On the Influence of Phenotype Plasticity on Genotype Diversity
... Numerous diversity indices have been suggested in the biology literature, but it was shown that no single index is universally superior [18]. In computational intelligence, diversity has been studied too, mainly in artificial life and evolutionary computation [19], [20]. Although developed for diffe ...
... Numerous diversity indices have been suggested in the biology literature, but it was shown that no single index is universally superior [18]. In computational intelligence, diversity has been studied too, mainly in artificial life and evolutionary computation [19], [20]. Although developed for diffe ...
2 Long-acting agonists: a new perspective
... ~ 2 -adrenoceptor agonists used as bronchodilators have played an important part in the treatment of asthma during the last 20 yrs. These selective drugs have the advantage over nonspecific ~-adrenoceptor agonists such as isoprenaline, being devoid particularly of cardiac sideeffects [1 ]. Selective ...
... ~ 2 -adrenoceptor agonists used as bronchodilators have played an important part in the treatment of asthma during the last 20 yrs. These selective drugs have the advantage over nonspecific ~-adrenoceptor agonists such as isoprenaline, being devoid particularly of cardiac sideeffects [1 ]. Selective ...
Page 1 of 36 012017-6 HIGHLIGHTS OF PRESCRIBING
... Respiratory depression, including fatal cases, have been reported during initiation and conversion of patients to methadone, and even when the drug has been used as recommended and not misused or abused [see Warnings and Precautions (5.1)]. Proper dosing and titration are essential and methadone hyd ...
... Respiratory depression, including fatal cases, have been reported during initiation and conversion of patients to methadone, and even when the drug has been used as recommended and not misused or abused [see Warnings and Precautions (5.1)]. Proper dosing and titration are essential and methadone hyd ...
Acetylcholine-Activated Potassium Channel as a Novel Target for AF
... practice with prevalence of over 2,200,000 and 1,300,000 in the United States and Japan, respectively. The prevalence of AF is strongly age dependent; less than 1% of individuals aged <60 years, but approximately 5% of those older than 65 years and about 8% of those older than 80 years are affected ...
... practice with prevalence of over 2,200,000 and 1,300,000 in the United States and Japan, respectively. The prevalence of AF is strongly age dependent; less than 1% of individuals aged <60 years, but approximately 5% of those older than 65 years and about 8% of those older than 80 years are affected ...
-handouts
... issue‐brief.pdf. Reviewed July 2010. Last accessed 14 October 2014. Chou R, Deyo R, Devine B, et al. The Effectiveness and Risks of Long‐Term Opioid Treatment of Chronic Pain. Evidence Report/Technology Assessment No. 218. (Prepared by the Pacific Northwest Evidence‐based Practice Center under Con ...
... issue‐brief.pdf. Reviewed July 2010. Last accessed 14 October 2014. Chou R, Deyo R, Devine B, et al. The Effectiveness and Risks of Long‐Term Opioid Treatment of Chronic Pain. Evidence Report/Technology Assessment No. 218. (Prepared by the Pacific Northwest Evidence‐based Practice Center under Con ...
Extract from the Clinical Evaluation Report for Ceftobiprole
... (Tarrago 2011, Beall 2011). The reported EU prevalence of S. pneumoniae isolates submitted to the EARS-NET surveillance network in 2010 with 3.7% penicillin resistance; 9.3% intermediate penicillin resistance; macrolide resistance among these isolates was 15% (EARS-NET 2012). Other important bacteri ...
... (Tarrago 2011, Beall 2011). The reported EU prevalence of S. pneumoniae isolates submitted to the EARS-NET surveillance network in 2010 with 3.7% penicillin resistance; 9.3% intermediate penicillin resistance; macrolide resistance among these isolates was 15% (EARS-NET 2012). Other important bacteri ...
Chronic l-Alpha Acetylmethadol in Rhesus Monkeys
... the simple FR schedule in monkeys receiving LAAM daily are presented as a percentage of the average rate of responding during the 10 cycles immediately preceding LAAM treatment. Results of drug discrimination studies are presented as the average percentage of responses on the naltrexone lever (i.e., ...
... the simple FR schedule in monkeys receiving LAAM daily are presented as a percentage of the average rate of responding during the 10 cycles immediately preceding LAAM treatment. Results of drug discrimination studies are presented as the average percentage of responses on the naltrexone lever (i.e., ...
Product Monograph
... As with levodopa, SINEMET® may cause involuntary movements and mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. Because carbidopa permits more levodopa to reach the brain and thus, more dopamine to be formed, dyskinesias may ...
... As with levodopa, SINEMET® may cause involuntary movements and mental disturbances. These reactions are thought to be due to increased brain dopamine following administration of levodopa. Because carbidopa permits more levodopa to reach the brain and thus, more dopamine to be formed, dyskinesias may ...
pharmacy technical assistance - Ministère de l`Éducation et de l
... A situational competency describes the situation in which students are placed to acquire learning, and allows for actions and results to vary from one student to another. It consists of the following features: The statement of the competency is the result of the job analysis, the orientations and ge ...
... A situational competency describes the situation in which students are placed to acquire learning, and allows for actions and results to vary from one student to another. It consists of the following features: The statement of the competency is the result of the job analysis, the orientations and ge ...
TAZORAC® Cream Prescribing Information
... Application of TAZORAC® Cream may cause excessive irritation in the skin of certain sensitive individuals. Some individuals may experience excessive pruritus, burning, skin redness or peeling. If these effects occur, the medication should either be discontinued until the integrity of the skin is res ...
... Application of TAZORAC® Cream may cause excessive irritation in the skin of certain sensitive individuals. Some individuals may experience excessive pruritus, burning, skin redness or peeling. If these effects occur, the medication should either be discontinued until the integrity of the skin is res ...
Document
... In fact rapidly decrease of BP is more dangerous • because decreased of Bp suddenly impaired cardiac and brain flow and MI and CVA risk increased. ...
... In fact rapidly decrease of BP is more dangerous • because decreased of Bp suddenly impaired cardiac and brain flow and MI and CVA risk increased. ...
ESC 2003
... "I could say I am pleased and not particularly surprised." It was already known to compare well to warfarin in efficacy while being easier to use How does this compare with using two antiplatelet drugs together? ...
... "I could say I am pleased and not particularly surprised." It was already known to compare well to warfarin in efficacy while being easier to use How does this compare with using two antiplatelet drugs together? ...
Full Prescribing Information
... General: Trimethoprim should be given with caution to patients with possible folate deficiency. Folates may be administered concomitantly without interfering with the antibacterial action of trimethoprim. Trimethoprim should also be given with caution to patients with impaired renal or hepatic funct ...
... General: Trimethoprim should be given with caution to patients with possible folate deficiency. Folates may be administered concomitantly without interfering with the antibacterial action of trimethoprim. Trimethoprim should also be given with caution to patients with impaired renal or hepatic funct ...
Riboflavin 0.1% (VibeX) for the treatment of keratoconus
... investigate the use of riboflavin and UVA irradiation in achieving crosslinking of corneal collagen. Using this method, Wollensak et al. [17] demonstrated a marked positive effect of crosslinking on the biomechanical properties of both porcine and human corneal tissue: crosslinking was shown to incr ...
... investigate the use of riboflavin and UVA irradiation in achieving crosslinking of corneal collagen. Using this method, Wollensak et al. [17] demonstrated a marked positive effect of crosslinking on the biomechanical properties of both porcine and human corneal tissue: crosslinking was shown to incr ...
SALT SOLID DISPERSIONS
... It is difficult to express in words the deep sense of gratitude that I have for my respected advisor, Dr. Tamara Minko. Her scientific curiosity, assertiveness at every critical step, generous encouragement and patience has made this thesis possible. She has become a role model for me not only as sh ...
... It is difficult to express in words the deep sense of gratitude that I have for my respected advisor, Dr. Tamara Minko. Her scientific curiosity, assertiveness at every critical step, generous encouragement and patience has made this thesis possible. She has become a role model for me not only as sh ...
the Kaloba Monograph PDF
... study: Even in 1980, only one case of rheumatic fever occurred during the working life of 12 general practitioners. Based on this minimal risk, the authors concluded that immediate antibiotic treatment should not be recommended. However, it is generally accepted that patients presenting with acute s ...
... study: Even in 1980, only one case of rheumatic fever occurred during the working life of 12 general practitioners. Based on this minimal risk, the authors concluded that immediate antibiotic treatment should not be recommended. However, it is generally accepted that patients presenting with acute s ...
μ-Opioid Receptor-Mediated Depression of the Hypothalamic
... brain regions that are thought to play a role in the addictive actions of drugs of abuse, including the ventral tegmental area, locus ceruleus, nucleus accumbens, and lateral hypothalamus (LH) (Nestler and Aghajanian, 1997; Peyron et al., 1998). The opiate morphine increases cAMP response element (C ...
... brain regions that are thought to play a role in the addictive actions of drugs of abuse, including the ventral tegmental area, locus ceruleus, nucleus accumbens, and lateral hypothalamus (LH) (Nestler and Aghajanian, 1997; Peyron et al., 1998). The opiate morphine increases cAMP response element (C ...
Opioid Withdrawal: A New Look At Medication
... clonidine and lofexidine were more effective than placebo in managing withdrawal from heroin or methadone and were more likely to be associated with treatment completion than placebo. The studies conclude that alpha-2 adrenergic agonists may be an alternative in treating opioid withdrawal.12 Sos et ...
... clonidine and lofexidine were more effective than placebo in managing withdrawal from heroin or methadone and were more likely to be associated with treatment completion than placebo. The studies conclude that alpha-2 adrenergic agonists may be an alternative in treating opioid withdrawal.12 Sos et ...
Submission Guidelines for the CADTH Common Drug Review
... applications for the review of submissions and resubmissions for drugs through the CADTH Common Drug Review (CDR) process. The Submission Guidelines for the CADTH Common Drug Review is a companion document to the Procedure for the CADTH Common Drug Review, a document that describes CDR procedures to ...
... applications for the review of submissions and resubmissions for drugs through the CADTH Common Drug Review (CDR) process. The Submission Guidelines for the CADTH Common Drug Review is a companion document to the Procedure for the CADTH Common Drug Review, a document that describes CDR procedures to ...
new insights into the role of environmental context in the expression
... environmental stimuli that consistently precede such responses, along with interoceptive stimuli arising from the drug itself, can acquire discriminative stimulus control over the occurrence of those responses. Clearly, the potential for drug–environment interactions is increased when drugs are admi ...
... environmental stimuli that consistently precede such responses, along with interoceptive stimuli arising from the drug itself, can acquire discriminative stimulus control over the occurrence of those responses. Clearly, the potential for drug–environment interactions is increased when drugs are admi ...
Basics and Potential Applications of Surfactants
... drugs. The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles which composed o ...
... drugs. The low solubility in biological fluids displayed by about 50% of the drugs still remains the main limitation in oral, parenteral, and transdermal administration. Among the existing strategies to overcome these drawbacks, inclusion of hydrophobic drugs into polymeric micelles which composed o ...
Rosiver - Galderma
... 12 weeks was statistically more effective than vehicle cream in terms of IGA success rate and absolute change in inflammatory lesion counts (p<0.001). Starting from 4 weeks of treatment, ROSIVER was significantly more effective than vehicle cream for both the co-primary efficacy endpoints (p<0.05). ...
... 12 weeks was statistically more effective than vehicle cream in terms of IGA success rate and absolute change in inflammatory lesion counts (p<0.001). Starting from 4 weeks of treatment, ROSIVER was significantly more effective than vehicle cream for both the co-primary efficacy endpoints (p<0.05). ...
Noxafil - Merck.com
... severe renal impairment (creatinine clearance <50 mL/min), unless an assessment of the benefit/risk to the patient justifies the use of Noxafil injection. (5.4, 8.6) Midazolam: Noxafil can prolong hypnotic/sedative effects. Monitor patients and benzodiazepine receptor antagonists should be availab ...
... severe renal impairment (creatinine clearance <50 mL/min), unless an assessment of the benefit/risk to the patient justifies the use of Noxafil injection. (5.4, 8.6) Midazolam: Noxafil can prolong hypnotic/sedative effects. Monitor patients and benzodiazepine receptor antagonists should be availab ...
see Warnings and - Boehringer Ingelheim
... Clinically significant hyponatremia (sodium <125 mmol/L) can develop during oxcarbazepine use. In the 14 controlled epilepsy studies 2.5% of oxcarbazepine-treated patients (38/1,524) had a sodium of less than 125 mmol/L at some point during treatment, compared to no such patients assigned placebo or ...
... Clinically significant hyponatremia (sodium <125 mmol/L) can develop during oxcarbazepine use. In the 14 controlled epilepsy studies 2.5% of oxcarbazepine-treated patients (38/1,524) had a sodium of less than 125 mmol/L at some point during treatment, compared to no such patients assigned placebo or ...