UTEROTONIC PROPERTIES OF NYMPHAEA ALBA ON ISOLATED MYOMETRIUM MODEL Original Article
... revealed the presence of alkaloids, flavonoids and saponins [29]. Data from the literature indicate that these compounds possess uterine stimulating effects [30–33]. It could therefore be understood that the presence of these biological principles in the ethanolic extract of N. alba, may account for ...
... revealed the presence of alkaloids, flavonoids and saponins [29]. Data from the literature indicate that these compounds possess uterine stimulating effects [30–33]. It could therefore be understood that the presence of these biological principles in the ethanolic extract of N. alba, may account for ...
New horizons in pulmonary arterial hypertension therapies
... translate into an improved safety profile, particularly with regards to gastrointestinal effects as, unlike iloprost and beraprost, selexipag and its metabolite do not stimulate gastric smooth muscle via the prostaglandin E (EP) receptors EP3 and EP1 [30]. In a phase II proof-of-concept study in 43 ...
... translate into an improved safety profile, particularly with regards to gastrointestinal effects as, unlike iloprost and beraprost, selexipag and its metabolite do not stimulate gastric smooth muscle via the prostaglandin E (EP) receptors EP3 and EP1 [30]. In a phase II proof-of-concept study in 43 ...
Cytochrome P450 and Chemical Toxicology
... Most of our understanding of bioactivation reactions is in the context of the generation of electrophilic products that become covalently bound to proteins and DNA. With drugs, there are examples in which a drug metabolite may have more intrinsic activity with a receptor than the parent compound (81 ...
... Most of our understanding of bioactivation reactions is in the context of the generation of electrophilic products that become covalently bound to proteins and DNA. With drugs, there are examples in which a drug metabolite may have more intrinsic activity with a receptor than the parent compound (81 ...
Effects of Aqueous Liver Enzyme Activities and Kidney Functions in Rats.
... Eighteen W eeks of Treatment: W hen we monitored effects of the Rhazya extract after eighteen weeks of treatment (Table 6), we found that all treated and control animals have a more or less comparable levels for lipid profile, TGs, HDL-c, LDL and cholesterol. The same observation was noticed too for ...
... Eighteen W eeks of Treatment: W hen we monitored effects of the Rhazya extract after eighteen weeks of treatment (Table 6), we found that all treated and control animals have a more or less comparable levels for lipid profile, TGs, HDL-c, LDL and cholesterol. The same observation was noticed too for ...
Mass-Balance Analyses of Boreal Forest Population
... in consumption translate into increased net production, a bottom– up effect. If GE equals 0 below a threshold of food supplies, then increased resource abundance will increase net production only after the threshold is exceeded. No bottom– up effect occurs when changes in consumption do not affect n ...
... in consumption translate into increased net production, a bottom– up effect. If GE equals 0 below a threshold of food supplies, then increased resource abundance will increase net production only after the threshold is exceeded. No bottom– up effect occurs when changes in consumption do not affect n ...
http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf
... test for nonassociative effects of DCS treatment, with each receiving the same CS and US used for trace conditioning but explicitly unpaired. Half of each age group served as saline controls, and half received daily treatment with the maximally effective dose of DCS for their age group (6.0 and 12.0 ...
... test for nonassociative effects of DCS treatment, with each receiving the same CS and US used for trace conditioning but explicitly unpaired. Half of each age group served as saline controls, and half received daily treatment with the maximally effective dose of DCS for their age group (6.0 and 12.0 ...
- University of Mississippi
... compound is chemically unique. NINDS uses well established rodent seizure models to screen in four categories: Standard Anti-Ictal Screening, Models of Pharmacoresistance, Identification/Differentiation, and Screening for Related Indications. These four areas test the compound’s efficacy in treating ...
... compound is chemically unique. NINDS uses well established rodent seizure models to screen in four categories: Standard Anti-Ictal Screening, Models of Pharmacoresistance, Identification/Differentiation, and Screening for Related Indications. These four areas test the compound’s efficacy in treating ...
Table of Common Herbs and Supplements
... (Adverse Drug Reactions or ADRs) OF HERB Root is dried for tablets, ...
... (Adverse Drug Reactions or ADRs) OF HERB Root is dried for tablets, ...
RESPIRATORY-FINAL
... represent a specialized type of stretch receptor) located in the tracheobronchial passages. ...
... represent a specialized type of stretch receptor) located in the tracheobronchial passages. ...
Transplacental Action of Diethylstilbestrol on
... Postnatal Treatment. One-half of the 64 DES-exposed females and one-half of the 59 vehicle-exposed females received one dose of DMBA (Eastman Organic Chemicals, Rochester, N. Y.; 10 mg in 1 ml of sesame oil) at 50 days of age, while the other half of each exposure group received 2 doses of DMBA (10 ...
... Postnatal Treatment. One-half of the 64 DES-exposed females and one-half of the 59 vehicle-exposed females received one dose of DMBA (Eastman Organic Chemicals, Rochester, N. Y.; 10 mg in 1 ml of sesame oil) at 50 days of age, while the other half of each exposure group received 2 doses of DMBA (10 ...
Does Oral Trenbolone Really Have the Best Steroid
... The drugs you will take during PCT include aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM). Aromatase inhibitors stop androgens from binding with estrogen receptors and SERMs are supposed to prevent their effects. However, with oral Trenbolone, users are split as to whether a ...
... The drugs you will take during PCT include aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM). Aromatase inhibitors stop androgens from binding with estrogen receptors and SERMs are supposed to prevent their effects. However, with oral Trenbolone, users are split as to whether a ...
Resveratrol
... Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references ...
... Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references ...
Nicotine
... systems. Most cigarettes (in the smoke inhaled) contain 1 to 3 milligrams of nicotine. Research suggests that, when smokers wish to achieve a stimulating effect, they take short quick puffs, which produce a low level of blood nicotine. This stimulates nerve transmission. When they wish to relax, the ...
... systems. Most cigarettes (in the smoke inhaled) contain 1 to 3 milligrams of nicotine. Research suggests that, when smokers wish to achieve a stimulating effect, they take short quick puffs, which produce a low level of blood nicotine. This stimulates nerve transmission. When they wish to relax, the ...
Bromide in drinking-water - World Health Organization
... revised in 1963 and in 1971 under the same title. In 1984–1985, the first edition of the WHO Guidelines for Drinking-water Quality (GDWQ) was published in three volumes: Volume 1, Recommendations; Volume 2, Health criteria and other supporting information; and Volume 3, Surveillance and control of c ...
... revised in 1963 and in 1971 under the same title. In 1984–1985, the first edition of the WHO Guidelines for Drinking-water Quality (GDWQ) was published in three volumes: Volume 1, Recommendations; Volume 2, Health criteria and other supporting information; and Volume 3, Surveillance and control of c ...
Protein Kinase C Mediates the Synergistic Interaction Between
... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
... between intrathecally administered ␣2AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the ␣2AARs are coexpressed on the terminals of primary afferent fibers in the spinal cord where they may mediate this phenome ...
Antipsychotic dosing: found in translation
... and steady state levels).30 The use of plasma levels to identify thresholds for clinical response or side effects has not been particularly successful, in part because antipsychotics are metabolized through the hepatic cytochrome P450 enzymes, which are subject to numerous genetic and environmental ...
... and steady state levels).30 The use of plasma levels to identify thresholds for clinical response or side effects has not been particularly successful, in part because antipsychotics are metabolized through the hepatic cytochrome P450 enzymes, which are subject to numerous genetic and environmental ...
Hepatotoxicity associated with illicit use of anabolic androgenic
... preferential anabolic activity and no androgenic one. Testosterone acts as an androgen either directly by binding to the androgen receptor or indirectly by conversion to 5alpha-dihydrotestosterone (DHT). The structural modification of AAS alters the relative anabolic or androgenic activity, the bind ...
... preferential anabolic activity and no androgenic one. Testosterone acts as an androgen either directly by binding to the androgen receptor or indirectly by conversion to 5alpha-dihydrotestosterone (DHT). The structural modification of AAS alters the relative anabolic or androgenic activity, the bind ...
Evidence for Chronically Altered Serotonin Function in the Cerebral
... in female users. Female MDMA users also had lower 5-hydroxyindoleacetic acid (5-HIAA, a serotonin metabolite) levels than did male MDMA users.30 Additionally, serotonin2A receptor binding has also been associated with sex differences, with women having reduced serotonin2A binding levels compared wit ...
... in female users. Female MDMA users also had lower 5-hydroxyindoleacetic acid (5-HIAA, a serotonin metabolite) levels than did male MDMA users.30 Additionally, serotonin2A receptor binding has also been associated with sex differences, with women having reduced serotonin2A binding levels compared wit ...
pharmacology_2
... C. Captopril D. Metoprolol E. Hygronium ANSWER: D 76.What mechanism of action of angiotensin II receptor antagonists A. Competitively bind to the angiotensin II receptors B. Competitively bind to the beta-adrenoreceptors C. Competitively bind to the alpha-adrenoreceptors D. Inhibit angiotensin-conve ...
... C. Captopril D. Metoprolol E. Hygronium ANSWER: D 76.What mechanism of action of angiotensin II receptor antagonists A. Competitively bind to the angiotensin II receptors B. Competitively bind to the beta-adrenoreceptors C. Competitively bind to the alpha-adrenoreceptors D. Inhibit angiotensin-conve ...
Macrolids
... compounds characterized by a macrocyclic lactone ring (usually containing 14 or 16 atoms) to which deoxy sugars are attached. The prototype drug, erythromycin, which consists of two sugar moieties attached to a 14-atom lactone ring, was obtained in 1952 from Streptomyces erythreus. Clarithromycin an ...
... compounds characterized by a macrocyclic lactone ring (usually containing 14 or 16 atoms) to which deoxy sugars are attached. The prototype drug, erythromycin, which consists of two sugar moieties attached to a 14-atom lactone ring, was obtained in 1952 from Streptomyces erythreus. Clarithromycin an ...
DIABETICS It is a metabolic disorder characterized by
... Pharmacokinetics: These drugs are well absorbed orally after being taken 1 to 30 minutes before meals. Both meglitinides are metabolized to inactive products by CYP3A4 in the liver and are excreted through the bile. Adverse effects: hypoglycemia, Weight gain is less of a problem with the meglitinide ...
... Pharmacokinetics: These drugs are well absorbed orally after being taken 1 to 30 minutes before meals. Both meglitinides are metabolized to inactive products by CYP3A4 in the liver and are excreted through the bile. Adverse effects: hypoglycemia, Weight gain is less of a problem with the meglitinide ...
Misc topic, Medicine and Drugs
... and precisely on the opiate receptor sites and interfere with the signal flowing through the nervous system. ...
... and precisely on the opiate receptor sites and interfere with the signal flowing through the nervous system. ...
CURRICULUM VITAE
... In order to improve the selectivity of CB-receptor ligands with an eye towards their therapeutic use, the threedimensional structure of CB receptors (and virtually all other GPCRs) needs to be characterized. In the absence of experimentally determined structures of cannabinoid receptors, information ...
... In order to improve the selectivity of CB-receptor ligands with an eye towards their therapeutic use, the threedimensional structure of CB receptors (and virtually all other GPCRs) needs to be characterized. In the absence of experimentally determined structures of cannabinoid receptors, information ...
Cyclophosphamide Modulates Rat Hepatic Cytochrome P450 2C11
... levels (Fig. 3, A and B) substantiated the effects of the drugs on the corresponding enzyme activities. Thus, ifosphamide elicits the same effects as cyclophosphamide on these two hepatic enzymes but re quires a higher dose. The feminization of the gender-dependent hepatic cytochrome P450 enzymes an ...
... levels (Fig. 3, A and B) substantiated the effects of the drugs on the corresponding enzyme activities. Thus, ifosphamide elicits the same effects as cyclophosphamide on these two hepatic enzymes but re quires a higher dose. The feminization of the gender-dependent hepatic cytochrome P450 enzymes an ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.