Mitochondrion 2
... • Main function is to produce energy in the form of ATP • Adenosine Triphosphate • Formed by metabolizing sugar • Cellular respiration • Oxidative metabolism • Proteins on inner membrane carry out this process ...
... • Main function is to produce energy in the form of ATP • Adenosine Triphosphate • Formed by metabolizing sugar • Cellular respiration • Oxidative metabolism • Proteins on inner membrane carry out this process ...
(4-HC) and Glutathione (GSH)
... COV434 human granulosa cell line, we tested the following hypotheses: 1) 4-HC, a preactivated form of cyclophosphamide, induces apoptosis; 2) GSH depletion induces apoptosis; and 3) GSH depletion enhances the apoptotic effects of 4-HC. Cells treated with 100 µM buthionine sulfoximine (BSO), a specif ...
... COV434 human granulosa cell line, we tested the following hypotheses: 1) 4-HC, a preactivated form of cyclophosphamide, induces apoptosis; 2) GSH depletion induces apoptosis; and 3) GSH depletion enhances the apoptotic effects of 4-HC. Cells treated with 100 µM buthionine sulfoximine (BSO), a specif ...
APOPTOSIS: An overview
... Caused by excessive apoptosis Process includes transfer of regulatory viral gene products (such as HIV-1 Tat) from HIV infected cells to bystander T cells Renders them susceptible to T cell receptorinduced, CD95-mediated apoptosis. ...
... Caused by excessive apoptosis Process includes transfer of regulatory viral gene products (such as HIV-1 Tat) from HIV infected cells to bystander T cells Renders them susceptible to T cell receptorinduced, CD95-mediated apoptosis. ...
mtCLIC/CLIC4 a Chloride Channel Protein Participates in Apoptosis
... [1], some sparse label was observed outside mitochondria. This label appeared to be cytosolic and not associated with any membrane-bound compartment. Almost all of the gold particles labeling mitochondria were in close association with cristae or peripheral inner membrane. A few gold particles appea ...
... [1], some sparse label was observed outside mitochondria. This label appeared to be cytosolic and not associated with any membrane-bound compartment. Almost all of the gold particles labeling mitochondria were in close association with cristae or peripheral inner membrane. A few gold particles appea ...
6. apoptosis
... APOPTOSIS: Role in Disease Cancer Apoptosis eliminates damaged cells (damage => mutations => cancer Tumor suppressor p53 controls senescence and apoptosis responses to damage Most cancer cells are defective in apoptotic response (damaged, mutant cells survive) ...
... APOPTOSIS: Role in Disease Cancer Apoptosis eliminates damaged cells (damage => mutations => cancer Tumor suppressor p53 controls senescence and apoptosis responses to damage Most cancer cells are defective in apoptotic response (damaged, mutant cells survive) ...
Functional domains of the BRCA2 protein
... Published in Expert Reviews in Molecular Medicine by Cambridge University Press (2001) ...
... Published in Expert Reviews in Molecular Medicine by Cambridge University Press (2001) ...
View Poster
... Objective & Hypotheses Programmed cell “suicide”—apoptosis—occurs in normal cells that turn cancerous (Böttger et al, 2008). The primary mechanism of apoptosis occurs in the nucleus using a special protein: p53, but secondary action may occur in the mitochondria, mediated by a certain enzyme: HAUSP ...
... Objective & Hypotheses Programmed cell “suicide”—apoptosis—occurs in normal cells that turn cancerous (Böttger et al, 2008). The primary mechanism of apoptosis occurs in the nucleus using a special protein: p53, but secondary action may occur in the mitochondria, mediated by a certain enzyme: HAUSP ...
rapid and easy estimation of apoptotic cells for clinical diagnostics
... Unlike the competitor methods, the proposed technology does not require target cell destruction in the process of apoptosis detection, since it uses cell surface biochemical markers of apoptosis. Besides, the technology provides high speed and high reproducibility of the measurements. Another known ...
... Unlike the competitor methods, the proposed technology does not require target cell destruction in the process of apoptosis detection, since it uses cell surface biochemical markers of apoptosis. Besides, the technology provides high speed and high reproducibility of the measurements. Another known ...
No Slide Title
... •MAVS (mitochondrial antiviral signaling) protein on MOM is key •dsRNA receptors bind MAVS & trigger interferon & cytokine Synthesis •Viruses also interact with mt in countless specific ways ...
... •MAVS (mitochondrial antiviral signaling) protein on MOM is key •dsRNA receptors bind MAVS & trigger interferon & cytokine Synthesis •Viruses also interact with mt in countless specific ways ...
P023 Lack of TXNIP protects beta cells against glucotoxicity Junqin
... and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified thioredoxin-interacting protein (TXNIP) as a novel pro-apoptotic beta cell factor that is induced by glucose suggesting that TXNIP may play a role in beta cell glucotoxicity. Incubati ...
... and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified thioredoxin-interacting protein (TXNIP) as a novel pro-apoptotic beta cell factor that is induced by glucose suggesting that TXNIP may play a role in beta cell glucotoxicity. Incubati ...
apoptosis - The University of Western Australia
... In a healthy cell, the outer membranes of its mitochondria express the protein Bcl-2 on their surface. Bcl-2 is bound to a molecule of the protein Apaf-1 ("apoptotic protease activating factor-1". Internal damage to the cell (e.g., from reactive oxygen species) causes Bcl-2 to release Apaf-1; a rela ...
... In a healthy cell, the outer membranes of its mitochondria express the protein Bcl-2 on their surface. Bcl-2 is bound to a molecule of the protein Apaf-1 ("apoptotic protease activating factor-1". Internal damage to the cell (e.g., from reactive oxygen species) causes Bcl-2 to release Apaf-1; a rela ...
Cell Death Process
... in Eukaryotes • Cell death can occur by either of two distinct mechanisms – apoptosis or necrosis. • Apoptosis: originally defined according to a set of characteristic ultrastructural features that include nuclear and cytoplasmic condensation, cell fragmentation and phagocytosis. • Necrosis: cell de ...
... in Eukaryotes • Cell death can occur by either of two distinct mechanisms – apoptosis or necrosis. • Apoptosis: originally defined according to a set of characteristic ultrastructural features that include nuclear and cytoplasmic condensation, cell fragmentation and phagocytosis. • Necrosis: cell de ...
Analyses of the Regulatory Mechanisms of Tankyrase and Its Role
... processes is often associated with cancer. Therefore, inhibition of tankyrases by small molecule inhibitors is a promising strategy for targeted cancer therapy. However, side effects of current inhibitors of tankyrases, due mainly to off-target inhibition of other PARP family proteins, hinder their ...
... processes is often associated with cancer. Therefore, inhibition of tankyrases by small molecule inhibitors is a promising strategy for targeted cancer therapy. However, side effects of current inhibitors of tankyrases, due mainly to off-target inhibition of other PARP family proteins, hinder their ...
Apoptosis Apoptosis is a process of cell death that is carried out by
... results from blocking the cellular mitochondria surface protein known as Bcl-2, which blocks apoptosis. When Bcl-2 is blocked the mitochondria becomes damaged, allowing cytochrome c to leak out. This stimulates a signaling cascade that starts the process of cell death resulting in the activation of ...
... results from blocking the cellular mitochondria surface protein known as Bcl-2, which blocks apoptosis. When Bcl-2 is blocked the mitochondria becomes damaged, allowing cytochrome c to leak out. This stimulates a signaling cascade that starts the process of cell death resulting in the activation of ...
No Slide Title
... ATM/p53 Signaling Pathway The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation, via IR damage to DNA, stimulates DNA repair and blocks cell cycle progression. One mechanism through which this occurs is ATM dependent phosphorylation of ...
... ATM/p53 Signaling Pathway The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation, via IR damage to DNA, stimulates DNA repair and blocks cell cycle progression. One mechanism through which this occurs is ATM dependent phosphorylation of ...
Cell Cycle
... Keep apoptotic pathway turned off by binding to a protein called Apaf-1 (apoptotic protease activating factor-1) Block release of cytochrome c by making it more difficult for the mitochondria to burst Internal damage to cell causes Bcl-2 protein to release Apaf-1 Apoptotic stimulus - Bcl-x (a relate ...
... Keep apoptotic pathway turned off by binding to a protein called Apaf-1 (apoptotic protease activating factor-1) Block release of cytochrome c by making it more difficult for the mitochondria to burst Internal damage to cell causes Bcl-2 protein to release Apaf-1 Apoptotic stimulus - Bcl-x (a relate ...
Dynamic redox potential change throughout apoptosis in cancer
... Apoptosis is said to occur when the cellular redox potential reaches its oxidative range and it is believed that the depletion of glutathione via active export mechanisms contributes towards driving oxidative stress. An understanding of the links between intracellular redox potential and cell death ...
... Apoptosis is said to occur when the cellular redox potential reaches its oxidative range and it is believed that the depletion of glutathione via active export mechanisms contributes towards driving oxidative stress. An understanding of the links between intracellular redox potential and cell death ...
M. S. Thesis Seminar Evert Njomen Chemistry Department
... synthesis of this peptide decreases with age coincident with the time that people are likely to develop AD. In addition, the precise mechanism of action of HN is currently unknown. We have synthesized residues 3 to 19 of HN known to be sufficient for its neuroprotective function by solid phase pepti ...
... synthesis of this peptide decreases with age coincident with the time that people are likely to develop AD. In addition, the precise mechanism of action of HN is currently unknown. We have synthesized residues 3 to 19 of HN known to be sufficient for its neuroprotective function by solid phase pepti ...
APOPTOSIS: An overview
... (e.g. TRAIL, FasL) activating initiator caspase 8 through induced proximity. can be initiated intrinsically through DNA damage (via cytochrome c) activating initiator caspase 9 through oligomerization. Initiator caspases 8 and 9 cleave and activate effector caspase 3, which leads to cell death. ...
... (e.g. TRAIL, FasL) activating initiator caspase 8 through induced proximity. can be initiated intrinsically through DNA damage (via cytochrome c) activating initiator caspase 9 through oligomerization. Initiator caspases 8 and 9 cleave and activate effector caspase 3, which leads to cell death. ...
APOPTOSIS: An overview
... (e.g. TRAIL, FasL) activating initiator caspase 8 through induced proximity. can be initiated intrinsically through DNA damage (via cytochrome c) activating initiator caspase 9 through oligomerization. Initiator caspases 8 and 9 cleave and activate effector caspase 3, which leads to cell death. ...
... (e.g. TRAIL, FasL) activating initiator caspase 8 through induced proximity. can be initiated intrinsically through DNA damage (via cytochrome c) activating initiator caspase 9 through oligomerization. Initiator caspases 8 and 9 cleave and activate effector caspase 3, which leads to cell death. ...
請參閱範例
... 蔡鈞州 曾博修 陳得源 徐再靜 中山醫學大學微生物免疫研究所 中山醫學大學生化暨生技研究所 台中榮民總醫院過敏免疫風濕科 Background: Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitochondrial-dependent ...
... 蔡鈞州 曾博修 陳得源 徐再靜 中山醫學大學微生物免疫研究所 中山醫學大學生化暨生技研究所 台中榮民總醫院過敏免疫風濕科 Background: Human parvovirus B19 (B19) is known to induce apoptosis that has been associated with a variety of autoimmune disorders. Although we have previously reported that B19 non-structural protein (NS1) induces mitochondrial-dependent ...
Extracellular Regulation of the Cell Cycle by Signal Transduction
... Ex: cytochrome c binds to Apaf (Apoptosis Pathway Activating Factor) Apaf-cytochrome c activates initiator caspase ...
... Ex: cytochrome c binds to Apaf (Apoptosis Pathway Activating Factor) Apaf-cytochrome c activates initiator caspase ...
PPT Version
... Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. ...
... Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. ...
apoptosis - Fort Bend ISD
... p53 first arrests cell growth between G1 S This allows for DNA repair during delay ...
... p53 first arrests cell growth between G1 S This allows for DNA repair during delay ...
Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.