PUMA shRNA (m) Lentiviral Particles: sc-37154-V
... PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same trans ...
... PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same trans ...
Apoptosis in oral lichen planus - BORA
... Apoptotic cell death may be a contributory cause of basal cell destruction in oral lichen planus (OLP). Therefore, the purpose of this study was to investigate the rate of apoptosis in OLP and the expression of two proteins (FasR and FasL) regulating this process. Biopsies from 18 patients with hist ...
... Apoptotic cell death may be a contributory cause of basal cell destruction in oral lichen planus (OLP). Therefore, the purpose of this study was to investigate the rate of apoptosis in OLP and the expression of two proteins (FasR and FasL) regulating this process. Biopsies from 18 patients with hist ...
FireizenSpr09
... the appropriate mutant cells and the identification of these mutants will be presented. ...
... the appropriate mutant cells and the identification of these mutants will be presented. ...
Guillain-Barre syndrome (GBS)
... Unfolding of protein to be transported Passing through a topologically distinct space: cytosol to ER; cytosol to mitochondria ...
... Unfolding of protein to be transported Passing through a topologically distinct space: cytosol to ER; cytosol to mitochondria ...
Newly solved structure reveals how cells resist oxygen
... does this by blocking the groove where ? binds The sun’s rays give life, but also take it away. RNA polymerase, the protein that initiates gene Singlet oxygen, a byproduct of the photosynthetic transcription. When the bacteria sense the process by which certain cells convert sunlight into presence o ...
... does this by blocking the groove where ? binds The sun’s rays give life, but also take it away. RNA polymerase, the protein that initiates gene Singlet oxygen, a byproduct of the photosynthetic transcription. When the bacteria sense the process by which certain cells convert sunlight into presence o ...
Berberine Use in Stimulating Apoptosis
... Treatment of human breast cancer cells (MCF-7 and MDA-MB-231 cells) with berberine induced inhibition of cell viability in concentration- and time-dependent manner irrespective of their estrogen receptor (ER) expression. This study revealed that Berberine was responsible for down-regulation of antia ...
... Treatment of human breast cancer cells (MCF-7 and MDA-MB-231 cells) with berberine induced inhibition of cell viability in concentration- and time-dependent manner irrespective of their estrogen receptor (ER) expression. This study revealed that Berberine was responsible for down-regulation of antia ...
APOPTOSIS AND NECROSIS APOPTOSIS All the cells in our body
... Cell death produced by a variety of injurious stimuli Cell injury in certain viral diseases Pathological atrophy in parenchymal organs after duct obstruction Cell death in tumors In some situations where cell death is mainly due to necrosis, the pathway of apoptosis may also contribute ...
... Cell death produced by a variety of injurious stimuli Cell injury in certain viral diseases Pathological atrophy in parenchymal organs after duct obstruction Cell death in tumors In some situations where cell death is mainly due to necrosis, the pathway of apoptosis may also contribute ...
The Fusarium toxin Enniatin exerts p53
... recombination were used to study ENN-induced cytotoxicity. In MTT assays, no significant influences of these proteins were detected, resulting for all HCT116 subclones at IC50 values in the low µM range at a 72 h drug exposure. ...
... recombination were used to study ENN-induced cytotoxicity. In MTT assays, no significant influences of these proteins were detected, resulting for all HCT116 subclones at IC50 values in the low µM range at a 72 h drug exposure. ...
Six Kingdoms Study Guide
... Mostly Asexual reproduction, but some may conjugate (swap DNA) Domain Eukarya, Kingdom Fungi Consumer/ Decomposers- Eukaryotes- Have tissues and organs, BUT not organ systems Chitin Cell Wall (Chitin is in crab shell)- So Don’t Move Root-like hyphae suck up moisture and nutrients Some help other pla ...
... Mostly Asexual reproduction, but some may conjugate (swap DNA) Domain Eukarya, Kingdom Fungi Consumer/ Decomposers- Eukaryotes- Have tissues and organs, BUT not organ systems Chitin Cell Wall (Chitin is in crab shell)- So Don’t Move Root-like hyphae suck up moisture and nutrients Some help other pla ...
f(matsuda) Lab of genome technology_IMS
... Abstract: The tumor suppressor gene p53 is mutated in more than half of all human cancers. Recent cancer genomic analyses have identified a number of genes mutated in cancer tissues, however the mutation of the p53 gene is still the most common alteration observed in the majority of human cancers. B ...
... Abstract: The tumor suppressor gene p53 is mutated in more than half of all human cancers. Recent cancer genomic analyses have identified a number of genes mutated in cancer tissues, however the mutation of the p53 gene is still the most common alteration observed in the majority of human cancers. B ...
Document
... E. coli is a free living, gram negative bacterium which colonizes the lower gut of animals. Since it is a model organism, a lot of experimental data is available. Furthermore, the complete genome sequence (Blattner et al., 1997) of this microbe has enormously helped to integrate a vast amount of bio ...
... E. coli is a free living, gram negative bacterium which colonizes the lower gut of animals. Since it is a model organism, a lot of experimental data is available. Furthermore, the complete genome sequence (Blattner et al., 1997) of this microbe has enormously helped to integrate a vast amount of bio ...
Course Outline - Purdue University
... “Energy Transduction in Biological Membranes” (2 credits) Fall, 2014 9:30-10:20 Tuesday and Thursday, in LILY G458 I. COURSE SUMMARY This course provides an introduction to (1) the biophysical and biochemical basis for energy transduction in biological membranes; and (2) the structure and functions ...
... “Energy Transduction in Biological Membranes” (2 credits) Fall, 2014 9:30-10:20 Tuesday and Thursday, in LILY G458 I. COURSE SUMMARY This course provides an introduction to (1) the biophysical and biochemical basis for energy transduction in biological membranes; and (2) the structure and functions ...
Diapositiva 1 - r
... Telomere-telomerase system and apoptosis are ubiquitarian in eukaryote species [10-13] (Fig. 3). In yeast, Saccharomyces cerevisiae, telomere-telomerase system does not allow further replications after 25±35 duplications and the cell dies by apoptosis [10], which is also triggered by: a) unsuccessfu ...
... Telomere-telomerase system and apoptosis are ubiquitarian in eukaryote species [10-13] (Fig. 3). In yeast, Saccharomyces cerevisiae, telomere-telomerase system does not allow further replications after 25±35 duplications and the cell dies by apoptosis [10], which is also triggered by: a) unsuccessfu ...
FST 12 Endoplasmic Reticulum Stress in Human Diseases
... Cell organelles, endoplasmic reticulum (ER) and mitochondria play an important role in the maintenance of cellular homeostasis and dysfunction of either or both have been implicated in many human diseases, including cancer, diabetes, cardiovascular, neurodegeneration and ischemia. The ER is the prim ...
... Cell organelles, endoplasmic reticulum (ER) and mitochondria play an important role in the maintenance of cellular homeostasis and dysfunction of either or both have been implicated in many human diseases, including cancer, diabetes, cardiovascular, neurodegeneration and ischemia. The ER is the prim ...
Cell signaling - Lectures For UG-5
... activation translocates to the cytoplasm where it binds the RI. SMAD6 binds SMAD4 preventing the binding of R-SMADs with the coSMAD. The levels of I-SMAD increase with TGF beta signaling suggesting that they are downstream targets of TGF-beta signaling. ...
... activation translocates to the cytoplasm where it binds the RI. SMAD6 binds SMAD4 preventing the binding of R-SMADs with the coSMAD. The levels of I-SMAD increase with TGF beta signaling suggesting that they are downstream targets of TGF-beta signaling. ...
ppt
... Receptors can be classified by their location in the cell. This is determined by whether or not their ligand can diffuse through the membrane. Cytoplasmic receptors have ligands, such as estrogen, that are small or nonpolar and can diffuse across the membrane. Membrane receptors have large or polar ...
... Receptors can be classified by their location in the cell. This is determined by whether or not their ligand can diffuse through the membrane. Cytoplasmic receptors have ligands, such as estrogen, that are small or nonpolar and can diffuse across the membrane. Membrane receptors have large or polar ...
Kingdoms and Domains 18.3
... • Kingdom of multicellular photosynthetic autotrophs that have cell walls containing cellulose. ...
... • Kingdom of multicellular photosynthetic autotrophs that have cell walls containing cellulose. ...
Steroidogenesis - Delta State University
... – Changes in the number of carbons – Location of double bond ...
... – Changes in the number of carbons – Location of double bond ...
In This Issue
... growth. Maturation and growth were restored by mutations in Tif6 that weaken the inhibitory protein’s association with the large subunit. Rpl10 mutants were also rescued by mutants of Efl1, a GTPase that promotes Tif6 release. The mutations in Efl1 appear to facilitate a conformational change analog ...
... growth. Maturation and growth were restored by mutations in Tif6 that weaken the inhibitory protein’s association with the large subunit. Rpl10 mutants were also rescued by mutants of Efl1, a GTPase that promotes Tif6 release. The mutations in Efl1 appear to facilitate a conformational change analog ...
In This Issue
... growth. Maturation and growth were restored by mutations in Tif6 that weaken the inhibitory protein’s association with the large subunit. Rpl10 mutants were also rescued by mutants of Efl1, a GTPase that promotes Tif6 release. The mutations in Efl1 appear to facilitate a conformational change analog ...
... growth. Maturation and growth were restored by mutations in Tif6 that weaken the inhibitory protein’s association with the large subunit. Rpl10 mutants were also rescued by mutants of Efl1, a GTPase that promotes Tif6 release. The mutations in Efl1 appear to facilitate a conformational change analog ...
Review Cell Death Signalling Pathways in the
... structures, DNA damage (e.g. mutagenic agents, cytostatics, antimetabolites), growth factor/cytokine deprivation, nucleotide/ATP deficiency, accumulation of misfolded proteins and other stress factors. While the initial triggers of diverse intrinsic apoptotic pathways may differ substantially, all o ...
... structures, DNA damage (e.g. mutagenic agents, cytostatics, antimetabolites), growth factor/cytokine deprivation, nucleotide/ATP deficiency, accumulation of misfolded proteins and other stress factors. While the initial triggers of diverse intrinsic apoptotic pathways may differ substantially, all o ...
pathway_cell_models_2006
... • Two types of formalism appearing in the literature: – data mining e.g. genome expression at gene or protein level contribute to conceptualisations of pathways ...
... • Two types of formalism appearing in the literature: – data mining e.g. genome expression at gene or protein level contribute to conceptualisations of pathways ...
5MO021 / 3MB002 Cell Biology, V10 READ INSTRUCTIONS
... A) Only target cells are exposed to aldosterone B) Only target cells contain receptors for aldosterone C) Aldosterone is unable to enter nontarget cells D) Nontarget cells destroy aldosterone before it can produce its effect E) Nontarget cells convert aldosterone to a hormone to which they do respon ...
... A) Only target cells are exposed to aldosterone B) Only target cells contain receptors for aldosterone C) Aldosterone is unable to enter nontarget cells D) Nontarget cells destroy aldosterone before it can produce its effect E) Nontarget cells convert aldosterone to a hormone to which they do respon ...
Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.