Paper Title
... First approach was based on the idea of selecting a subset of properties with high orthogonality. To prove this idea, 544 properties from AAIndex were clustered by K-means algorithm [20] into {5, 6, 7, 8, 9, 10} clusters and 20,000 of experiments were proceeded on MMP dataset for each cluster count ...
... First approach was based on the idea of selecting a subset of properties with high orthogonality. To prove this idea, 544 properties from AAIndex were clustered by K-means algorithm [20] into {5, 6, 7, 8, 9, 10} clusters and 20,000 of experiments were proceeded on MMP dataset for each cluster count ...
Role of N-linked oligosaccharide chains in the processing and
... demonstrated. One of the four glycosylation sites had a different carbohydrate structure from those of the other three glycosylation sites and this varied glycosylation was responsible for the appearance of two forms of the H protein. The functional glycosylation sites were ...
... demonstrated. One of the four glycosylation sites had a different carbohydrate structure from those of the other three glycosylation sites and this varied glycosylation was responsible for the appearance of two forms of the H protein. The functional glycosylation sites were ...
PowerPoint Format - Kinexus Bioinformatics Corporation
... expression and phosphorylations data generated with 650 to 850 antibodies Over 3 million protein measurements Searchable by protein, treatment or cell/tissue type Over 99% unpublished data ...
... expression and phosphorylations data generated with 650 to 850 antibodies Over 3 million protein measurements Searchable by protein, treatment or cell/tissue type Over 99% unpublished data ...
Structural Basis of Perturbed pKa Values of Catalytic Groups in
... their state of protonation, and the state of protonation is determined, at first approximation, by the intrinsic pK a of the given group. Table 1 lists the intrinsic pK a values of the catalytic groups found in either protein or RNA enzymes. For these groups to be activated as nucleophiles, the ioni ...
... their state of protonation, and the state of protonation is determined, at first approximation, by the intrinsic pK a of the given group. Table 1 lists the intrinsic pK a values of the catalytic groups found in either protein or RNA enzymes. For these groups to be activated as nucleophiles, the ioni ...
What roles do proteins (polypeptides) play? 1. Enzymes (catalysts) 2
... • 19 of the 20 are chiral Steroisomers • 4 different groups bonded to Cα • These molecules cannot be superimposed (are mirror images of each other) • Therefore they are not identical, and are referred to as stereoisomers. • Using spectrographic instrumentation, the two configurations can be decipher ...
... • 19 of the 20 are chiral Steroisomers • 4 different groups bonded to Cα • These molecules cannot be superimposed (are mirror images of each other) • Therefore they are not identical, and are referred to as stereoisomers. • Using spectrographic instrumentation, the two configurations can be decipher ...
Structural and functional features of the intracellular amino
... relay gating tension to the core channel subunits. The topology of MEC-4 is such that both the amino terminus and the carboxyl terminus are intracellular with a large extracellular loop between two ...
... relay gating tension to the core channel subunits. The topology of MEC-4 is such that both the amino terminus and the carboxyl terminus are intracellular with a large extracellular loop between two ...
Poster for RCPSC mee.. - University of Alberta
... environmental stress (heat, UV irradiation), and chemotherapeutic agents. The accumulation of ceramide activates JNK/SAPK, PKCζ, caspases as well as PP1 and PP2A. Substrates of PP1 and PP2A that are dephosphorylated in response to either ceramide-inducing agonists or addition of exogenous ceramide i ...
... environmental stress (heat, UV irradiation), and chemotherapeutic agents. The accumulation of ceramide activates JNK/SAPK, PKCζ, caspases as well as PP1 and PP2A. Substrates of PP1 and PP2A that are dephosphorylated in response to either ceramide-inducing agonists or addition of exogenous ceramide i ...
A Survey of Flexible Protein Binding Mechanisms and their
... Many cellular functions rely on interactions between protein pairs and higher oligomers. We have recently shown that binding mechanisms are robust and owing to the minimal frustration principle, just as for protein folding, are governed primarily by the protein’s native topology, which is characteri ...
... Many cellular functions rely on interactions between protein pairs and higher oligomers. We have recently shown that binding mechanisms are robust and owing to the minimal frustration principle, just as for protein folding, are governed primarily by the protein’s native topology, which is characteri ...
Fast procedure for reconstruction of full
... Rotkiewicz and Skolnick • Vol. 00, No. 00 • Journal of Computational Chemistry ...
... Rotkiewicz and Skolnick • Vol. 00, No. 00 • Journal of Computational Chemistry ...
clinical toxicology unit
... plasma drug concentration, an individual’s pharmacokinetic idiosyncrasies can be identified and the drug dosage adjusted to provide effective therapy without the risk of toxic and/ or ...
... plasma drug concentration, an individual’s pharmacokinetic idiosyncrasies can be identified and the drug dosage adjusted to provide effective therapy without the risk of toxic and/ or ...
BR22, a 26 kDa thyroid transcription factor-1 associated protein
... with dibutyryl cyclic adenosine monophosphate (Bt2cAMP) for 5 days (D5) (a gift from C.R.M. Mendelson at UT Southwestern Medical Center, Dallas, Texas) and H441 cells (NCI-H441, a human lung, papillary adenocarcinoma cells) was used to generate complimentary DNA (cDNA) by using the SMART (BD Bioscie ...
... with dibutyryl cyclic adenosine monophosphate (Bt2cAMP) for 5 days (D5) (a gift from C.R.M. Mendelson at UT Southwestern Medical Center, Dallas, Texas) and H441 cells (NCI-H441, a human lung, papillary adenocarcinoma cells) was used to generate complimentary DNA (cDNA) by using the SMART (BD Bioscie ...
c - SchoolRack
... Chapter 2: Basic Chemistry Highlites Essential Elements of Life About 25 of the 92 elements are essential to life Carbon, hydrogen, oxygen, and nitrogen make up 96% of living matter Most of the remaining 4% consists of calcium, phosphorus, potassium, and sulfur Trace elements are those required by ...
... Chapter 2: Basic Chemistry Highlites Essential Elements of Life About 25 of the 92 elements are essential to life Carbon, hydrogen, oxygen, and nitrogen make up 96% of living matter Most of the remaining 4% consists of calcium, phosphorus, potassium, and sulfur Trace elements are those required by ...
Jacob/Meselson/Brenner
... The mRNA hypothesis was confirmed by Sydney Brenner, Jacob, and Matthew Meselson in a very simple way. They showed that when a virus infects a bacterial cell, a virus-specific RNA is made that is rapidly associated with preexisting bacterial ribosomes (figure 11.1). The bacterial ribosomes were norm ...
... The mRNA hypothesis was confirmed by Sydney Brenner, Jacob, and Matthew Meselson in a very simple way. They showed that when a virus infects a bacterial cell, a virus-specific RNA is made that is rapidly associated with preexisting bacterial ribosomes (figure 11.1). The bacterial ribosomes were norm ...
ESCRT requirements for EIAV budding | SpringerLink
... of the ESCRT-III subunits through direct, ordered interactions between Vps20p/CHMP6, Snf7p/CHMP4A-C, Vps24p/Did3p/CHMP3, and Vps2p/Did4p/CHMP2A-B [18-21]. The ESCRT-III subunits appear to form paired helical filaments that constrict the bud neck [19,22-31], although their precise architecture and co ...
... of the ESCRT-III subunits through direct, ordered interactions between Vps20p/CHMP6, Snf7p/CHMP4A-C, Vps24p/Did3p/CHMP3, and Vps2p/Did4p/CHMP2A-B [18-21]. The ESCRT-III subunits appear to form paired helical filaments that constrict the bud neck [19,22-31], although their precise architecture and co ...
Construction of Recombinant Expression Vectors to Study the Effect
... Escherichia coli. How thioredoxin promotes protein solubility is not known, although a catalytic contribution involving the formation of disulphide bonds in the E. coli cytoplasm has been proposed. In this study, we have cloned the proteinase inhibitor II (PI2) gene from potato into wild type pET-32 ...
... Escherichia coli. How thioredoxin promotes protein solubility is not known, although a catalytic contribution involving the formation of disulphide bonds in the E. coli cytoplasm has been proposed. In this study, we have cloned the proteinase inhibitor II (PI2) gene from potato into wild type pET-32 ...
Recombinant DNA in Medicine Industry
... Ej: Vaccine for the AIDS virus has been prepared by producing on of the HIV glycoproteins with this system ...
... Ej: Vaccine for the AIDS virus has been prepared by producing on of the HIV glycoproteins with this system ...
The RAGNYA fold: a novel fold with multiple topological variants
... other contexts, forms the catalytic domain of both DNA- and RNA-templated RNA polymerases, while the latter domain is found in translation elongation factors (10,19,20). Both of these domains have been derived from duplication of the same 3-stranded precursor, followed by dimerization. Despite being ...
... other contexts, forms the catalytic domain of both DNA- and RNA-templated RNA polymerases, while the latter domain is found in translation elongation factors (10,19,20). Both of these domains have been derived from duplication of the same 3-stranded precursor, followed by dimerization. Despite being ...
The Theme of Oxidative Phosphorylation in Glycolysis and Cellular
... The main point of oxidative phosphorylation is the transfer of electrons from NADH and FADH2 to power ATP production. Similarly, the main purpose of playing arcade games is to win tickets for prizes (okay, and also maybe to have fun and earn high scores in the games). NADH is more often the electron ...
... The main point of oxidative phosphorylation is the transfer of electrons from NADH and FADH2 to power ATP production. Similarly, the main purpose of playing arcade games is to win tickets for prizes (okay, and also maybe to have fun and earn high scores in the games). NADH is more often the electron ...
characterization of proteins from the cytoskeleton of giardia lamblia
... (Sheir-Neiss, Lai & Morris, 1978; Water & Kleinsmith, 1976) and different organelles (McKeithan&Rosenbaum, 1981), showing that normally segregated tubulin species are competent to co-assemble. To explain structural diversity of microtubules in vivo, one possibility is that assembly is specifically m ...
... (Sheir-Neiss, Lai & Morris, 1978; Water & Kleinsmith, 1976) and different organelles (McKeithan&Rosenbaum, 1981), showing that normally segregated tubulin species are competent to co-assemble. To explain structural diversity of microtubules in vivo, one possibility is that assembly is specifically m ...
TIBS Review - Structural Genomics Consortium
... BRDT has a central role in chromatin remodelling during spermatogenesis as indicated by the importance of its first bromodomain in maintaining chromatin architecture of the sperm head [50]. A recent study delineated BRDT’s role in re-organizing chromatin, facilitating histone eviction and replacemen ...
... BRDT has a central role in chromatin remodelling during spermatogenesis as indicated by the importance of its first bromodomain in maintaining chromatin architecture of the sperm head [50]. A recent study delineated BRDT’s role in re-organizing chromatin, facilitating histone eviction and replacemen ...
Structure-function of the ADP/ATP carrier
... visualized that a translocation channel exists within each subunit formed by the three repeat domains along the pseudo threefold symmetry axis. Another model depends on the dirneric structure of these carriers. T h e carrier homodirners have been shown to have only one binding site for specific inhi ...
... visualized that a translocation channel exists within each subunit formed by the three repeat domains along the pseudo threefold symmetry axis. Another model depends on the dirneric structure of these carriers. T h e carrier homodirners have been shown to have only one binding site for specific inhi ...
Solid State NMR Investigation of Toxic Particles Formed
... In Figure 7 the 2D RAD spectrum (left graph) shows that F19 has more peaks associated with interactions among neighboring amino acids. In the center graph the orange, dotted, vertical lines represent proximity interactions between F19 and I31 and leads us to the hypothesis that the structure of Aβ42 ...
... In Figure 7 the 2D RAD spectrum (left graph) shows that F19 has more peaks associated with interactions among neighboring amino acids. In the center graph the orange, dotted, vertical lines represent proximity interactions between F19 and I31 and leads us to the hypothesis that the structure of Aβ42 ...
Toxic shock syndrome toxin-1 from Staphylococcus aureus Product
... TCR and residues on α-1 chain of an class II MHC molecule. This interaction causes activation of the T-cell and induces a major immune response that often has pathological consequences. Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consul ...
... TCR and residues on α-1 chain of an class II MHC molecule. This interaction causes activation of the T-cell and induces a major immune response that often has pathological consequences. Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consul ...
analyzing gene and protein sequences
... -click on any of the accession numbers displayed and you will be able to view information about that sequence such as definition, source, classification, journal articles, comments, amino acid sequence, and the nucleotide sequence. -scroll down to the bottom of the page to see the nucleotide sequenc ...
... -click on any of the accession numbers displayed and you will be able to view information about that sequence such as definition, source, classification, journal articles, comments, amino acid sequence, and the nucleotide sequence. -scroll down to the bottom of the page to see the nucleotide sequenc ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.