cancer - ichapps.com
... Mechanism of action: The nitrosoureas exert cytotoxic effects by an alkylation that inhibits replication of RNA and protein synthesis and also they alkylate DNA in resting cells, cytotoxicity is expressed primarily on cells that are actively dividing. Therefore, non dividing cells can escape death i ...
... Mechanism of action: The nitrosoureas exert cytotoxic effects by an alkylation that inhibits replication of RNA and protein synthesis and also they alkylate DNA in resting cells, cytotoxicity is expressed primarily on cells that are actively dividing. Therefore, non dividing cells can escape death i ...
7-Antiparasitic Chemotherapy
... • First two single cycle, second two multiple cycles • Key point-- Several drugs affect blood schizonts, only primaquine affects tissue schizonts ...
... • First two single cycle, second two multiple cycles • Key point-- Several drugs affect blood schizonts, only primaquine affects tissue schizonts ...
GENERAL FARMACOLOGY
... Clearance (Cl) of a drug is the volume of plasma from which the drug is completely removed per unit of time. The amount of eliminated drug is proportional to its concentration in the blood CL=rate of elimination/C Half-life (t1/2) of a drug is the time taken for plasma drug concentration to reduce t ...
... Clearance (Cl) of a drug is the volume of plasma from which the drug is completely removed per unit of time. The amount of eliminated drug is proportional to its concentration in the blood CL=rate of elimination/C Half-life (t1/2) of a drug is the time taken for plasma drug concentration to reduce t ...
Drugs - Images
... Types of Drugs -Narcotics • Drugs that have a painkilling effect- also known as Analgesics. They work by depressing the central nervous system. e.g. -heroin -opium -morphine -OxyContin (synthetic opiate) ...
... Types of Drugs -Narcotics • Drugs that have a painkilling effect- also known as Analgesics. They work by depressing the central nervous system. e.g. -heroin -opium -morphine -OxyContin (synthetic opiate) ...
Absorption, distribution, metabolism and excretion
... * Two drugs may have affinity for plasma protein binding sites, thus compete with each other leading to drug interactions. * An example: Phenylbutazone and salicylates can displace warfarin (oral anticoagulant) and oral hypoglycemics from plasma proteins. * Drugs highly bound to plasma proteins are ...
... * Two drugs may have affinity for plasma protein binding sites, thus compete with each other leading to drug interactions. * An example: Phenylbutazone and salicylates can displace warfarin (oral anticoagulant) and oral hypoglycemics from plasma proteins. * Drugs highly bound to plasma proteins are ...
RTC ANTIBIOTICS CEPHALOSPORINS AND PENICILLINS
... • Ceftobiprole may be FDA approved, however Ceftaroline is already approved ...
... • Ceftobiprole may be FDA approved, however Ceftaroline is already approved ...
Drugs - Kaleem Rasheed
... the last month and 20% had used illegal drugs in the last year • 13% of boys reported taking drugs in the last month compared to 11% of girls • Use increased with age. Six percent of 11-year-olds had used drugs in the last year compared to 39% of 15-year-olds ...
... the last month and 20% had used illegal drugs in the last year • 13% of boys reported taking drugs in the last month compared to 11% of girls • Use increased with age. Six percent of 11-year-olds had used drugs in the last year compared to 39% of 15-year-olds ...
Coated balloons
... Mechanism of action • Paclitaxel is a potent inhibitor of smooth muscle cell proliferation, SMC migration, and extracellular matrix formation in vitro, with all three phases of the restenosis process inhibited effectively • The effective transfer of drug to the arterial wall is controlled by how th ...
... Mechanism of action • Paclitaxel is a potent inhibitor of smooth muscle cell proliferation, SMC migration, and extracellular matrix formation in vitro, with all three phases of the restenosis process inhibited effectively • The effective transfer of drug to the arterial wall is controlled by how th ...
Antiulcer Drugs - Dr. Brahmbhatt`s Class Handouts
... • Histamine-2 receptor antagonists • Prevent acid reflux by competitively blocking the H2 receptors of the parietal cells in the stomach, thus reducing gastric acid secretion • SE: rare, diarrhea and inhibition of liver enzymes • Examples: ...
... • Histamine-2 receptor antagonists • Prevent acid reflux by competitively blocking the H2 receptors of the parietal cells in the stomach, thus reducing gastric acid secretion • SE: rare, diarrhea and inhibition of liver enzymes • Examples: ...
Anti-biotics
... one of the drugs of choice for the treatment of any abscess in which the involvement of obligate anaerobes is suspected (e.g., lung, brain, or intraabdominal abscesses). Other antibacterial agents should be used in combination with metronidazole if facultative and aerobic pathogens are also thought ...
... one of the drugs of choice for the treatment of any abscess in which the involvement of obligate anaerobes is suspected (e.g., lung, brain, or intraabdominal abscesses). Other antibacterial agents should be used in combination with metronidazole if facultative and aerobic pathogens are also thought ...
ANTIBIOTICS
... inactivate some e.g. ampicillin but not others cloxacillin or meropenem To overcome this mechanism of resistance , B-Lactamase inhibitors are added to the antibiotic e.g. clavulanic acid added to ampicillin = augmentin ...
... inactivate some e.g. ampicillin but not others cloxacillin or meropenem To overcome this mechanism of resistance , B-Lactamase inhibitors are added to the antibiotic e.g. clavulanic acid added to ampicillin = augmentin ...
Efflux transporters
... some degree in the circulation of the fetus via passive diffusion and active transporters located on the fetal and maternal side of the tropoblast layer, p-gp on the maternal side of the tropoblast layer mediates the active efflux of lipophillic drugs from the fetal compartment. • Excretion of drugs ...
... some degree in the circulation of the fetus via passive diffusion and active transporters located on the fetal and maternal side of the tropoblast layer, p-gp on the maternal side of the tropoblast layer mediates the active efflux of lipophillic drugs from the fetal compartment. • Excretion of drugs ...
QuinTMP_Lowy
... Chemical Structure: Trimethoprim-sulfamethoxazole combines two agents. Trimethoprim is a pyrimidine that was synthesized as a dihydrofolate reductase inhibitor with the goal of sequentially inhibiting folate synthesis by potentiating sulfa activity. Sulfamethoxazole is a paraaminobenzoic acid (PABA) ...
... Chemical Structure: Trimethoprim-sulfamethoxazole combines two agents. Trimethoprim is a pyrimidine that was synthesized as a dihydrofolate reductase inhibitor with the goal of sequentially inhibiting folate synthesis by potentiating sulfa activity. Sulfamethoxazole is a paraaminobenzoic acid (PABA) ...
Drug Excretion
... Treatment of drug intoxication (cholestyramine with digoxin) Treatment failure (tetracycline with oral contraceptive) 3. Excretion of drugs by other routes: Quantitatively unimportant and mainly dependent on simple diffusion of unionized drug. A. Excretion in breast milk: almost any drug present ...
... Treatment of drug intoxication (cholestyramine with digoxin) Treatment failure (tetracycline with oral contraceptive) 3. Excretion of drugs by other routes: Quantitatively unimportant and mainly dependent on simple diffusion of unionized drug. A. Excretion in breast milk: almost any drug present ...
Foundations in Microbiology
... A cell with a damaged membrane dies from disruption in metabolism or lysis. These drugs have specificity for a particular microbial group, based on differences in types of lipids in their cell membranes. _____________ interact with phospholipids and cause leakage, particularly in gramnegative bacter ...
... A cell with a damaged membrane dies from disruption in metabolism or lysis. These drugs have specificity for a particular microbial group, based on differences in types of lipids in their cell membranes. _____________ interact with phospholipids and cause leakage, particularly in gramnegative bacter ...
GENERAL PHARMACOLOGY (absorption)
... mucous membrane of respiratory system rapid absorption (due to large surface area) provide local action limited systemic effect Low bioavailability less side effects. no first pass effect ...
... mucous membrane of respiratory system rapid absorption (due to large surface area) provide local action limited systemic effect Low bioavailability less side effects. no first pass effect ...
lec.11-426
... Considerable variation is possible in the tertiary amino group with retention of neuroleptic activity. The basic nitrogen could be a part of a six membered ring, (piperidine, 1,2,3,6-tetrahydropyridyl, or piperazinyl). Replacement of the sixmembered basic heterocycle by larger or smaller or uncycliz ...
... Considerable variation is possible in the tertiary amino group with retention of neuroleptic activity. The basic nitrogen could be a part of a six membered ring, (piperidine, 1,2,3,6-tetrahydropyridyl, or piperazinyl). Replacement of the sixmembered basic heterocycle by larger or smaller or uncycliz ...
Meiosis x Mitosis Phase Meiosis I Meiosis II Mitosis
... The cell separates in 2 identical cells and the duplicated chromosomes are in the cells ...
... The cell separates in 2 identical cells and the duplicated chromosomes are in the cells ...
H. Antifungal agents
... - Amphotericin is 10X more active which can be taken systemically. - Mechanism of action: have affinity to ergosterols containing membranes, ...
... - Amphotericin is 10X more active which can be taken systemically. - Mechanism of action: have affinity to ergosterols containing membranes, ...
Drug design Ligand-based drug design
... Semi-empirical, ab initio quantum chemistry methods, or density functional theory are often used to provide optimized parameters for the molecular mechanics calculations and also provide an estimate of the electronic properties (electrostatic potential, polarizability, etc.) of the drug candidate th ...
... Semi-empirical, ab initio quantum chemistry methods, or density functional theory are often used to provide optimized parameters for the molecular mechanics calculations and also provide an estimate of the electronic properties (electrostatic potential, polarizability, etc.) of the drug candidate th ...
f211 1.1.3 cell division
... the mitosis phase, it first undergoes a synthesis or S phase where each chromosome is duplicated and consists of two sister chromatids joined together by a specific DNA sequence known as a centromere. ...
... the mitosis phase, it first undergoes a synthesis or S phase where each chromosome is duplicated and consists of two sister chromatids joined together by a specific DNA sequence known as a centromere. ...
Pharmacokinetics
... – INCREASED PROTEIN BINDING = less free drug available to the tissues – DECREASED PROTEIN BINDING = more free drug available to the tissues. • Albumin is the main protein in circulation and is made in the LIVER. Animals with either liver disease or protein-losing enteropathies/nephropathies will hav ...
... – INCREASED PROTEIN BINDING = less free drug available to the tissues – DECREASED PROTEIN BINDING = more free drug available to the tissues. • Albumin is the main protein in circulation and is made in the LIVER. Animals with either liver disease or protein-losing enteropathies/nephropathies will hav ...