Here - European Macrophage and Dendritic Cell Society
... joining groups which perform basic research with a strong focus on translating scientific results into pharmaceutical, agricultural and industrial applications. We would like to acknowledge the material support for the meeting which we have received from VIB. Despite the economical crisis, we are al ...
... joining groups which perform basic research with a strong focus on translating scientific results into pharmaceutical, agricultural and industrial applications. We would like to acknowledge the material support for the meeting which we have received from VIB. Despite the economical crisis, we are al ...
Chapter 20
... Travel with veins in superficial tissues/arteries in deeper tissues. Have the same three tunics as blood vessels but walls are much thinner and lymph pressure is very low. They also have lymph nodes scattered along their length to filter the lymph. ...
... Travel with veins in superficial tissues/arteries in deeper tissues. Have the same three tunics as blood vessels but walls are much thinner and lymph pressure is very low. They also have lymph nodes scattered along their length to filter the lymph. ...
Surfactant proteins and the inflammatory and immune response in
... ison with patients with a cough. Increased levels of SPD are found in the BALF of patients with eosinophilic pneumonia compared with healthy controls.20 Surfactant protein A prevents inhibition of surfactant activity by blood proteins. Leakage of blood components into the alveolar space as a result ...
... ison with patients with a cough. Increased levels of SPD are found in the BALF of patients with eosinophilic pneumonia compared with healthy controls.20 Surfactant protein A prevents inhibition of surfactant activity by blood proteins. Leakage of blood components into the alveolar space as a result ...
Pulp responses
... bind to the same cellular receptor. This receptor is composed of two related, but non-identical, subunits that transmit intracellular signals via a pathway that is mostly shared with certain other receptors. These include the Toll family of innate immune receptors and the receptor for IL-18. IL-1α … ...
... bind to the same cellular receptor. This receptor is composed of two related, but non-identical, subunits that transmit intracellular signals via a pathway that is mostly shared with certain other receptors. These include the Toll family of innate immune receptors and the receptor for IL-18. IL-1α … ...
Pulparesponser
... Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells. They form an important part of the inflammatory response of the body against infection. These cytokines increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes, the cells ...
... Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells. They form an important part of the inflammatory response of the body against infection. These cytokines increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes, the cells ...
Bacterial Biofilms Resist Key Host Defenses
... or implanted medical devices, and in those also infected with HIV. In all these cases, the host immune system is marginally or severely compromised. One key antibacterial mechanism within the innate immune system depends on phagocytes, including neutrophils and macrophages, engulfing and killing mic ...
... or implanted medical devices, and in those also infected with HIV. In all these cases, the host immune system is marginally or severely compromised. One key antibacterial mechanism within the innate immune system depends on phagocytes, including neutrophils and macrophages, engulfing and killing mic ...
Acute lung injury: how the lung inflammatory response works P.A. Ward
... causing tissue injury are released from recruited PMN and activated lung macrophages [4]. These include toxin oxygen (O2, hydrogen peroxide, etc.) and nitrogen (nitrosyl, peroxynitrite, etc.) products, together with proteases released from these phagocytic cells. Under certain conditions C5a can int ...
... causing tissue injury are released from recruited PMN and activated lung macrophages [4]. These include toxin oxygen (O2, hydrogen peroxide, etc.) and nitrogen (nitrosyl, peroxynitrite, etc.) products, together with proteases released from these phagocytic cells. Under certain conditions C5a can int ...
The Adjuvants Aluminum Hydroxide And MF59 Induce Monocyte And
... shown). Gated cells up-regulate the costimulatory molecule CD86 (B7-2) and down-regulate the monocyte lineage marker CD14 (Fig. 2B, bottom). None of these changes were induced by LPS. Similar effects were found on pure monocytes (data not shown). No other cell type present in PBMCs showed any phenot ...
... shown). Gated cells up-regulate the costimulatory molecule CD86 (B7-2) and down-regulate the monocyte lineage marker CD14 (Fig. 2B, bottom). None of these changes were induced by LPS. Similar effects were found on pure monocytes (data not shown). No other cell type present in PBMCs showed any phenot ...
New Insights on the Pathogenesis of Invasive Cryptococcus neoformans
... with certain immune functions, such as oxidative killing by phagocytes. If this is the case, the high antibody dose might increase phagocytosis but inhibit killing, thereby promoting the dissemination of Cn [11]. The effect of antibodies is further complicated by the genetic background of the host. ...
... with certain immune functions, such as oxidative killing by phagocytes. If this is the case, the high antibody dose might increase phagocytosis but inhibit killing, thereby promoting the dissemination of Cn [11]. The effect of antibodies is further complicated by the genetic background of the host. ...
Chapter 1 General introduction and outine of the thesis
... Skin resident immune cells include dermal Tcells and macrophages (Mφ) and epidermal Langerhans cells7,8. These cells are important for immune surveillance, but also prevent the immune system from reacting to harmless agents7. ...
... Skin resident immune cells include dermal Tcells and macrophages (Mφ) and epidermal Langerhans cells7,8. These cells are important for immune surveillance, but also prevent the immune system from reacting to harmless agents7. ...
Murine Effector Cells Crosstalk between Human IgG Isotypes and
... system in patients. Humanization had as a consequence that efficacy studies performed in mouse models, which represent a crucial step in preclinical development, are more difficult to interpret because of gaps in our knowledge of the activation of murine effector cells by human IgG (hIgG) remain. We ...
... system in patients. Humanization had as a consequence that efficacy studies performed in mouse models, which represent a crucial step in preclinical development, are more difficult to interpret because of gaps in our knowledge of the activation of murine effector cells by human IgG (hIgG) remain. We ...
Histology Lymphoid system General Concepts Functions Provides
... c. Plasma cells differentiate from B lymphocytes and produce humoral antibodies. d. Macrophages and dendritic cells phagocytose foreign matter, enhance the body’s response to antigen by “presenting” antigen to lymphocytes, and secrete immunomodulatory factors. 4. Lymph vessels a. Are thin-walled ves ...
... c. Plasma cells differentiate from B lymphocytes and produce humoral antibodies. d. Macrophages and dendritic cells phagocytose foreign matter, enhance the body’s response to antigen by “presenting” antigen to lymphocytes, and secrete immunomodulatory factors. 4. Lymph vessels a. Are thin-walled ves ...
Metabolic syndrome: the danger signal in atherosclerosis
... manifestations that occur after decades of silent progression. Despite recent progress in the treatment of cardiovascular disease associated with a significant reduction of death rates from 1990 to 2000, atherosclerotic disease is still the leading cause of mortality in developed countries (AHA 2006 ...
... manifestations that occur after decades of silent progression. Despite recent progress in the treatment of cardiovascular disease associated with a significant reduction of death rates from 1990 to 2000, atherosclerotic disease is still the leading cause of mortality in developed countries (AHA 2006 ...
Metabolic syndrome: the danger signal in
... manifestations that occur after decades of silent progression. Despite recent progress in the treatment of cardiovascular disease associated with a significant reduction of death rates from 1990 to 2000, atherosclerotic disease is still the leading cause of mortality in developed countries (AHA 2006 ...
... manifestations that occur after decades of silent progression. Despite recent progress in the treatment of cardiovascular disease associated with a significant reduction of death rates from 1990 to 2000, atherosclerotic disease is still the leading cause of mortality in developed countries (AHA 2006 ...
Immunogen, antigen, epitope, hapten
... TH cells are “helper cells” that send signals (via cytokines and surface proteins) to other cells of the immune system. The TH cells function as the “brain” of the immune system. ...
... TH cells are “helper cells” that send signals (via cytokines and surface proteins) to other cells of the immune system. The TH cells function as the “brain” of the immune system. ...
Leishmania species: models of intracellular parasitism
... gondii and Trypanosoma cruzi. The relationship between such organisms and their host cells is particularly intriguing because, not only are macrophages capable of potent microbicidal activity, but in their antigen-presenting capacity they can orchestrate the developing immune response. Thus, to init ...
... gondii and Trypanosoma cruzi. The relationship between such organisms and their host cells is particularly intriguing because, not only are macrophages capable of potent microbicidal activity, but in their antigen-presenting capacity they can orchestrate the developing immune response. Thus, to init ...
Innate Immune Response to the Dimorphic Fungal Pathogen
... IFN-γ and lipopolysaccharide (LPS) showed a similar fungicidal effect to that observed in non-stimulated macrophages [22,30]. These results may suggest that the fungicidal/fungistatic effect exerted by macrophages against Coccidioides depends on the fungal morphotype, indicating that arthroconidia a ...
... IFN-γ and lipopolysaccharide (LPS) showed a similar fungicidal effect to that observed in non-stimulated macrophages [22,30]. These results may suggest that the fungicidal/fungistatic effect exerted by macrophages against Coccidioides depends on the fungal morphotype, indicating that arthroconidia a ...
Pulparesponser
... Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells. They form an important part of the inflammatory response of the body against infection. These cytokines increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes, the cells ...
... Both IL-1α and IL-1β are produced by macrophages, monocytes and dendritic cells. They form an important part of the inflammatory response of the body against infection. These cytokines increase the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes, the cells ...
Thioaptamer decoy targeting of AP-1 proteins influences cytokine
... Viral haemorrhagic fever (VHF) is caused by a number of viruses, including arenaviruses. The pathogenesis is believed to involve dysregulation of cytokine production. The arenaviruses Lassa virus and Pichinde virus have a tropism for macrophages and other reticuloendothelial cells and both appear to ...
... Viral haemorrhagic fever (VHF) is caused by a number of viruses, including arenaviruses. The pathogenesis is believed to involve dysregulation of cytokine production. The arenaviruses Lassa virus and Pichinde virus have a tropism for macrophages and other reticuloendothelial cells and both appear to ...
The Pathogenesis of Abdominal Aortic Aneurysms
... perfusion of elastase, have been used to elucidate the role of various proteases during aneurysm formation. These models, as well as studies on human aortic tissue, suggest that various matrix metalloproteinase proteinases (MMPs), derived from macrophages and aortic smooth muscle cells, play an inte ...
... perfusion of elastase, have been used to elucidate the role of various proteases during aneurysm formation. These models, as well as studies on human aortic tissue, suggest that various matrix metalloproteinase proteinases (MMPs), derived from macrophages and aortic smooth muscle cells, play an inte ...
Agent Based Modeling of Atherosclerosis: A Concrete Help in
... and subsequent presentation by major histocompatibility complex class II at the macrophages surface. Recognition of ox-LDL by macrophages and naive B cells leads, by T helper lymphocytes cooperation, to the activation of humoral response and production of OLAB. When the OLAB/ox-LDL immune complexes ...
... and subsequent presentation by major histocompatibility complex class II at the macrophages surface. Recognition of ox-LDL by macrophages and naive B cells leads, by T helper lymphocytes cooperation, to the activation of humoral response and production of OLAB. When the OLAB/ox-LDL immune complexes ...
Title Hypoxia, innate immunity and infection in the lung Author(s
... expression of specific pattern recognition receptors on alveolar epithelial cells and resident macrophages and dendritic cells which recognise microbial structures and initiate innate immune responses which promote the clearance of potentially infectious agents. In a range of diseases, the mucosal s ...
... expression of specific pattern recognition receptors on alveolar epithelial cells and resident macrophages and dendritic cells which recognise microbial structures and initiate innate immune responses which promote the clearance of potentially infectious agents. In a range of diseases, the mucosal s ...
EVALUATION OF SOME MEDICINAL PLANTS FOR
... abilitity of LPS to increase macrophage activity, it could provide a second signal for synergistic induction of NO synthesis in macrophages, and may act synergistically with other mitogens in host defense system’s against microbial infection. Compound 5 activated both T and B lymphocytes signifying ...
... abilitity of LPS to increase macrophage activity, it could provide a second signal for synergistic induction of NO synthesis in macrophages, and may act synergistically with other mitogens in host defense system’s against microbial infection. Compound 5 activated both T and B lymphocytes signifying ...
Wheat Amylase Trypsin Inhibitors as Triggers of
... Family of up to 11 similar, small and compact proteins 5(4) intramolecular SS-bonds, resistant to intestinal degradation Pest control (inhibition of parasite enzymes) Tatham & Shewry, Clin Exp Allergy 2008 ...
... Family of up to 11 similar, small and compact proteins 5(4) intramolecular SS-bonds, resistant to intestinal degradation Pest control (inhibition of parasite enzymes) Tatham & Shewry, Clin Exp Allergy 2008 ...
Macrophage
Macrophages (Greek: big eaters, from makros ""large"" + phagein ""eat""; abbr. MΦ) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to the surface of healthy body cells on its surface in a process called phagocytosis. Macrophages were first discovered by Élie Metchnikoff, a Russian bacteriologist, in 1884. They are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They play a critical role in non-specific defense (innate immunity), and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes. In humans, dysfunctional macrophages cause severe diseases such as chronic granulomatous disease that result in frequent infections.Beyond increasing inflammation and stimulating the immune system, macrophages also play an important anti-inflammatory role and can decrease immune reactions through the release of cytokines. Macrophages that encourage inflammation are called M1 macrophages, whereas those that decrease inflammation and encourage tissue repair are called M2 macrophages. This difference is reflected in their metabolism, M1 macrophages have the unique ability to metabolize arginine to the ""killer"" molecule nitric oxide, whereas M2 macrophages have the unique ability to metabolize arginine to the ""repair"" molecule ornithine.Human macrophages are about 21 micrometres (0.00083 in) in diameter and are produced by the differentiation of monocytes in tissues. They can be identified using flow cytometry or immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68.