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Guideline for the diagnosis and management of hypertension in adults
Guideline for the diagnosis and management of hypertension in adults

RIVM rapport 370030002 Trends in drug substances detected in
RIVM rapport 370030002 Trends in drug substances detected in

... (Table 2). The weight-loss drugs identified are associated with serious adverse effects and have also been frequently identified in weight-loss products in other countries. In an attempt to assess adverse effects in the Netherlands, a national database was accessed for information on potential intox ...
Vernalization Gene Architecture as a Predictor of Growth Habit in
Vernalization Gene Architecture as a Predictor of Growth Habit in

... facultative forms can be planted in the fall or spring. Growth habit is important because it determines the range of adaptation. Winter and fall-sown facultative varieties generally yield more than spring-planted forms, provided that they have sufficient winter hardiness. However, a lack of winter ...
The effect of morphine on the activity evoked in
The effect of morphine on the activity evoked in

... connected to an electrometer (W-P Instruments Model M-4AI~M), and were amplified, displayed on a cathode ray oscilloscope and evaluated with an averaging computer (Fabri-Tek 1062; the number of computer addresses used was 512 or 1024) after having been stored on tape (Philips Aria-Log 7). The experi ...
Original salbutamol versus similar salbutamol in
Original salbutamol versus similar salbutamol in

... A problem that arises at the time of prescribing a medicine as part of a cost-effective strategy is the replacement of original medicines by similar products. It is necessary to have available scientific evidence so as to determine, by means of bioequivalence studies, that a similar active ingredien ...
University of Groningen The a-typical effects of olanzapine on body
University of Groningen The a-typical effects of olanzapine on body

... designed to be antagonistic on 5-HT2A/C and dopamine receptors [1,2] for treatment of schizophrenia and bipolar disorder. However, besides its effect on psychotic illnesses, Olanzapine in humans causes body weight gain and increases the risk of developing type 2 Diabetes [3-5]. The underlying mechan ...
SERIES ‘‘UPDATE ON TUBERCULOSIS’’ Number 4 in this Series
SERIES ‘‘UPDATE ON TUBERCULOSIS’’ Number 4 in this Series

... 2HRZE/6HE was significantly inferior to the 6-month regimen 2HRZE/4HR [19]. A systematic review has also shown that regimens utilising rifampicin only for the first 1–2 months had significantly higher rates of failure, relapse and acquired drug resistance compared with regimens that used rifampicin ...
Hypertension, Review and Updates
Hypertension, Review and Updates

... Electronic Blood Pressure Monitor • The patient should be calmly seated for at least 5 minutes, with his or her back well supported and arm supported at the level of the heart. His or her feet should touch the floor and legs should not be crossed. The patient should be instructed not to talk prior a ...
The Role of CYP3A4 mRNA Transcript with Shortened 3
The Role of CYP3A4 mRNA Transcript with Shortened 3

... the metabolism of a variety of xenobiotics and endobiotics, including drugs, environmental chemicals, ...
Olanzapine causes hypothermia, inactivity, a deranged
Olanzapine causes hypothermia, inactivity, a deranged

... et al., 2001), in skeletal muscle (Hajduch et al., 1999) and adipose tissue (Yang et al., 2009). The wide-spread distribution of putative action site for Olanzapine explains the multitude of mechanisms and various time–dose relationships that have been reported with Olanzapine treatment in humans. E ...
Drugs of Abuse in Saliva: A Review
Drugs of Abuse in Saliva: A Review

... into 1 l-nor-A9-THC-9-carboxylic acid (THC-COOH) which circulates in blood and is the most prevalent metabolite found in urine (20). Therefore, this metabolite has been recommended for confirmatory testing of samples identified as positive in screening procedures (24). If THC-COOH is not transferred ...
Assessment report - Voncento - HUMAN COAGULATION FACTOR
Assessment report - Voncento - HUMAN COAGULATION FACTOR

... Haemophilia A (congenital FVIII deficiency): Prophylaxis and treatment of bleeding in patients with haemophilia A. Voncento 250 IU/600 IU is indicated in adults and adolescents from 12-18 years. The legal basis for this application refers to: Article 8.3 of Directive 2001/83/EC - complete and indepe ...
SERIES ‘‘PULMONARY HYPERTENSION: BASIC CONCEPTS FOR PRACTICAL MANAGEMENT’’
SERIES ‘‘PULMONARY HYPERTENSION: BASIC CONCEPTS FOR PRACTICAL MANAGEMENT’’

... blood test that reflected increased or decreased vasoconstrictive and remodelling activity and this marker would be exquisitely sensitive to improvements rendered by new therapies. The currently available markers of vascular function are largely markers of endothelial cell and/or platelet dysfunctio ...
modafinil - Awake Institute, LLC
modafinil - Awake Institute, LLC

... Modafinil has a hyperthermic effect (i.e. elevates core body temperature) (28,32) with temperature increase of 0.15-0.2 degrees. This could have implications on heat tolerance. However, one study concluded that it is not very clear if the hyperthermic effect with modafinil may actually result from s ...
technical monographs - Nutramax Laboratories
technical monographs - Nutramax Laboratories

... 30. Au RY, Au AY, Frondoza CF. Suppression of TNF- ␣ , IL-1␤, iNOS, and P38 expression by the combination of avocado soy unsaponifiables, glucosamine, and chondroitin sulfate in human macrophage-like THP-1 cells. [abstract] In Proceedings of the Osteoarthritis Research Society International. 11th Wo ...
Salvia Divinorum: Establish Restrictions But Don`t Criminalize It
Salvia Divinorum: Establish Restrictions But Don`t Criminalize It

... Health determined that 1.8 million Americans had used Salvia in their lifetime. The survey found that Salvia use decreases with age, and that many respondents had already used Salvia by age 18.xxiv Studies have also found that Salvia can be acquired through online retailers, many based in foreign co ...
Product Monograph ZANTAC
Product Monograph ZANTAC

... metabolized drug in 24 hours). There is a significant linear correlation between the dose administered and the inhibitory effect upon gastric acid secretion for oral doses up to 300 mg. A plasma ranitidine concentration of 50 ng/mL has an inhibitory effect upon stimulated gastric acid secretion of a ...
Paritaprevir / Ritonavir / Ombitasvir and Dasabuvir
Paritaprevir / Ritonavir / Ombitasvir and Dasabuvir

... © Commonwealth of Australia 2017 This work is copyright. You may reproduce the whole or part of this work in unaltered form for your own personal use or, if you are part of an organisation, for internal use within your organisation, but only if you or your organisation do not use the reproduction fo ...
Obagi Tretinoin - ZO Skin Health
Obagi Tretinoin - ZO Skin Health

... to the sun. Therapy with tretinoin may make your skin more susceptible to sunburn and other adverse effects of the sun, so unprotected exposure to natural or artificial sunlight should be minimized. Laboratory findings. When laboratory mice are exposed to artificial sunlight, they often develop skin ...
Amphetamine-Type Stimulants: A Global Review, 1996
Amphetamine-Type Stimulants: A Global Review, 1996

... present paper is an attempt to assess the validity of this proposition. The subject is too vast and intricate to cover in a single review, but guidance for achieving a manageable focus can be found in two areas: the level of international consensus in defining a critical area and the nature of the s ...
Drug treatments for Parkinson`s
Drug treatments for Parkinson`s

... – symptoms that aren’t connected to movement problems. These include anxiety and depression, pain and constipation. Parkinson’s drugs are not used to treat the symptoms of Parkinson’s that are not related to movement. These types of non-motor symptoms will be treated separately depending on the prob ...
ALLEGRA-D - hebust.edu.cn
ALLEGRA-D - hebust.edu.cn

... The pharmacokinetics of fexofenadine hydrochloride and pseudoephedrine hydrochloride when administered separately have been well characterized. Fexofenadine pharmacokinetics were linear for oral doses of fexofenadine hydrochloride up to 120 mg twice daily. The mean elimination half-life of fexofenad ...
Ketorolac Tromethamine Injection, USP
Ketorolac Tromethamine Injection, USP

... Ketorolac tromethamine injection is indicated for the short-term (≤5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ketorolac tromethamine injection, and oral ...
A Use of Metformin in the Setting of ficiency Mild-to-Moderate Renal Insuf
A Use of Metformin in the Setting of ficiency Mild-to-Moderate Renal Insuf

... points for contraindication to metformin were considered to be appropriate at 1.4 mg/dL in women and 1.5 mg/dL in men. This was based on the calculated ability to remove 3 g of metformin (an amount slightly beyond the maximum daily U.S. dose) at steady-state levels within 24–48 h. In fact, the abili ...
DENDRIMERS - Pharmawiki.in
DENDRIMERS - Pharmawiki.in

... their use as unimolecular micelles and ‘dendritic boxes’ for the noncovalent encapsulation of drug molecules ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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