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ppt
ppt

... •allows K+ to flow out of the cell or Cl- to flow inside the cell •causing a slight hyperpolarization of the postsynaptic cell •moves the postsynaptic cell further from firing an action potential ...
fleming_Oct
fleming_Oct

... dendrites and soma to the branching ends of the axon. The neuron shown here is a motor neuron. Motor neurons originate in the brain or spinal cord and send their axons to the muscles or glands of the body. ...
the limbic system
the limbic system

... transduce the glutamate signal into electrical & biochemical events in the postsynaptic neuron. The -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor opens {unconditionally} in response to glutamate binding and mediates most of the rapid excitatory postsynaptic curre ...
Transmission at the Synapse and the
Transmission at the Synapse and the

... excitatory synapse on another neuron, and the two nerve endings form an axoaxonal synapse. o There are 3 mechanisms of presynaptic inhibition:  Activation of chloride channels in the PRE-synaptic neuron – that hyperpolarizes the excitatory nerve ending and thus reduced the magnitude of excitatory a ...
Sample Prelab Assignment - Neurobiology Laboratory
Sample Prelab Assignment - Neurobiology Laboratory

... in the postsynaptic neuron.  Depolarization of the presynaptic neuron causes an influx of calcium at the  nerve terminal, therefore allowing the release of synaptic vesicles. The transmitters in the vesicles then  diffuse across the synaptic cleft and bind to receptors on the postsynaptic neuron. Th ...
Excitatory and inhibitory transmission in the superior olivary complex
Excitatory and inhibitory transmission in the superior olivary complex

... Maintenance of high transmission rates is a major physiological problem since it causes severe depletion of the pool of readily releasable synaptic vesicles. Consequently, there is considerable depression in the number of vesicles released following each sequential action potential of the train. Th ...
Pull out the stops for plasticity
Pull out the stops for plasticity

... synapse as that analysed in the current study9. The activity of various metabotropic receptors, including mGlu1, can increase glutamatemediated responses through this pathway10. It will be interesting to investigate whether the mGlu1-triggered blockade of SK channels identified by Tigaret et al. act ...
Synaptic Transmission Lecture
Synaptic Transmission Lecture

... • Allows rapid and synchronous firing of interconnected cells ...
introduction
introduction

... • Inhibition in the CNS can be; postsynaptic presynaptic ...
9-18-04 Nervous System Peripheral No1
9-18-04 Nervous System Peripheral No1

... – All ganglionic transmission is cholinergic (acetylcholine) • Drugs that block ganglionic transmission block either parasympathetic or sympathetic depending on which is active • This is a paradox many have a problem grasping ...
Boardworks Respiration
Boardworks Respiration

... The heart pumps blood around the body in the blood vessels. Each time it pumps it causes the blood vessels to throb. This is called a pulse. To take your pulse: 1. Hold out one hand with the palm facing up. 2. Put the index and middle fingers of your other hand together. 3. Press these fingers light ...
big
big

... serotonin, increasing duration of its effects in the synapse. ...
Stochastic fluctuations of the synaptic function
Stochastic fluctuations of the synaptic function

... discussed in our recent papers where we addressed it by using a Brownian model for diffusion of glutamate molecules in the synaptic cleft (Di Maio and Ventriglia, 2000; Ventriglia and Di Maio, 2000a, 2000b, 2001). 2. Model and Simulation results The Brownian motion model of synaptic transmission use ...
The synapse.
The synapse.

... Advantages of the double-barrel electrode. The preceding slide was a drawing of the electrode tips. Real tips of the two barrels is not likely to be of the same length. The drawing at the right is more likely to occur. What this allows is to record differentially where the longer electrode is intra ...
Chapter 3 Synapses
Chapter 3 Synapses

... • Two EPSPs in rapid succession at one synapse are additive • Same for IPSPs Spatial Summation • Synaptic inputs from separate locations combine their effects on a neuron ...
Exam 3 suggested answers
Exam 3 suggested answers

... [Total on this part of the exam was 62, but it is counted as being out of 60, i.e. there were 2 free points.] (1) What general question about visual system plasticity are these experiments designed to answer? [4 points; 1 sentence] Is LTP the cellular mechanism that undelies ocular dominance plastic ...
Lecture 7 – Synaptic Transmission II -
Lecture 7 – Synaptic Transmission II -

... 5. NMDA receptors are blocked by external Mg2+, which binds to a site within the pore at negative resting potentials. Thus, current carried by AMPA and kainate receptors largely determines EPSP at negative resting potentials. However, during strong synaptic activity, the postsynaptic cell depolarize ...
Synapses and neurotransmitters
Synapses and neurotransmitters

... • Only 2.5 nm apart • Allows flow of ions from one neuron to another • Bi directional • Used when you need very fast reaction, say for defensive beahviour, that sort of thing • No receptor or binding site, but a connexon ...
Working Together for a World Free of Chemical Weapons
Working Together for a World Free of Chemical Weapons

... The Central Nervous System (CNS) is composed of the brain and spinal cord; it coordinates thoughts, memory and other complex processes, such as the body’s reaction to stimuli. A synapse is the gap between two nerve cells (neurons) through which chemical signalling molecules (neurotransmitters) pass ...
The Synapse
The Synapse

... thousands of these messages and integrates this input to bring about only one of two possible outcomes - the neuron stays in a resting state or it generates an action potential to communicate with another neuron. ...
Part 1: True/False
Part 1: True/False

... 2. __ T The EPSPs in the central nervous system are much smaller than end plate potentials. 3. __ T An IPSP can depolarize or hyperpolarize a cell. 4. __ F All neurotransmitters are synthesized in the soma and carried to the axon terminal through axoplasmic transport. 5. __ F The two main families o ...
2014 chemical signal..
2014 chemical signal..

... -A substance released by one neuron and acting rapidly, briefly and at short range on the membrane of adjacent (postsynaptic) neuron, causing excitation or inhibition. ...
Syllabus
Syllabus

... Passive  electrical  properties  of  neurons   ...
Nerve cells - Spark (e
Nerve cells - Spark (e

... In biology are defined dendrites the minor fibers branching from the neuron, they carry nerve signals in centripetal direction. The dendrites are shorter and thinner than the axon. ...
Part 1: True/False
Part 1: True/False

... 13. Which of the following is a metabotropic receptor? A. nACh receptor B. AMPA receptor C. NMDA receptor D. muscarinic receptor E. Kinate receptor 14. Which is the strongest piece of evidence that Otto Loewi provided proving that chemical synaptic transmission exists: A. Showing that stimulating th ...
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Long-term depression

Long-term depression (LTD), in neurophysiology, is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress. LTD in the hippocampus and cerebellum have been the best characterized, but there are other brain areas in which mechanisms of LTD are understood. LTD has also been found to occur in different types of neurons that release various neurotransmitters, however, the most common neurotransmitter involved in LTD is L-glutamate. L-glutamate acts on the N-methyl-D- asparate receptors (NMDARs), α-amino-3-hydroxy-5-methylisoxazole-4-propionicacid receptors (AMPARs), kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) during LTD. It can result from strong synaptic stimulation (as occurs in the cerebellar Purkinje cells) or from persistent weak synaptic stimulation (as in the hippocampus). Long-term potentiation (LTP) is the opposing process to LTD; it is the long-lasting increase of synaptic strength. In conjunction, LTD and LTP are factors affecting neuronal synaptic plasticity. LTD is thought to result mainly from a decrease in postsynaptic receptor density, although a decrease in presynaptic neurotransmitter release may also play a role. Cerebellar LTD has been hypothesized to be important for motor learning. However, it is likely that other plasticity mechanisms play a role as well. Hippocampal LTD may be important for the clearing of old memory traces. Hippocampal/cortical LTD can be dependent on NMDA receptors, metabotropic glutamate receptors (mGluR), or endocannabinoids. The result of the underlying-LTD molecular mechanism is the phosphorylation of AMPA glutamate receptors and their elimination from the surface of the parallel fiber-Purkinje cell (PF-PC) synapse.LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information.
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