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Protein misfolding associated to mild modifications of local cellular pH
Protein misfolding associated to mild modifications of local cellular pH

... mutants: Gly26Arg (a substitution mutant with a gain in a positive charge), and Lys1070 (showing a deletion of a Lisine residue). Structural analysis shows that acidic pH induces a strong conformational shift, decreasing the cooperative denaturation pattern, and the hydrophobic cavities present in t ...
Biological Macromolecules
Biological Macromolecules

... Comprises sugars and polymers of sugars Used for variety of functions ...
Topics
Topics

... energy and form simpler end products ...
Cell Metabolism - Florida International University
Cell Metabolism - Florida International University

...  A globular (functional) protein that acts as a biological catalyst. 1) Contains special properties for regulation and catalysis (speed up) of specific chemical reactions 2) These enzymes are not being changed or used up in the process ...
Which of the following is a coenzyme associated with cellular
Which of the following is a coenzyme associated with cellular

... metabolize more fats for ATP which maintains blood glucose levels B. have the same number of mitochondria as a "couch potato" C. produce large quantities of lactate and ...
Protein Function Foldable Activity
Protein Function Foldable Activity

... Some proteins are messenger proteins which help to signal and coordinate certain bodily activities. These proteins are usually hormones, and one important example is insulin. Insulin sends signals to control blood-sugar concentration. ...
Script of Carbohydrates video
Script of Carbohydrates video

... Dehydration synthesis of a disaccharide (3.9) (look for the water) The reverse of this = hydrolysis (digestion) (look for the water) ...
Chemistry of Glycolysis
Chemistry of Glycolysis

... 3‐P DH is positive (+6.7 kJ/mole), the reaction proceeds to the right because A) triose phosphate isomerase supplies so much starting material. B) The product of the reaction is consumed as soon as it is made. C) there are too few molecules of starting material available. D) The Gibbs free energy is ...
Practice Test Questions
Practice Test Questions

... fermentation, ethanol or lactic acid phosphorylation, ATP an exchange reaction, FADH2 and NAD+ hydrogenation, NADPH2 ...
video slide
video slide

... • Chitin, another structural polysaccharide, is found in the exoskeleton of insects and the cell walls of fungi. • Chitin can be used as surgical thread because it is gradually reabsorbed by the body. • Chitin is not very digestible; only species that eat mainly insects can break it down easily. ...
The endoplasmic reticulum and the Golgi
The endoplasmic reticulum and the Golgi

...  SER enzymes regulate glycogen metabolism cAMP-dependent glycogen phosphorylase here! GlycogenG-1-PG-6-P Why does muscle SER lack glucose-6-phosphorylase? Why does hepatocyte SER have glucose-6-phosphorylase? ...
Photosynthesis and Cellular Respiration Review
Photosynthesis and Cellular Respiration Review

... 1. Describe the ways in which ATP can be used to perform cell work. 2. Explain the difference between oxidation and reduction reactions. Be sure to mention the changes in energy that accompany these reactions. 3. Illustrate the reaction performed by dehydrogenase enzymes. 4. What is the role played ...
NAME_________________ 1 BIO 451 13th
NAME_________________ 1 BIO 451 13th

... Binding of GTP induces a conformational change in Gα that causes it to dissociate from Gβδ . GTP binding also increases the affinity of Gα for adenylate cyclase, which is thereby activated. ...
Microbial metabolism
Microbial metabolism

... difference between these two – also a note on this slide saying I just want them to know that for both SLP and OP the energy yielod is greatest for aerobic respiration, lowest for fermentation and intermediate for anaerobic respiration; and also that in fermentation there is ONLY substrate level pho ...
glycogen
glycogen

... Since glycolysis releases little ATP, further reactions continue to convert pyruvic acid to acetyl CoA and then citric acid in the ...
Four Types of Organic Molecules
Four Types of Organic Molecules

... Chains can be straight, branched, or arranged in closed rings. Hydrocarbons contain carbon and hydrogen only, and are hydrophobic. H—C and C—C bonds are nonpolar. Hydrocarbons make up fossil fuels, and parts of cellular organic molecules such as fats and phospholipids. ...
Enzymes
Enzymes

... 3. Excess carbohydrates are stored as ______ in plants. 4. List two functions of a Lipid. ...
40Ch35nutrition02200..
40Ch35nutrition02200..

...  In humans ...
D (+)-Glucose, anhydrous
D (+)-Glucose, anhydrous

... Glucose is one of the major components of nutritional supplement solutions used in fed-batch biomanufacturing of recombinant proteins, monoclonal antibodies, viral vectors for gene therapy and viral vaccines from mammalian and insect cell cultures. Addition of such glucose containing supplements in ...
Review game
Review game

... 200 What is the final electron acceptor in the electron transport chain? Oxygen 300 Define chemiosmosis. Process of making ATP by movement of protons to provide energy so phosphorylation can occur 400 What is the name of the enzyme that is used to phosphorylate ADP into ATP? ATP synthase 500 What is ...
Replacement of threonine residues by serine and alanine in a
Replacement of threonine residues by serine and alanine in a

... the sequence context or by restrictions due to the conformation of the region into which the phosphorylatable residues are embedded. By systematically mutating putative phosphorylation sites into serine residues we have found a third phosphorylatable residue, T-1823, at the myosin heavy chain. The p ...
Liver- integrated lecture
Liver- integrated lecture

... • Acetyl~CoA is mostly converted to ketone bodies (small amount is oxidized completely) • Ketone bodies and FA are preferred by many tissues over glucose; they can also suppress proteolysis and BCA oxidation in muscle • Cooperation of tissues : liversynthesizes glucose, muscle and gut supply the sub ...
lect11
lect11

...  synthesis of glucose from a variety of non-carbohydrate metabolites  lactate, glycerol and the carbon skeletons of certain amino acids can all be used as substrates (propionyl-CoA can also be used) ...
gluconeogenesis
gluconeogenesis

... The brain alone requires about 120 g of glucose each day—more than half of all the glucose stored as glycogen in muscle and liver. However, the supply of glucose from these stores is not always sufficient; between meals and during longer fasts, or after vigorous exercise, glycogen is depleted. For t ...
2.5 Organelles Cooperate
2.5 Organelles Cooperate

... • A Lysosome fuses with it to mix its digestive enzymes with the food. Color the lysosome green. • Glucose from the food is released into the cytoplasm and absorbed by the mitochondria. Color the mitochondria blue. • Mitochondria perform respiration. During respiration mitochondria use glucose to ma ...
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Phosphorylation



Phosphorylation is the addition of a phosphate (PO43−) group to a protein or other organic molecule. Phosphorylation and its counterpart, dephosphorylation, turn many protein enzymes on and off, thereby altering their function and activity. Protein phosphorylation is one type of post-translational modification.Protein phosphorylation in particular plays a significant role in a wide range of cellular processes. Its prominent role in biochemistry is the subject of a very large body of research (as of March 2015, the Medline database returns over 240,000 articles on the subject, largely on protein phosphorylation).
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