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Adverse drug reaction reports of patients and healthcare
Adverse drug reaction reports of patients and healthcare

... numbers of variables to a small number of uncorrelated linear combinations that represent most of the information found in the original variables.16,17 The CATPCA based on two dimensions was conducted to investigate which elements of information possibly correlate. In CATPCA, the variance account fo ...
DO NOW
DO NOW

... Use the pictures on the sheets at your table to fill in your phenotypes and genotypes. ...
Statement on the use of EFV in children less than 3 years of age
Statement on the use of EFV in children less than 3 years of age

... On 02 May 2013, the US Food and Drug Administration (FDA) expanded the indication for efavirenz (EFV) to include paediatric patients at least three months old and weighing at least 3.5 kg. Historically efavirenz has not been used in children < 3 years of age or < 10kg because the correct dosing was ...
AORN Guideline Gap Analysis Tool: Moderate Sedation
AORN Guideline Gap Analysis Tool: Moderate Sedation

... recommended dose, recommended dilution, onset, duration, effects, potential adverse reactions, drug compatibility, and contraindications for each medication used during moderate sedation. Are medications for moderate sedation and their antagonists administered under the direct supervision of a licen ...
Oral Fluid Drug Screen Device
Oral Fluid Drug Screen Device

... compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and i ...
Colistin® - Colistimethate sodium for injection
Colistin® - Colistimethate sodium for injection

... elderly, provided renal function is normal. Limited data are available on use in neonates which suggest kinetics are similar to children and adults but the possibility of higher peak serum levels and prolonged half-life in these patients should be considered and serum levels monitored. ...
World Antimalarial Resistance Network (WARN) IV: Clinical
World Antimalarial Resistance Network (WARN) IV: Clinical

... were important drug-concentration related toxicities, which could well have been missed due to the paucity of the available data, these could be best recognized through this database. A better understanding of the pharmacokinetic properties of antimalarials and a more clear definition of therapeutic ...
DSG - TMA
DSG - TMA

... Process, Shop Floor Control, Manufacturing, QC, QA, Handling and Shipping, SOPs etc. ...
Pharmacology introduction Lecture three Dr. nahlah 21-10
Pharmacology introduction Lecture three Dr. nahlah 21-10

... 2. Irreversible which is usually long-lasting for new enzyme synthesis, e.g., irreversible anticholinesterases. Action on specific receptors (Drug Receptor Interactions): receptors are macromolecular protein structures present on cell membrane or within the cell (cytoplasmic or nuclear) that react s ...
Chapter 14: Mendel and the Gene Idea
Chapter 14: Mendel and the Gene Idea

... 2. Dominantly Inherited Disorders: Not all harmful alleles are recessive. i. Achondroplasia, a form of dwarfism, is caused by a dominant allele. Because dwarfism affects one in 10,000, 99.99% of the population is homozygous recessive. ii. Lethal alleles tend to be recessive because even heterozygous ...
L12 Intro to Inheritance Fa08
L12 Intro to Inheritance Fa08

... Probability & the Punnett Square • Rule of Multiplication – For independent events, the probability of a compound event is the product of the separate events • E.g. probability that an F1 generation will have BB ...
Controlled Substance Abuse Prevention Act Section Summary
Controlled Substance Abuse Prevention Act Section Summary

... substance for longer than 90 consecutive days. This section requires a practitioner to complete a validated peer reviewed assessment about the patient’s risk for abuse, dependency and addiction. It also requires a practitioner to conduct an investigation to determine an evidence based diagnosis of t ...
Module 2 Good Clinical Practice (GCP)
Module 2 Good Clinical Practice (GCP)

... - Safety and efficacy (Phase II & Phase III) ...
Guidance on format of the RMP in the EU for Generics
Guidance on format of the RMP in the EU for Generics

... Pulmonary arterial hypertension (PAH) is a disease which causes increased blood pressure in the lungs and can lead to right heart failure and early death. Hypertension occurs when most of the very small arteries throughout the lungs narrow in diameter, which increases the resistance to blood flow th ...
Opioid Drugs in Patients With Liver Disease: A Systematic Review
Opioid Drugs in Patients With Liver Disease: A Systematic Review

... no practical method to test or predict the clinical observations, at least a part of most opiates are metabolized by the liver. Therefore, the administration of opioids to patients with liver failure is high risk and requires precaution be taken to minimize their side effects (15, 16). The current s ...
PRESCRIBING GUIDELINES FOR DRY EYE SYNDROME
PRESCRIBING GUIDELINES FOR DRY EYE SYNDROME

... Dry Eye Syndrome is generally classified according to a combination of symptoms and signs. It has been classified as mild, moderate & severe based on both symptoms & signs, but with an emphasis on symptoms over signs. Due to the nature of dry eye disease, this classification is imprecise because cha ...
3 Amphetamines in the Treatment of Attention
3 Amphetamines in the Treatment of Attention

... MAOIs or furazolidone should wait for at least two weeks before starting therapy with an amphetamine product. Some patients taking tricyclic antidepressants with amphetamines may experience a change in the efficacy or adverse effects of their antidepressant. Dose adjustment may be necessary in these ...
Guide to Migraine Medications
Guide to Migraine Medications

... cannot be predicted. If one Triptan fails, another within the class may well succeed. Triptans should be taken as early as possible in the headache phase of an attack. If you have migraine with aura, you should not expect the Triptan to affect the aura symptom. The Triptans only act on the headache ...
Guidance  for  Industry
Guidance for Industry

... BE documentationmay be useful during the INDNDA period to establishlinks between(1) early and late clinical trial formulations;(2) formulationsusedin clinical trial and stability studies,if different; (3) clinical trial formulationsand to-be-marketeddrug product; and (4) other comparisons,as appropr ...
Alcohol and Drugs Strategy
Alcohol and Drugs Strategy

... Health problems from drinking do not just affect people who are dependent on alcohol, or who drink to get drunk. Drinking above low-risk guidelines (see Box one below) can cause many harmful effects, including liver problems, reduced fertility, high blood pressure, increased risk of various cancers ...
enrofloxacin - Ballston Spa Veterinary Clinic
enrofloxacin - Ballston Spa Veterinary Clinic

... Make sure to tell your veterinarian what other medication or supplements you are giving your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. The f ...
Screening system for drug-induced
Screening system for drug-induced

... obtained TdP threshold values with the actual risk reported in the literature. For this purpose, we used the risk categories by Redfern and Fig. 1. Diagram of the assay system. Dose-inhibition curves of drugs were determined for six ion channels from in vitro experiments using Lawrence (7, 16, 17) w ...
Clin_Pharmac_antibacterial
Clin_Pharmac_antibacterial

... Initial choice of therapy relies on a clinical diagnosis and, in turn, a presumptive microbiological diagnosis. Such ‘blind therapy’ is directed at the most likely pathogen(s) responsible for a particular syndrome such as meningitis, urinary tract infection or pneumonia. Examples of ‘blind therapy’ ...
Genetics[1] - Turner
Genetics[1] - Turner

... • There are multiple alleles in a population causing 4 or more phenotypes of a trait to exist • KEEP IN MIND ▫ There may be multiple alleles within the population, but individuals have only two of those alleles  Why? …because individuals have only two biological parents. We inherit half of our gene ...
Corel Ventura - untitled.chp
Corel Ventura - untitled.chp

... thalidomide was never approved in the US market largely because of the circumspection of Frances Kelsey, a drug evaluator of the Food and Drug Administration (FDA) at the time.3 The Kefauver-Harris Bill amended the federal Food, Drug and Cosmetic Act (1962) by requiring all drugs to be proven safe a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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