Staphylococcus aureus infection induces protein A–mediated
... idiotype B cells. The effects of SpA during natural infection, however, have not been addressed. Acutely activated B cells, or plasmablasts (PBs), were analyzed to dissect the ongoing immune response to infection through the production of monoclonal antibodies (mAbs). The B cells that were activated ...
... idiotype B cells. The effects of SpA during natural infection, however, have not been addressed. Acutely activated B cells, or plasmablasts (PBs), were analyzed to dissect the ongoing immune response to infection through the production of monoclonal antibodies (mAbs). The B cells that were activated ...
Chronic ulcerative stomatitis and lichen planus:
... Lee et al. characterized the CUS protein autoantigen and showed it to be a variant of the p53-like KET gene [6]. The CUS protein seems to be very important for epithelial development and regeneration. Anti-CUS protein antibodies may interfere with normal CUS protein function leading to chronic ulcer ...
... Lee et al. characterized the CUS protein autoantigen and showed it to be a variant of the p53-like KET gene [6]. The CUS protein seems to be very important for epithelial development and regeneration. Anti-CUS protein antibodies may interfere with normal CUS protein function leading to chronic ulcer ...
1Laboratory of Complement Biology, New York Blood - HAL
... antibody screening tests, since test RBCs do not express these antigens. However, they can be detected when a pre-transfusion cross-match is performed between samples of RBC to be transfused and patient serum. The third level of antigenic complexity between SCD patient and donor RBCs that can accoun ...
... antibody screening tests, since test RBCs do not express these antigens. However, they can be detected when a pre-transfusion cross-match is performed between samples of RBC to be transfused and patient serum. The third level of antigenic complexity between SCD patient and donor RBCs that can accoun ...
clin exp rheum 27/1 - Clinical and Experimental Rheumatology
... characterized by multisystem involvement with variable and frequently overlapping clinical manifestations. Abnormal immune regulation patterns and persistent inflammation are ACTD hallmarks. In such a context, autoimmunity/inflammation-associated cellular and molecular networks drive a complex of reac ...
... characterized by multisystem involvement with variable and frequently overlapping clinical manifestations. Abnormal immune regulation patterns and persistent inflammation are ACTD hallmarks. In such a context, autoimmunity/inflammation-associated cellular and molecular networks drive a complex of reac ...
Tong, LF, Balakrishan G, Kochan JP, et al. Assessment of
... principle of immunoabsorption. The allergen of interest is first bound to a solid-phase support such as a paper disk, plastic microtiter well, or cellulose sponge. The patient’s serum is then incubated with the allergen-coupled solid phase. If the patient has antibodies specific for the allergen, th ...
... principle of immunoabsorption. The allergen of interest is first bound to a solid-phase support such as a paper disk, plastic microtiter well, or cellulose sponge. The patient’s serum is then incubated with the allergen-coupled solid phase. If the patient has antibodies specific for the allergen, th ...
Immune function across generations: integrating mechanism and
... Brambell 1970; table 1). There is recent evidence that invertebrates, which do not produce antibodies, also have some mechanism of maternal transmission of immunity to the next generation (Huang & Song 1999; Moret & Schmid-Hempel 2001). Neonatal vertebrates have limited ability to synthesize antibod ...
... Brambell 1970; table 1). There is recent evidence that invertebrates, which do not produce antibodies, also have some mechanism of maternal transmission of immunity to the next generation (Huang & Song 1999; Moret & Schmid-Hempel 2001). Neonatal vertebrates have limited ability to synthesize antibod ...
the manipulations of magromolecular substances during fertilization
... theories originally proposed by Breinl and Haurowitz (1930), Mudd (1932) and Pauling (1940) and more recently developed by Karush (1961). I wish only to remark that the clonal selection theories do not eliminate the assumption of template mechanisms, but simply restrict these to the "DNA makes RNA m ...
... theories originally proposed by Breinl and Haurowitz (1930), Mudd (1932) and Pauling (1940) and more recently developed by Karush (1961). I wish only to remark that the clonal selection theories do not eliminate the assumption of template mechanisms, but simply restrict these to the "DNA makes RNA m ...
IgG and IgA Antibody Profiling with the PEPperCHIP
... corresponding antibody. Other strong IgG responses were directed against various epitopes of herpes simplex virus, a common pathogen with a very high rate of infestation. Less strong IgG responses were observed against multiple epitopes of Toxoplasma gondii, a parasitic protozoan that causes toxopla ...
... corresponding antibody. Other strong IgG responses were directed against various epitopes of herpes simplex virus, a common pathogen with a very high rate of infestation. Less strong IgG responses were observed against multiple epitopes of Toxoplasma gondii, a parasitic protozoan that causes toxopla ...
Autoimmune Diseases - The Dartmouth Undergraduate Journal of
... Women’s Disease? Approximately one-third of the risk of developing an autoimmune disease can be attributed to heritable factors, especially gender. Women account for about 75% of the estimated 23.5 million people in America afflicted by autoimmune diseases, and autoimmune diseases constitute some of ...
... Women’s Disease? Approximately one-third of the risk of developing an autoimmune disease can be attributed to heritable factors, especially gender. Women account for about 75% of the estimated 23.5 million people in America afflicted by autoimmune diseases, and autoimmune diseases constitute some of ...
Analysis of the Original Antigenic Sin Antibody Response to the
... We evaluated the effect of sequential exposure to C. trachomatis antigenic variants on antibody responses. We demonstrated that OAS antibodies to serovar C EBs are readily detectable by the MIF assay from sera of mice primed with serovar C and boosted with serovars A, K, H, or B. Homologous boosting ...
... We evaluated the effect of sequential exposure to C. trachomatis antigenic variants on antibody responses. We demonstrated that OAS antibodies to serovar C EBs are readily detectable by the MIF assay from sera of mice primed with serovar C and boosted with serovars A, K, H, or B. Homologous boosting ...
Why Is It So Difficult To Develop A Malaria Vaccine?
... AMAl from different P. falciparum isolates have been published and analysis of these sequences reveal that AMA-l occurs as distinct allelic variants that differ by a number of point mutations (Dutta, Lee, H, & E., 2007). In subdomain I, there are at least 41 polymorphic nucleotides and at least 49 d ...
... AMAl from different P. falciparum isolates have been published and analysis of these sequences reveal that AMA-l occurs as distinct allelic variants that differ by a number of point mutations (Dutta, Lee, H, & E., 2007). In subdomain I, there are at least 41 polymorphic nucleotides and at least 49 d ...
comparative characterization of porins from salmonella typhio
... (Fig. 1 b). The extent of purity of the porin preparation at different purification steps was cross-checked with SDS PAGE using 10% gel. The porins were resolved onto this gel under reduced and non-reduced conditions (Fig. 2). Unheated Trition X-lOO treated Iysozyme-EDTA cell envelope showed many p ...
... (Fig. 1 b). The extent of purity of the porin preparation at different purification steps was cross-checked with SDS PAGE using 10% gel. The porins were resolved onto this gel under reduced and non-reduced conditions (Fig. 2). Unheated Trition X-lOO treated Iysozyme-EDTA cell envelope showed many p ...
Exacerbation of autoantibody-mediated
... in mice with other genetic backgrounds, such as BALB/C, there were no consequences (not shown). In contrast, a sharp drop in platelet counts was observed in mice that received both the virus and the antiplatelet antibody (P ⫽ .0286 for mice treated with antiplatelet antibody and LDV versus antibody ...
... in mice with other genetic backgrounds, such as BALB/C, there were no consequences (not shown). In contrast, a sharp drop in platelet counts was observed in mice that received both the virus and the antiplatelet antibody (P ⫽ .0286 for mice treated with antiplatelet antibody and LDV versus antibody ...
Renal Pathology- Transplantation
... decade, it has become more and more clear that some cases of AMR with DSAs which are otherwise similar, do not have detectable C4d in biopsy sample. These C4d negative cases showed peritubular capillaritis and/or increased endothelial activation. • Gradually it became clear that both C4d staining an ...
... decade, it has become more and more clear that some cases of AMR with DSAs which are otherwise similar, do not have detectable C4d in biopsy sample. These C4d negative cases showed peritubular capillaritis and/or increased endothelial activation. • Gradually it became clear that both C4d staining an ...
Agglutination Reactions
... with a given bacterium in tubes. 2. Addition of bacteria to these tubes with constant concentration (same amount and concentration for all tubes). 3. If the person was infected with these bacteria, a visible agglutination will form in the tube of equivalent concentration of serum Abs. This tube is t ...
... with a given bacterium in tubes. 2. Addition of bacteria to these tubes with constant concentration (same amount and concentration for all tubes). 3. If the person was infected with these bacteria, a visible agglutination will form in the tube of equivalent concentration of serum Abs. This tube is t ...
Preparation of polyclonal antibody against porcine - Funpec-RP
... Mammalian defensins are classified as α, β, and θ defensins based on the connectivity of three disulfide bridges (Lehrer and Ganz, 2002; Selsted and Ouellette, 2005). Evolutionarily, b-defensins are the oldest of the defensins (Sang et al. 2006). In pigs, only β-defensins have been found, which were ...
... Mammalian defensins are classified as α, β, and θ defensins based on the connectivity of three disulfide bridges (Lehrer and Ganz, 2002; Selsted and Ouellette, 2005). Evolutionarily, b-defensins are the oldest of the defensins (Sang et al. 2006). In pigs, only β-defensins have been found, which were ...
Ronald van Ree
... B-cells and antibodies have not received the attention they deserve compared to T-cells. They do however produce the antibodies that cause the disease!! Reasons to study IgE/IgG/IgA antibody responses: • They are a good read-out of the nature of the immune response • It needs to be established when ...
... B-cells and antibodies have not received the attention they deserve compared to T-cells. They do however produce the antibodies that cause the disease!! Reasons to study IgE/IgG/IgA antibody responses: • They are a good read-out of the nature of the immune response • It needs to be established when ...
1986 Hohenboken et al.: Inheritance of active and passive humoral
... with humoral immunity. Neutrophils and macrophages are important phagocytic cell types in ruminants. Cell Mediated Immunity Some pathogenic organisms are resistant to destruction by phagocytosis, and for these, cell mediated immunity is an important ...
... with humoral immunity. Neutrophils and macrophages are important phagocytic cell types in ruminants. Cell Mediated Immunity Some pathogenic organisms are resistant to destruction by phagocytosis, and for these, cell mediated immunity is an important ...
The role of HIV-specific antibody-dependent cellular cytotoxicity in
... to the direct antiviral effects of Tetherin by modulating cell surface expression of virus protein, the immunomodulatory effects are linked to the endocytosis of the molecule. Using the model lentivirus Friend Retrovirus, they demonstrated that C57BL/6 mice encoding endocytosis-competent Tetherin ex ...
... to the direct antiviral effects of Tetherin by modulating cell surface expression of virus protein, the immunomodulatory effects are linked to the endocytosis of the molecule. Using the model lentivirus Friend Retrovirus, they demonstrated that C57BL/6 mice encoding endocytosis-competent Tetherin ex ...
University of Groningen Dengue and Chikungunya virus van
... to stabilize the E protein while transiting acid compartments during virus egress. It stays associated with M at low pH, and is released after secretion of the particle in the pH-neutral extracellular space [30-33]. DENV-infected cells have been described to secrete virions with varying maturation d ...
... to stabilize the E protein while transiting acid compartments during virus egress. It stays associated with M at low pH, and is released after secretion of the particle in the pH-neutral extracellular space [30-33]. DENV-infected cells have been described to secrete virions with varying maturation d ...
Autobio`s complete product list
... Gonococcus Kit for the screening of Gonococcus in human initial stream of urine or secretion Chlamydia trachomatis Kit for the screening of Chlamydia trachomatis in human secretion Mycoplasma (UU) Kit for the screening of UU in human midstream urine or secretion CE-marked Mycoplasma (MH) Kit for the ...
... Gonococcus Kit for the screening of Gonococcus in human initial stream of urine or secretion Chlamydia trachomatis Kit for the screening of Chlamydia trachomatis in human secretion Mycoplasma (UU) Kit for the screening of UU in human midstream urine or secretion CE-marked Mycoplasma (MH) Kit for the ...
Pathogenic implications for autoantibodies against C-reactive protein and other acute phase proteins
... host-defense functions. Native CRP plays several important roles by calcium-dependent binding to specific ligands, such as PC in oxidized phospholipids on damaged cell membranes [6] or LDL [51], fibronectin [52, 53] and protein A [54]. The ability to bind nuclear structures at physiological ionic st ...
... host-defense functions. Native CRP plays several important roles by calcium-dependent binding to specific ligands, such as PC in oxidized phospholipids on damaged cell membranes [6] or LDL [51], fibronectin [52, 53] and protein A [54]. The ability to bind nuclear structures at physiological ionic st ...
Arthritis an autoimmune disorder: Demonstration of In
... For evaluation of anti arthritic drugs inflammation and T-cell and B-cell mediated response by including collagen type-II (bovine collagen). This foreign collagen produces auto immune response. Type II collagen as an auto antigen in human RA and collagen-induced arthrit is (CIA), Most autoimmune dis ...
... For evaluation of anti arthritic drugs inflammation and T-cell and B-cell mediated response by including collagen type-II (bovine collagen). This foreign collagen produces auto immune response. Type II collagen as an auto antigen in human RA and collagen-induced arthrit is (CIA), Most autoimmune dis ...
Anti-nuclear antibody
Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). In some individuals, antibodies to human antigens are produced.There are many subtypes of ANAs such as anti-Ro antibodies, anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to nuclear pore complexes, anti-centromere antibodies and anti-sp100 antibodies. Each of these antibody subtypes binds to different proteins or protein complexes within the nucleus. They are found in many disorders including autoimmunity, cancer and infection, with different prevalences of antibodies depending on the condition. This allows the use of ANAs in the diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren's syndrome, scleroderma, mixed connective tissue disease, polymyositis, dermatomyositis, autoimmune hepatitis and drug induced lupus.The ANA test detects the autoantibodies present in an individual's blood serum. The common tests used for detecting and quantifying ANAs are indirect immunofluorescence and enzyme-linked immunosorbent assay (ELISA). In immunofluorescence, the level of autoantibodies is reported as a titre. This is the highest dilution of the serum at which autoantibodies are still detectable. Positive autoantibody titres at a dilution equal to or greater than 1:160 are usually considered as clinically significant. Positive titres of less than 1:160 are present in up to 20% of the healthy population, especially the elderly. Although positive titres of 1:160 or higher are strongly associated with autoimmune disorders, they are also found in 5% of healthy individuals. Autoantibody screening is useful in the diagnosis of autoimmune disorders and monitoring levels helps to predict the progression of disease. A positive ANA test is seldom useful if other clinical or laboratory data supporting a diagnosis are not present.