrane
and
what
are
the
 different
functions
of
the
proteins?

Know
how
to
identify
each.
 ...
Bioinformatics approaches for functional
Bioinformatics approaches for functional

... functions of membrane proteins have been investigated with several computational approaches, such as developing databases, analyzing the structure ^ function relationship and establishing algorithms to discriminate different type of membrane proteins. However, compilation of bioinformatics resources ...
Identification and expression of the first nonmammalian amyloid‐β
Identification and expression of the first nonmammalian amyloid‐β

... physiological roles of APP, APLP1 and APLP2 still remain elusive. APP has been implicated in cell–cell adhesion [32], neurite outgrowth [33] and kinesin-mediated vesicular transport [34] or may function as a heparan sulfate proteoglycan core protein [35]. Furthermore, following its translocation to ...
Identification of Novel microRNA Regulatory Proteins in Neurons
Identification of Novel microRNA Regulatory Proteins in Neurons

... protein levels of the translational repressor Pumilio2 (Pum2) (Fiore et al., 2009). For the RNAi screening experiment, we decided to analyze the function of miR-134 using a Luciferase reporter assay. We selected a reporter gene containing an miR 134 target 3’UTR downstream of the Luciferase coding s ...
The hnRNP C Proteins Contain a Nuclear Retention Sequence That
The hnRNP C Proteins Contain a Nuclear Retention Sequence That

... the cytoplasm. These shuttling hnRNP proteins include hnRNP A1, K, and E (Pifiol-Roma and Dreyfuss, 1992, 1993a; Michael et al., 1995b). While in the cytoplasm, hnRNP A1 is associated with mRNA, suggesting that shuttling hnRNP proteins accompany mRNA from the point of its emergence from the transcri ...
Protein for Athletes
Protein for Athletes

... of muscle, it is estimated that 10 to 14 g of additional protein is needed each day,2 although others dispute this claim. In addition to possible growth of muscle, protein is a highly versatile nutrient and is involved in other functions that are crucial to sports performance: cell regulation, muscl ...
the elastin gene
the elastin gene

... significance of "acidic" and "basic" keratins in this respect? 6. What are the main crosslinks in keratin? How can they be broken to partially solubilise the protein? How does increased crosslinking affect keratin's properties? 7. Keratin is the main component of hair. How are individual keratin mol ...
AlgPred: prediction of allergenic proteins and mapping of
AlgPred: prediction of allergenic proteins and mapping of

... WHO 2001 recommendations and recognized the uncertainties associated with different tests. They suggest weight of evidence approach rather than a specific decision tree approach (suggested in FAO/WHO 2001). They recommended various tests for examining allergenic behavior of proteins that includes so ...
allosteric activator
allosteric activator

... change of enzyme synthesis and degradation so that ultimately determine enzyme level at any point in time. In many instances, transcriptional regulation determines the concentrations of specific enzyme, with enzyme proteins degradation playing a minor role. In other instances, protein synthesis is c ...
College Accounting: A Practical Approach, Cdn
College Accounting: A Practical Approach, Cdn

... 20) Which of the following events occurs after the formation of disulfide bonds during the conversion of preproinsulin to mature insulin? A) folding of proinsulin into a stable conformation B) transport of the molecule through the membranes C) cleavage of the peptide sequence that joins the A and B ...
The dinitrogenase reductase
The dinitrogenase reductase

... nitrogen in the synthesis of a variety of compounds, such as carbamoyl phosphate, Trp, His, glucosamine-6-P, CTP, and AMP. • The amino groups of most other amino acids are derived from glutamate via transamination. ...
A new subfamily of fungal subtilases: structural and functional
A new subfamily of fungal subtilases: structural and functional

... Pleurotus ostreatus produces several extracellular proteases which are believed to be involved in the regulation of the ligninolytic activities of this fungus. Recently, purification and characterization of the most abundant P. ostreatus extracellular protease (PoSl) have been reported. The sequence ...
Co-opting sulphur-carrier proteins from primary metabolic pathways
Co-opting sulphur-carrier proteins from primary metabolic pathways

... BE-7585A cluster. Subsequent genome sequencing uncovered a few genes encoding sulphur-carrier proteins that are probably involved in the biosynthesis of primary metabolites but only one activating enzyme gene in the A. orientalis genome. Further experiments showed that this activating enzyme can ade ...
Balancing Redox Cofactor Generation and ATP Synthesis: Key
Balancing Redox Cofactor Generation and ATP Synthesis: Key

... well-established metabolite production profiles of the organism (Cripps et al, 2009; Tang et al., 2009) showed no significant fermentative metabolism, consistent with the aerobic status. The microaerobic ‘‘switch,’’ generated by a fivefold reduction in aeration, decreased redox potentials to betwee ...
6. Proteins
6. Proteins

Organic Molecules and Water 1. In most animal cells, a complex
Organic Molecules and Water 1. In most animal cells, a complex

... molecules. The backbones of carbon molecules can be of any size and may contain from one carbon atom to thousands of carbon atoms. 13. A fat is a kind of lipid that can store energy for a long period of time. Fats are made up of long chains of carbon and oxygen atoms bonded to a backbone structure. ...
complete
complete

... Objectives: ...
lec4-5-biosynthesis_specificity
lec4-5-biosynthesis_specificity

... – Usage of molecular biological methods such as random mutagenesis or gene shuffling for generating large diverse DNA libraries – Gene expression – High-throughput screening for the identification of highly selective mutant enzymes ...
Pseudomonas aeruginosa lytic bacteriophage oKMV
Pseudomonas aeruginosa lytic bacteriophage oKMV

... phiKMV-resistant mutant strain established that the phage phiKMV resistance mechanism is a complex process, possibly involving post-transcriptional regulation of the type IV pili biogenesis genes. A second putative host receptor protein (PA4736) was identified by a library scale yeast two-hybrid scr ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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