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Megace - Bristol
Megace - Bristol

... anorexia/cachexia and significant weight loss. Of the 100 patients entered on study, 65 met all inclusion/exclusion criteria, had at least two additional post baseline weight measurements over a 12-week period or had one post baseline weight measurement but dropped out for therapeutic failure. Patie ...
Molecular differences between GM
Molecular differences between GM

... “GMO Safety: The following statement was deduced from your findings: Conventional breeding causes more changes in plants than the introduction of a single transgene. Can you make such a generalisation? After all, you only looked at barley. Have comparable studies been carried out on other geneticall ...
SUSCEPTIBILITY PROFILE OF STREPTOCOCCUS PYOGENES
SUSCEPTIBILITY PROFILE OF STREPTOCOCCUS PYOGENES

... and clindamycin is the preferred antibiotic in the treatment of patients with serious soft tissue infections, due to its ability to inhibit the production of several streptococcal virulence factors. Currently, resistance to erythromycin and related antibiotics represents a significant cause for conc ...
Mechanisms of Evolution: Genetic Drift and Natural Selection
Mechanisms of Evolution: Genetic Drift and Natural Selection

... members of the population is its gene pool. For each gene, every individual has only two alleles, but there may be more than two alleles in the gene pool, each with its own frequency. Evolution is frequently defined genetically as a change in the frequency of one or more alleles in the gene pool fro ...
Section 11.3 Other Patterns of Inheritance
Section 11.3 Other Patterns of Inheritance

Principles of Heredity
Principles of Heredity

... In the formation of gametes, the members of a pair of alleles separate (or segregate) cleanly from each other so that only one member is included in each gamete. Each gamete has an equal probability of containing either member of the allele pair. ...
presentation ( format)
presentation ( format)

... • SGRQ score • TDI score improvement of >= 1 unit (%) • Days with no rescue (%)* • Days able to perform activities (%)* ...
Leukaemia Section t(5;12)(q31;p13) in MDS, AML and AEL in Oncology and Haematology
Leukaemia Section t(5;12)(q31;p13) in MDS, AML and AEL in Oncology and Haematology

... with leukemia and congenital fibrosarcoma. DNA / RNA 9 exons; alternate splicing Protein The gene encodes an ETS family transcription factor; the product of this gene contains a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions, and a C-terminal ETS DNA-binding dom ...
Tussionex (hydrocodone resin complex
Tussionex (hydrocodone resin complex

... Phenyltoloxamine, acts as competitive inhibitor of histamine2. As with other antihistamines, it is possible that its sedative and tranquillizing characteristics may contribute to its antitussive action.3 In addition, phenyltoloxamine in a similar manner to other antihistamines has been shown to pote ...
Airgas template
Airgas template

... Type of Medication Errors • Inappropriate prescribing of the drug • Extra, omitted, or wrong doses • Administration of drug to wrong patient • Administration of drug by wrong route or rate • Failure to give medication within prescribed time • Incorrect preparation of a drug • Improper technique whe ...
A case for psilocybin
A case for psilocybin

... That the studies replicated one another is a source of confidence in their findings. However, there were also informative differences between the studies. The group at JHU led by Griffiths et al. investigated the effects of a very low dose (1–3 mg/70 kg, placebo-like) versus high dose (22 mg/70 kg) ...
Prescribing Information
Prescribing Information

... anti-diabetic medication requirements, insulin levels, and psychiatric symptoms may provide an early assessment of response (within 6 weeks) and may help guide early dose titration. Improvements in cushingoid appearance, acne, hirsutism, striae, and body weight occur over a longer period of time and ...
Ch.23 Study Guide
Ch.23 Study Guide

... this allele from all human populations? A) Natural selection is a positive force, so it does not eliminate alleles. B) In populations where endemic malaria is present, heterozygotes have an important advantage: They are resistant to malaria and therefore are more likely to survive and produce offspr ...
Pregabalin Communication - South West Yorkshire Partnership NHS
Pregabalin Communication - South West Yorkshire Partnership NHS

... In common with other CNS depressant medications it is likely that when pregabalin is used in combination with other CNS depressants that there is an additive sedative effect which may impact on the ability to perform tasks, when used alongside alcohol there is an increased risk of death due to respi ...
Symptomatic Relief Policy
Symptomatic Relief Policy

CHRONIC USE OF OXYBUTYNIN AND SPINAL RETENTION AND HEMATURIA
CHRONIC USE OF OXYBUTYNIN AND SPINAL RETENTION AND HEMATURIA

... CHRONIC USE OF OXYBUTYNIN AND SPINAL ANESTHESIA: A CASE OF POSTOPERATIVE URINARY RETENTION AND HEMATURIA Adriano BS Hobaika* Overactive bladder is a disorder characterized by micturition urgency with or without incontinence and with an increased urinary frequency and nocturia. Oxybutynin is the most ...
Pharmacodynamics
Pharmacodynamics

... effects normally predominate, unless the muscarinic receptors are blocked. (No problem for nerves releasing ACh locally onto nicotinic receptors, however). ...
File
File

... A high incidence (up to 50%) of gastrointestinal and CNS side effects is produced Gastric irritation, nausea, anorexia, gastric bleeding and diarrhoea are produced Frontal headache, dizziness, ataxia, mental confusion, hallucination, depression and psychosis can occur Because of prominent adverse ef ...
CONROE lSD - the Conroe ISD Police Department
CONROE lSD - the Conroe ISD Police Department

... • Death • There have been many cases where a drinker falls asleep, lapses into a coma and dies. Many times, the drinker is surrounded by friends, but help is not summoned because they are unaware of the severity of the drinker’s condition. Binge drinking, where drinkers consume excessive amounts of ...
Name
Name

... In animals and in some plants, one pair of chromosomes is different in the two sexes. For example, in humans there are 22 similar pairs of chromosomes (autosomes) and the 23rd pair may be different (sex chromosomes). The sex chromosomes are similar in females and both are referred to as the "X" chro ...
View - SciTechnol
View - SciTechnol

... accident and heard a voice screaming for help at 15:00, the time when the tragic accident occurred. FBs occurred in rapid succession when her condition was severe. TP (2-mg tablet) was administered 3 times daily, and an additional tablet (2 mg) was given when FBs were severe. FBs began to decrease 1 ...
Ernest P - Parthenon Management Group
Ernest P - Parthenon Management Group

... to you and what made it the right path? EN: I also had a strong interest in music. When I was five years old, I started taking piano lessons. When I became a teenager and as my voice changed to a baritone, I became aware that I could sing. The choir master of our church in India, recognizing that I ...
TB1 - BIOCHEM, Bidichandani, Genetic Diseases
TB1 - BIOCHEM, Bidichandani, Genetic Diseases

... 2. histopathalogical examination shows segmental necrosis of muscle fibers which are eventually replaced by adipose or connective tissue. Identification of the dystrophin gene by positional cloning 1. The dystrophin gene was initially mapped to Xp21 for several reasons a. Female with DMD had X-autos ...
controlled drugs
controlled drugs

... have its own controlled drugs cabinet. The sister or acting sister in charge of the operating department is responsible for supplies from all the controlled drugs cabinets. To ensure controlled drugs are readily available, the sister or acting sister in charge may delegate control of access (key hol ...
Clinical Terminologies 1
Clinical Terminologies 1

... • In case of approved pharmaceutical products: A noxious and unintended response at doses normally used or tested in human. • In case of new unregistered pharmaceutical products ( or those products which are not yet approved for the medical condition where they are being tested): A noxious and unint ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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