Seroprevalence of Mycoplasma pneumoniae in HIV
... microlitre or the HIV-infected person has any of the AIDSdefining clinical illnesses. Mycoplasmal infection is highly significant clinically in AIDS, even if it is only one example of an opportunistic infection, as opportunistic infections are reportedly the direct cause of death in more than 80 % o ...
... microlitre or the HIV-infected person has any of the AIDSdefining clinical illnesses. Mycoplasmal infection is highly significant clinically in AIDS, even if it is only one example of an opportunistic infection, as opportunistic infections are reportedly the direct cause of death in more than 80 % o ...
Atypical serological profiles in hepatitis B virus infection Robério A
... homology, are highly cross-reactive at the T-cell level [15]. Thus, HBe antigen, because of its small size, may traverse the placenta and elicit HBe/HBcAg-specific T-helper cell tolerance in utero [16]. Consequently, it may lead to fetal immunotolerance not only to HBeAg but also to HBcAg, and still ...
... homology, are highly cross-reactive at the T-cell level [15]. Thus, HBe antigen, because of its small size, may traverse the placenta and elicit HBe/HBcAg-specific T-helper cell tolerance in utero [16]. Consequently, it may lead to fetal immunotolerance not only to HBeAg but also to HBcAg, and still ...
Duration of post-vaccination immunity against yellow - Arca
... yellow fever neutralising antibodies persisting in primo-vaccinated adults. The time since vaccination was grouped in arbitrary categories to determine the length of time that it takes for the immune response to decline and warrant the need for revaccination. Study subjects were grouped according to ...
... yellow fever neutralising antibodies persisting in primo-vaccinated adults. The time since vaccination was grouped in arbitrary categories to determine the length of time that it takes for the immune response to decline and warrant the need for revaccination. Study subjects were grouped according to ...
Synthesis and Characterization of Hapten-Protein
... protein. The higher ratio of hapten usually increases the strength and specificity of the immune response. However, there is a risk that a high degree of substitution could adversely affect the activity and specificity of antibodies produced (16). Besides, the formations of protein-hapten conjugates ...
... protein. The higher ratio of hapten usually increases the strength and specificity of the immune response. However, there is a risk that a high degree of substitution could adversely affect the activity and specificity of antibodies produced (16). Besides, the formations of protein-hapten conjugates ...
Localized Maternal Proteins in Xenopus
... themselves stained. No staining is detectable in the animal hemisphere, as demonstrated in Fig. 2A, which shows an animal hemisphere view of the same egg as in Fig 2B. Fertilized eggs stained with MAbs from hybridoma D44G8 show distinct reticulated areas confined to the vegetal cortex. This is illus ...
... themselves stained. No staining is detectable in the animal hemisphere, as demonstrated in Fig. 2A, which shows an animal hemisphere view of the same egg as in Fig 2B. Fertilized eggs stained with MAbs from hybridoma D44G8 show distinct reticulated areas confined to the vegetal cortex. This is illus ...
F1-ATPase`
... times with PBS containing 0.5% NP-40 (washing buffer). Antigen-coated plates could be used immediately or stored in a moist chamber at 4°C for up to several months. Hybridoma culture fluids were incubated in the antigen-coated wells for 2 h at 4°C, then rinsed off with washing buffer. Goat antimouse ...
... times with PBS containing 0.5% NP-40 (washing buffer). Antigen-coated plates could be used immediately or stored in a moist chamber at 4°C for up to several months. Hybridoma culture fluids were incubated in the antigen-coated wells for 2 h at 4°C, then rinsed off with washing buffer. Goat antimouse ...
Monoclonal Antibodies for Therapeutic Use: Specific Characteristics
... ANSM)[16] followed by the EMA[17] published guidelines to mitigate the risks of undesirable effects during the first administration of an innovative medicinal product to humans. Recent guidelines relate to the development of biosimilars, including MoAb.[18] However, there are no guidelines on the cl ...
... ANSM)[16] followed by the EMA[17] published guidelines to mitigate the risks of undesirable effects during the first administration of an innovative medicinal product to humans. Recent guidelines relate to the development of biosimilars, including MoAb.[18] However, there are no guidelines on the cl ...
Artificial Immune Systems
... and builds a response to them that can remain in the body over a long period of time. This remarkable information processing biological system has caught the attention of computer science in recent years. A novel computational intelligence technique inspired by immunology has emerged, called Artific ...
... and builds a response to them that can remain in the body over a long period of time. This remarkable information processing biological system has caught the attention of computer science in recent years. A novel computational intelligence technique inspired by immunology has emerged, called Artific ...
Brucellosis in Animals - Cairo University Scholars
... PCR is particularly useful in case of tissues and fluids contaminated with nonviable or low numbers of Brucella organisms in diagnosis, It can detect Brucella DNA. A good sensitivity of PCR was reported by Fekete et al. (1990 a and 1990b), Baily et al. (1992) and Da Costa et al. (1996). ...
... PCR is particularly useful in case of tissues and fluids contaminated with nonviable or low numbers of Brucella organisms in diagnosis, It can detect Brucella DNA. A good sensitivity of PCR was reported by Fekete et al. (1990 a and 1990b), Baily et al. (1992) and Da Costa et al. (1996). ...
Immune Complex Deposits as a Characteristic Feature of
... Systemic autoimmune diseases, such as systemic lupus erythematosus (lupus, SLE), rheumatoid arthritis and systemic sclerosis (scleroderma), occur in up to 5-8% of the human population. Based on frequency of occurrence, they are the third most common diseases after cardiovascular pathologies and canc ...
... Systemic autoimmune diseases, such as systemic lupus erythematosus (lupus, SLE), rheumatoid arthritis and systemic sclerosis (scleroderma), occur in up to 5-8% of the human population. Based on frequency of occurrence, they are the third most common diseases after cardiovascular pathologies and canc ...
Morphology of autoimmune hepatitis - pathologie
... play a prominent role in the immune defences as well as in the inflammatory reactions of the liver in general. They are components of the monocytic macrophage system. They are capable of migration, replication, and thus expansion. As macrophages they are involved in the primary phase of the cell-med ...
... play a prominent role in the immune defences as well as in the inflammatory reactions of the liver in general. They are components of the monocytic macrophage system. They are capable of migration, replication, and thus expansion. As macrophages they are involved in the primary phase of the cell-med ...
HIV-specific antibody- dependent cellular cytotoxicity
... risk of acquisition and appeared to block a potentially protective role for ADCC antibodies. Thus, non-neutralizing ADCC antibodies are under intense interest as a potentially protective immune response to HIV. ADCC in HIV & SIV ...
... risk of acquisition and appeared to block a potentially protective role for ADCC antibodies. Thus, non-neutralizing ADCC antibodies are under intense interest as a potentially protective immune response to HIV. ADCC in HIV & SIV ...
Autoimmunity to glomerular antigens in
... MO, U.S.A.) was performed as described by Fornasieri et al. [32]. A standard curve of an internal reference serum, known to contain high levels of IgA or IgG antibodies to the respective antigens, was incubated in each plate and the test results were converted to arbitrary units after subtraction of ...
... MO, U.S.A.) was performed as described by Fornasieri et al. [32]. A standard curve of an internal reference serum, known to contain high levels of IgA or IgG antibodies to the respective antigens, was incubated in each plate and the test results were converted to arbitrary units after subtraction of ...
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA
... precipitation of an antigen onto insoluble particles of aluminum potassium sulfate, also known as ‘potash alum’, before immunization was responsible for better antibody responses than that of soluble antigen alone. Since this discovery and for approximately 60 years, alum was believed to induce a “d ...
... precipitation of an antigen onto insoluble particles of aluminum potassium sulfate, also known as ‘potash alum’, before immunization was responsible for better antibody responses than that of soluble antigen alone. Since this discovery and for approximately 60 years, alum was believed to induce a “d ...
Hen egg yolk antibodies - Les Presses agronomiques de Gembloux
... with the mammalian IgG. However, it has become clear that this is inappropriate, especially because of fundamental structural differences between IgG and IgY molecules, which will be discussed in more details later. IgY makes up about 75% of the total immunoglobulin pool. The serum concentrations of ...
... with the mammalian IgG. However, it has become clear that this is inappropriate, especially because of fundamental structural differences between IgG and IgY molecules, which will be discussed in more details later. IgY makes up about 75% of the total immunoglobulin pool. The serum concentrations of ...
O A RIGINAL RTICLES
... primarily as the sentinels of the innate immune system. Exposure to small numbers of pneumococci in the airways results in the production of low, sub-cytolytic concentrations of pneumolysin, which induce production of the potent neutrophil chemoattractant, interleukin-8 (IL-8), by airway epithelium ...
... primarily as the sentinels of the innate immune system. Exposure to small numbers of pneumococci in the airways results in the production of low, sub-cytolytic concentrations of pneumolysin, which induce production of the potent neutrophil chemoattractant, interleukin-8 (IL-8), by airway epithelium ...
Arterioscler Thromb Vasc Biol. - Arteriosclerosis, Thrombosis, and
... take up oxidized LDL through the scavenger receptor pathway and initiate an adaptive immune response by possibly presenting lipid antigens on CD 1 receptors6 and peptide antigens on human leukocyte antigen-DR (HLA-DR) receptors.7 The existence of a pre-existing, natural immune response against oxidi ...
... take up oxidized LDL through the scavenger receptor pathway and initiate an adaptive immune response by possibly presenting lipid antigens on CD 1 receptors6 and peptide antigens on human leukocyte antigen-DR (HLA-DR) receptors.7 The existence of a pre-existing, natural immune response against oxidi ...
The immune system
... response cannot be induced, e.g. steel nails used in surgery at repositions of broken bones, plastic material (shams) in ...
... response cannot be induced, e.g. steel nails used in surgery at repositions of broken bones, plastic material (shams) in ...
carbamazepine in a patient with severe serum
... rash induced by carbamazepine to an immunological disorder, because 80% of carbamazepine can bind to proteinl' and the skin rash does not appear for seven days. 1 We have described a patient who showed the classic clinical picture of serum sickness.7 Carbamazepine specific delayed type hypersensitiv ...
... rash induced by carbamazepine to an immunological disorder, because 80% of carbamazepine can bind to proteinl' and the skin rash does not appear for seven days. 1 We have described a patient who showed the classic clinical picture of serum sickness.7 Carbamazepine specific delayed type hypersensitiv ...
Prevalence of Serum IgG and Neutralizing Factors Against
... The neutralizing titer was reported as the highest serum dilution that inhibited the rAAV transduction by 50% compared with the control without serum and correlated with the amount of protein quantified in each well after cell lysis by Bradford assay. Statistical analyses Results are presented as m ...
... The neutralizing titer was reported as the highest serum dilution that inhibited the rAAV transduction by 50% compared with the control without serum and correlated with the amount of protein quantified in each well after cell lysis by Bradford assay. Statistical analyses Results are presented as m ...
Clustering and commonalities among autoimmune diseases
... syndrome due to the vasculo-sclerotic narrowing seen in SSc, absence of anti-ds-DNA, low propensity for immune-complex formation, and infrequent renal disease relative to SLE. There is a (relatively) specific serological signature, autoantibody to the uridine (U)-rich-ribonucleoprotein (U1-RNP autoan ...
... syndrome due to the vasculo-sclerotic narrowing seen in SSc, absence of anti-ds-DNA, low propensity for immune-complex formation, and infrequent renal disease relative to SLE. There is a (relatively) specific serological signature, autoantibody to the uridine (U)-rich-ribonucleoprotein (U1-RNP autoan ...
Induction of immune responses to bovine herpesvirus type 1 gD in
... a situation where there is an unavoidable window of susceptibility to disease following the decline of maternally derived antibody and prior to the development of active humoral responses (MacDonald, 1992). This window of susceptibility occurs because the maternal titre capable of inhibiting the res ...
... a situation where there is an unavoidable window of susceptibility to disease following the decline of maternally derived antibody and prior to the development of active humoral responses (MacDonald, 1992). This window of susceptibility occurs because the maternal titre capable of inhibiting the res ...
Document
... against a high proportion of a panel of human cells , which is used to screen for reactivity; therefore, acceptable donors are difficult to find. Also, high-PRA patients are at higher risk for early graft failure. ...
... against a high proportion of a panel of human cells , which is used to screen for reactivity; therefore, acceptable donors are difficult to find. Also, high-PRA patients are at higher risk for early graft failure. ...
A Introduction
... own constituents parts as its self, which result in an immune response against its own tissues and cells. Autoimmune diseases are the disorders in which the body’s immune system reacts against its own tissues and form autoantibodies which attack its own antigens. Paul Ehrlich at the beginning of the ...
... own constituents parts as its self, which result in an immune response against its own tissues and cells. Autoimmune diseases are the disorders in which the body’s immune system reacts against its own tissues and form autoantibodies which attack its own antigens. Paul Ehrlich at the beginning of the ...
Anti-nuclear antibody
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some individuals, antibodies to human antigens are produced.There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren's syndrome, scleroderma, mixed connective tissue disease, polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.The ANA test detects the autoantibodies present in an individual's blood serum. The common tests used for detecting and quantifying ANAs are indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). In immunofluorescence, the level of autoantibodies is reported as a titre. This is the highest dilution of the serum at which autoantibodies are still detectable. Positive autoantibody titres at a dilution equal to or greater than 1:160 are usually considered as clinically significant. Positive titres of less than 1:160 are present in up to 20% of the healthy population, especially the elderly. Although positive titres of 1:160 or higher are strongly associated with autoimmune disorders, they are also found in 5% of healthy individuals. Autoantibody screening is useful in the diagnosis of autoimmune disorders and monitoring levels helps to predict the progression of disease. A positive ANA test is seldom useful if other clinical or laboratory data supporting a diagnosis are not present.