BARTH SYNDROME: CARDIOLIPIN ALTERATIONS LINKED TO
... Using Barth syndrome patient-derived cells and HeLa cells in which tafazzin was knocked down, we show that cardiolipin is required for apoptosis. Cardiolipin provides an anchor and activating platform for caspase8 translocation to, and embedding in, the mitochondrial membrane3. Consistent with a key ...
... Using Barth syndrome patient-derived cells and HeLa cells in which tafazzin was knocked down, we show that cardiolipin is required for apoptosis. Cardiolipin provides an anchor and activating platform for caspase8 translocation to, and embedding in, the mitochondrial membrane3. Consistent with a key ...
投影片 1
... dangerous cells from an organism without damaging surrounding cells and tissues Necessary for normal embryogenesis Maintenance of tissue homeostasis ...
... dangerous cells from an organism without damaging surrounding cells and tissues Necessary for normal embryogenesis Maintenance of tissue homeostasis ...
FERM domain proteins
... Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members, K Takeuchi et al, J Cell Bio 125:1371-1384(1994) ...
... Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members, K Takeuchi et al, J Cell Bio 125:1371-1384(1994) ...
Ενδοκυττάρια ∆ιαµερίσµατα, ∆ιαλογή και µεταφορά πρωτεινών
... • Depends on a matrix-targeting signal: The presequence • Cleavable, usually located at the N-terminus •usually 12-15 residues long •amphiphilic, with positively charged residues on one side of an a-helix ...
... • Depends on a matrix-targeting signal: The presequence • Cleavable, usually located at the N-terminus •usually 12-15 residues long •amphiphilic, with positively charged residues on one side of an a-helix ...
Pharmaceutical re-activation of pathways in non
... Since there are other types of protein microarrays, such as category called functional protein microarrays, which can tell us about protein-protein and protein-drug interactions. These tools will be useful in these future experiments. Then through continued experiments we may find conclusive evidenc ...
... Since there are other types of protein microarrays, such as category called functional protein microarrays, which can tell us about protein-protein and protein-drug interactions. These tools will be useful in these future experiments. Then through continued experiments we may find conclusive evidenc ...
UvA-DARE (Digital Academic Repository) Mitochondria in neutrophil
... their apoptosis. Most prominent amongst these proteins in neutrophils are Mcl-1 and Bfl-1. The main function of Mcl-1 in neutrophils seems to be inhibition of Bax translocation 5, but this thesis has demonstrated that the role of Bfl-1 in the apoptotic process is far from obvious. The function of Ba ...
... their apoptosis. Most prominent amongst these proteins in neutrophils are Mcl-1 and Bfl-1. The main function of Mcl-1 in neutrophils seems to be inhibition of Bax translocation 5, but this thesis has demonstrated that the role of Bfl-1 in the apoptotic process is far from obvious. The function of Ba ...
Conformational Analysis of a Set of Peptides Corresponding
... Introduction to Ribosome Ribosome contains one mRNA and two tRNA ...
... Introduction to Ribosome Ribosome contains one mRNA and two tRNA ...
Seznam 10 nejvýznamějších publikací
... Clothier, R., Hermann, F., Klahm, L. K., de Lange, J., Liebsch, M. and Vanparys, P. The Principles of Good Laboratory Practice: Application to In Vitro Toxicology Studies. ATLA, 1999, vol. 27, no. 4, p. 539-577. 2. Horák, D., Červinka, M., and Půža, V. Hydrogels in endovascular embolization. VI. Tox ...
... Clothier, R., Hermann, F., Klahm, L. K., de Lange, J., Liebsch, M. and Vanparys, P. The Principles of Good Laboratory Practice: Application to In Vitro Toxicology Studies. ATLA, 1999, vol. 27, no. 4, p. 539-577. 2. Horák, D., Červinka, M., and Půža, V. Hydrogels in endovascular embolization. VI. Tox ...
Celltasia: Celltasia was born of frustration, on a number of levels
... Mitochondria are also involved in a number of other cellular processes, such as cell death (apoptosis), cell growth and the cell cycle. They have also been implicated in a number of human diseases. Mitochondria are about 1 micrometer in diameter. It was once thought that the shape of the mitochondri ...
... Mitochondria are also involved in a number of other cellular processes, such as cell death (apoptosis), cell growth and the cell cycle. They have also been implicated in a number of human diseases. Mitochondria are about 1 micrometer in diameter. It was once thought that the shape of the mitochondri ...
Cancer Attributes of Cancerous Tumors Unregulated cell division
... with Malignancy. Metastatic cells break their contacts with other cells and the ECM in their tissue of origin, and as a result, metastatic cells can invade adjoining tissue or enter the circulation and establish themselves in a distant site. ! Angiogenesis (formation of new blood vessels): tumor gro ...
... with Malignancy. Metastatic cells break their contacts with other cells and the ECM in their tissue of origin, and as a result, metastatic cells can invade adjoining tissue or enter the circulation and establish themselves in a distant site. ! Angiogenesis (formation of new blood vessels): tumor gro ...
Full version (PDF file)
... have used different ligands. In this study rhNRG-1 was focused on, due to the fact that rhNRG-1 was administered by IV to clinically relevant chronic rat models of doxorubicin-induced cardiomyopathy, and cardiac function and survival were improved (Liu et al. 2006). And it is the only one whose safe ...
... have used different ligands. In this study rhNRG-1 was focused on, due to the fact that rhNRG-1 was administered by IV to clinically relevant chronic rat models of doxorubicin-induced cardiomyopathy, and cardiac function and survival were improved (Liu et al. 2006). And it is the only one whose safe ...
Center for Eukaryotic Structural Genomics (CESG)
... solubility in E. coli during the time course of expression was associated with high-level incorporation of protoporphyrin IX into the heme domain of the fusion protein. The fl-cytb5 could be liberated from the fusion by site-specific proteolysis, which permitted spontaneous incorporation into membra ...
... solubility in E. coli during the time course of expression was associated with high-level incorporation of protoporphyrin IX into the heme domain of the fusion protein. The fl-cytb5 could be liberated from the fusion by site-specific proteolysis, which permitted spontaneous incorporation into membra ...
Chapter 15 Regulation of Cell Number Normal and Cancer Cells
... Mutated Tumor-suppressor genes are mutated alles of negative regulators (for example p53) of the cell cycle. They can represent dominant or recessive alleles. For recessive mutations, the tumor cell will lack any copy of the corresponding wild-type allele. ...
... Mutated Tumor-suppressor genes are mutated alles of negative regulators (for example p53) of the cell cycle. They can represent dominant or recessive alleles. For recessive mutations, the tumor cell will lack any copy of the corresponding wild-type allele. ...
Apoptosis (programmed cell death) plays many important roles in
... Crossed Hawaiian males to unc-24 him-8 dpy-20 hermaphrodites and picked non-UD cross-progeny, 4-5 to a plate. Selfed and picked recombinant (UnD and DnU) F2s. These were scored for Him. Of the DnUs: ...
... Crossed Hawaiian males to unc-24 him-8 dpy-20 hermaphrodites and picked non-UD cross-progeny, 4-5 to a plate. Selfed and picked recombinant (UnD and DnU) F2s. These were scored for Him. Of the DnUs: ...
Abstract - BMB Reports
... signal in autophagy. We showed that many ER residents such as BiP contain evolutionally conserved arginylation permissive pro-N-degrons and that certain inducers like dsDNA or proteasome inhibitors cause their translocation into the cytoplasm where they bind midfolded proteins and undergo amino-term ...
... signal in autophagy. We showed that many ER residents such as BiP contain evolutionally conserved arginylation permissive pro-N-degrons and that certain inducers like dsDNA or proteasome inhibitors cause their translocation into the cytoplasm where they bind midfolded proteins and undergo amino-term ...
Biofundamentals -Cell Death: Necrosis and Apoptosis
... Necrosis is death due to unexpected and accidental cell damage. A number of toxic chemical or physical events can cause necrosis: toxins, radiation, heat, trauma, lack of oxygen due the blockage of blood flow, etc. These physical or chemical insults can lead to the lethal disruption of cell structur ...
... Necrosis is death due to unexpected and accidental cell damage. A number of toxic chemical or physical events can cause necrosis: toxins, radiation, heat, trauma, lack of oxygen due the blockage of blood flow, etc. These physical or chemical insults can lead to the lethal disruption of cell structur ...
cover_article_1135_en_US
... via Ca2+/calmodulin (CaM)/signaling to human vacuolar protein sorting 34 (hVps34) due to AKT inhibition. DC120 also attenuated the inhibitory effect of AKT on C-Raf by decreasing the phosphorylation of C-Raf at Ser259 and activated the mitogen-activated protein kinase (MAPK) pathway. The activation ...
... via Ca2+/calmodulin (CaM)/signaling to human vacuolar protein sorting 34 (hVps34) due to AKT inhibition. DC120 also attenuated the inhibitory effect of AKT on C-Raf by decreasing the phosphorylation of C-Raf at Ser259 and activated the mitogen-activated protein kinase (MAPK) pathway. The activation ...
HSC70 (Hsp73) Protein (active) Catalog# SPR
... Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacte ...
... Hsp70 genes encode abundant heat-inducible 70-kDa hsps (hsp70s). In most eukaryotes hsp70 genes exist as part of a multigene family. They are found in most cellular compartments of eukaryotes including nuclei, mitochondria, chloroplasts, the endoplasmic reticulum and the cytosol, as well as in bacte ...
Genetic screens: apoptosis in C. elegans
... development •Histogenic cell death: up to a half of the neurons normally die during development of parts of the brain. •Phylogenic cell death: the loss of the vertebrate tail during human fetal development. •Morphogenic cell death: the loss of mesenchyme between the digit. •Cancer: damaged precancer ...
... development •Histogenic cell death: up to a half of the neurons normally die during development of parts of the brain. •Phylogenic cell death: the loss of the vertebrate tail during human fetal development. •Morphogenic cell death: the loss of mesenchyme between the digit. •Cancer: damaged precancer ...
(1605P) ZBH-1205: A Novel Camptothecin Derivate Revealed
... induction of cell cycle arrest remains the same among three Topo I drugs. Consistent with this, there was a time and dose dependent decrease in pro-caspase-3 and PARP expression, and a significant increase in active-caspase-3. In tumor xenografts, a stronger tumor growth inhibition was observed with ...
... induction of cell cycle arrest remains the same among three Topo I drugs. Consistent with this, there was a time and dose dependent decrease in pro-caspase-3 and PARP expression, and a significant increase in active-caspase-3. In tumor xenografts, a stronger tumor growth inhibition was observed with ...
ABSTRACT - University of Colorado
... • Normally present in presynaptic region associated with vesicle membrane • Two point mutations A53T and A30P cause earlier onset PD • -Synuclein protein is natively unfolded, can form fibrillar aggregates in vitro ...
... • Normally present in presynaptic region associated with vesicle membrane • Two point mutations A53T and A30P cause earlier onset PD • -Synuclein protein is natively unfolded, can form fibrillar aggregates in vitro ...
Abstract Research Paper: Student: Degree:
... College: Sciences and Humanities Date: December 2015 Pages: 23 This paper will examine P53, a gene that can be mutated into an oncogenic form that can cause extensive cellular damage. Such mutations can induce a loss of cell cycle control and promote abnormal cellular growth resulting in tumor forma ...
... College: Sciences and Humanities Date: December 2015 Pages: 23 This paper will examine P53, a gene that can be mutated into an oncogenic form that can cause extensive cellular damage. Such mutations can induce a loss of cell cycle control and promote abnormal cellular growth resulting in tumor forma ...
Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.