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... other biological molecules have been identified that contain metals that are important, if not essential, for structure and/or function. Metals can perform functions that cannot otherwise be achieved, such as electrolyte balance (important for processes that include the firing of neurons), as well a ...
... other biological molecules have been identified that contain metals that are important, if not essential, for structure and/or function. Metals can perform functions that cannot otherwise be achieved, such as electrolyte balance (important for processes that include the firing of neurons), as well a ...
Slides
... A Therapeutic Target Critical to Improving Outcomes William J. Gradishar, MD Professor of Medicine Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago, IL ...
... A Therapeutic Target Critical to Improving Outcomes William J. Gradishar, MD Professor of Medicine Robert H. Lurie Comprehensive Cancer Center Northwestern University Feinberg School of Medicine Chicago, IL ...
Freeman 1e: How we got there
... • Sterilization is the killing of all organisms, including viruses. Heat is the most widely used method of sterilization. Often, however, we cannot attain sterility, but we can still control microorganisms effectively by limiting their growth, the process of inhibition. • Death from heating is an ex ...
... • Sterilization is the killing of all organisms, including viruses. Heat is the most widely used method of sterilization. Often, however, we cannot attain sterility, but we can still control microorganisms effectively by limiting their growth, the process of inhibition. • Death from heating is an ex ...
PolyMedix Presents Antibiotic Data at the 50th Interscience
... “Antimicrobial Activities of Structurally Diverse Host Defense Protein Mimics” R. Scott, CE Budu, A. Khanna, D. Clements In this study, compounds from three structurally diverse series of host defense protein mimics were identified that were highly active against recent clinical isolates of Gram-pos ...
... “Antimicrobial Activities of Structurally Diverse Host Defense Protein Mimics” R. Scott, CE Budu, A. Khanna, D. Clements In this study, compounds from three structurally diverse series of host defense protein mimics were identified that were highly active against recent clinical isolates of Gram-pos ...
Revisão - Química Nova
... be used as valuable models for the design of new analogues with optimized biological properties. The latest review published by Kinghorn and collaborators 14 emphasized the importance of natural products in drug discovery. Of the 210 small-molecule therapeutic agents included in the recent World Hea ...
... be used as valuable models for the design of new analogues with optimized biological properties. The latest review published by Kinghorn and collaborators 14 emphasized the importance of natural products in drug discovery. Of the 210 small-molecule therapeutic agents included in the recent World Hea ...
Final Presentation
... The combinations of anti-HIV drugs are used to treat AIDS patients because of their high potency in viral suppression and a delay in drug resistance. Indinavir is our “CHOSEN” drug. ...
... The combinations of anti-HIV drugs are used to treat AIDS patients because of their high potency in viral suppression and a delay in drug resistance. Indinavir is our “CHOSEN” drug. ...
- ISpatula
... by using letters A,B,C… and numbers as subscripts as A13 ,C19,, so in different isolated new compounds in order to make it less complicated in name instead of using the name of the fungus( Gibberell fujikurio )to name the secondary metabolites 4- It is tetracylic type of cyclic diterpenoid from acyc ...
... by using letters A,B,C… and numbers as subscripts as A13 ,C19,, so in different isolated new compounds in order to make it less complicated in name instead of using the name of the fungus( Gibberell fujikurio )to name the secondary metabolites 4- It is tetracylic type of cyclic diterpenoid from acyc ...
Pharmacokinetics
... drug B may both bind to plasma proteins; one may have a higher affinity than the other Altered excretion: some drugs may act directly on the kidney and decrease the excretion of other drugs ...
... drug B may both bind to plasma proteins; one may have a higher affinity than the other Altered excretion: some drugs may act directly on the kidney and decrease the excretion of other drugs ...
interactions between antihypertensive agents and other drugs
... acting drugs may lead to additive or even over-additive effects (potentiation). A well-known example is the combination of i.v. verapamil and a ß-blocker, which may cause additive impairment of cardiac A-V conduction and the risk of A-V block. Another possibility is the inhibition of the therapeutic ...
... acting drugs may lead to additive or even over-additive effects (potentiation). A well-known example is the combination of i.v. verapamil and a ß-blocker, which may cause additive impairment of cardiac A-V conduction and the risk of A-V block. Another possibility is the inhibition of the therapeutic ...
Cancer Treatment Drugs
... alkaloids, derived from the periwinkle plant, were developed over forty years ago. They bind to ᵝ-tubulin, one of the proteins making up microtubules, and prevent tubulin / microtubule polymer assembly. The prototype vinca alkaloid, vincristine, is now used almost exclusively in the treatment of lym ...
... alkaloids, derived from the periwinkle plant, were developed over forty years ago. They bind to ᵝ-tubulin, one of the proteins making up microtubules, and prevent tubulin / microtubule polymer assembly. The prototype vinca alkaloid, vincristine, is now used almost exclusively in the treatment of lym ...
Antimicrobial drugs in Respiratory Infection
... Spectrum: slightly less active than ciprofloxacin and ofloxacin against gram-negative bacteria but have greater activity against gram-positive cocci, including S pneumoniae and some strains of enterococci and methicillin-resistant Staphylococcus aureus (MRSA). The broadest-spectrum fluoroquinolones ...
... Spectrum: slightly less active than ciprofloxacin and ofloxacin against gram-negative bacteria but have greater activity against gram-positive cocci, including S pneumoniae and some strains of enterococci and methicillin-resistant Staphylococcus aureus (MRSA). The broadest-spectrum fluoroquinolones ...
GENERAL FARMACOLOGY
... catalyze the reduction of azo (-N=N-) and nitro (-NO2) compounds e.g. prontosil converted to sulfonamide. c) Hydrolysis: Drug metabolism by hydrolysis is restricted to esters and amines (by esterases and amidases) are found in plasma and other tissues like liver. It means splitting of drug molecule ...
... catalyze the reduction of azo (-N=N-) and nitro (-NO2) compounds e.g. prontosil converted to sulfonamide. c) Hydrolysis: Drug metabolism by hydrolysis is restricted to esters and amines (by esterases and amidases) are found in plasma and other tissues like liver. It means splitting of drug molecule ...
汤慧芳_大环内酯类&林可霉素
... • Quinupristin/dalfopristin is injected intravenously (the drug is incompatible with a saline medium). • The combination drug penetrates macrophages and polymorpho nucleocytes, a property that is important, because VRE are intracellular. Levels in the CSF are low. Both compounds undergo ...
... • Quinupristin/dalfopristin is injected intravenously (the drug is incompatible with a saline medium). • The combination drug penetrates macrophages and polymorpho nucleocytes, a property that is important, because VRE are intracellular. Levels in the CSF are low. Both compounds undergo ...
Biochemistry I, Spring Term 2002 - Second Exam:
... d) cannot be applied when inhibitors are present. 7. The specific activity of an enzyme a) the rate of product production over time. b) the total mass of the protein in a purification. c) should increase during a purification. d) is not a useful criteria for monitoring purity. 8. In gel filtration c ...
... d) cannot be applied when inhibitors are present. 7. The specific activity of an enzyme a) the rate of product production over time. b) the total mass of the protein in a purification. c) should increase during a purification. d) is not a useful criteria for monitoring purity. 8. In gel filtration c ...
Here - Molecular Graphics and Modelling Society
... Division of Medicinal Chemistry and Structural Biology, School of Pharmacy, University of Nottingham, Nottingham, UK. *Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, UK The major urinary protein (MUP) is a member of the lipocalin family that ...
... Division of Medicinal Chemistry and Structural Biology, School of Pharmacy, University of Nottingham, Nottingham, UK. *Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, UK The major urinary protein (MUP) is a member of the lipocalin family that ...
Fungal Infections
... During the 1990s use of ketoconazole diminished because of the release of the triazoles-fluconazole and itraconazole (2002voriconazole). ...
... During the 1990s use of ketoconazole diminished because of the release of the triazoles-fluconazole and itraconazole (2002voriconazole). ...
Some Principles in the Chemotherapy of Bacterial Infections—I
... Modes of Action of Chemotherapeutic Agents In general, bactericidal drugs act in one of three ways. They either affect the bacterial cell wall, so interfering with the cell's osmotic defences and causing it to absorb water and burst; or they affect the cell membrane and so probably cause loss of vit ...
... Modes of Action of Chemotherapeutic Agents In general, bactericidal drugs act in one of three ways. They either affect the bacterial cell wall, so interfering with the cell's osmotic defences and causing it to absorb water and burst; or they affect the cell membrane and so probably cause loss of vit ...
Antimycobacterial Drugs
... Mycobacteria are intrinsically resistant to most antibiotics. Because they grow slowly compared with other bacteria, antibiotics that are most active against growing cells are relatively ineffective. Mycobacterial cells can also be dormant and thus completely resistant to many drugs or killed only v ...
... Mycobacteria are intrinsically resistant to most antibiotics. Because they grow slowly compared with other bacteria, antibiotics that are most active against growing cells are relatively ineffective. Mycobacterial cells can also be dormant and thus completely resistant to many drugs or killed only v ...
Combining Kinetic Ligand Binding and 3D Tumor Invasion
... cell migration2. Traditionally, the discovery of novel agents has been guided by the affinity of the ligand for the receptor under equilibrium conditions, largely ignoring the kinetic aspects of the ligandreceptor interaction. However, awareness of the importance of binding kinetics has started to i ...
... cell migration2. Traditionally, the discovery of novel agents has been guided by the affinity of the ligand for the receptor under equilibrium conditions, largely ignoring the kinetic aspects of the ligandreceptor interaction. However, awareness of the importance of binding kinetics has started to i ...
Lecture 05 - binding quant - Cal State LA
... (theoretically, KD = EC50), it does not account for agonists that do not produce the maximum effect. Modified occupancy theory: modified to separate the binding affinity from the intrinsic activity () of the compound. That is, a compound can bind tightly, but cause a little or no effect. ...
... (theoretically, KD = EC50), it does not account for agonists that do not produce the maximum effect. Modified occupancy theory: modified to separate the binding affinity from the intrinsic activity () of the compound. That is, a compound can bind tightly, but cause a little or no effect. ...
A nematode kinesin required for cleavage furrow advancement
... rigid along the pole-to-pole axis and rocks back and forth as a unit during spindle elongation. In CeMKLP1(RNAi) embryos, rocking and elongation occurred, but the spindle often flexed at the equator. This effect is best seen in real time but can also be seen in Figure 1 (compare f with b). The incre ...
... rigid along the pole-to-pole axis and rocks back and forth as a unit during spindle elongation. In CeMKLP1(RNAi) embryos, rocking and elongation occurred, but the spindle often flexed at the equator. This effect is best seen in real time but can also be seen in Figure 1 (compare f with b). The incre ...
Document
... • Sumatriptan and rizatriptan (1992 and 1998, respectively) for migraines. However, it is difficult to estimate from case studies the average or aggregate effect of new drugs on ability to work ...
... • Sumatriptan and rizatriptan (1992 and 1998, respectively) for migraines. However, it is difficult to estimate from case studies the average or aggregate effect of new drugs on ability to work ...
Pharmacokinetics
... drug B may both bind to plasma proteins; one may have a higher affinity than the other Altered excretion: some drugs may act directly on the kidney and decrease the excretion of other drugs ...
... drug B may both bind to plasma proteins; one may have a higher affinity than the other Altered excretion: some drugs may act directly on the kidney and decrease the excretion of other drugs ...
3. Antiproliferative and antimetabolic drugs
... • Binding to the εchain of CD3, a monomorphic component of the T-cell receptor complex involved in antigen recognition, cell signaling, and proliferation ...
... • Binding to the εchain of CD3, a monomorphic component of the T-cell receptor complex involved in antigen recognition, cell signaling, and proliferation ...