Using Traditional Ecological Knowledge to Improve Holistic
... Key Words: consensus-building process; ecosystem-level management alternatives; fishing seascape; loop analysis; pressurestate-response framework; traditional ecological knowledge; transdisciplinary modeling INTRODUCTION Fisheries have traditionally been managed using speciesspecific regulations for ...
... Key Words: consensus-building process; ecosystem-level management alternatives; fishing seascape; loop analysis; pressurestate-response framework; traditional ecological knowledge; transdisciplinary modeling INTRODUCTION Fisheries have traditionally been managed using speciesspecific regulations for ...
Patient-Derived Xenograft Models: An Emerging
... immunosuppression have been used in these studies. Supplementary Table S1 lists the principal characteristics of the most commonly used mouse strains, including their level of immune suppression as well as advantages or disadvantages. For hormone-sensitive tumors, some studies have used hormone supp ...
... immunosuppression have been used in these studies. Supplementary Table S1 lists the principal characteristics of the most commonly used mouse strains, including their level of immune suppression as well as advantages or disadvantages. For hormone-sensitive tumors, some studies have used hormone supp ...
Insulin-like Growth Factor: Current Concepts and New
... cancer, for which no reliable screening method exists and is desperately needed, results have also been inconsistent. Whereas one cohort exhibited a trend towards increased IGF-1 levels and risk of ovarian cancer in younger patients [34], a larger cohort exhibited no association between IGFBP3, IGFB ...
... cancer, for which no reliable screening method exists and is desperately needed, results have also been inconsistent. Whereas one cohort exhibited a trend towards increased IGF-1 levels and risk of ovarian cancer in younger patients [34], a larger cohort exhibited no association between IGFBP3, IGFB ...
Management of Graves` Disease in Children and Adolescents
... to minimize residual T and decrease tumour risk. Post I-131, T4 Px to prevent raised TSH No evidence for increase birth defects in offspring of pts Px w/ I-131 Careful FU for all GD pts. Should include regular exam of TG. All new T nodules Bx / excised. Radiation-related thyroid tumours more t ...
... to minimize residual T and decrease tumour risk. Post I-131, T4 Px to prevent raised TSH No evidence for increase birth defects in offspring of pts Px w/ I-131 Careful FU for all GD pts. Should include regular exam of TG. All new T nodules Bx / excised. Radiation-related thyroid tumours more t ...
Chronic Treatment with Dopamine Receptor Antagonists
... drugs (Tarsy and Baldessarini, 1974). The chronic treatment of rodents with neuroleptics does not usually result in the obvious dyskinetic movements of tardive dyskinesia, but does result in an increased sensitivity to the motor stimulatory effects of dopamine agonists, accompanied by an increase in ...
... drugs (Tarsy and Baldessarini, 1974). The chronic treatment of rodents with neuroleptics does not usually result in the obvious dyskinetic movements of tardive dyskinesia, but does result in an increased sensitivity to the motor stimulatory effects of dopamine agonists, accompanied by an increase in ...
Case History - Children`s Hospital of Michigan
... DXM). Dextrorphan blocks the NMDA receptor (calcium channel) by binding to the PCP (phencyclidine) site. In fact, the structural similarities between DXM and PCP may cause a false positive drug screen for PCP. DXM has also been shown to block N- and L-type voltage-dependent calcium channels and nico ...
... DXM). Dextrorphan blocks the NMDA receptor (calcium channel) by binding to the PCP (phencyclidine) site. In fact, the structural similarities between DXM and PCP may cause a false positive drug screen for PCP. DXM has also been shown to block N- and L-type voltage-dependent calcium channels and nico ...
Guidelines for use of Digoxin (Lanoxin )
... 1. Digoxin preparations must be stored in tightly covered, light resistant containers at room temp. 2. FOLLOW CLOSELY (especially in patients receiving diuretics or amphotericin) for decreased serum potassium (K), magnesium (Mg), or thyroxine (T4) along with increased calcium (Ca) will increase digo ...
... 1. Digoxin preparations must be stored in tightly covered, light resistant containers at room temp. 2. FOLLOW CLOSELY (especially in patients receiving diuretics or amphotericin) for decreased serum potassium (K), magnesium (Mg), or thyroxine (T4) along with increased calcium (Ca) will increase digo ...
Allopatric Mimicry - Sierra Herps Logo
... model and mimic occur together, thus maintaining a lower number of red bands. A related hypothesis is that there is gene flow in predator populations from areas where there are models to areas were there are no models. The same map (Figure 13) can be invoked to illustrate this possible phenomenon. H ...
... model and mimic occur together, thus maintaining a lower number of red bands. A related hypothesis is that there is gene flow in predator populations from areas where there are models to areas were there are no models. The same map (Figure 13) can be invoked to illustrate this possible phenomenon. H ...
Benzodiazepines Dr A Battersby 16th March 2012
... • No BDZ negative urine screens in last 4 mths • Evidence from history and symptoms that pt is physically dependent on BDZ • You believe benefits of Tx will outweigh the adverse effects and risks eg diversion • You are happy to take clinical responsibility ...
... • No BDZ negative urine screens in last 4 mths • Evidence from history and symptoms that pt is physically dependent on BDZ • You believe benefits of Tx will outweigh the adverse effects and risks eg diversion • You are happy to take clinical responsibility ...
Full-Text PDF
... to this pocket can prevent PDKs from binding to PDC but with minimal effect on the function of the enzyme complex. To identify new compounds that could potentially inhibit PDK1 through binding to the lipoamide-binding pocket, a virtual screening was carried out using Libdock [35] module of Discovery ...
... to this pocket can prevent PDKs from binding to PDC but with minimal effect on the function of the enzyme complex. To identify new compounds that could potentially inhibit PDK1 through binding to the lipoamide-binding pocket, a virtual screening was carried out using Libdock [35] module of Discovery ...
Serum Transaminase Elevations as Indicators of - UNC
... dose and duration of exposure. In addition, many chemicals preferentially affect certain cell populations but not others in the same host. Major histologic lesions of the liver due to chemical toxicity include fatty change, hepatocellular death, and hepatobiliary lesions. Granulomatous and mixed his ...
... dose and duration of exposure. In addition, many chemicals preferentially affect certain cell populations but not others in the same host. Major histologic lesions of the liver due to chemical toxicity include fatty change, hepatocellular death, and hepatobiliary lesions. Granulomatous and mixed his ...
Uncoupling between noradrenergic and serotonergic neurons as a
... hypersensitivity, as displayed by adenylyl cyclase activity coupled to DA in the prefrontal cortex [7]. Interestingly, both the locomotor hyperactivity and the hypersensitivity of cortical D1 receptors were not obtained when dopaminergic cell bodies were destroyed chemically by a 6-hydroxy-dopamine ...
... hypersensitivity, as displayed by adenylyl cyclase activity coupled to DA in the prefrontal cortex [7]. Interestingly, both the locomotor hyperactivity and the hypersensitivity of cortical D1 receptors were not obtained when dopaminergic cell bodies were destroyed chemically by a 6-hydroxy-dopamine ...
antipsychotics- - Department of Psychiatric Nursing
... the last century that it was established as a separate entity amongst other mental disorders. Many treatments have been devise: ...
... the last century that it was established as a separate entity amongst other mental disorders. Many treatments have been devise: ...
Adaptation, density dependence and the responses of trophic level
... The responses of abundances to the extrinsic per capita mortality rates are obtained by differentiating the equilibrium conditions for equations (1a–d) with respect to each of the di. The resulting formulae can be simplified somewhat by assuming that the equilibrium of the system is locally stable. ...
... The responses of abundances to the extrinsic per capita mortality rates are obtained by differentiating the equilibrium conditions for equations (1a–d) with respect to each of the di. The resulting formulae can be simplified somewhat by assuming that the equilibrium of the system is locally stable. ...
Steroids - Montana Narcotics Officers Association
... Although different types of steroids exist naturally in humans, the drugs commonly known as anabolic steroids are synthetic chemical compounds designed to create certain effects that natural hormones cause in the body. Steroid is the generic name given to compounds having a basic ring structure simi ...
... Although different types of steroids exist naturally in humans, the drugs commonly known as anabolic steroids are synthetic chemical compounds designed to create certain effects that natural hormones cause in the body. Steroid is the generic name given to compounds having a basic ring structure simi ...
Hormesis: Once Marginalized, Evidence Now Supports Hormesis as
... Arndt–Schulz law at the time) had to be marginalized, and (2) a credible alternative had to be formulated, and this becoming the threshold dose-response model, the model on which 20th century clinical pharmacology, toxicology, and risk assessment would be based. The most notable critic of Schulz was ...
... Arndt–Schulz law at the time) had to be marginalized, and (2) a credible alternative had to be formulated, and this becoming the threshold dose-response model, the model on which 20th century clinical pharmacology, toxicology, and risk assessment would be based. The most notable critic of Schulz was ...
The Frequency of Sister Chromatid Exchanges in Cultured Human
... MTZ was originally introduced to treat Trichomonas vaginalis infections. Moreover, MTZ has been proposed as a drug of choice against Helicobacter pylori, which is considered the etiological agent for active chronic gastritis. It is reported that this nitroimidazole derivative binds covalently to gua ...
... MTZ was originally introduced to treat Trichomonas vaginalis infections. Moreover, MTZ has been proposed as a drug of choice against Helicobacter pylori, which is considered the etiological agent for active chronic gastritis. It is reported that this nitroimidazole derivative binds covalently to gua ...
Carboxylesterases Are Uniquely Expressed among Tissues and
... model induced by high-fat feeding, two model systems relevant to disease. Overall these data show that each mouse Ces gene has its own distinctive tissue expression pattern and suggest that some CES may have tissue-specific roles in lipid metabolism and xenobiotic clearance. ...
... model induced by high-fat feeding, two model systems relevant to disease. Overall these data show that each mouse Ces gene has its own distinctive tissue expression pattern and suggest that some CES may have tissue-specific roles in lipid metabolism and xenobiotic clearance. ...
Chemoprevention_review_final_revision_HMW_edit_title
... figure indicates that COX2 has potential to be a target for chemoprevention. As these 4 malignancies total more than half of the cancer deaths in UK and USA, this emphasises the need for chemoprevention against colon, breast, prostate and lung cancer. NSAIDs show clear efficacy as chemopreventive ag ...
... figure indicates that COX2 has potential to be a target for chemoprevention. As these 4 malignancies total more than half of the cancer deaths in UK and USA, this emphasises the need for chemoprevention against colon, breast, prostate and lung cancer. NSAIDs show clear efficacy as chemopreventive ag ...
BIOLOGICAL VERIFICATION AND QUALITY ASSESSMENT OF A NATURAL HEPATOPROTECTIVE RECIPE Original Article
... for healthcare in different cultures throughout the world [1]. The World Health Organization (WHO) estimates that 80% of the world populations rely on natural medicines of plant origin for their primary healthcare [2], so the demand of such drugs is becoming universal as people became more cognisant ...
... for healthcare in different cultures throughout the world [1]. The World Health Organization (WHO) estimates that 80% of the world populations rely on natural medicines of plant origin for their primary healthcare [2], so the demand of such drugs is becoming universal as people became more cognisant ...
Lecture 3 - Renin Angiotensin Pathway
... • The renin-angiotensin pathway is integral to controlling blood volume and pressure. Pathway overactivation causes hypertension. • It is controlled by the action of two main enzymes renin and angiotensin-converting enzyme (ACE). • Drugs have been developed as ACE inhibitors, angiotensin II receptor ...
... • The renin-angiotensin pathway is integral to controlling blood volume and pressure. Pathway overactivation causes hypertension. • It is controlled by the action of two main enzymes renin and angiotensin-converting enzyme (ACE). • Drugs have been developed as ACE inhibitors, angiotensin II receptor ...
clinical course and cellular pathology of tardive dyskinesia
... can suggest the regions that likely contain the neurochemical disorder underlying TD. The firm association between striatal dopamine-receptor blockade and antipsychotic drug action was established early and has been consistently confirmed in subsequent study (4,7,53). It has been suggested that anti ...
... can suggest the regions that likely contain the neurochemical disorder underlying TD. The firm association between striatal dopamine-receptor blockade and antipsychotic drug action was established early and has been consistently confirmed in subsequent study (4,7,53). It has been suggested that anti ...
Steroids and athletes: Genes work overtime
... Once inside the nucleus, the steroid-receptor complex binds to specific areas within the DNA (regulatory sites) to induce gene transcription, which directs the synthesis of specific proteins (Figure 5). A brief review of protein synthesis follows so we can understand how this happens. DNA (deoxyribo ...
... Once inside the nucleus, the steroid-receptor complex binds to specific areas within the DNA (regulatory sites) to induce gene transcription, which directs the synthesis of specific proteins (Figure 5). A brief review of protein synthesis follows so we can understand how this happens. DNA (deoxyribo ...
Pyrethroid Insecticides: Use, Environmental Fate, and
... Also in contrast to OP insecticides, pyrethroids exhibit low toxicity to mammals and birds, while also demonstrating strong selectivity for insects and invertebrates (Ecobichon, 1996; Fishel, 2005). Chronic animal feeding studies have produced high no-effect levels, indicating both a low potential t ...
... Also in contrast to OP insecticides, pyrethroids exhibit low toxicity to mammals and birds, while also demonstrating strong selectivity for insects and invertebrates (Ecobichon, 1996; Fishel, 2005). Chronic animal feeding studies have produced high no-effect levels, indicating both a low potential t ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.