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LO #1
LO #1

... Neurons are complex organs (computers?) that receive signals from many other neurons; summation of excitation and inhibition by postsynaptic neurons permits a neuron to integrate the electrical information provided by all synapses acting on it at any given moment. There are many clinical application ...
Channelrhodopsin as a tool to study synaptic
Channelrhodopsin as a tool to study synaptic

... temporal precision to investigate processes that typically operate on millisecond time scales. Channelrhodopsin2-based stimulation opens the possibility to stimulate distributed populations of genetically defined neurons using light. However, due to expression level differences, reliability and timi ...
Nutrition - Paignton Online
Nutrition - Paignton Online

... desserts, milk, fruit and vegetables. The most common sugars are glucose, fructose (fruit sugar) and galactose. Sugars, especially glucose, provide an instant burst of energy to the body. If the diet is low in glucose, the body will make it up using protein. Most of us eat too much sugar, which is b ...
A4a - Viktor`s Notes for the Neurosurgery Resident
A4a - Viktor`s Notes for the Neurosurgery Resident

... How, during development, neurons find "right" targets and make "right" synaptic connections? 1) growing axons have growth cones at their tips which migrate through tissues.  cones are guided by attractants and repellents in tissues.  SEMIPHORINS - proteins that repel / attract growth cones (depend ...
Action Potential: Resting State
Action Potential: Resting State

... • All action potentials are _______________ and are independent of stimulus intensity • Strong stimuli can generate an action potential more often than weaker stimuli • The CNS determines stimulus intensity by the _ ...
Synapse
Synapse

... 5. Its amplitude (very small) about 0.5 mv • To produce action potential must be summated. • The summation is of 2 types: spatial and temporal summation ...
Cellular Mechanisms of Learning and Memory
Cellular Mechanisms of Learning and Memory

... in the target hippocampal neurons. This facilitation is called long-term potentiation (LTP). LTP can be studied in the intact animal, where it can last for days and even weeks. It can also be examined in slices of hippocampus and in cell culture for several hours. ...
Neuroplasticity
Neuroplasticity

... part in firing it, some growth process or metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is increased.’ ...
Regulation of Astrocyte Plasticity
Regulation of Astrocyte Plasticity

... It should be noted that these effects are not limited to cerebellar cortex. Kleim et al. (papers and absts) have described synaptogenesis and changes in synapse morphology in association with the same AC motor learning procedure in the somatosensory-somatomotor forelimb cortex of rats. The first mor ...
presentation
presentation

... Multiple synapses for each presynaptic/postsynaptic neuron pair increase the odds that the information is received by the post synaptic neuron even if some synapses fail ...
Diffusion
Diffusion

... pass from the mother to the fetus by diffusion, and waste substances to diffuse from the fetus back to the mother. The placenta can filter out certain molecules and bacteria, but is unable to stop many harmful substances such as alcohol, chemicals and some types of virus from reaching the fetus. 8 o ...
How Neurons Communicate - Computing Science and Mathematics
How Neurons Communicate - Computing Science and Mathematics

... • Inhibitory inputs are on the dendrites or around the soma • They may be depolarising, hyperpolarising or make no change to the membrane potential • The receptor ion channels pass potassium or chloride ions – Equilibrium potential is near threshold (just above or below) ...
Physiology 2 - Sheet #6 - Dr.Loai Al-Zgoul - Done by: Yara
Physiology 2 - Sheet #6 - Dr.Loai Al-Zgoul - Done by: Yara

... and transmits its effect on the postsynaptic neuron. Finally, the neurotransmitter is either reabsorbed by the presynaptic cell, and then repackaged for future release, or else it is broken down metabolically by enzymes. Synapses depend greatly on the postsynaptic neuron’s receptors rather than on t ...
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File

... be released from the presynaptic membrane, diffuse across the synaptic cleft to reach the post synaptic membrane and bind to the neuroreceptors there. It is about 0.5 msec. ...
BOX 25.3 GIANT SYNAPTIC TERMINALS: ENDBULBS AND
BOX 25.3 GIANT SYNAPTIC TERMINALS: ENDBULBS AND

... ventral cochlear nucleus (Fig. 25.18A), and (2) calyceal endings, which are found in the medial nucleus of the trapezoid body. Calyces are so large that it is possible to use patch electrodes to record and clamp the presynaptic terminal while simultaneously doing the same with their postsynaptic tar ...
Chapter 13
Chapter 13

... Damage to supp. motor area disrupts ability to learn sequences of responses in which the performance of one response serves as a signal that the next response must be made (e.g push in lever, then turn in to the left) Premotor cortex plays a role in programming complex movements, and using sensory i ...
Diffusion 1 of 27 © Boardworks Ltd 2011
Diffusion 1 of 27 © Boardworks Ltd 2011

... Carbon dioxide diffuses from body tissues into the bloodstream and is exhaled via the lungs. Where does gas exchange take place in the lungs? 12 of 27 ...
Drugs
Drugs

... Alcohol is a depressant, it works by slowing down the nervous system and relaxing the brain. Alcohol can reach the brain in just one minute. Too much alcohol can damage the brain cells and cause depression. The liver breaks down alcohol to remove this toxic drug from the body. Too much alcohol can d ...
MS Word Version
MS Word Version

... • A second type of mACh receptor is found in the central nervous system, and in the heart. • Acetylcholine acts indirectly at these receptors, producing a slow inhibition of the postsynaptic cells. • In the heart, this effect decreases the heart rate. • Acetylcholine is inhibitory at these muscarini ...
BLoA Neurotransmission
BLoA Neurotransmission

... between the two neurons. The change in potential is going to affect little vesicles, little blobs of membrane inside the presynaptic neuron. These vesicles contain the neurotransmitters, which are synthesized in the presynaptic cell, and stored in the vesicles ...
Overview Synaptic plasticity Synaptic strength
Overview Synaptic plasticity Synaptic strength

... Associative learning in a CA1 microcircuit ...
Neurons Communicate by Neurotransmission
Neurons Communicate by Neurotransmission

... move toward the membrane of the axon terminal. When the vesicles reach the membrane, they fuse with the membrane and release their contents into the synaptic space. The molecules contained in the vesicles are chemical compounds called neurotransmitters. Each vesicle contains many molecules of a neur ...
3-8_NeuronDiversity_SalmaA
3-8_NeuronDiversity_SalmaA

... Glutamatergic neurons: Glutamate is one of two primary excitatory amino acid neurotransmitter, the other being Aspartate. Glutamate receptors are one of four categories, three of which are ligand-gated ion channels and one of which is a G-protein coupled receptor (often referred to as GPCR).Glutamat ...
Nerve Impulse Transmission
Nerve Impulse Transmission

... vesicles containing neurotransmitters ...
Central nervous system
Central nervous system

... of time – spatial summation occurs when single synapse receives many EPSPs from many presynaptic cells ...
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Long-term depression

Long-term depression (LTD), in neurophysiology, is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. LTD in the hippocampus and cerebellum have been the best characterized, but there are other brain areas in which mechanisms of LTD are understood. LTD has also been found to occur in different types of neurons that release various neurotransmitters, however, the most common neurotransmitter involved in LTD is L-glutamate. L-glutamate acts on the N-methyl-D- asparate receptors (NMDARs), α-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptors (AMPARs), kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) during LTD. It can result from strong synaptic stimulation (as occurs in the cerebellar Purkinje cells) or from persistent weak synaptic stimulation (as in the hippocampus). Long-term potentiation (LTP) is the opposing process to LTD; it is the long-lasting increase of synaptic strength. In conjunction, LTD and LTP are factors affecting neuronal synaptic plasticity. LTD is thought to result mainly from a decrease in postsynaptic receptor density, although a decrease in presynaptic neurotransmitter release may also play a role. Cerebellar LTD has been hypothesized to be important for motor learning. However, it is likely that other plasticity mechanisms play a role as well. Hippocampal LTD may be important for the clearing of old memory traces. Hippocampal/cortical LTD can be dependent on NMDA receptors, metabotropic glutamate receptors (mGluR), or endocannabinoids. The result of the underlying-LTD molecular mechanism is the phosphorylation of AMPA glutamate receptors and their elimination from the surface of the parallel fiber-Purkinje cell (PF-PC) synapse.LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information.
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