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Ligand binding interaction studies
... Ligand binding interaction studies In the search for new chemical entities (NCE) that are able to interact with a selected disease relevant target, biologists and chemists spend significant efforts in developing and applying very advanced screening assays. These target-based assays are used in scree ...
... Ligand binding interaction studies In the search for new chemical entities (NCE) that are able to interact with a selected disease relevant target, biologists and chemists spend significant efforts in developing and applying very advanced screening assays. These target-based assays are used in scree ...
An investigation into mechanisms of action of colchicine, zinc
... blocking the inflammatory response, which prevents uric acid crystal formation in gout (Ly et al 2007). Secondly it is thought to act by inhibiting cellular pathways in the inflammatory response to stop the secretion of cytokines (involved in promotion of cell signaling) and chemokines (involved in ...
... blocking the inflammatory response, which prevents uric acid crystal formation in gout (Ly et al 2007). Secondly it is thought to act by inhibiting cellular pathways in the inflammatory response to stop the secretion of cytokines (involved in promotion of cell signaling) and chemokines (involved in ...
CARDIAC TOXICITY OF CANCER THERAPEUTIC AGENTS
... • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
... • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
Department of Pharmacology
... Student’s attendance during the seminars is mandatory – only 1 unjustified absence during the whole course will be accepted. The absence during the seminar must be justified by a duly authorised document (doctor’s note, University’s letter, letter from other authorities, etc.) Students with un ...
... Student’s attendance during the seminars is mandatory – only 1 unjustified absence during the whole course will be accepted. The absence during the seminar must be justified by a duly authorised document (doctor’s note, University’s letter, letter from other authorities, etc.) Students with un ...
CARDIAC TOXICITY OF CANCER THERAPEUTIC AGENTS
... • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
... • Capecitabine is metabolized to fluorouracil, preferentially in tumor cells and is less toxic. ...
70-ORGANIC PHARMACEUTICAL CHEMISTRY III
... Aims are the critical knowledge and thorough examination of synthesis, structure, correlation of structure with drug action, fate of the drugs in the organism, sites of loss, therefore duration of drug action. Aim is also to familiarise the students with relations governing molecules acting on CNS a ...
... Aims are the critical knowledge and thorough examination of synthesis, structure, correlation of structure with drug action, fate of the drugs in the organism, sites of loss, therefore duration of drug action. Aim is also to familiarise the students with relations governing molecules acting on CNS a ...
Antibiotic Choices - CriticalCareMedicine / FrontPage
... Bewrare serious side effects: hepatic necrosis, GI upset, arrhythmias, rash *P450 inhibitor – multiple drug interactions Used only for mild-moderate CAP due to multidrug resistant S. pneumoniae ...
... Bewrare serious side effects: hepatic necrosis, GI upset, arrhythmias, rash *P450 inhibitor – multiple drug interactions Used only for mild-moderate CAP due to multidrug resistant S. pneumoniae ...
Pharmacology Definitions
... response from the cell. The antagonist shows no selectivity for the activated state of the receptor and hence the receptor is not activated. Antagonists show affinity for the receptor binding site, having a complementary structure, however have zero efficacy and thus no response is ever achieved by ...
... response from the cell. The antagonist shows no selectivity for the activated state of the receptor and hence the receptor is not activated. Antagonists show affinity for the receptor binding site, having a complementary structure, however have zero efficacy and thus no response is ever achieved by ...
log P
... How to see whether the relationship is meaningful? 1. by observing ‘goodness of fit’ Regression or correlation coefficient (r) tells how well the equation explains the variance in activity in terms of physicochemical parameters (usually quoted as r2) If r=1, a perfect fit (observed=calculated activi ...
... How to see whether the relationship is meaningful? 1. by observing ‘goodness of fit’ Regression or correlation coefficient (r) tells how well the equation explains the variance in activity in terms of physicochemical parameters (usually quoted as r2) If r=1, a perfect fit (observed=calculated activi ...
IN-SILICO PROTEIN LIGAND INTERACTION STUDY OF TYPICAL ANTIPSYCHOTIC DRUGS
... prolactin elevation [5], respectively. Studies have demonstrated that the atypical antipsychotics generally have a much lower affinity for D2-receptors than the older, conventional antipsychotic agents [68]. The antipsychotic effects of neuroleptic drugs are mediated by dopamine DA-2 receptors, and ...
... prolactin elevation [5], respectively. Studies have demonstrated that the atypical antipsychotics generally have a much lower affinity for D2-receptors than the older, conventional antipsychotic agents [68]. The antipsychotic effects of neuroleptic drugs are mediated by dopamine DA-2 receptors, and ...
DESMODIUM TRIANGULARE Research Article
... Administration of methanolic extract (50mg/kg body weight and 250mg/kg body weight) inhibited DLA induced solid tumor in a dose defendant manner when compared to control group The tumor volume in untreated control mice was 3.24 ± 01.11 on day 30 and this was reduced to 1.64 ± 0.72 with( 49.38%) redu ...
... Administration of methanolic extract (50mg/kg body weight and 250mg/kg body weight) inhibited DLA induced solid tumor in a dose defendant manner when compared to control group The tumor volume in untreated control mice was 3.24 ± 01.11 on day 30 and this was reduced to 1.64 ± 0.72 with( 49.38%) redu ...
Hydrogen Bonding: The Last Mystery in Drug Design?
... methyl groups point ‘downwards’ [15]. Superpositions of 3-keto-17-hydroxysteroids and 3-hydroxy-17-ketosteroids, using a modified version of the computer program SEAL [18][19], indicate that these steroids may bind to the corticosteroid-binding globulin in a different mode. Whereas all 3-keto-17hydr ...
... methyl groups point ‘downwards’ [15]. Superpositions of 3-keto-17-hydroxysteroids and 3-hydroxy-17-ketosteroids, using a modified version of the computer program SEAL [18][19], indicate that these steroids may bind to the corticosteroid-binding globulin in a different mode. Whereas all 3-keto-17hydr ...
Powerpoint
... • Catechol-O-methyl transferase (COMT) is SAMdependent methyltransferase • Entacapone and tolcapone are used as COMT inhibitors in Parkinson’s disease treatment • Hypothesis: – Further investigation of NAD-binding proteins may uncover a potential new drug target for entacapone and tolcapone Repositi ...
... • Catechol-O-methyl transferase (COMT) is SAMdependent methyltransferase • Entacapone and tolcapone are used as COMT inhibitors in Parkinson’s disease treatment • Hypothesis: – Further investigation of NAD-binding proteins may uncover a potential new drug target for entacapone and tolcapone Repositi ...
File
... Tightly bound – released very slowly. these drugs have very long duration of action (not freed to be broken down or excreted) , slowly released into the reactive tissue. ...
... Tightly bound – released very slowly. these drugs have very long duration of action (not freed to be broken down or excreted) , slowly released into the reactive tissue. ...
Protein-Ligand Binding
... “targeted molecules” that work by binding to a specific protein and thus blocking its activity. The statin drugs are a good example: people with higher cholesterol levels are at greater risk for heart attacks, and the statins lower cholesterol levels by binding and blocking a protein involved in the ...
... “targeted molecules” that work by binding to a specific protein and thus blocking its activity. The statin drugs are a good example: people with higher cholesterol levels are at greater risk for heart attacks, and the statins lower cholesterol levels by binding and blocking a protein involved in the ...
2. Complexation and Protein Binding
... emulsions, ointments and suppositories and certain drugs may be due to the formation of organic molecular complexes. The incompatibility may be manifested as a precipitate, flocculate, delayed biological absorption, loss of preservative action, or other undesirable physical, chemical, and pharmacolo ...
... emulsions, ointments and suppositories and certain drugs may be due to the formation of organic molecular complexes. The incompatibility may be manifested as a precipitate, flocculate, delayed biological absorption, loss of preservative action, or other undesirable physical, chemical, and pharmacolo ...
4th Lecture Updated - Home - KSU Faculty Member websites
... Inhibitors of bacterial protein synthesis, Macrolides, contd. Pharmacokinetics, contd.: Clarithromycin is absorbed rapidly from the GIT after oral administration, but 1st-pass metabolism reduces its bioavailability to ~ 50%. It may be given with or without food The extended-release form, typi ...
... Inhibitors of bacterial protein synthesis, Macrolides, contd. Pharmacokinetics, contd.: Clarithromycin is absorbed rapidly from the GIT after oral administration, but 1st-pass metabolism reduces its bioavailability to ~ 50%. It may be given with or without food The extended-release form, typi ...
Chemistry 400 A
... 15. Which functional group was critical in making a birth control pill that could be taken orally? 16. What structural feature distinguishes estrogen from both progesterone and testosterone? 17. Depo-provera is a long lasting progesterone mimic. What functional group is present to achieve this effec ...
... 15. Which functional group was critical in making a birth control pill that could be taken orally? 16. What structural feature distinguishes estrogen from both progesterone and testosterone? 17. Depo-provera is a long lasting progesterone mimic. What functional group is present to achieve this effec ...
General Pharmakokinetics
... Placental barrier. Placental membranes are lipid and allow free passage of lipophilic drug, while restricting hydrophilic drugs. The placental P-gp also serves to limit foetal exposure to maternally administered drugs. However restricted amounts of nonlipid soluble drugs, when present in high conce ...
... Placental barrier. Placental membranes are lipid and allow free passage of lipophilic drug, while restricting hydrophilic drugs. The placental P-gp also serves to limit foetal exposure to maternally administered drugs. However restricted amounts of nonlipid soluble drugs, when present in high conce ...
In-vitro susceptibility of Giardia lamblia to albendazole
... This book outlines the proceedings of the 10th Inter- strength, as it allows attention to be devoted to some of the national Symposium on Medical Virology, held in October, “ less glamorous ” topics in clinical virology. The reviews are authoritatively written and up-to-date, 1990 at Newport Beach, ...
... This book outlines the proceedings of the 10th Inter- strength, as it allows attention to be devoted to some of the national Symposium on Medical Virology, held in October, “ less glamorous ” topics in clinical virology. The reviews are authoritatively written and up-to-date, 1990 at Newport Beach, ...
General Pharmacokinetics
... Placental barrier. Placental membranes are lipid and allow free passage of lipophilic drug, while restricting hydrophilic drugs. The placental P-gp also serves to limit foetal exposure to maternally administered drugs. However restricted amounts of nonlipid soluble drugs, when present in high conce ...
... Placental barrier. Placental membranes are lipid and allow free passage of lipophilic drug, while restricting hydrophilic drugs. The placental P-gp also serves to limit foetal exposure to maternally administered drugs. However restricted amounts of nonlipid soluble drugs, when present in high conce ...
b.pharm v semister - Andhra University
... 8. Fermentative production of penicillin/Neomycin (Demonstration) 9. Fermentative production of glutamic acid (Demonstration); 10. Microbiological assay of penicillin including construction of standard curve; 11. Test for presence of fungi in tap water; 12. Determination of minimum inhibitory concen ...
... 8. Fermentative production of penicillin/Neomycin (Demonstration) 9. Fermentative production of glutamic acid (Demonstration); 10. Microbiological assay of penicillin including construction of standard curve; 11. Test for presence of fungi in tap water; 12. Determination of minimum inhibitory concen ...
COLCHICINE IN THE CHEMOTHERAPY OF CANCER
... using the left common carotid artery. Temporary occlusion of the artery distal to the point of injection prevented the dye passing directly into the cerebral circulation, and no complications were observed in any of their patients. They were able to demonstrate the detailed anatomy of the aorta and ...
... using the left common carotid artery. Temporary occlusion of the artery distal to the point of injection prevented the dye passing directly into the cerebral circulation, and no complications were observed in any of their patients. They were able to demonstrate the detailed anatomy of the aorta and ...
Pharmacophore Approach in Drug Discovery
... • The risk with the SOSA approach is to prepare a molecule already synthesized by the initial inventors and their early competitors. • In fact, in optimizing another therapeutic profile than that of the initial one, the medicinal chemist will rapidly prepare analogues with chemical structures very d ...
... • The risk with the SOSA approach is to prepare a molecule already synthesized by the initial inventors and their early competitors. • In fact, in optimizing another therapeutic profile than that of the initial one, the medicinal chemist will rapidly prepare analogues with chemical structures very d ...