INSILICO DRUG DESIGN AND MOLECULAR DOCKING STUDIES OF SOME NOVEL
... Objective: Cancer is a disease characterized by uncontrollable, irreversible, independent, autonomous, uncoordinated and relatively unlimited and abnormal over growth of tissues. Benzothiazole is an important class of heterocyclic compound which possess interesting biological activities like anti-tu ...
... Objective: Cancer is a disease characterized by uncontrollable, irreversible, independent, autonomous, uncoordinated and relatively unlimited and abnormal over growth of tissues. Benzothiazole is an important class of heterocyclic compound which possess interesting biological activities like anti-tu ...
COMPLETE PRESCRIBING INFORMATION
... estrogen-plus-progestin therapy compared with using estrogen-alone regimens. These include an increased risk of myocardial infarction, pulmonary embolism, invasive breast cancer and ovarian cancer. Systematic absorption may occur with the use of Premarin® Vaginal Cream. Warnings and precautions asso ...
... estrogen-plus-progestin therapy compared with using estrogen-alone regimens. These include an increased risk of myocardial infarction, pulmonary embolism, invasive breast cancer and ovarian cancer. Systematic absorption may occur with the use of Premarin® Vaginal Cream. Warnings and precautions asso ...
Gastroenterology
... Treatment of hypercalcemia Cessation of possible causative drugs Mild pancreatitis is treated for several days with supportive care consisting of analgesia, IVF, and NPO. Consider nasogastric tube for ileus or vomiting. Role of antibiotic prophylaxis (in absence of necrosis) is controversi ...
... Treatment of hypercalcemia Cessation of possible causative drugs Mild pancreatitis is treated for several days with supportive care consisting of analgesia, IVF, and NPO. Consider nasogastric tube for ileus or vomiting. Role of antibiotic prophylaxis (in absence of necrosis) is controversi ...
Inhibition of platelet aggregability by losartan in essential hypertension
... were within the range reported in other studies 12 and not different when measurements were repeated 30 days after (p < 0.05). Baseline plasma levels of PAI-1 in hypertensive subjects averaged 78.68 ± 50.40 ng/ml during the placebo period (fig. 2). Although these values were 66% higher than those fo ...
... were within the range reported in other studies 12 and not different when measurements were repeated 30 days after (p < 0.05). Baseline plasma levels of PAI-1 in hypertensive subjects averaged 78.68 ± 50.40 ng/ml during the placebo period (fig. 2). Although these values were 66% higher than those fo ...
July - EFSA
... the uncertainties in the database on reproduction and development, was no longer required. The Panel also concluded, in view of the well described species differences in toxicokinetics, showing a low level of free BPA in humans compared with rats, that a default uncertainty factor of 100 applied to ...
... the uncertainties in the database on reproduction and development, was no longer required. The Panel also concluded, in view of the well described species differences in toxicokinetics, showing a low level of free BPA in humans compared with rats, that a default uncertainty factor of 100 applied to ...
Epigallocatechin 3-Gallate and Green Tea Catechins
... plays a functional role in cell transformation and cancer formation, and glucose-regulated protein 78 is associated with the multidrug resistance phenotype of many types of cancer cells. The many targets of polyphenols that have been discovered and continue to be discovered are very likely dependent ...
... plays a functional role in cell transformation and cancer formation, and glucose-regulated protein 78 is associated with the multidrug resistance phenotype of many types of cancer cells. The many targets of polyphenols that have been discovered and continue to be discovered are very likely dependent ...
Morphine HO- Group is needed for activity HO
... there were few pharmacological tools for the study of δ receptors. As a consequence, our understanding of their function is much more limited than those of the other opioid receptors.Recent work indicates that exogenous ligands which activate the delta receptors mimic the phenomenon known as 'ischem ...
... there were few pharmacological tools for the study of δ receptors. As a consequence, our understanding of their function is much more limited than those of the other opioid receptors.Recent work indicates that exogenous ligands which activate the delta receptors mimic the phenomenon known as 'ischem ...
COMPLETE PRESCRIBING INFORMATION
... estrogen-plus-progestin therapy compared with using estrogen-alone regimens. These include an increased risk of myocardial infarction, pulmonary embolism, invasive breast cancer and ovarian cancer. Systematic absorption may occur with the use of Premarin® Vaginal Cream. Warnings and precautions asso ...
... estrogen-plus-progestin therapy compared with using estrogen-alone regimens. These include an increased risk of myocardial infarction, pulmonary embolism, invasive breast cancer and ovarian cancer. Systematic absorption may occur with the use of Premarin® Vaginal Cream. Warnings and precautions asso ...
Toxicologic Pathology Induced Oxidative Liver Damage -Carotene on Methotrexate
... Cetinkaya et al. 2006; Cetin et al. 2008) and decreasing SOD activities (Cetinkaya et al. 2006; Cetin et al. 2008). The oxidative damage increasing with MTX in liver tissue was prevented by dosing b-carotene for 21 days prior to MTX administration. It plays an important role in protecting cell membr ...
... Cetinkaya et al. 2006; Cetin et al. 2008) and decreasing SOD activities (Cetinkaya et al. 2006; Cetin et al. 2008). The oxidative damage increasing with MTX in liver tissue was prevented by dosing b-carotene for 21 days prior to MTX administration. It plays an important role in protecting cell membr ...
Synergism and Antagonism in Toxicity of Mixtures
... environmental half-lives they are assumed to be “pseudopersistents” due to their polar and non-volatile nature which prevents them from escaping the aquatic realm (Hernando et al., 2006). Additionally, the constant input of pharmaceuticals may also induce toxic effects even in trace amounts due to h ...
... environmental half-lives they are assumed to be “pseudopersistents” due to their polar and non-volatile nature which prevents them from escaping the aquatic realm (Hernando et al., 2006). Additionally, the constant input of pharmaceuticals may also induce toxic effects even in trace amounts due to h ...
Potential applications of mussel modelling
... The definition of a model is a simplified (often mathematical) description of a system, created in order to assist in understanding calculations and predictions. Models are particularly useful in the identification of areas that require further research but are also useful for practical management o ...
... The definition of a model is a simplified (often mathematical) description of a system, created in order to assist in understanding calculations and predictions. Models are particularly useful in the identification of areas that require further research but are also useful for practical management o ...
DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF
... induced emesis. The adult dose is 8 mg and its metabolites are excreted in urine with about 10% of unchanged drug and having 67% of bioavailability through oral route. In the present investigation FDT of Ondansetron HCl was developed by maximizing the porous structure of the tablet matrix, incorpora ...
... induced emesis. The adult dose is 8 mg and its metabolites are excreted in urine with about 10% of unchanged drug and having 67% of bioavailability through oral route. In the present investigation FDT of Ondansetron HCl was developed by maximizing the porous structure of the tablet matrix, incorpora ...
ANTIDEPRESSANTS: SSRIs (p.1) 1. Introduction SSRIs (Selective
... 10. Specific SSRIs: fluvoxetine/Prozac the SSRI “grandparent” molecule…started it all, became available in 1988 considered a new line of drugs for tx of depression almost the efficacy of imipramine/Tofranil with no cardiovas SEs ? more acceptable/fewer side effects --- greater compliance rates allow ...
... 10. Specific SSRIs: fluvoxetine/Prozac the SSRI “grandparent” molecule…started it all, became available in 1988 considered a new line of drugs for tx of depression almost the efficacy of imipramine/Tofranil with no cardiovas SEs ? more acceptable/fewer side effects --- greater compliance rates allow ...
Wrath Thor UNSIN
... 5-HT1B 5-HT1B receptors can be found both pre- and post-synaptically in various areas of the brain outside of the OFC, including the basal ganglia and the striatum.4 By administering a 5-HT1B agonist as treatment for wrath, it is likely that many adverse side effects would occur as a result of dispe ...
... 5-HT1B 5-HT1B receptors can be found both pre- and post-synaptically in various areas of the brain outside of the OFC, including the basal ganglia and the striatum.4 By administering a 5-HT1B agonist as treatment for wrath, it is likely that many adverse side effects would occur as a result of dispe ...
Redalyc.Neurobiological alterations in alcohol addiction: a review
... GABA or γ-amino-butyric acid is the principal inhibitory neurotransmitter in the brain, and the GABAergic system plays an important role in the behavioural and pharmacological effects of ethanol. GABAA receptor protein complex is composed of five subunits, assembled to form a channel across the neur ...
... GABA or γ-amino-butyric acid is the principal inhibitory neurotransmitter in the brain, and the GABAergic system plays an important role in the behavioural and pharmacological effects of ethanol. GABAA receptor protein complex is composed of five subunits, assembled to form a channel across the neur ...
Liver Enlargement - STP Regulatory Policy Papers
... from other peroxisome proliferators, in Sprague-Dawley rats, CD1 mice, and Beagle dogs, treatment for fourteen (rats) or twenty-eight (mice and dogs) days produced liver enlargement in all three species (Richert et al. 2008). Although the magnitude of the change in absolute and/or relative liver wei ...
... from other peroxisome proliferators, in Sprague-Dawley rats, CD1 mice, and Beagle dogs, treatment for fourteen (rats) or twenty-eight (mice and dogs) days produced liver enlargement in all three species (Richert et al. 2008). Although the magnitude of the change in absolute and/or relative liver wei ...
How Toxic is Amiodarone to the Liver?
... Low doses can be consumed with impunity by the majority of the population, but as the dose of alcohol increases (implying exposure to high blood concentrations), so does the likelihood of serious hepatic damage [5]. Nonetheless, a significant portion of patients demonstrate resistance to the negativ ...
... Low doses can be consumed with impunity by the majority of the population, but as the dose of alcohol increases (implying exposure to high blood concentrations), so does the likelihood of serious hepatic damage [5]. Nonetheless, a significant portion of patients demonstrate resistance to the negativ ...
Recent advances in natural products from plants for
... hepatitis are much more likely to have liver cell damage and cirrhosis, and some may eventually develop HCC, which is unfortunately, and very often, a fatal malignancy without cure. Although treatment options exist for most of the liver diseases, many types remain incurable and the emergence of drug ...
... hepatitis are much more likely to have liver cell damage and cirrhosis, and some may eventually develop HCC, which is unfortunately, and very often, a fatal malignancy without cure. Although treatment options exist for most of the liver diseases, many types remain incurable and the emergence of drug ...
1 The northern pocket gopher (Thomomys talpoides) is a rodent
... Induced infertility is another method of biological control that is still in its infancy (Miller and Fagerstone 2000). Although this approach shows promise, there are many biological and regulatory hurdles before this becomes a cost-effective method to control gopher reproductive rates (Miller and F ...
... Induced infertility is another method of biological control that is still in its infancy (Miller and Fagerstone 2000). Although this approach shows promise, there are many biological and regulatory hurdles before this becomes a cost-effective method to control gopher reproductive rates (Miller and F ...
Regulation of Brain Reward by the Endocannabinoid System: A
... early 1990s and are named so because they were first found to activate the same receptors as natural cannabinoids. The two most widely studied endocannabinoids are N-arachidonoylethanolamide (AEA), also called anandamide [36], and 2-arachidonoylglycerol (2-AG) [37, 38]. It should be noted that AEA c ...
... early 1990s and are named so because they were first found to activate the same receptors as natural cannabinoids. The two most widely studied endocannabinoids are N-arachidonoylethanolamide (AEA), also called anandamide [36], and 2-arachidonoylglycerol (2-AG) [37, 38]. It should be noted that AEA c ...
Basics Pharmacology Review - Dr. Roland Halil
... aka “Take this life-saving therapy; it has no risks, but it’ll cost you $1 million and you’ll need blood tests twice daily” ...
... aka “Take this life-saving therapy; it has no risks, but it’ll cost you $1 million and you’ll need blood tests twice daily” ...
Development of Antiestrogens and Their Use in Breast Cancer
... endogenous pool of estrogens. Biologically available estrogen can also be reduced by increased catabolism or altering the plasma level of estrogen-binding protein. Another way to inter fere with estrogen activity is to block it at the level of its receptor in estrogen target tissues. Development of ...
... endogenous pool of estrogens. Biologically available estrogen can also be reduced by increased catabolism or altering the plasma level of estrogen-binding protein. Another way to inter fere with estrogen activity is to block it at the level of its receptor in estrogen target tissues. Development of ...
Safety Assessment and Dose Selection for First-in
... oncology, treatment duration in FIH studies may considerably exceed preclinical coverage in animal studies. Most of these considerations are applicable to mAbs in general. The high species specificity of the sequence/structure of most immune receptors targeted by mAbs makes the selection of an appro ...
... oncology, treatment duration in FIH studies may considerably exceed preclinical coverage in animal studies. Most of these considerations are applicable to mAbs in general. The high species specificity of the sequence/structure of most immune receptors targeted by mAbs makes the selection of an appro ...
Basics Pharmacology Review - Dr. Roland Halil
... Clinical Pharmacist, Bruyere Academic Family Health Team March 2014 [email protected] (Partially adapted from slides by Marc Riachi, R.Ph.) ...
... Clinical Pharmacist, Bruyere Academic Family Health Team March 2014 [email protected] (Partially adapted from slides by Marc Riachi, R.Ph.) ...
Hepatitis B (HBV)
... Hepatitis A (HAV) • Similar to that of a typical viral syndrome; often goes unrecognized • Spread via the fecal-oral route by oral ingestion of fecal contaminants • Contaminated water, shellfish from contaminated water, food contaminated by handlers infected with hepatitis A • Also spread by oral-a ...
... Hepatitis A (HAV) • Similar to that of a typical viral syndrome; often goes unrecognized • Spread via the fecal-oral route by oral ingestion of fecal contaminants • Contaminated water, shellfish from contaminated water, food contaminated by handlers infected with hepatitis A • Also spread by oral-a ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.