Antimicrobial Medications
... of chemical successfully used as antimicrobial Discovered by Paul Erlich in for treatment of syphilis Prontosil dye effective against streptococcal infections No effect on Streptococcus growing in vitro Enzymes in blood split prontosil into small sulfonamide molecules Sulfonamide was the f ...
... of chemical successfully used as antimicrobial Discovered by Paul Erlich in for treatment of syphilis Prontosil dye effective against streptococcal infections No effect on Streptococcus growing in vitro Enzymes in blood split prontosil into small sulfonamide molecules Sulfonamide was the f ...
1
... acute lymphoblastic leukemia who require L-asparaginase in their treatment regimen, but are hypersensitive to the native forms of L-asparaginase. PEG modified liposomes containing doxorubicin are indicated for patients with AIDS-related advanced Kaposi’s sarcoma [18]. Macromolecular therapeutics has ...
... acute lymphoblastic leukemia who require L-asparaginase in their treatment regimen, but are hypersensitive to the native forms of L-asparaginase. PEG modified liposomes containing doxorubicin are indicated for patients with AIDS-related advanced Kaposi’s sarcoma [18]. Macromolecular therapeutics has ...
Immunology Stack - University of Arizona
... (azoles). Other unique compounds are also targeted but these are the big hitters. ...
... (azoles). Other unique compounds are also targeted but these are the big hitters. ...
Fragment approaches in structure
... 2004; Hajduk & Greer, 2007), and a number of drugs entering clinical trials have been discovered using these techniques (Card et al., 2005; Gill et al., 2005; Petros et al., 2006). The major new advance is to begin with much smaller (molecular weight Mr < 250) compounds. This has significant advanta ...
... 2004; Hajduk & Greer, 2007), and a number of drugs entering clinical trials have been discovered using these techniques (Card et al., 2005; Gill et al., 2005; Petros et al., 2006). The major new advance is to begin with much smaller (molecular weight Mr < 250) compounds. This has significant advanta ...
313-1A (1)
... It is an orally active non-peptidic hypotensive agent acting through its high affinity for Angiotensin II receptor sites of the smooth muscles, kidney and adrenal glands. It does not inhibit ACE, therefore avoiding the serious side effects of ACE inhibitors. ...
... It is an orally active non-peptidic hypotensive agent acting through its high affinity for Angiotensin II receptor sites of the smooth muscles, kidney and adrenal glands. It does not inhibit ACE, therefore avoiding the serious side effects of ACE inhibitors. ...
Mechanism of Action
... expressed in 30-94% of colon carcinomas • bcl-2 expression is a negative prognostic indicator in Dukes C primary CRC1 • bcl-2 expression confers a multidrug resistant phenotype to many cell lines including resistance to camptothecins2-4 ...
... expressed in 30-94% of colon carcinomas • bcl-2 expression is a negative prognostic indicator in Dukes C primary CRC1 • bcl-2 expression confers a multidrug resistant phenotype to many cell lines including resistance to camptothecins2-4 ...
A REVIEW ON ANTHELMINTIC DRUGS AND THEIR FUTURE SCOPE Review Article PIYUSH YADAV*, RUPALI SINGH
... In other words, anthelmintics are drugs that are used for the treatment of infections caused by the worms, flukes, nematodes, round worms, tapeworms etc. Anthelmintics are the tropical and veterinary types of medicines which are of huge importance. Parasitic wor ...
... In other words, anthelmintics are drugs that are used for the treatment of infections caused by the worms, flukes, nematodes, round worms, tapeworms etc. Anthelmintics are the tropical and veterinary types of medicines which are of huge importance. Parasitic wor ...
evaluation of the interaction of loratadine and desloratadine with p
... maximum equivalent to only 19% total inhibition (Fig. 1B). Moreover, the IC50 of ⬃43 M was about 4-fold greater than that for L. For DL, the IC50 was ⬃880 times the maximum observed plasma concentration (Cmax) following the recommended dose (5 mg; Banfield et al., 2001a,b). The results described he ...
... maximum equivalent to only 19% total inhibition (Fig. 1B). Moreover, the IC50 of ⬃43 M was about 4-fold greater than that for L. For DL, the IC50 was ⬃880 times the maximum observed plasma concentration (Cmax) following the recommended dose (5 mg; Banfield et al., 2001a,b). The results described he ...
CNS STIMULANTS
... of compounds more resistant to metabolism and better able to cross the blood-brain barrier. These effects increase the proportion of central to peripheral ...
... of compounds more resistant to metabolism and better able to cross the blood-brain barrier. These effects increase the proportion of central to peripheral ...
the chembiobank and eu-openscreen initiatives in chemical
... have boosted an urgent need for new antibacterial agents with novel modes of action.1 In this sense, FtsZ (Figure 1) “a widely conserved tubulin-like GTPase” has recently been proposed as an attractive target for antibacterial drug discovery due to its essential role in bacterial cell division.2 Rec ...
... have boosted an urgent need for new antibacterial agents with novel modes of action.1 In this sense, FtsZ (Figure 1) “a widely conserved tubulin-like GTPase” has recently been proposed as an attractive target for antibacterial drug discovery due to its essential role in bacterial cell division.2 Rec ...
Metabolism of drugs
... NADPH and Oxygen More than 100 cytochrome P-450 isoenzymes are identified and grouped into more than 20 families – 1, 2 and 3 … Sub-families are identified as A, B, and C etc. In human - only 3 isoenzyme families important – CYP1, CYP2 and CYP3 CYP 3A4/5 carry out biotransformation of largest number ...
... NADPH and Oxygen More than 100 cytochrome P-450 isoenzymes are identified and grouped into more than 20 families – 1, 2 and 3 … Sub-families are identified as A, B, and C etc. In human - only 3 isoenzyme families important – CYP1, CYP2 and CYP3 CYP 3A4/5 carry out biotransformation of largest number ...
Isoquinoline Alkaloids
... in color. To obtain the latex by incision of the ripening capsule , just changing in color from blue-green to yellow. The latex tubes opine one into another. The incision made at night , the milky exudates oozes out, but rapidly turns brown and coagulates , collected the next morning by scrapping fr ...
... in color. To obtain the latex by incision of the ripening capsule , just changing in color from blue-green to yellow. The latex tubes opine one into another. The incision made at night , the milky exudates oozes out, but rapidly turns brown and coagulates , collected the next morning by scrapping fr ...
benzoyl benzoic acid based 1,3,4-oxadiazole analogues
... activity in carrageenan-induced rat paw edema and analgesic activity by tail immersion method. In synthesized compounds, the free carboxylic group, which is responsible for gastric side effects, was derivatized by heterocyclic 1,3,4-oxadiazole bioactive core, which showed good interaction with COX-2 ...
... activity in carrageenan-induced rat paw edema and analgesic activity by tail immersion method. In synthesized compounds, the free carboxylic group, which is responsible for gastric side effects, was derivatized by heterocyclic 1,3,4-oxadiazole bioactive core, which showed good interaction with COX-2 ...
Antifungal Agents Overview - Canadian Antimicrobial Resistance
... the synthesis of beta1,3-D-glucan. This compound is a major component of the fungal cell wall and is synthesized by the enzyme glucan synthase. The echinocandins bind to a subunit of the gene that produces glucan synthase. The echinocandins are fungicidal agents. Caspofungin was the first of the ech ...
... the synthesis of beta1,3-D-glucan. This compound is a major component of the fungal cell wall and is synthesized by the enzyme glucan synthase. The echinocandins bind to a subunit of the gene that produces glucan synthase. The echinocandins are fungicidal agents. Caspofungin was the first of the ech ...
4 Warm Up: Different Phases 2-18-15 Q1. What is the end result of
... the two identical daughter cells that are formed; results in growth. Meiosis: Cell division in which one diploid cell produces four hapliod cells calle ed sex cells or gamates, which have half the # of chromosomes as a parent cell. DNA: Deoxyribonucleic acid; master copy of an organism's information ...
... the two identical daughter cells that are formed; results in growth. Meiosis: Cell division in which one diploid cell produces four hapliod cells calle ed sex cells or gamates, which have half the # of chromosomes as a parent cell. DNA: Deoxyribonucleic acid; master copy of an organism's information ...
EGFR TYROSINE KINASE TARGETED COMPOUNDS: IN VITRO
... aimed at further exploration of the SAR of this novel template, led to the discovery of highly selective compounds that target EGFR. Benzothiazoles act via competing with ATP for binding at the catalytic domain of EGFR-TK (Noolvi et al., 2012). The characteristic features of ATP binding site are; ad ...
... aimed at further exploration of the SAR of this novel template, led to the discovery of highly selective compounds that target EGFR. Benzothiazoles act via competing with ATP for binding at the catalytic domain of EGFR-TK (Noolvi et al., 2012). The characteristic features of ATP binding site are; ad ...
F1-Single Domain Antibody Service.ai
... (see below). The antigen-binding site of these unusual heavy chain antibodies is formed only by a single heavy chain variable domain, designated as single domain antibodies (sdAbs). sdAbs combine the advantages of conventional antibodies with important features of smaller molecule sdAb drugs. The un ...
... (see below). The antigen-binding site of these unusual heavy chain antibodies is formed only by a single heavy chain variable domain, designated as single domain antibodies (sdAbs). sdAbs combine the advantages of conventional antibodies with important features of smaller molecule sdAb drugs. The un ...
Zentel - FiloBase
... Generic Albenza (Albendazole) - 400mg 30 pills for $52.65 Albenza (Albendazole) is used to treat infections caused by worms. Albendazole works by keeping the worm from absorbing sugar (glucose), so that the worm loses energy and dies. ...
... Generic Albenza (Albendazole) - 400mg 30 pills for $52.65 Albenza (Albendazole) is used to treat infections caused by worms. Albendazole works by keeping the worm from absorbing sugar (glucose), so that the worm loses energy and dies. ...
Introduction to Medicinal Chemistry
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
Interaction of quinidine, disopyramide and
... nidine-melanin complexes (Table 1), similar stability and prevalence of weak binding sites in both types of complex are observed. The total number of binding sites (n1 þ n2) is lower by about 40% in the case of quinidine, compared with the chloroquine-melanin complex. However, the disopyramide-melan ...
... nidine-melanin complexes (Table 1), similar stability and prevalence of weak binding sites in both types of complex are observed. The total number of binding sites (n1 þ n2) is lower by about 40% in the case of quinidine, compared with the chloroquine-melanin complex. However, the disopyramide-melan ...
Physicochemical properties of drug action
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
... structural requirements for the drug. Thus, affinity represents kinetic constants that relate to the drug and the receptor. The drug elicits a pharmacological response after its interaction with the receptor. A given drug may act on more than one receptor differing both in function and in binding ch ...
2016 department of medicine research day
... analogues were administered by oral gavage (P<0.001). These studies suggest that selected analogues of metformin have potent anticancer activity in preclinical work with TNBC and pancreatic cancer cells. This comprehensive structure-activity research on the antitumor activity of metformin has not b ...
... analogues were administered by oral gavage (P<0.001). These studies suggest that selected analogues of metformin have potent anticancer activity in preclinical work with TNBC and pancreatic cancer cells. This comprehensive structure-activity research on the antitumor activity of metformin has not b ...
AntiretroviralAgents..
... • First class of anti-HIV agents developed • Active vs. HIV-1 and HIV-2 • Need to undergo intracellular anabolic phosphorylation to triphosphate form of the drug or metabolic intermediate to be active vs. HIV • Mechanism - NRTI-TP’s inhibit the HIV RT by competing with normal nucleoside triphosphate ...
... • First class of anti-HIV agents developed • Active vs. HIV-1 and HIV-2 • Need to undergo intracellular anabolic phosphorylation to triphosphate form of the drug or metabolic intermediate to be active vs. HIV • Mechanism - NRTI-TP’s inhibit the HIV RT by competing with normal nucleoside triphosphate ...