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EVALUATION OF REMIFENTANIL IN ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY N. EL B
EVALUATION OF REMIFENTANIL IN ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY N. EL B

... The narrow margin of safety concerning depression of spontaneous respiration must be considered seriously. Another disadvantage to consider would be the constrictive effects of morphine derivatives on the ampulla of Vater. However, if this does not surface as an added difficulty, then this possible ...
Bio.B.2- Genetics
Bio.B.2- Genetics

... A trait is a specific ...
ACUTE RENAL FAILURE
ACUTE RENAL FAILURE

... in some of these reports. ...
Mendel`s Experiments and the Laws of Inheritance
Mendel`s Experiments and the Laws of Inheritance

High-Intensity Statin Therapy
High-Intensity Statin Therapy

... demonstrated a reduction in major cardiovascular events. Statins and doses that are approved by the U.S. FDA but were not tested in the RCTs reviewed are listed in italics. *Individual responses to statin therapy varied in the RCTs and should be expected to vary in clinical practice. There might be ...
Ivermectin for the treatment of demodicosis
Ivermectin for the treatment of demodicosis

... Dog to receive ivermectin treatment: 1. I, the undersigned, am the owner or the authorized agent for the owner of the above named dog and agree to the extralabel use of the drug ivermectin to treat the dog’s skin disease. 2. I understand that ivermectin is being dispensed for extralabel use, which ...


... Pregnancy and Lactation : Although Co-trimoxazole has been used during pregnancy without deleterious sequelae, animal studies have indicated a risk of teratogenic effects. Co-trimoxazole may interfere with folic acid metabolism. The risk of hyperbilirubinemia and kernicterus has led to a recommendat ...
Drug-induced peptic ulcer disease
Drug-induced peptic ulcer disease

... high as 35%.7 Advising patients to take enteric coated tablets or to take the preparation after food may minimise gastrointestinal symptoms as dyspepsia, but as for NSAIDs ulceration is mainly attributable to its systemic effect on prostaglandin synthesis. 5 Co-prescription of aspirin with standard ...
Unit 3: Genetics
Unit 3: Genetics

...  Dominant Allele: an allele that hides a recessive trait; usually characterized by a capital letter.  Recessive Allele: an allele that can be “masked” or hidden by a dominant allele; usually characterized by a lower-case letter ...
Q&A: Evolutionary capacitance Open Access Joanna Masel
Q&A: Evolutionary capacitance Open Access Joanna Masel

... So capacitor genes provide mutational robustness, which is lost in the knockout? The phenotypes of mutants such as gene knockouts are more variable than the phenotypes of the wild type [26], but this does not necessarily reflect mutational robustness. It does demonstrate the high robustness provided ...
Non-opioid Analgesics and Adjuvants
Non-opioid Analgesics and Adjuvants

... – Single-entity drugs, eg, morphine – Tramadol ...
Multi-target therapeutics - Corporate-ir
Multi-target therapeutics - Corporate-ir

... such as cancer, or diseases that affect multiple tissues or cell types such as diabetes and immunoinflammatory disorders. Combination drugs that impact multiple targets simultaneously are better at controlling complex disease systems, are less prone to drug resistance and are the standard of care in ...
Drug Research on Land Transport Act Blood Specimens
Drug Research on Land Transport Act Blood Specimens

... 225 drivers who had no alcohol in their blood were tested for drug use. 87 (39%) of these drivers showed no evidence at all of drug use. Of the 138 (61%) drivers who showed evidence of drug use, it is possible that 75 (33%) may not have used a drug prior to the crash. The type of drug detected was ...
File
File

... • The syndrome of hypertensive emergency was first described by Volhard and Fahr in 1914 • In 1939 the1-year mortality of 79% and a median survival of 10.5 months • Approximately 1% of patients with hypertension will develop a hypertensive crises at some point during their lives. 7% before BP treatm ...
Formulation and evaluation of delayed-onset extended
Formulation and evaluation of delayed-onset extended

... Several studies have demonstrated circadian rhythmicity for all body functions. Incidence of several cardiovascular events, like myocardial infarction, stroke and sudden cardiac death, also exhibit circadian rhythm (1, 2). These events are often observed early in the morning as the blood pressure (B ...
http://www
http://www

... foreign clinical data package after its completion, to suggest a bridging study, the approval in the new region can be delayed. How can a bridging study be best designed and conducted in new regions, while the data package is being completed in the original region, so that approval applications may ...
The Genetics of Horse Coat Color
The Genetics of Horse Coat Color

... of  genetic  inheritance.  More  often  than  not,   white  coats  are  a  result  of  a  genetic  mutation   at  a  particular  locus  as  the  foal  is  developing.   This  mutation  can  then  be  passed  to  the   offspring  of ...
The Significance of the Fossil Record
The Significance of the Fossil Record

... pool. For each gene, every individual has only two alleles, but there may be more than two alleles in the gene pool, each with its own frequency. Evolution is frequently defined genetically as a change in the frequency of one or more alleles in the gene pool from one generation to the next. As the f ...
clinical practice guide lines for management of barbiturates
clinical practice guide lines for management of barbiturates

... It is used primarily for treatment of physiological dependence on long acting benzodiazepines arising from treatment of an underlying condition. The patient must be cooperative and able to adhere to dosing regimens and must not be abusing alcohol or other drugs. ...
Product Information: Tiotropium bromide
Product Information: Tiotropium bromide

... Metabolism does not occur to any great extent in young healthy volunteers, as indicated by 74% renal excretion of unchanged drug after an intravenous dose. The major metabolic pathway is non-enzymatic ester cleavage to the alcohol N-methylscopine and dithienylglycolic acid that are inactive on musca ...
A study of prescription pattern of Non steroidal anti
A study of prescription pattern of Non steroidal anti

... The study has got few limitations. Duration of study was short (five months) hence effect of seasonal variation on NSAID prescription pattern could not be determined. Study was conducted only in medicine department (due to rural set up, this department handles maximum patient load) and other clinica ...
BARTONELLA-LIKE ORGANISMS
BARTONELLA-LIKE ORGANISMS

... J.J. Burrascano Jr. M.D. ...
Population Genetics (Learning Objectives)
Population Genetics (Learning Objectives)

... - The frequency of homozygous recessive individuals = q2 = 1 in 10,000 or 0.0001. - The frequency of the recessive allele (q) is the square root of 0.0001 = 0.01. - The frequency of the dominant allele (p) is p = 1 - q or 1 0.01 = 0.99. The frequency of carriers (heterozygous individuals) is ...
Date Rape Drugs
Date Rape Drugs

... though it is sometimes found in powder, tablet, or capsules. The effects of the drug begin 10 to 20 minutes after taking it and last up to 4 hours. ...
THE SAFE HANDLING, COLLECTION AND DISPOSAL OF DRUGS
THE SAFE HANDLING, COLLECTION AND DISPOSAL OF DRUGS

... Act). It is advisable to lock the substance away and a police officer will be contacted by the Headteacher/ Deputy Headteacher. The police officer will be asked to collect it and dispose of it appropriately. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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