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MONDAY BIO I 1,2,5,7 Period 2-10
MONDAY BIO I 1,2,5,7 Period 2-10

... Using mathematics, he realized he could determine the “genotype” of an organism using a Punnett Square ...
LIVALO - Kowa Pharmaceuticals America
LIVALO - Kowa Pharmaceuticals America

... serious liver injury with clinical symptoms and/or hyperbilirubinemia or jaundice occurs during treatment with LIVALO, promptly interrupt therapy. If an alternate etiology is not found do not restart LIVALO. As with other HMG-CoA reductase inhibitors, LIVALO should be used with caution in patients w ...
Drug discovery and development: India
Drug discovery and development: India

... there was no systematic effort in India to explore medicinal plants — or other Indian flora — for biological activity. More recently, however, the Department of Indian Systems of Medicine has been created under the Ministry of Health and Family Welfare, which is initiating programmes for the systema ...
comparative efficacy of combined use of diclofenac with
comparative efficacy of combined use of diclofenac with

... among the most powerful drugs of this kind, while being one of the best tolerated which acts by inhibiting cyclooxygenase activity with a reduction in tissue production of prostaglandins such as PgF2alpha and PgE2.2 Diclofenac and its metabolites are excreted in both urine and bile. The lack of ente ...
Opportunistic screening for haemochromatosis
Opportunistic screening for haemochromatosis

... found in very low frequency. The H63D is an older mutation. • Type 1, the most common, is an autosomal recessive condition caused by a mutation in HFE which was the first haemochromatosis gene identified and primarily found in northern Europeans. A single mutation in HFE results in the substituting ...
Headache treatment:
Headache treatment:

... pain reliever, you should continue taking these with each headache. However: Do not use pain relievers more than nine days per month on average, or more than two doses per episode. If a pain reliever does not control your headache, talk to your healthcare provider for other suggestions. People with ...
Genetics - walker2016
Genetics - walker2016

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Diagnostic Clinical Genome and Exome Sequencing
Diagnostic Clinical Genome and Exome Sequencing

... and the fragments are selected with the use of artificial DNA or RNA baits that are complementary to targeted DNA (not shown). The sequencing process starts with the binding of the end of each DNA fragment to a solid matrix and in situ amplification (Panel D), and the DNA fragments are then sequence ...
Vitex agnus
Vitex agnus

... genital system. In actual clinical trials, the fruit Agni casti fructus was shown to relieve premenstrual syndrome (PMS) and especially breast swelling and pain, due to its dopaminergic effect. Although approximately 50% or more of young women suffer from PMS, there is no generally accepted therapy ...
S Diagnostic Clinical Genome and Exome Sequencing review article
S Diagnostic Clinical Genome and Exome Sequencing review article

... and the fragments are selected with the use of artificial DNA or RNA baits that are complementary to targeted DNA (not shown). The sequencing process starts with the binding of the end of each DNA fragment to a solid matrix and in situ amplification (Panel D), and the DNA fragments are then sequence ...
No Slide Title
No Slide Title

... v (virescent seedling) and pr (purple aleurone) are linked on chromosome 5. Assume that a female plant is known to be heterozygous for all three traits. Nothing is known about the arrangement of the mutant alleles on the paternal and maternal homologs of this heterozygote, the sequence of the genes, ...
Hot Tooth
Hot Tooth

... duration, no metabolites), and Diazepam (active metabolites) Reversal agent: Flumazenil (Romazicon) Contraindications and drug interactions ( Triazolam and protease inhibitors for HIV treatment) Nitrous oxide Monitoring Profound anesthesia is still required Lindemann et al. J Endod 2008;34:1167 ...
Lecture Outlines [10-12](100 KB pdf file)
Lecture Outlines [10-12](100 KB pdf file)

... Our nuclear genes trace back to many other common ancestors, some presumably from this time period, some more recent, and others which are older. Because of genetic recombination of nuclear genes, it is much more difficult than with mitochondrial DNA to trace back to the common ancestor. The Y chrom ...
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... Aldehyde oxidase (AO) is a molybdenum cofactor containing enzyme localized in the cytosol with relatively high expression levels in human hepatocytes. It is of increasing importance for drug development with an increasing number of new chemical entities (NCE) found to be substrates. Hepatic expressi ...
投影片 1 - Center for Ethics of Science and Technology
投影片 1 - Center for Ethics of Science and Technology

... Declaration on Bioethical Norms:the subjects of right to genetic privacy include: testee, consanguine relatives and other relevant groups. Accord with Article 14 of The International Declaration on Human Genetic Data:the objects of right to genetic privacy include: the individual privacy that take p ...
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Rebop Lab 2007 rebop_lab_2007

... Reebop come from the father, and half come from the mother. Reebops have only one or two genes on each chromosome (humans on the other hand may have hundreds or thousands of genes on each chromosome!). Genes are segments of a chromosome that code for a trait, for example, in Reebops there is a gene ...
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22-7. Antibacterials

... fever, and angioedema. Rarely (about 1 in 10 000) there is anaphylactic shock which can be fatal (about 1 in 100 000 treatment courses). Allergies are least likely when penicillins are given orally and most likely with local application. Metabolic opening of the β-lactam ring creates a highly reacti ...
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Severe water intoxication secondary to the concomitant intake of

... enuresis and nocturia and bleeding disorders (e.g. von Willebrand’s disease).1 The individual tailoring of drug treatment has been particularly emphasized, since recent pharmacokinetics and pharmacodynamics studies have highlighted a considerable variability not only in regard to DDAVP formulation ( ...
2016 BSMC syllabus - Friday - Therapeutics Education Collaboration
2016 BSMC syllabus - Friday - Therapeutics Education Collaboration

... way that is rude : done or made without permission, right, or good reason ...


... Elevation: Clinically relevant increases in serum cholesterol were seen in 5.3% of venlafaxine patients and 0.0% of placebo patients treated for at least 3 months in trials. Consider measurement of serum cholesterol levels during long-term treatment. Use in Patients With Concomitant Illness: Use Eff ...
tooth sensitivity endodontic emergency
tooth sensitivity endodontic emergency

... duration, no metabolites), and Diazepam (active metabolites) Reversal agent: Flumazenil (Romazicon) Contraindications and drug interactions ( Triazolam and protease inhibitors for HIV treatment) Nitrous oxide Monitoring Profound anesthesia is still required Lindemann et al. J Endod 2008;34:1167 ...
Faculty Responsibilities for CME Activities
Faculty Responsibilities for CME Activities

... 1. An individual (and his/her spouse or partner and children) who is in a position to control the content of the educational activity. Such individuals include, but are not limited to: Editor-in-Chief, Associate Editor, CME Editor, Planning Committee Member, freelance writer, author, LCMEI employee, ...
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Pharmacology

... A particular drug might be good for more than one thing, but the drug company has to choose for which use they want to seek approval. • If the drug is ultimately approved, the approval will be for that indication only. • Later, the FDA may approve the drug to treat a different indication after condu ...
Advanced Arnica
Advanced Arnica

... Advanced Arnica is a safe, all-natural medicine that uses multiple forms of Arnica in five powerful, yet gentle potencies: 6X, 30X, 6C, 30C, and LM1. This formula includes natural ingredients that have been used successfully by physicians for more than 200 years, with a proven safety record. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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