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FORMULATION AND EVALUATION OF SUSTAINED RELEASE MULTIPLE EMULSION OF HYDROXYPROGESTERONE Research Article
FORMULATION AND EVALUATION OF SUSTAINED RELEASE MULTIPLE EMULSION OF HYDROXYPROGESTERONE Research Article

... The present work was undertaken with the aim to design multiple emulsions for intramuscular drug delivery of hydroxy progesterone. The O/W/O multiple emulsions were prepared. The most promising use of multiple emulsion system is in the area of sustained release drug formulations because of the extra ...
Drug Diversion and Best Prescriptive Practices
Drug Diversion and Best Prescriptive Practices

... • Allowed to refuse a particular type of treatment. States have different laws regarding end-of-life and palliative care pain management, but most laws allow higher than usual doses and more frequent administration of controlled substances to control pain for those facing death. The U.S. Drug Enforc ...
Barnsley Area Prescribing Committee
Barnsley Area Prescribing Committee

... 5. To request earlier specialist review or seek specialist advice when necessary. 6. Report to and seek advice from the specialist on any aspect of patient care that is of concern to the GP and may affect treatment. 7. Refer back to specialist if the patient’s condition deteriorates, as advised. 8. ...
Drug Diversion and Best Prescriptive Practices WWW.RN.ORG ®
Drug Diversion and Best Prescriptive Practices WWW.RN.ORG ®

... Nociceptive (acute) pain occurs as a response to stimulation of the peripheral nerves, such as from trauma. Acute pain relates directly to the type and extent of injury and is usually self-limiting in that, as the condition that caused the pain heals, the pain subsides. Acute pain may be related to ...
Human evolutionary genomics: ethical and
Human evolutionary genomics: ethical and

... under selection based on the selective sweep model of positive selection (Figure I). In this model, a beneficial mutation arises in an individual and rapidly increases in prevalence over generations until it reaches high prevalence or fixation (100% prevalence). The adaptive allele also brings with ...
MULTILABEL - A Useful Addition to the FORMAT Procedure
MULTILABEL - A Useful Addition to the FORMAT Procedure

... recently, that resulted in extra work. One was that it could accept only mutually exclusive categories. The second was that multiple labels could not be specified for the same value. The MULTILABEL option introduced in version 8.2 overcomes these two limitations. This option has some useful applicat ...
View Abstract - The Journal of Phytopharmacology
View Abstract - The Journal of Phytopharmacology

... effect of this prolonged gastric residence time.5 Advantages: 1) The bioavailability of therapeutic agents can be significantly enhanced especially for those which get metabolized in the upper GIT by this gastro retentive drug delivery approach in comparison to the administration of non gastro reten ...
Chapter_005
Chapter_005

... Fig. 5-2. Dose-response curves demonstrating efficacy and potency. A, Efficacy, or “maximal efficacy,” is an index of the maximal response a drug can produce. The efficacy of a drug is indicated by the height of its dose-response curve. In this example, meperidine has greater efficacy than pentazoc ...
the facts on marijuana
the facts on marijuana

... Anecdotal testimonials are the only evidence favoring smoked marijuana over oral THC for therapeutic purposes. Further research is called for to determine whether other compounds within marijuana might have medicinal properties as well, but at this juncture any such indications are purely experiment ...
Unlicensed and “Off-label” Medicines
Unlicensed and “Off-label” Medicines

... • Using a medicine for a different illness to that stated in the licence. Doctors may have found that the medicine works very well for this illness or condition. This use may be supported by expert groups, but the drug manufacturer has not extended the licence. • Using a medicine in an age group o ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... mood stabilizers [3]. Sodium valproate is first line therapy for primary generalized seizures such as tonic-clonic, myoclonic, atonic and absence seizures. It can be used as both mono and adjunctive therapy for partial seizures and can be very useful in patients with mixed type of seizure disorders ...
Physicochemical properties of drug action
Physicochemical properties of drug action

... They are not mirror images and have different physicochemical properties and pharmacological activity. Because different distances separate the functional groups of these isomers. They generally do not fit to the same receptor equally well and if these functional groups are pharmacophores the isomer ...
ESTIMATION AND VALIDATION OF STABILITY INDICATING UV SPECTROPHOTOMETRIC
ESTIMATION AND VALIDATION OF STABILITY INDICATING UV SPECTROPHOTOMETRIC

... determination of Guaiphenesin in bulk and prepared solid dosage form (tablet). The method was fast and economical and it was also selective and sensitive for the desirable range. Results of the analysis were validated as per ICH guidelines and by recovery studies. Stability testing study includes th ...
Overview of drug-interactions between coumarin
Overview of drug-interactions between coumarin

... stabilized on warfarin therapy, who, after 6 days of noscapine treatment for cough, developed an INR of 7.2 (3 weeks earlier his INR had been 3.0). Noscapine was withdrawn, warfarin was discontinued for one day, and the patient was treated with vitamin K. The INR normalized to 2.3 [13]. It is well k ...
PDF
PDF

... been recorded (NCBI Accession Nos. KJ544248, KJ783456, KP269078, and KJ874959). Pena et al. (2000) named this polymorphic site as S 2I 2 variant due to the presence of the I 2 allele. However, an additional duplication of the inserted 10 bp sequence (the S 2 I 3 variant) has not been recognized in a ...
632  Dundee  Drive Wilmington,  NC 28405
632 Dundee Drive Wilmington, NC 28405

... constituents of the device. It is far more uncertain what would be required as the legal standard for approval of the product as a drug. This illustrates the importance of properly categorizing a combination product as a device when it meets the definition. This is not to imply that devices are inad ...
1-11-17 PPT
1-11-17 PPT

... b.Narrow and useful for gram negative anaerobes c. Narrow and useful for gram negative aerobes d.Narrow and useful for gram positive anaerobes ...
PDF
PDF

... DILI in several case reports,8,9 but other potentially hepatotoxic pharmaceuticals or herbal supplements had also been ingested in these cases. In 2009, the US Food and Drug Administration (FDA) recalled several Hydroxycut slimming supplements (Iovate Health Sciences International) following 23 case ...
the Information Breaking Medical
the Information Breaking Medical

... to 70 percent of new drug approvals received their first marketing approval outside the United States. That drug "lag" has persisted despite increased knowledge regarding the use of drugs in general and growing understanding of how they affect diseases. The lag persists even for biotechnology-based ...
Guide to Fibromyalgia Management
Guide to Fibromyalgia Management

... a small percentage of people taking tramadol have reported seizures, particularly after combining Ultracet with other medications that are known to put patients at risk for developing seizures, it is important to first carefully assess an individual’s medication profile. The Treatment Of Centrally M ...
Chemical Structure of Donepezil Pharmacokinetics
Chemical Structure of Donepezil Pharmacokinetics

... that are associated with significant losses of presynaptic cholinergic function in the brain. Donepezil enhances cholinergic transmission by reducing the enzymatic degradation of acetylcholine. Donepezil is 1200 times more selective for acetylcholinesterase rather than butylcholinesterase. ...
Canker Sore Treatment
Canker Sore Treatment

... Recently, a new prescription drug, Debacterol, has been released. Debacterol is applied to the ulcer and helps to seal it and allow it to heal. ...
Escort accompanying discharge after ambulatory - STOP-Bang
Escort accompanying discharge after ambulatory - STOP-Bang

... by an infusion drug regimen was not explored. This study used healthy volunteers who did not experience preoperative anxiety, sleep deprivation or postoperative pain which may require analgesia. Furthermore, this could not be extrapolated to the elderly population or different ethnic groups. Nonethe ...
EVALUATION OF REMIFENTANIL IN ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY N. EL B
EVALUATION OF REMIFENTANIL IN ENDOSCOPIC RETROGRADE CHOLANGIO-PANCREATOGRAPHY N. EL B

... The narrow margin of safety concerning depression of spontaneous respiration must be considered seriously. Another disadvantage to consider would be the constrictive effects of morphine derivatives on the ampulla of Vater. However, if this does not surface as an added difficulty, then this possible ...
Bio.B.2- Genetics
Bio.B.2- Genetics

... A trait is a specific ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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