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Mendelian Genetics - Austin Peay State University
Mendelian Genetics - Austin Peay State University

... – Humans have multiple types of surface antigens on RBC's – The nature of these surface proteins determines a person's Blood Type. – There are 3 alleles which determine blood type IA, IB, or IO. This is referred to as having multiple alleles – Human blood types are designated as A, B or O. • Type A ...
Treatment Guidelines HTN, DM, Hyperlipidemia
Treatment Guidelines HTN, DM, Hyperlipidemia

... 30 and 69 years received medication to lower DBP to a level <90 mm Hg. Results showed a reduction in cerebrovascular events, heart failure, and overall mortality in patients treated to the DBP target level. ...
Antiallergic agents
Antiallergic agents

... Drugs are metabolized by CYP- 450 enzymes (Terfenadine and Astemisole) .  In patients with liver diseases, in case of higher daily doses, with administration of drugs that also are metabolized by CYP- 450 enzymes can cause ventricular tachycardia.  Examples of such drugs: ...
9th International Workshop on Clinical
9th International Workshop on Clinical

... Cape Town, South Africa, 5University of St. Andrews, The School of Medicine, St. Andrews, United Kingdom, 6University Centre for Chronic Diseases Dekkerswald Groesbeek the Netherlands and Radboud University Medical Center, Department of Lung ...
Monitoring Opioid Adherence in Chronic Pain Patients: Tools
Monitoring Opioid Adherence in Chronic Pain Patients: Tools

... public health concern in the United States. In recent years, the expanded use of opioid analgesics for the treatment of chronic non-cancer pain, and the introduction of high-dose, extended-release opioid formulations have both improved access to these drugs and increased misuse, abuse, and diversion ...
File - University Children`s Eye Center
File - University Children`s Eye Center

... During an ophthalmic exam, the doctor will evaluate your child’s visual acuity, eye movement, eye alignment, and overall health of the eye. Your child will also be screened and evaluated for amblyopia (“lazy eye”), strabismus (misaligned or “crossed” eyes), cataracts, glaucoma, retinal  abnormalitie ...
HIV Management in the Primary Care Setting
HIV Management in the Primary Care Setting

...  Screen: Baseline DXA scan should be completed in postmenopausal women and men aged > 50 years  Periodic monitoring thereafter – assess other risk factors  Treat: According to NOF guidelines:  Vitamin D and/or calcium supplementation  Bisphosphonate if indicated Primary Care Guidelines for the ...
anticholinergic drugs
anticholinergic drugs

... • Partially metabolised by the liver. • Eliminated primarily in the urine. • Half life of about 4 hours. ...
IOSR Journal of Applied Chemistry (IOSR-JAC)
IOSR Journal of Applied Chemistry (IOSR-JAC)

... aggregation more rapidly, more consistently, and to a greater extent than do standard and higher doses of clopidogrel in healthy volunteers and in patients with coronary artery disease. A pharmacodynamic study suggests that acute coronary syndrome (ACS) patients can be safely switched from clopidogr ...
A Triumph in the War Against Cancer
A Triumph in the War Against Cancer

... Terry, Darren and Stephen flew up from the Los Angeles area, and Kelly drove over from her place in Winlock. One by one they went into the bedroom, sat at LaDonna’s bedside and said goodbye. CML is one of the four main types of adult leukemia, but it is not common, striking 5,000 people in the Unite ...
2012 exam answers - Learning on the Loop
2012 exam answers - Learning on the Loop

... Science 90948 (1.9): Demonstrate understanding of biological ideas relating to genetic variation ...
2.2 Diuretics - Doncaster and Bassetlaw Hospitals NHS Foundation
2.2 Diuretics - Doncaster and Bassetlaw Hospitals NHS Foundation

... As with spironolactone patients with impaired renal function or those with potassium levels at the higher end of the usual range are at greater risk of developing hyperkalaemia. Indeed patients with hyperkalaemia (or those with a creatinine clearance < 50ml/min) should not be started on eplerenone. ...
Pain Relief Connection - Patient Care Services
Pain Relief Connection - Patient Care Services

... duration of analgesia is listed as 1- 2 hours, route is IV/IM and dosing is only available in mg, and not mcg. There is a similar mislabeling problem with oxycodone/Oxycontin. § ò Only one drug may be converted at a time, so that if the patient is on more than one opioid, calculations by hand are st ...
TOXICOLOGY LECTURES
TOXICOLOGY LECTURES

... • Used in the treatment of depressive and bipolar disorders, therefore it is used in a population at relatively high risk for overdose • Narrow therapeutic index and intoxication is a relatively frequent complication of therapy • Gradual onset of intoxication is far more common that acute toxicity • ...
Fulltext PDF - Indian Academy of Sciences
Fulltext PDF - Indian Academy of Sciences

... English. In India, the counsellor working in an urban setting has to communicate with and counsel individuals from multiple language backgrounds in the course of a single day (Elackatt 2013). An easily understood word for ‘gene’ or ‘genetic disorder’ is not available in any vernacular language. Such ...
November 2014 - Deferrals
November 2014 - Deferrals

... • Approximately 29 are alive after 2 years if clinical symptoms of HT-1 developed before 2 months of age; • Approximately 74 are alive after 2 years if clinical symptoms of HT-1 developed between 2 and 6 months of age; and • Approximately 96 are alive after 2 years if clinical symptoms of HT-1 devel ...
How to Guide - High Alert Medications
How to Guide - High Alert Medications

... Eckman MH, Levine HJ, Salem DN, Pauker SG. Making decisions about antithrombolytic therapy in heart disease: Decision analytic and cost-effectiveness issues. Chest. ...
Genet Mol Res, 13 - Funpec-RP
Genet Mol Res, 13 - Funpec-RP

... Sakou, 2011), although most of these studies were conducted over 30 years ago and were based on low-quality plain films. A Japanese nationwide multicenter survey of 347 subjects with OPLL reported an incidence in first-degree relatives of 23%, and of 22% in other relatives (Terayama, 1989). In the p ...
Genetics Jeopardy
Genetics Jeopardy

... are the chances their offspring will have the disorder? ...
HST.161 Molecular Biology and Genetics in Modern Medicine
HST.161 Molecular Biology and Genetics in Modern Medicine

... If the genotypes of the grandparents are not known, then the PHASE of the marker with respect to the disease gene is not known. (i.e. we knew A is linked to the disease gene in model 1 in the previous data, but without the grandparental genotypes it is equally possible that a is linked to the disea ...
George Wells - International Society of Evidence
George Wells - International Society of Evidence

... • Novel agents have been developed to replace vitamin K antagonists (VKAs) such as warfarin – direct thrombin inhibitor, dabigatran – direct FXa inhibitors, rivaroxaban and apixaban • Novel agents ...
Methoxyflurane - Queensland Ambulance Service
Methoxyflurane - Queensland Ambulance Service

... • To reduce the risk of occupational exposure to methoxyflurane, officers are to ensure the following: - Only one dose of 3 mL should be administered per patient 
 whilst in the ambulance vehicle. - No single officer should administer more than two doses 
 of methoxyflurane in the ambulance vehicle ...
Cutaneous Side Effects of New Antitumor Drugs
Cutaneous Side Effects of New Antitumor Drugs

... malignant tumors has paved the way for the development of new drugs for medical tumor therapy. In addition to cytotoxic drugs, drugs with specific molecular targets (so-called “targeted therapies”) and new immunological therapeutic approaches are being implemented. Since an increasing number of pati ...
Modes of selection: directional, balancing and disruptive RR Rr rr
Modes of selection: directional, balancing and disruptive RR Rr rr

... Disruptive selection favors fixation, like directional selection, but either allele can be the one whose fixation is favored. Again there are two principal mechanisms: -- heterozygote disadvantage (“it’s better to be pure”) -- positive frequency dependence (“the rich get richer”) All of these proces ...
Locomotor Effects of Acute and Repeated Threshold Doses of
Locomotor Effects of Acute and Repeated Threshold Doses of

... guidelines (Principles of Laboratory Animal Care, National Institutes of Health Publication 85-23). Apparatus. Behavior was monitored in custom-designed activity chambers (Segal and Kuczenski, 1987). Briefly, each of the chambers was located in a sound-attenuated cabinet maintained on a 14-h/10-h li ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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