introduction - RUJA - Universidad de Jaén
... exposures; and 3) Assess the influence of ecological interactions on the sensitivity response of aquatic species to agrochemicals. The working hypothesis under this scenarios and objectives is that agrochemicals exposure due to prevailing agriculture intensive practices has negative effects on the ...
... exposures; and 3) Assess the influence of ecological interactions on the sensitivity response of aquatic species to agrochemicals. The working hypothesis under this scenarios and objectives is that agrochemicals exposure due to prevailing agriculture intensive practices has negative effects on the ...
Striatal D2 / D3 Receptor Occupancy, ... and Side Effects with Amisulpride: An Iodine-123-Iodobenzamide SPET Study
... Up to now, there are different models about the mechanisms of the atypical action of amisulpride. It may be related to its preferential autoreceptor binding, especially at low doses. Alternatively, its preferential interaction with the limbic dopaminergic system may give it the benefit of atypicality ...
... Up to now, there are different models about the mechanisms of the atypical action of amisulpride. It may be related to its preferential autoreceptor binding, especially at low doses. Alternatively, its preferential interaction with the limbic dopaminergic system may give it the benefit of atypicality ...
TAMOXIFEN: SAFE WORK PRACTICES INFORMATION PAGE
... developing (fetal through adolescent) human genital tract (Cunha GR et al., 1987). Thus, emphasizing the need for caution to prevent inadvertent exposure of the developing fetus to this compound. Tamoxifen is included on the “Dangerous Properties of Industrial Materials” listing of know human carcin ...
... developing (fetal through adolescent) human genital tract (Cunha GR et al., 1987). Thus, emphasizing the need for caution to prevent inadvertent exposure of the developing fetus to this compound. Tamoxifen is included on the “Dangerous Properties of Industrial Materials” listing of know human carcin ...
A New Approach to Homeostatic Regulation: Towards a Unified
... which has to deal with the laws according to which substances unite to form chemical compounds’’ [1]. Chemical stoichiometry involves a complex of limitations controlling the interactions between chemical elements. Also in biology, there are boundaries to how chemical elements are assembled, especia ...
... which has to deal with the laws according to which substances unite to form chemical compounds’’ [1]. Chemical stoichiometry involves a complex of limitations controlling the interactions between chemical elements. Also in biology, there are boundaries to how chemical elements are assembled, especia ...
The Stability and Persistence of Mutualisms Embedded in
... In other words, that effects must be greater than interaction effects. Because this is a rather strict condition for stability, it has been suggested that mutualisms are, in general, destabilizing, and should be less likely in the real world than other types of interactions (May, 1973). Numerous inv ...
... In other words, that effects must be greater than interaction effects. Because this is a rather strict condition for stability, it has been suggested that mutualisms are, in general, destabilizing, and should be less likely in the real world than other types of interactions (May, 1973). Numerous inv ...
Pesticide effects on freshwater zooplankton: an ecological perspective
... PII: S0269-7491(00)00110-X ...
... PII: S0269-7491(00)00110-X ...
morphine
... C. Effects of opioids with both agonist and antagonist actions: • Buprenorphine binds μ receptors with high affinity but low intrinsic activity. • It dissociates slowly from the receptor making it an alternative to methadone for treatment of opioid withdrawal. • It functions as an antagonist at δ an ...
... C. Effects of opioids with both agonist and antagonist actions: • Buprenorphine binds μ receptors with high affinity but low intrinsic activity. • It dissociates slowly from the receptor making it an alternative to methadone for treatment of opioid withdrawal. • It functions as an antagonist at δ an ...
Serotonergic Manipulations Both Potentiate and Reduce Brain
... duration of 500 ms and consisted of 0.1-ms rectangular cathodal pulses that were delivered with 100-Hz frequency. The current intensity delivered was adjusted for each animal and typically ranged from 100 to 250 A. After successful familiarization with this procedure (two sessions of 100 reinforcer ...
... duration of 500 ms and consisted of 0.1-ms rectangular cathodal pulses that were delivered with 100-Hz frequency. The current intensity delivered was adjusted for each animal and typically ranged from 100 to 250 A. After successful familiarization with this procedure (two sessions of 100 reinforcer ...
Tetracyclines
... concentrations are somewhat blunted. Elimination is primarily biliary, and no dosage adjustment is needed for patients with renal insufficiency. In addition to the tetracycline class effects, the chief adverse effect of tigecycline is nausea, which occurs in up to one third of patients, and occasion ...
... concentrations are somewhat blunted. Elimination is primarily biliary, and no dosage adjustment is needed for patients with renal insufficiency. In addition to the tetracycline class effects, the chief adverse effect of tigecycline is nausea, which occurs in up to one third of patients, and occasion ...
Modeling multiple nonconsumptive effects in
... exacerbation of the ecosystem impacts of fishing down large marine predators (Madin et al. 2010). Yet, despite this wealth of empirical studies, there remains a dearth of empirically informed models of NCEs. This lack of data-informed models is not due to a lack of theoretical work on NCEs. The theo ...
... exacerbation of the ecosystem impacts of fishing down large marine predators (Madin et al. 2010). Yet, despite this wealth of empirical studies, there remains a dearth of empirically informed models of NCEs. This lack of data-informed models is not due to a lack of theoretical work on NCEs. The theo ...
Marijuana - Destiny High School
... • Describe physical consequences of marijuana use. • Describe mental and emotional consequences of using marijuana. • Explain how marijuana use can increase traffic accidents. • Explain the dangers of using inhalants. • Describe physical consequences of using steroids. ...
... • Describe physical consequences of marijuana use. • Describe mental and emotional consequences of using marijuana. • Explain how marijuana use can increase traffic accidents. • Explain the dangers of using inhalants. • Describe physical consequences of using steroids. ...
bio identical hormones - Riverton Healthcare For Women
... Bioidentical hormones are manufactured in the lab to have the same molecular structure as the hormones made by your own body. By contrast, synthetic hormones are intentionally different. Drug companies can’t patent a bioidentical structure, so they invent synthetic hormones that are patentable (Prem ...
... Bioidentical hormones are manufactured in the lab to have the same molecular structure as the hormones made by your own body. By contrast, synthetic hormones are intentionally different. Drug companies can’t patent a bioidentical structure, so they invent synthetic hormones that are patentable (Prem ...
PHYTOCHEMICAL EVALUATION AND HEPATOPROTECTIVE ACTIVITY OF FRESH JUICE OF A. JUSS Research Article
... which no mortality was found, hence the doses of 200 mg/kg, 500mg/kg body weight were selected approximately for pharmacological studies. For assessment of hepatoprotective activity, the degree of hepatotoxicity developed was determined by withdrawing blood and evaluatin ...
... which no mortality was found, hence the doses of 200 mg/kg, 500mg/kg body weight were selected approximately for pharmacological studies. For assessment of hepatoprotective activity, the degree of hepatotoxicity developed was determined by withdrawing blood and evaluatin ...
Fatty acid amide hydrolase - The Scripps Research Institute
... structure of FAAH also revealed that this enzyme possesses a remarkable collection of channels that appear to grant it simultaneous access to both the membrane and cytoplasmic compartments of the cell (Figure 4), possibly to facilitate substrate binding, product release and catalytic turnover. These ...
... structure of FAAH also revealed that this enzyme possesses a remarkable collection of channels that appear to grant it simultaneous access to both the membrane and cytoplasmic compartments of the cell (Figure 4), possibly to facilitate substrate binding, product release and catalytic turnover. These ...
Non-steroidal anti- inflammatory drugs (NSAIDs)
... For understanding the concept… Inhibition of prostaglandin synthesis by a number of unrelated compounds • Cortisol (a steroidal anti-inflammatory agent) • inhibit phospholipase A2 activity (therefore arachidonic acid, ...
... For understanding the concept… Inhibition of prostaglandin synthesis by a number of unrelated compounds • Cortisol (a steroidal anti-inflammatory agent) • inhibit phospholipase A2 activity (therefore arachidonic acid, ...
B2B Basics Pharmacology Review
... Michael Lewis makes this point convincingly using statistics from major league baseball: “Over a long season the luck evens out, and skill shines through.” Mauboussin, M. Decision-Making for Investors: Theory, Practice & Pitfalls. May 24, 2004 http://www.retailinvestor.org/pdf/decisionmaking.pdf Acc ...
... Michael Lewis makes this point convincingly using statistics from major league baseball: “Over a long season the luck evens out, and skill shines through.” Mauboussin, M. Decision-Making for Investors: Theory, Practice & Pitfalls. May 24, 2004 http://www.retailinvestor.org/pdf/decisionmaking.pdf Acc ...
Patterns of Drug-induced Liver Injury
... Liver biopsy rarely diagnostic in isolation and no longer considered mandatory for diagnosis (NIDDK/NIH Clinical Research Workshop – Fontana, Hepatology ...
... Liver biopsy rarely diagnostic in isolation and no longer considered mandatory for diagnosis (NIDDK/NIH Clinical Research Workshop – Fontana, Hepatology ...
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces
... training drug was considered as no substitution (Solinas et al., 2006). Data Analysis. All data are presented as mean 6 S.E.M. For allodynia testing, psychometric behavioral analysis was performed to compute the log stiffness that would have resulted in the 50% paw withdrawal rate, as previously des ...
... training drug was considered as no substitution (Solinas et al., 2006). Data Analysis. All data are presented as mean 6 S.E.M. For allodynia testing, psychometric behavioral analysis was performed to compute the log stiffness that would have resulted in the 50% paw withdrawal rate, as previously des ...
Local Anesthetics
... A: Cartoon of the sodium channel in an axonal membrane in the resting (m gates closed, h gate open), activated (m gates open, h gate open), and inactivated states (m gates open, h gate closed). Recovery from the inactivated, refractory state requires closure of the m gates and opening of the h gate ...
... A: Cartoon of the sodium channel in an axonal membrane in the resting (m gates closed, h gate open), activated (m gates open, h gate open), and inactivated states (m gates open, h gate closed). Recovery from the inactivated, refractory state requires closure of the m gates and opening of the h gate ...
Section II. Autonomic Drugs Chapter 6. Introduction to Autonomic
... transmission takes place through the release of small amounts of transmitter substances from the nerve terminals into the synaptic cleft. The transmitter crosses the cleft by diffusion and activates or inhibits the postsynaptic cell by binding to a specialized receptor molecule. By using drugs that ...
... transmission takes place through the release of small amounts of transmitter substances from the nerve terminals into the synaptic cleft. The transmitter crosses the cleft by diffusion and activates or inhibits the postsynaptic cell by binding to a specialized receptor molecule. By using drugs that ...
Beetles
... While other research programmes have been developed involving different mechanisms, such as neutral theory (see Hubbell 2001), few have incorporated important behavioural mechanisms which can possibly alter species distributions and abundances. ...
... While other research programmes have been developed involving different mechanisms, such as neutral theory (see Hubbell 2001), few have incorporated important behavioural mechanisms which can possibly alter species distributions and abundances. ...
The role of mixotrophic protists in the biological carbon pump
... describes consumption of inorganic nutrients by photoautotrophic phytoplankton, which in turn supports zooplankton and ultimately higher trophic levels. Pathways centred on bacteria provide mechanisms for nutrient recycling. This structure lies at the foundation of most models used to explore biogeo ...
... describes consumption of inorganic nutrients by photoautotrophic phytoplankton, which in turn supports zooplankton and ultimately higher trophic levels. Pathways centred on bacteria provide mechanisms for nutrient recycling. This structure lies at the foundation of most models used to explore biogeo ...
General Anaesthetics
... injection site pain, Inadvertent injection – Acute porphyria, hypotension, apnea, resp depression, hyperalgesia, local necrosis, ...
... injection site pain, Inadvertent injection – Acute porphyria, hypotension, apnea, resp depression, hyperalgesia, local necrosis, ...
Heart Glucocorticoids Activate Cardiac Mineralocorticoid Receptors
... online Data Supplement at http://hyper.ahajournals.org). Apoptosis in cardiac tissue was measured in sections cut from paraffinembedded sections by TUNEL (Roche; please see the online ...
... online Data Supplement at http://hyper.ahajournals.org). Apoptosis in cardiac tissue was measured in sections cut from paraffinembedded sections by TUNEL (Roche; please see the online ...
PDF
... pest species often create new economic pests out of other pest species that had previously been of minor or sporadic importance. These species, known as secondary pests, are those which in “normal” growing seasons do not inflict major crop damage, although significant outbreaks may sometimes be stim ...
... pest species often create new economic pests out of other pest species that had previously been of minor or sporadic importance. These species, known as secondary pests, are those which in “normal” growing seasons do not inflict major crop damage, although significant outbreaks may sometimes be stim ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.