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2nd Quarter Conference Call - Emisphere Technologies, Inc.
2nd Quarter Conference Call - Emisphere Technologies, Inc.

... Safe Harbor Statement Regarding Forward-Looking Statements ...
NOTE: The provided figures may be useful and beneficial
NOTE: The provided figures may be useful and beneficial

... 3. Steroid hormones such as testosterone (gonadal androgen) lead to differentiation of the male reproductive system. However, if the receptors for the hormones are non-functional due to a mutation in the gene for the androgenreceptor protein, a condition called “complete androgen insensitivity” is l ...
OPIATE ANALGESICS AND ANTAGONISTS
OPIATE ANALGESICS AND ANTAGONISTS

... commonly employed in obstetrics also causes less urine retention ...
A short introduction to pharmacokinetics
A short introduction to pharmacokinetics

... a pharmacokinetic study is often huge. As an example, in a typical study of bioequivalence in man, there are generally not less than 12 plasma samples in at least 18 subjects treated with two formulations of the same drug. The consequence is that not less than 12 × 18 × 2 = 432 set of data (time, pl ...
Herbal Medicines: Are they really safe?
Herbal Medicines: Are they really safe?

... being “100% natural – no side effects” or “a safe alternative to prescription drugs”. Even more concerning is the number of patients who believe a combination of their regular prescription drugs and complementary therapies can only be beneficial. The volume of literature available has increased over ...
Advanced Arnica
Advanced Arnica

... Advanced Arnica is a safe, all-natural medicine that uses multiple forms of Arnica in five powerful, yet gentle potencies: 6X, 30X, 6C, 30C, and LM1. This formula includes natural ingredients that have been used successfully by physicians for more than 200 years, with a proven safety record. ...
Zofran and the Devastating Risk of Birth Defects
Zofran and the Devastating Risk of Birth Defects

... at least 200 reports of birth defects in children who were exposed to Zofran during pregnancy. The most common birth defect reported to GSK was congenital heart defects, though other defects including cleft lip and palate, intrauterine death, still birth, and severe malformations were also reported. ...
PowerPoint Slides
PowerPoint Slides

... VENCLEXTA [prescribing information]. South San Francisco, CA: Genentech; 2016.; Mulligan S. Breakthroughs in chronic lymphocytic leukemia 2014 - 2015. Presented at: Asia Pacific Hematology Consortium/Bridging the Gap 2015. February 1, 2015. ...
Case report: paracetamol poisoning in a 2-year
Case report: paracetamol poisoning in a 2-year

... detoxified by glutathione until the store is depleted. The NAPQI will then bind to cellular proteins causing damage and cell death. The 4-stage clinical manifestation is also well documented although it may be non-specific in paediatric patients. During the first few hours, the patient may present w ...
Introduction and Background to Genetic Approach File
Introduction and Background to Genetic Approach File

... What we observe (e.g. hair coat) or measure (e.g. milk yield). In general, external expression of an animal ...
Lack of association between single nucleotide
Lack of association between single nucleotide

... The environmental risk factors of CKD occurrence and progression that have been recognized up to date are not sufficient enough for identification of groups of people at higher risk of the disease development as well as to develop new and efficient treatment methods. In a view of foregoing there are ...
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doc Midterm exam

... (a) There were about 6% fewer double crossovers observed than would be expected if a crossover between one of the gene pairs had no influence on the probability of a crossover between the adjacent gene pair. (b) There were about 6% more double crossovers observed than would be expected if a crossove ...
CLINICAL PATHWAY FOR UNCOMPUCATED ATRIAL FIBRILLATION
CLINICAL PATHWAY FOR UNCOMPUCATED ATRIAL FIBRILLATION

... 7. For patients with AF who have mechanical heart valves, the target intensity of anticoagulation should be based on the type of prosthesis, maintaining an INR of at least 2.5. (Level of Evidence: B) 8. Antithrombotic therapy is recommended for patients with atrial flutter as for those with AF. (Lev ...
Sulfadimethoxine - Doctors Foster and Smith
Sulfadimethoxine - Doctors Foster and Smith

... sulfa drugs. Not for use in pregnant or lactating animals (female animals nursing their young). ...
Dr E Harrop – Spasticity, Dystonia and Symptom Management in
Dr E Harrop – Spasticity, Dystonia and Symptom Management in

... • Mechanisms operating during development can profoundly modify the consequences of nerve damage (pain circuits under go postnatal maturation) • Generally, the later the injury the worse the risk of developing NP (birth injuries to brachial plexus rarely cause it) • Phantom limb rare in congenital a ...
otezla - Celgene
otezla - Celgene

... serious adverse event for patients exposed to OTEZLA® was nephrolithiasis (0.3%). The most common adverse reactions leading to discontinuation for patients taking OTEZLA® were nausea, diarrhea, psoriasis, headache, and vomiting. In the Phase 3 psoriatic arthritis studies, diarrhea, nausea, and heada ...
Chapter 8: Fundamentals of Genetics
Chapter 8: Fundamentals of Genetics

... either homozygous phenotypes – both alleles show ii. Incomplete Dominance: a heterozygote shows a phenotype that is intermediate between 2 homozygous phenotypes – neither allele is expressed fully 1. in incomplete dominance only phenotype is intermediate 2. since there are no dominant alleles – uppe ...
PatrickChapter2
PatrickChapter2

... hydrogen and an electron rich heteroatom (N or O) The electron deficient hydrogen is usually attached to a heteroatom (O or N) The electron deficient hydrogen is called a hydrogen bond donor The electron rich heteroatom is called a hydrogen bond acceptor ...
AP Chapter 14-15 Study Guide: Chromosomes and Mendelian
AP Chapter 14-15 Study Guide: Chromosomes and Mendelian

... of the offspring from his first cross.) Much to his surprise, the F2 generation had plants in a ratio of 3 tall to 1 short. From this experiment and others using different traits, Mendel developed several conclusions 10. Mendel realized that the gene for short plants did get passed on, but it was hi ...
Basics of Genetic Assessment and Counseling
Basics of Genetic Assessment and Counseling

... • Charcot-Marie-Tooth - also known as hereditary motor and sensory neuropathy type I (HMSN I) has been shown to result from a small duplication on short arm of chromosome ...
Medication Safety and Administration
Medication Safety and Administration

... • Stop the line. If you have concerns or questions, do not give the medication until you feel the concerns/questions have been answered. • If a patient or caregiver questions the medication you are going to administer: STOP! Double check the order and if necessary, call the provider to verify the or ...
Slide 1
Slide 1

... Ausio Pharmaceuticals, LLC ...
Erectile Dysfunction and Cardiovascular Disease
Erectile Dysfunction and Cardiovascular Disease

... Myocardial Ischemia During Sexual Activity in Patients with CAD All Patients with myocardial ischemia during sexual activity had also ischemia on Holter ...
Bacino et al., 2015
Bacino et al., 2015

... phenotype is unusual or atypical compared to previously reported cases. In the case of metabolic disorders, sequencing can reveal underlying defects previously undetected by biochemical studies, such as Argininemia [18] and mitochondrial DNA depletion disorders [12]. Peroxisomal biogenesis disorders ...
Meiosis Mitosis Genetics Study Guide
Meiosis Mitosis Genetics Study Guide

... ____________________ . One allele is not completely dominant over the other in (23) _________________ _______________ . Both alleles contribute to the heterozygous phenotype in (24) ______________________ . Genes that have more than 2 possible alleles are said to be (25) ______________ ____________ ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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