• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Management of Hypertension - Kementerian Kesihatan Malaysia
Management of Hypertension - Kementerian Kesihatan Malaysia

... were the most current at the time of printing. Specific attempts were made to use local data and publications to ensure local relevance. Adherence to this guideline may not necessarily lead to the best clinical outcome in individual patient care. Every health care provider is responsible for the car ...
CIPRO XR 81532274, R.1 02/11
CIPRO XR 81532274, R.1 02/11

... urinary excretion of ciprofloxacin is virtually complete within 24 hours after dosing. The renal clearance of ciprofloxacin, which is approximately 300 mL/minute, exceeds the normal glomerular filtration rate of 120 mL/minute. Thus, active tubular secretion would seem to play a significant role in i ...
Behavioural analysis of the acute and chronic effects of MDMA
Behavioural analysis of the acute and chronic effects of MDMA

... that MDMA produced a significant hypothermic response over the first 2 days, but not day 3, in the acute drug treatment phase (P<0.05), after which body temperature was comparable with that of the saline controls. Analysis of the effect of MDMA on spontaneous locomotor output revealed an interaction ...
1 - Krishikosh
1 - Krishikosh

... blood cell pigment called hemoglobin. Some anemic individuals have an altered form of this gene, i.e. an allele. which makes a defective hemoglobin protein unable to carry the normal amount of oxygen to the body cells. ...
FULL PRESCRIBING INFORMATION
FULL PRESCRIBING INFORMATION

... for adult patients. In general, dosage adjustments may proceed at approximately weekly intervals. The patient should be observed for a sufficient duration at a given dose to ensure that a maximal benefit has been achieved before a dose increase is considered. In dose-response (fixed-dose) studies (p ...
Fentanyl - Spirit of Healing: Alberta First Nations Conquering
Fentanyl - Spirit of Healing: Alberta First Nations Conquering

... clients at 17 participating harm reduction sites were asked to complete an anonymous questionnaire describing what drugs they used within the last three days and provide a urine sample to test for fentanyl. Nearly 30% of participants tested positive for fentanyl even though 73% did not report using ...
Depressants Sedative Hypnotics
Depressants Sedative Hypnotics

... • Decreases academic performance • Reduces psychomotor functioning • Effects can occur for long periods after the drugs are discontinued • Impairments decrease over time (usually) ...
Epidural Analgesia in Infants and Children
Epidural Analgesia in Infants and Children

... anesthetics and other protein-bound drugs. Preterm infants have even lower levels of α-1-acid glycoprotein than term infants making them particularly susceptible to local anesthetic toxicity. Decreased levels of serum proteins lead to increased unbound, pharmacologically active drug and increased CN ...
Determination of MDMA and its Metabolites in Blood and Urine by
Determination of MDMA and its Metabolites in Blood and Urine by

... Biological samples were obtained from six male healthy volunteers who were recreational users of MDMA.All participants gave the written informed consent and the study was approved by the institutional reviewboard and authorized by the Spanish Ministry of Health (AEMno. 98/112). MDMAwas obtained from ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These
HIGHLIGHTS OF PRESCRIBING INFORMATION These

... Clinically significant hyponatremia (sodium <125 mmol/L) can develop during oxcarbazepine use. In the 14 controlled epilepsy studies 2.5% of oxcarbazepine-treated patients (38/1,524) had a sodium of less than 125 mmol/L at some point during treatment, compared to no such patients assigned placebo or ...
Sotalol versus Amiodarone in Treatment of Atrial Fibrillation
Sotalol versus Amiodarone in Treatment of Atrial Fibrillation

... conversion, or maintenance of sinus rhythm. For each group, a meta-analysis was performed to obtain the common relative success of the primary endpoint (AF conversion). Additionally, data were extracted for adverse events. The statistical analysis was performed by using the Comprehensive Meta-Analys ...
Powder - Farmasi Unand
Powder - Farmasi Unand

... Bulky doses or large volume can be more easily taken by the patient, it mean a powder is a good way of administering it. ...
Data Sheet Name of Medicine Presentation
Data Sheet Name of Medicine Presentation

... Naltrexone Hydrochloride proved superior to placebo in measures of drinking including abstention rates (51% vs. 23%), number of drinking days, and relapse (31% vs. 60%). In a second study with 82 alcohol-dependent patients, the group of patients receiving Naltrexone Hydrochloride were shown to have ...
Development, Physical-Chemical Stability, and Release Studies of
Development, Physical-Chemical Stability, and Release Studies of

... The objective of this study was to evaluate the influence of excipients on the release of spironolactone from four alcohol-free suspensions (pharmaceutical compounding) of spironolactone 5 mg/mL suitable for pediatric use. In addition, the comparison of the physical and chemical stability of the sus ...
Linköping University Post Print Blood-brain barrier penetration of the
Linköping University Post Print Blood-brain barrier penetration of the

... multidrug resistance (MDR) gene MDR1 (also known as ABCB1). P-gp is a membrane-bound ATP-dependent efflux transporter present at high concentrations in the apical membrane of the endothelial cells of the brain capillaries (Beaulieu et al., 1997; Biegel et al., 1995). P-gp and other drug transporters ...
Opposite effects of MDMA
Opposite effects of MDMA

... its euphoric effects. MDMA releases serotonin (5-HT), norepinephrine (NE), and dopamine through an interaction with the corresponding presynaptic monoamine uptake transporter. 5HT transport inhibitors block MDMA-induced 5-HT release in vitro or in animals and also attenuate the subjective and cardio ...
It is Possible Find an Antidepressant with Faster Onset of Action
It is Possible Find an Antidepressant with Faster Onset of Action

... impairments, altered thought content as well as alteration of mnemonic functions [31,61,62]. Thus, testing the impact of chronic ketamine on these items in longer-term controlled studies is critical. Distressing adverse events following ketamine infusion, as anxiety, might raise the risk of suicidal ...
Design of Genetical Genomics Studies Which Use Two
Design of Genetical Genomics Studies Which Use Two

... School of Mathematical Sciences Centre for Statistics ...
Illumina VariantStudio User Guide
Illumina VariantStudio User Guide

... Definitions. "Application Specific IP" means Illumina owned or controlled intellectual property rights that pertain to this Product (and use thereof) only with regard to specific field(s) or specific application(s). Application Specific IP excludes all Illumina owned or controlled intellectual prope ...
Full-Text PDF
Full-Text PDF

... Poor solubility is one of the main problems faced by researchers during drug development. Commonly, even with the use of current computational “filters” to minimize this problem, compounds that are active in vitro may lack adequate pharmacokinetic properties and/or may be difficult to formulate [1]. ...
Adalat OROS PI
Adalat OROS PI

... after Adalat OROS administration and reach a plateau at approximately six hours after the first dose. For subsequent doses, relatively constant plasma concentrations at this plateau are maintained with minimal fluctuations over the 24 hour dosing interval. At steady state, the bioavailability of Ada ...
PRODUCT INFORMATION METHADONE SYRUP
PRODUCT INFORMATION METHADONE SYRUP

... evaluated for modifiable risk factors, such as concomitant medications with cardiac effects, drugs which might cause electrolyte abnormalities, and drugs which might act as inhibitors of methadone metabolism. Dependence In common with all opioids, prolonged use of methadone has the potential to prod ...
Important Drug Information
Important Drug Information

... toxic effect, mucositis. However, there are some regimens which divide the dose over three successive days (20-25 mg/m2 or 0.4-0.8 mg/kg). It is thought that this regimen has greater effectiveness although at a cost of higher toxicity. Administration of doxorubicin in a weekly regimen has been shown ...
Genetic balancers
Genetic balancers

... non-conditional recessive lethal mutations, at present the largest class of lethal, cannot be kept as homozygotes, and in heterozygotes the mutations can be lost easily through segregation unless there is a means to identify the heterozygotes that carry them. Maintenance of the heterozygous genotype ...


... subject.’ The FDA publicly stated numerous times that it ...
< 1 ... 36 37 38 39 40 41 42 43 44 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report