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Brains, Synapses and Neurotransmitters
Brains, Synapses and Neurotransmitters

... Behaviour, so, we had better know how the nervous system works The nervous system is made up, basically, of two types of cells • Neurons ...
Synaptic transmission
Synaptic transmission

... • In most of the areas of brain, norepinephrine probably activates excitatory receptors, but in a few areas, it activates inhibitory receptors instead. Norepinephrine is also secreted by most postganglionic neurons of the sympathetic nervous system, where it excites some organs but inhibits others. ...
Chapter 3: The Biological Bases of Behavior
Chapter 3: The Biological Bases of Behavior

... – Receptor sites ...
Acetate Acetylcholine (ACh)
Acetate Acetylcholine (ACh)

... ...
Uncaging Compunds: - Florida State University
Uncaging Compunds: - Florida State University

... and dendrites overlap in the neuropil a synapse sometimes forms, and synaptic transmission occurs when APs reaches the synapse. – Action potentials invade the presynaptic terminal causing glutamate to be released and then to bind onto receptors on the postsynaptic spine. – 1:1 correspondence between ...
Neural Control II
Neural Control II

... chemically-mediated signal may cause cells to lose the ability to respond to it; habituation • When receptor proteins are exposed to high levels of neurotransmitter molecules for prolonged periods, the postsynaptic cell often responds by decreasing the number of receptor proteins in its membrane; ma ...
Powerpoint slides
Powerpoint slides

... Electrical activity of the neuron ...
Neuron_glia interaction
Neuron_glia interaction

... Diffuses into the ECS. Presynaptic bind and inhibition of its own release. ...
Chemistry of Neurotransmitters
Chemistry of Neurotransmitters

... • They are ligand-gated ion channels. The receptors for stimulatory transmitters mediate the inflow of cations (mainly Na+). When these open after binding of the transmitter, local depolarization of the postsynaptic membrane occurs. ...
The Nervous System
The Nervous System

... • Found in the brain • Prevents the receptor nerve from being overstimulated • When it accumulates it has a sedative effect • Valium, Xanax and Ativan work by allowing GABA to accumulate – More GABA, more relaxed ...
Learning Objectives
Learning Objectives

... They are ligand-gated ion channels. The receptors for stimulatory transmitters mediate the inflow of cations (mainly Na+). When these open after binding of the transmitter, local depolarization of the postsynaptic membrane occurs. By contrast, inhibitory neurotransmitters (GABA and glycine) allow Cl ...
The basic Hebb rule
The basic Hebb rule

... • Models of such intrinsic plasticity show that neurons can be remarkably robust to external perturbations if they adjust their conductances to maintain specified functional characteristics • Intrinsic and synaptic plasticity can interact in interesting ways. For example, shifts in intrinsic excitab ...
Document
Document

... Specialized for the release and reception of neurotransmitters Typically composed of two parts: ...
Slide 1
Slide 1

... 2. Allow the simulation of different neuron models 3. Allow the incorporation of new neural features into neuron models without needing to modify the simulator code. 4. Real-time simulation of middle-scale neural networks (thousands of neurons). ...
Can You Remember My Name? Part 2
Can You Remember My Name? Part 2

... • Short-term plasticities – Facilitation (paired pulse facilitation): 100-200 ms; increased Ca++  increased p(NT release) – Post-tetanic potentiation: 5-10 sec – Depression: hundreds of ms – few minutes; caused by repetitive stimulation causing a decrease in p(NT release). ...
E.4 Neurotransmitters and Synapses
E.4 Neurotransmitters and Synapses

... such as eating and having sex. But in cocaine users, dopamine keeps stimulating those cells, creating a "high" -- a euphoric feeling that lasts anywhere from five to 15 minutes. But then the drug begins to wear off, leaving the person feeling let-down and depressed, resulting in a desire to smoke mo ...
Threshold Stimulus
Threshold Stimulus

... Synaptic Transmission • Neurotransmitters diffuse across synaptic cleft toward postsynaptic ...
Neurotransmitters & Synapses - IB
Neurotransmitters & Synapses - IB

... • Which NT diffused? • Which receptors do they bind to? • Which ions flow in/out of the post-synaptic neurone? • Whether or not depolarization reaches threshold ...
Neurons - Jordan High School
Neurons - Jordan High School

... Action potential begins between -60 & -55 mV (threshold) Stimulus triggers action potential, or not at all if doesn’t meet threshold ...
John F. MacDonald 2014 - Canadian Association for Neuroscience
John F. MacDonald 2014 - Canadian Association for Neuroscience

... mammalian central nervous system. These receptors (eventually termed NMDA receptors) were later found to be blocked by magnesium in a voltage-dependent manner, and required for long-term synaptic modifications thought to underlie some forms of learning. By virtue of their voltage-dependence, NMDA re ...
Lecture-08-2013-Bi
Lecture-08-2013-Bi

... Magee & Johnston, J Physiol (1995) ...
2016-2017_1stSemester_Exam2_180117_final
2016-2017_1stSemester_Exam2_180117_final

... Estimated number of synapses established by parallel fibers on a Purkinje cell Speed of fast anterograde transport ...
Lipids
Lipids

... A protein consists of one or more polypeptide chains folded into a highly specific 3D shape. There are up to four levels of structure in a protein: primary, secondary, tertiary and quaternary. Each of these play an important role in the overall structure and function of the protein. 22 of 12 ...
PNS and Transmission
PNS and Transmission

... Transmission • Transmission is carried out by molecules called neurotransmitters. These are stored in vesicles in the axon terminals. • Impulse reaches terminal  opens calcium channels  Calcium enters the terminal  vesicles move toward membrane for exocytosis neurotransmitters are released and ...
Membrane Biophysics and Synaptic Physiology
Membrane Biophysics and Synaptic Physiology

... dependence of release, two models and mechanisms? •Multivesicular release, when and where? •Synaptic ...
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Long-term depression

Long-term depression (LTD), in neurophysiology, is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. LTD in the hippocampus and cerebellum have been the best characterized, but there are other brain areas in which mechanisms of LTD are understood. LTD has also been found to occur in different types of neurons that release various neurotransmitters, however, the most common neurotransmitter involved in LTD is L-glutamate. L-glutamate acts on the N-methyl-D- asparate receptors (NMDARs), α-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptors (AMPARs), kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) during LTD. It can result from strong synaptic stimulation (as occurs in the cerebellar Purkinje cells) or from persistent weak synaptic stimulation (as in the hippocampus). Long-term potentiation (LTP) is the opposing process to LTD; it is the long-lasting increase of synaptic strength. In conjunction, LTD and LTP are factors affecting neuronal synaptic plasticity. LTD is thought to result mainly from a decrease in postsynaptic receptor density, although a decrease in presynaptic neurotransmitter release may also play a role. Cerebellar LTD has been hypothesized to be important for motor learning. However, it is likely that other plasticity mechanisms play a role as well. Hippocampal LTD may be important for the clearing of old memory traces. Hippocampal/cortical LTD can be dependent on NMDA receptors, metabotropic glutamate receptors (mGluR), or endocannabinoids. The result of the underlying-LTD molecular mechanism is the phosphorylation of AMPA glutamate receptors and their elimination from the surface of the parallel fiber-Purkinje cell (PF-PC) synapse.LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information.
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