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IN VITRO ANTIMICROBIAL ACTIVITY OF THE SIDDHA DRUGS SEENTHIL SARKARAI... NILAVEMBU KUDINEER AGAINST LEPTOSPIRA
... anticancer, spasmodic, hepatoproductive, nephroprotective, ...
... anticancer, spasmodic, hepatoproductive, nephroprotective, ...
novel paradigms for drug discovery shotgun
... area of small molecule therapeutic discovery. The goal is to create a comprehensive in silico drug discovery pipeline to increase the odds of initial preclinical hits and leads leading to significantly better outcomes downstream in the clinic. The knowledge-based drug discovery pipeline will adopt a ...
... area of small molecule therapeutic discovery. The goal is to create a comprehensive in silico drug discovery pipeline to increase the odds of initial preclinical hits and leads leading to significantly better outcomes downstream in the clinic. The knowledge-based drug discovery pipeline will adopt a ...
Supplementary Material
... Time simulated in the OvTM model replicates the length of patient data sets, even if those times are shorter than drug half-life, as in the case of therapeutic antibodies. Time simulated is also limited by the diffusion rates of drugs. In order to track all contacts between a molecule and any cell w ...
... Time simulated in the OvTM model replicates the length of patient data sets, even if those times are shorter than drug half-life, as in the case of therapeutic antibodies. Time simulated is also limited by the diffusion rates of drugs. In order to track all contacts between a molecule and any cell w ...
Study guide for research assistants
... Note that all 220,000 compounds were initially screened at a single concentration (3 µM) and that hits from this first round of screening were then tested over a range of concentrations. This is a pretty standard approach. The paper says, "A number of other inhibitors from unique structural classes ...
... Note that all 220,000 compounds were initially screened at a single concentration (3 µM) and that hits from this first round of screening were then tested over a range of concentrations. This is a pretty standard approach. The paper says, "A number of other inhibitors from unique structural classes ...
Topic 1 Organic Structures and Interactions of Drugs
... • Strongest of the intermolecular bonds (20-40 kJ mol-1) • Takes place between groups of opposite charge • The strength of the ionic interaction is inversely proportional to the distance between the two charged groups • Stronger interactions occur in hydrophobic environments • The strength of intera ...
... • Strongest of the intermolecular bonds (20-40 kJ mol-1) • Takes place between groups of opposite charge • The strength of the ionic interaction is inversely proportional to the distance between the two charged groups • Stronger interactions occur in hydrophobic environments • The strength of intera ...
Pathways of spindle assembly
... on a bipolar spindle. At the onset of each M phase, the interphase cytoplasmic microtubule complex dissolves and a bipolar spindle is assembled. The mechanism of spindle assembly not only differs between meiotic and mitotic systems [l]; somatic, embryonic and gametic cells all seem to have different ...
... on a bipolar spindle. At the onset of each M phase, the interphase cytoplasmic microtubule complex dissolves and a bipolar spindle is assembled. The mechanism of spindle assembly not only differs between meiotic and mitotic systems [l]; somatic, embryonic and gametic cells all seem to have different ...
Zero order kinetics
... 1. Drugs may bind to plasma protein (P.P.) reversibly. They circulate in a protein – bound and free state and in dynamic equilibrium. 2. The free fraction is pharmacologically active and can diffuse through capillary wall, produce it's systemic effects, metabolized, dialysed or excreted. 3. The prot ...
... 1. Drugs may bind to plasma protein (P.P.) reversibly. They circulate in a protein – bound and free state and in dynamic equilibrium. 2. The free fraction is pharmacologically active and can diffuse through capillary wall, produce it's systemic effects, metabolized, dialysed or excreted. 3. The prot ...
ppt - Department of Public Health Pharmacology & Tox.
... • Imidazoles block the synthesis of ergosterol, the primary cell sterol of fungi thereby altering the cell membrane permeability of yeasts and fungi. • They also impair enzymes required for fatty acid synthesis and also cause toxic concentrations of hydrogen peroxide to develop intracellularly due t ...
... • Imidazoles block the synthesis of ergosterol, the primary cell sterol of fungi thereby altering the cell membrane permeability of yeasts and fungi. • They also impair enzymes required for fatty acid synthesis and also cause toxic concentrations of hydrogen peroxide to develop intracellularly due t ...
Combined effects of bisphosphonate and radiation on fibrosarcoma
... using ZOL in practice, combined treatment with other agents should be encouraged, we suppose. The aim of this study was to determine whether the anti-tumor effect of BPs can be strengthen when it was combined with other antitumor drugs. In this present study, we found that combination of ZOL with et ...
... using ZOL in practice, combined treatment with other agents should be encouraged, we suppose. The aim of this study was to determine whether the anti-tumor effect of BPs can be strengthen when it was combined with other antitumor drugs. In this present study, we found that combination of ZOL with et ...
Mutational Analysis of the Enzymatic Domain of Clostridium difficile
... Figure 3A: actin condensation and cell rounding in the inhibitor assay. ...
... Figure 3A: actin condensation and cell rounding in the inhibitor assay. ...
Insulin - Harper College
... - Cell-cycle nonspecific (CCNS) = act on any phase during the cell cycle - kill the cell during the dividing & resting phase of cell cycle: alkylating drugs, antitumor antibiotics, hormones - Cell-cycle specific (CCS) = act on a specific phase of the cell cycle - effective against rapidly growing Ca ...
... - Cell-cycle nonspecific (CCNS) = act on any phase during the cell cycle - kill the cell during the dividing & resting phase of cell cycle: alkylating drugs, antitumor antibiotics, hormones - Cell-cycle specific (CCS) = act on a specific phase of the cell cycle - effective against rapidly growing Ca ...
Drugs - World of Teaching
... the last month and 20% had used illegal drugs in the last year • 13% of boys reported taking drugs in the last month compared to 11% of girls • Use increased with age. Six percent of 11-year-olds had used drugs in the last year compared to 39% of 15-year-olds ...
... the last month and 20% had used illegal drugs in the last year • 13% of boys reported taking drugs in the last month compared to 11% of girls • Use increased with age. Six percent of 11-year-olds had used drugs in the last year compared to 39% of 15-year-olds ...
Lecture 14 - Harper College
... - Interferes w/ either all phases or a specific phase of the cell cycle (pg. 575, fig. VII-I) Anticancer Drugs - Cell-cycle nonspecific (CCNS) = act on any phase during the cell cycle - kill the cell during the dividing & resting phase of cell cycle: alkylating drugs, antitumor antibiotics, hormones ...
... - Interferes w/ either all phases or a specific phase of the cell cycle (pg. 575, fig. VII-I) Anticancer Drugs - Cell-cycle nonspecific (CCNS) = act on any phase during the cell cycle - kill the cell during the dividing & resting phase of cell cycle: alkylating drugs, antitumor antibiotics, hormones ...
Combinatorial Platinum(IV)-Peptide/Co-drug Conjugates as Multimodal Targeted Anticancer Agents.
... Platinum(II) anticancer drug cisplatin is one of the most important chemotherapeutic drug in clinical use but is limited by its high toxicity and severe sideeffects. Platinum(IV) anticancer prodrugs can overcome these limitations by resisting premature aquation and binding to essential plasma protei ...
... Platinum(II) anticancer drug cisplatin is one of the most important chemotherapeutic drug in clinical use but is limited by its high toxicity and severe sideeffects. Platinum(IV) anticancer prodrugs can overcome these limitations by resisting premature aquation and binding to essential plasma protei ...
FACTORS MODIFYING DRUG EFFECTS
... Gastric and intestinal stasis during an attack of Migraine interferes absorption of drugs ...
... Gastric and intestinal stasis during an attack of Migraine interferes absorption of drugs ...
Introduction to Anti-Fungals
... - Unlike ketoconazole and itraconazole, fluconazole has high bioavailability and has the least effects of all azoles on cytochrome P450 enzymes - It is the agent most used in treatment of mucocutaneous candidiasis. Voriconazole: - new, good absorption, high bioavailability and less plasma protein bi ...
... - Unlike ketoconazole and itraconazole, fluconazole has high bioavailability and has the least effects of all azoles on cytochrome P450 enzymes - It is the agent most used in treatment of mucocutaneous candidiasis. Voriconazole: - new, good absorption, high bioavailability and less plasma protein bi ...
An Innovative Approach to New Antimicrobial Drugs SUMMARY
... further development towards clinically useful drugs. SIGNIFICANCE This project will address the problem of resistance to antibiotics through the design of transition state analogues for DHFR, a known ...
... further development towards clinically useful drugs. SIGNIFICANCE This project will address the problem of resistance to antibiotics through the design of transition state analogues for DHFR, a known ...
Med Drugs 8 Keynote
... 1. Geometric Isomerism and Cisplatin Only the cis isomer has a therapeutic effect. Once inside the cell, the Cl- ions are exchanged for water molecules. ...
... 1. Geometric Isomerism and Cisplatin Only the cis isomer has a therapeutic effect. Once inside the cell, the Cl- ions are exchanged for water molecules. ...
Cell Cycle
... Which phase of Meiosis does half the chromosomes go to one cell and the other half go to the other cell when it splits ...
... Which phase of Meiosis does half the chromosomes go to one cell and the other half go to the other cell when it splits ...
8th Lecture 1433
... * Two drugs may have affinity for plasma protein binding sites, thus compete with each ...
... * Two drugs may have affinity for plasma protein binding sites, thus compete with each ...
Homogeneous GTP Binding Assay For G
... GTP binding assay. Agonist binding to GPCRs stimulates the guanine nucleotide exchange, GDP bound to Gα subunit of heterotrimeric Gproteins, dissociates and is replaced by GTP. Karo Bio’s AlphaKey™ technology is based on BioKey® peptide probes that e.g. specifically bind to the Gαi subunit in a conf ...
... GTP binding assay. Agonist binding to GPCRs stimulates the guanine nucleotide exchange, GDP bound to Gα subunit of heterotrimeric Gproteins, dissociates and is replaced by GTP. Karo Bio’s AlphaKey™ technology is based on BioKey® peptide probes that e.g. specifically bind to the Gαi subunit in a conf ...
Human Pregnane X Receptor - Clinical Cancer Research
... coactivators and corepressors. Although paclitaxel disrupts the interaction of hPXR with corepressors, it augments the interaction with coactivators, thus leading to a net stimulation of hPXR transcriptional activity. These mechanisms may also be relevant to the regulation of hPXR by other xenobioti ...
... coactivators and corepressors. Although paclitaxel disrupts the interaction of hPXR with corepressors, it augments the interaction with coactivators, thus leading to a net stimulation of hPXR transcriptional activity. These mechanisms may also be relevant to the regulation of hPXR by other xenobioti ...
The amino acid Tyrosine
... pseudoephedrine is used for its vasoconstriction activity ( α-adrenergic activity ) in the treatment of rhinitis . And all products based on ephedrine and pseudoephedrine are banned from the Sport activities ,classified as a Doping agent (The use of performance-enhancing drugs in human sport is comm ...
... pseudoephedrine is used for its vasoconstriction activity ( α-adrenergic activity ) in the treatment of rhinitis . And all products based on ephedrine and pseudoephedrine are banned from the Sport activities ,classified as a Doping agent (The use of performance-enhancing drugs in human sport is comm ...