6. DISCUSSION
... Histocompatibility class II antigens are present in a limited number of cell types. In the swine they are expressed on all B cells, on APCs and in a variable number of resting and activated T cells (Saalmuller et al., 1991; Bullido et al., 1997b). In the present investigation, it was possible to ide ...
... Histocompatibility class II antigens are present in a limited number of cell types. In the swine they are expressed on all B cells, on APCs and in a variable number of resting and activated T cells (Saalmuller et al., 1991; Bullido et al., 1997b). In the present investigation, it was possible to ide ...
Vortrag - Institut für Pathologie Prof. Dr. Klaus Richter, Hannover
... 2. Laboratory requirements for morphological diagnostics at an Institute of Pathology Apart from the technical expertise of the pathologist diagnostics doing the hepatic diagnostics, an institute of pathology must meet certain technical requirements: · Fixation of liver tissue immediately after extr ...
... 2. Laboratory requirements for morphological diagnostics at an Institute of Pathology Apart from the technical expertise of the pathologist diagnostics doing the hepatic diagnostics, an institute of pathology must meet certain technical requirements: · Fixation of liver tissue immediately after extr ...
ACUTE ANTERIOR UVEITIS AND HLA-B27: INFECTIOUS BACKGROUND, SYSTEMIC INFLAMMATION,
... jejuni, and Borrelia burgdorferi were measured using enzyme-linked immunosorbent assay (ELISA), ...
... jejuni, and Borrelia burgdorferi were measured using enzyme-linked immunosorbent assay (ELISA), ...
autoimmunity - Thyroid Disease Manager
... The genes for the HLA-A, B, C and HLA-DR, DP, DQ molecules are on chromosome 6, and comprise some of the genes in a large immune response control complex (Fig. 7-5). Each cell surface HLA molecule is made up of 2 peptide chains; an chain and 2 microglobulin for class I molecules, and and chai ...
... The genes for the HLA-A, B, C and HLA-DR, DP, DQ molecules are on chromosome 6, and comprise some of the genes in a large immune response control complex (Fig. 7-5). Each cell surface HLA molecule is made up of 2 peptide chains; an chain and 2 microglobulin for class I molecules, and and chai ...
Human ProBNP and proBNP-derived Peptides (BNP and NT
... proBNP biochemistry, such as proBNP/NT-proBNP glycosylation or incomplete proBNP processing, could significantly influence the current approach to both BNP and NT-proBNP measurements. As HyTest researchers demonstrated, NT-proBNP glycosylation negatively affects its recognition by some antibodies (8 ...
... proBNP biochemistry, such as proBNP/NT-proBNP glycosylation or incomplete proBNP processing, could significantly influence the current approach to both BNP and NT-proBNP measurements. As HyTest researchers demonstrated, NT-proBNP glycosylation negatively affects its recognition by some antibodies (8 ...
The Role of Donor‐Specific HLA Alloantibodies in Liver
... complement activation, immunoglobulin subclass, common epitopes shared between unique antigens). Resolving variability among centers requires recognition that SPI and MFI metrics are not quantifiable measures of antibody (i.e. MFI is not a titer). It is critical that manufacturers minimize lot-to-lo ...
... complement activation, immunoglobulin subclass, common epitopes shared between unique antigens). Resolving variability among centers requires recognition that SPI and MFI metrics are not quantifiable measures of antibody (i.e. MFI is not a titer). It is critical that manufacturers minimize lot-to-lo ...
AN IMMUNOGENETIC STUDY OF SPECIES
... and E l l U (column 8), showing that the sera of these two backcross birds contained one or more substances different from those (Ps-1.Ps-2.Ps-3) in D967Y2. As may be seen by the reactions of the sera of these two birds, D820V2 and E l l U , in columns 3 and 4 of table 1, the antigenic constituents ...
... and E l l U (column 8), showing that the sera of these two backcross birds contained one or more substances different from those (Ps-1.Ps-2.Ps-3) in D967Y2. As may be seen by the reactions of the sera of these two birds, D820V2 and E l l U , in columns 3 and 4 of table 1, the antigenic constituents ...
Correlations among measles virus
... Immunity to measles is conferred by the interplay of humoral and cellular immune responses, the latter being critical in maintaining long-term recall response. Therefore, it is important to evaluate measles-specific humoral and cellular immunity in populations several years after vaccination and und ...
... Immunity to measles is conferred by the interplay of humoral and cellular immune responses, the latter being critical in maintaining long-term recall response. Therefore, it is important to evaluate measles-specific humoral and cellular immunity in populations several years after vaccination and und ...
IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF
... from day to day with an error of ± 10 per cent, provided freshly prepared platelets were used. One unit of antibody activity was defined arbitrarily as that amount required to fix 4 U of C' under conditions shown in Figure 2. The serum sample used in this figure, obtained 1 week post partum from Mot ...
... from day to day with an error of ± 10 per cent, provided freshly prepared platelets were used. One unit of antibody activity was defined arbitrarily as that amount required to fix 4 U of C' under conditions shown in Figure 2. The serum sample used in this figure, obtained 1 week post partum from Mot ...
prolactin and autoimmune diseases prolakt
... PATIENTS WHO DID NOT HAVE AUTOIMMUNE DISEASES Because prolactin is associated with immune system activity, there has been interest in examining hyperprolactinemia patients for autoantibodies. Hyperprolactinemia men, many of whom had prolactinomas, had significantly more positive tests for fluorescen ...
... PATIENTS WHO DID NOT HAVE AUTOIMMUNE DISEASES Because prolactin is associated with immune system activity, there has been interest in examining hyperprolactinemia patients for autoantibodies. Hyperprolactinemia men, many of whom had prolactinomas, had significantly more positive tests for fluorescen ...
Pathophysiology and Clinical Spectrum of Infections in Systemic
... and lymphoproliferative diseases, and triggers the development of autoimmune diseases. In 1971 Evans83 described a high prevalence of the virus in the sera of patients who had SLE, and in 1997 EBV was proposed as an etiologic cause for SLE, rather than an incidental finding. The pathogenesis is mole ...
... and lymphoproliferative diseases, and triggers the development of autoimmune diseases. In 1971 Evans83 described a high prevalence of the virus in the sera of patients who had SLE, and in 1997 EBV was proposed as an etiologic cause for SLE, rather than an incidental finding. The pathogenesis is mole ...
Antibodies Targeting Hsa and PadA Prevent Platelet - Serval
... were analyzed on a 12% acrylamide gel and dialyzed against 100 volumes of phosphate-buffered saline (PBS) twice for 2 h at 4°C. The protein concentrations were determined with the Bio-Rad protein assay, using bovine serum albumin (BSA) as standard. Binding of Hsa-LysA2 and PadA-LysA2 fusion proteins ...
... were analyzed on a 12% acrylamide gel and dialyzed against 100 volumes of phosphate-buffered saline (PBS) twice for 2 h at 4°C. The protein concentrations were determined with the Bio-Rad protein assay, using bovine serum albumin (BSA) as standard. Binding of Hsa-LysA2 and PadA-LysA2 fusion proteins ...
An Approach to the Patient Refractory to Platelets Transfusion
... An Approach to the Patient Refractory to Platelets Transfusion HLA-antigen negative "compatible" platelets This is a similar approach to the technique used to provide compatible RBCs for patients who have RBC antibodies. The laboratory finds units lacking only those antigens to which the patient ha ...
... An Approach to the Patient Refractory to Platelets Transfusion HLA-antigen negative "compatible" platelets This is a similar approach to the technique used to provide compatible RBCs for patients who have RBC antibodies. The laboratory finds units lacking only those antigens to which the patient ha ...
Definition of the disease
... Definition of the disease: Query (Q) fever (or Coxiellosis) is a zoonosis that occurs in most countries. Humans generally acquire infection through air-borne transmission from animal reservoirs, especially from domestic ruminants, but other domestic and wildlife animals (pets, rabbits, birds, etc.) ...
... Definition of the disease: Query (Q) fever (or Coxiellosis) is a zoonosis that occurs in most countries. Humans generally acquire infection through air-borne transmission from animal reservoirs, especially from domestic ruminants, but other domestic and wildlife animals (pets, rabbits, birds, etc.) ...
Lymphocytic hypophysitis: a rare or underestimated disease?
... autoimmune endocrine or non-endocrine disorders. It can also occur less frequently in prepubertal or post-menopausal women and in men. Headache, visual field impairment and more rarely diplopia are due to extrasellar pituitary enlargement with optic chiasma compression and/or to invasion of cavernou ...
... autoimmune endocrine or non-endocrine disorders. It can also occur less frequently in prepubertal or post-menopausal women and in men. Headache, visual field impairment and more rarely diplopia are due to extrasellar pituitary enlargement with optic chiasma compression and/or to invasion of cavernou ...
NS1 antigen ELISA
... Dengue fever caused by dengue virus (DENV), a member of Flaviviridae leads to large global disease burden. Detection of immunoglobulin M (IgM) and nucleic acid to DENV, and virus isolation have been used for laboratory diagnostic assays for dengue. Nonstructural 1 (NS1) antigen which releases from D ...
... Dengue fever caused by dengue virus (DENV), a member of Flaviviridae leads to large global disease burden. Detection of immunoglobulin M (IgM) and nucleic acid to DENV, and virus isolation have been used for laboratory diagnostic assays for dengue. Nonstructural 1 (NS1) antigen which releases from D ...
Sperm Agglutination, Sperm Shaky Head
... Objectives of this work were: 1) to investigate the infertile patients with immunological infertility through the assessment of their results of semen analysis, sperm agglutination (SA) and sperm shaky head movement (SSM). 2) Study the recovery of sperm-cervical mucus interaction in infertile couple ...
... Objectives of this work were: 1) to investigate the infertile patients with immunological infertility through the assessment of their results of semen analysis, sperm agglutination (SA) and sperm shaky head movement (SSM). 2) Study the recovery of sperm-cervical mucus interaction in infertile couple ...
Establishment of immunohistochemical double staining
... called nivolumab and pembrolizumab have been approved for clinical trials by the FDA in the United States for treatment against these cancer forms since the response in patients is good and the extended ...
... called nivolumab and pembrolizumab have been approved for clinical trials by the FDA in the United States for treatment against these cancer forms since the response in patients is good and the extended ...
Serologic Analysis of the IgG Antibody Response in
... lifelong immunity, breakthrough infections can occur months to years after VZV immunization and are caused by wild-type virus as a result of vaccine failure.4 Vaccine failure can be divided into 2 types. Whereas primary failure is defined as nonmeasurable immune response on primary vaccination, seco ...
... lifelong immunity, breakthrough infections can occur months to years after VZV immunization and are caused by wild-type virus as a result of vaccine failure.4 Vaccine failure can be divided into 2 types. Whereas primary failure is defined as nonmeasurable immune response on primary vaccination, seco ...
Antibodies to N**-(A^-isopentenyI) adenosine and its nucleotide
... i 6 Ado and to quantitate the amount of that nucleotide. The sane order of selectivity was expressed whether the nucleotides were free or in a tRNA molecule. Interaction of the antibody with compounds from the i 6 Ado family demonstrated dominance of the hydrophobic isopentenyl group and the importa ...
... i 6 Ado and to quantitate the amount of that nucleotide. The sane order of selectivity was expressed whether the nucleotides were free or in a tRNA molecule. Interaction of the antibody with compounds from the i 6 Ado family demonstrated dominance of the hydrophobic isopentenyl group and the importa ...
... innate (natural or nonspecific) and the acquired (adaptive or specific) immune responses 1. Innate immunity Most encounters with microorganisms do not result in disease. The few microbes that manage to cross the barriers of skin, mucus, cilia, and pH are usually eliminated by innate immune mechanism ...
5. Thrombocytopenia
... chemotherapy and manifested as microangiopathic hemolytic anemia, thrombocytopenia, renal failure, neurologic findings, and fever. HUS caused by infection and is manifested as acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. Deficiency of ADAMTS 13 produces a defecti ...
... chemotherapy and manifested as microangiopathic hemolytic anemia, thrombocytopenia, renal failure, neurologic findings, and fever. HUS caused by infection and is manifested as acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia. Deficiency of ADAMTS 13 produces a defecti ...
A human SARS-CoV neutralizing antibody against epitope on S2
... gested with BstNI since a number of BstNI sites randomly exist in the variable region of antibody. As shown in Fig. 1B, all the 13 clones contained a similar size of full-length scFv around 750 bp. However, each scFv clone showed a unique BstNI-digested fingerprinting pattern (Fig. 1C), indicating th ...
... gested with BstNI since a number of BstNI sites randomly exist in the variable region of antibody. As shown in Fig. 1B, all the 13 clones contained a similar size of full-length scFv around 750 bp. However, each scFv clone showed a unique BstNI-digested fingerprinting pattern (Fig. 1C), indicating th ...
Immune complex formation in IgA nephropathy
... ‘normal’ IgA that should have been secreted at mucosal surfaces but has mistakenly found its way into the circulation. In fact, the pattern of O-glycosylation is different between mucosal and serum IgA1 in the same individual and IgA1 directed against mucosal pathogens is poorly O-galactosylated com ...
... ‘normal’ IgA that should have been secreted at mucosal surfaces but has mistakenly found its way into the circulation. In fact, the pattern of O-glycosylation is different between mucosal and serum IgA1 in the same individual and IgA1 directed against mucosal pathogens is poorly O-galactosylated com ...
Anti-nuclear antibody
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some individuals, antibodies to human antigens are produced.There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren's syndrome, scleroderma, mixed connective tissue disease, polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.The ANA test detects the autoantibodies present in an individual's blood serum. The common tests used for detecting and quantifying ANAs are indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). In immunofluorescence, the level of autoantibodies is reported as a titre. This is the highest dilution of the serum at which autoantibodies are still detectable. Positive autoantibody titres at a dilution equal to or greater than 1:160 are usually considered as clinically significant. Positive titres of less than 1:160 are present in up to 20% of the healthy population, especially the elderly. Although positive titres of 1:160 or higher are strongly associated with autoimmune disorders, they are also found in 5% of healthy individuals. Autoantibody screening is useful in the diagnosis of autoimmune disorders and monitoring levels helps to predict the progression of disease. A positive ANA test is seldom useful if other clinical or laboratory data supporting a diagnosis are not present.